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British Journal of Radiology

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https://www.readbyqxmd.com/read/30226413/aguix-%C3%A2-from-bench-to-bedside-transfer-of-an-ultrasmall-theranostic-gadolinium-based-nanoparticle-to-clinical-medicine
#1
François Lux, Vu Long Tran, Eloïse Thomas, Sandrine Dufort, Fabien Rossetti, Matteo Martini, Charles Truillet, Tristan Doussineau, Guillaume Bort, Franck Denat, Frédéric Boschetti, Goran Angelovski, Alexandre Detappe, Yannick Crémillieux, Nathalie Mignet, Bich-Thuy Doan, Benoit Larrat, Sébastien Meriaux, Emmanuel Barbier, Stéphane Roux, Peter Fries, Andreas Müller, Marie-Caline Abadjian, Carolyn Anderson, Emmanuelle Canet-Soulas, Penelope Bouziotis, Muriel Barberi-Heyob, Céline Frochot, Camille Verry, Jacques Balosso, Michael Evans, Jacqueline Sidi-Boumedine, Marc Janier, Karl Butterworth, Stephen McMahon, Kevin Prise, Marie-Thérèse Aloy, Dominique Ardail, Claire Rodriguez-Lafrasse, Erika Porcel, Sandrine Lacombe, Ross Berbeco, Awatef Allouch, Jean-Luc Perfettini, Cyrus Chargari, Eric Deutsch, Géraldine Le Duc, Olivier Tillement
AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration...
September 18, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30226081/measurement-of-splenic-stiffness-by-2d-shear-wave-elastography-in-patients-with-extrahepatic-portal-vein-obstruction
#2
Kumble Seetharama Madhusudhan, Ragini Kilambi, Shalimar, Peush Sahni, Raju Sharma, Deep Narayan Srivastava, Arun Kumar Gupta
OBJECTIVE: To assess the accuracy of splenic stiffness (SS) measured by 2D-shear wave elastography (SWE) for predicting variceal bleeding in the patients with extrahepatic portal vein obstruction (EHPVO). METHODS: 52 patients with EHPVO (mean age: 22.29 years; 26 each males and females) were included in the study after obtaining approval from the institute ethics committee. All patients initially underwent upper gastrointestinal endoscopy followed by ultrasonography, including 2D-SWE on the Aixplorer Supersonic Imagine scanner...
September 18, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30160176/dynamic-mri-of-the-pelvic-floor-comparison-of-performance-in-supine-vs-left-lateral-body-position
#3
Khoschy Schawkat, Bettina Pfister, Helen Parker, Henriette Heinrich, Borna K Barth, Dominik Weishaupt, Mark Fox, Caecilia S Reiner
OBJECTIVE: To investigate the performance of MR-defecography (MRD) in lateral body position as an alternative to supine position. METHODS: 22 consecutive patients (16 females; mean age 51 ± 19.4) with obstructed defecation and 20 healthy volunteers (11 females; mean age 33.4 ± 11.5) underwent MRD in a closed-configuration 3T-MRI in supine and lateral position. MRD included T2 weighted images at rest and during defecation after filling the rectum with 250 ml water-based gel...
September 18, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30215550/the-feasibility-of-synthetic-mri-in-breast-cancer-patients-comparison-of-t2-relaxation-time-with-multi-echo-spin-echo-t2-mapping-method
#4
Yongsik Jung, Sung-Min Gho, Seung Nam Back, Taeyang Ha, Doo Kyoung Kang, Tae Hee Kim
OBJECTIVE: To compare the T2 relaxation times acquired with synthetic MRI to those of multi-echo spin-echo sequences and to evaluate the usefulness of synthetic MRI in the clinical setting. METHODS: From January 2017 to May 2017, we included 51 patients with newly diagnosed breast cancer, who underwent additional synthetic MRI and multi -echo spin-echo (MESE) T2 mapping sequences. Synthetic MRI technique uses a multiecho and multi-delay acquisition method for the simultaneous quantification of physical properties such as T1 and T2 relaxation times and proton density image map...
September 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30215546/pre-clinical-imaging-for-establishment-and-comparison-of-orthotopic-non-small-cell-lung-carcinoma-in-search-for-models-reflecting-clinical-scenarios
#5
Rozina Aktar, Antje Dietrich, Falk Tillner, Shady Kotb, Steffen Löck, Henning Willers, Michael Baumann, Mechthild Krause, Rebecca Bütof
Objective Clinically relevant animal models of non-small cell lung carcinoma (NSCLC) are required for the validation of novel treatments. We compared two different orthotopic transplantation techniques as well as imaging modalities to identify suitable mouse models mimicking clinical scenarios. Methods We used three genomically diverse NSCLC cell lines [National Cancer Institute (NCI)-H1703 adenosquamous cell carcinoma, NCI-H23 adenocarcinoma and A549 adenocarcinoma) for implanting tumour cells either as spheroids or cell suspension into lung parenchyma...
September 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30215531/non-occlusive-mesenteric-ischaemia-ct-findings-clinical-outcomes-and-assessment-of-the-diameter-of-the-superior-mesenteric-artery-don-t-forget-the-reperfusion-process
#6
Maria Antonietta Mazzei, Francesco Gentili, Francesco Giuseppe Mazzei, Roberto Grassi, Luca Volterrani
No abstract text is available yet for this article.
September 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209959/dosimetric-assessment-of-tumor-control-probability-in-intensity-and-volumetric-modulated-radiotherapy-plans
#7
Hesheng Wang, Benjamin T Cooper, Peter Schiff, Nicholas J Sanfilippo, S Peter Wu, Kenneth S Hu, Indra J Das, Jinyu Xue
OBJECTIVE: Radiobiological models have been used to calculate the outcomes of treatment plans based on dose-volume relationship. This study examines several radiobiological models for the calculation of tumor control probability (TCP) of intensity modulated radiotherapy plans for the treatment of lung, prostate, and head and neck (H&N) cancers. METHODS: Dose volume histogram (DVH) data from the intensity modulated radiotherapy plans of 36 lung, 26 prostate, and 87  H&N cases were evaluated...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209958/colonic-distention-and-patient-acceptance-of-ct-colonography-supine-prone-versus-left-right-lateral-scanning
#8
Noriaki Takahashi, Koichi Nagata, Atsushi Iyama, Teppei Mikami, Hidenori Kanazawa, Hiroshi Saito
OBJECTIVE: To prospectively evaluate and complete the colonic distention and patient acceptance of CT colonography (CTC) in the supine/prone and left/right lateral positions. METHODS: A total of 220 consecutive patients were alternately allocated to the supine/prone positioning or left/right lateral positioning group. Two readers scored the degree of colonic distention by segment using a 4-point Likert scale (4 = optimal, 3 = adequate, 2 = inadequate, 1 = collapsed)...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209957/determination-of-mammographic-breast-density-using-a-deep-convolutional-neural-network
#9
Alexander Ciritsis, Cristina Rossi, Ilaria De Martini, Matthias Eberhard, Magda Marcon, Anton S Becker, Nicole Berger, Andreas Boss
OBJECTIVE: High breast density is a risk factor for breast cancer. The aim of this study was to develop a deep convolutional neural network (dCNN) for the automatic classification of breast density based on the mammographic appearance of the tissue according to the American College of Radiology Breast Imaging Reporting and Data System (ACR BI-RADS) Atlas. MATERIALS AND METHODS: In this study, 20,578 mammography single views from 5,221 different patients (58.3 ± 11...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209956/combined-application-of-isotropic-three-dimensional-fast-spin-echo-3d-fse-cube-with-2-point-dixon-fat-water-separation-flex-and-3d-fse-cube-in-mr-dacryocystography
#10
Ping Liu, Qiuxia Wang, Chengdong Peng, Ban Luo, Jing Zhang
OBJECTIVE: To evaluate the image quality of magnetic resonance dacryocystography (MRD) using 3D-FSE-Cube and 3D-FSE-Cube-Flex sequences to examine the lacrimal drainage system (LDS). METHOD: Twenty-one healthy volunteers underwent 3D-FSE-Cube and 3D-FSE-Cube-Flex MRD after topical administration of compound sodium chloride eye drops. Two radiologists assessed LDS images in a blinded fashion. The signal-to-noise ratio (SNR) of fluid-filling and the contrast-to-noise ratio (CNR) of fluid-turbinate were compared between the two sequences...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209954/value-of-pet-mri-for-assessing-tumor-resectability-in-nsclc-intra-individual-comparison-with-pet-ct
#11
Michael Messerli, Felipe Barbosa, Magda Marcon, Urs J Muehlematter, Paul Stolzmann, René Warschkow, Gaspar Delso, Edwin Egw Ter Voert, Martin W Huellner, Thomas Frauenfelder, Patrick Veit-Heibach
OBJECTIVE: The purpose of this study was to compare the diagnostic accuracy of positron emission tomography (PET)/MRI with PET/CT for determining tumor resectability of non-small cell lung cancer (NSCLC). METHODS: Sequential trimodality PET/CT/MRI was performed in 36 patients referred with the clinical question of resectability assessment in NSCLC. PET/CT and PET/MR images including T1 -weighted sequence (T1-Dixon) and respiration gated T2 -weighted sequence (T2-Propeller) were evaluated for resectability-defining factors; i...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209953/bi-plane-and-single-plane-angiography-a-study-to-compare-contrast-usage-and-radiation-doses-for-adult-cardiac-patients-in-diagnostic-studies
#12
Keith Smith, James Crowhurst, Darren Walters, Deborah Starkey
OBJECTIVE: This study compares the performance of bi-plane coronary angiography against single plane angiography in terms of the volume of contrast used (ml) and the total Dose Area Product (DAP) (uGym2 ) to the patient measured directly via flat panel detectors. METHODS: A total of 5176 adult diagnostic cardiac angiograms from a hospital in Brisbane, Australia were retrospectively studied. Patients with aortograms, iliac or femoral artery imaging, and stenting or graft interventions were excluded...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30209952/effect-of-androgen-deprivation-and-radiation-therapy-on-mri-fiber-tractography-in-prostate-cancer-can-we-assess-treatment-response-on-imaging
#13
Sandeep Hedgire, Aoife Kilcoyne, Alexey Tonyushkin, Yun Mao, Jennifer W Uyeda, Debra A Gervais, Mukesh G Harisinghani
OBJECTIVES: To evaluate quantitative changes in Diffusion Tensor Magnetic Resonance Tractography in prostate cancer following androgen deprivation and radiation therapy. METHODS: 22 patients with elevated PSA and biopsy proven prostate carcinoma who underwent MRI of the prostate at 1.5 T with an endorectal coil were included. Group A) was the study group (n = 11), participants who underwent androgen deprivation and/ or radiation therapy and group B) were Gleason-matched control group (n = 11) participants who did not undergo such therapy...
September 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30168728/3d-ct-segmentation-of-cam-type-femoroacetabular-impingement-reliability-and-relationship-of-cam-lesion-with-anthropomorphic-features
#14
Lihua Zhang, Joel E Wells, Riham Dessouky, Adam Gleason, Rajiv Chopra, Yonatan Chatzinoff, Nicholas P Fey, Yin Xi, Avneesh Chhabra
OBJECTIVE: Evaluate feasibility and reliability of 3DCT semi-automatic segmentation and volumetrics of CAM lesions in femoroacetabular impingement and determine correlations with anthropometrics. METHODS: A consecutive series of 43 patients with CAM type FAI underwent 3DCT. 20 males and 23 females (30 unilateral and 13 bilateral symptomatic hips) were included. 56 CAM lesions and femoral heads were segmented by two readers. Radial images were obtained for alpha angles...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30160173/ultrasmall-superparamagnetic-iron-oxide-nanoparticle-uptake-as-noninvasive-marker-of-aortic-wall-inflammation-on-mri-proof-of-concept-study
#15
Sandeep Hedgire, Cicely Krebill, Gregory R Wojtkiewicz, Irai Oliveira, Brian B Ghoshhajra, Udo Hoffmann, Mukesh G Harisinghani
OBJECTIVE: Radiation therapy for cancer can lead to atherosclerosis by inducing inflammatory changes in the vascular wall. It is difficult to quantitatively measure inflammation on CT and MRI studies. The purpose of this study was to assess the use of ferumoxytol, an ultrasmall superparamagnetic iron oxide nanoparticle, as a noninvasive marker of vessel wall inflammation secondary to radiation therapy in pancreatic cancer patients in comparison with healthy volunteers. METHODS: MRI of upper abdomen (T1 , T2 , multi echo T2 * weighted imaging) was performed on 3 T magnet before and 48 h after intravenous administration of ferumoxytol in pancreatic cancer patients who underwent radiation therapy (n = 8) and in healthy volunteers (n = 8)...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30129789/patterns-of-failure-in-rectal-cancer-with-positive-circumferential-resection-margin-after-surgery-following-preoperative-chemoradiation-a-propensity-score-matching-analysis
#16
Youngkyong Kim, Dae Yong Kim, Tae Hyun Kim, Sun Young Kim, Ji Yeon Baek, Min Ju Kim, Hee Jin Chang, Yongjun Cha, Sung Chan Park, Jae Hwan Oh
OBJECTIVE: To compare the patterns of failure between rectal cancer patients with negative and positive circumferential resection margin (CRM) after surgery following preoperative chemoradiation. METHODS: Of 944 stage II-III rectal cancer patients treated with radical surgery following preoperative chemoradiation, 74 patients (7.8%) showed positive CRM. Each 72 patients from negative and positive CRM groups were identified by propensity score matching and compared in terms of survival outcomes and patterns of failure...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30102564/improving-diagnostic-accuracy-in-clinically-ambiguous-paediatric-appendicitis-a-retrospective-review-of-ultrasound-and-pathology-findings-with-focus-on-the-non-visualised-appendix
#17
B S Kelly, S M Bollard, A Weir, C O'Brien, D Mullen, M Kerin, P McCarthy
OBJECTIVE: To compare pre-operative ultrasound to histopathological results and retrospectively assess the diagnostic accuracy of ultrasound in paediatric appendicitis. METHODS: 5 year review of all appendectomies performed in patients <16 years old in a tertiary referral university hospital. 983 patients had an appendicectomy over the time period while 189 patients had a preoperative ultrasound. We retrospectively reviewed all of the preoperative imaging in conjunction with the reports for the 189 patients; our aim was to determine the sensitivity of preoperative ultrasound for the diagnosis of acute appendicitis...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30102558/review-of-risk-factors-of-secondary-cancers-among-cancer-survivors
#18
Charlotte Demoor-Goldschmidt, Florent de Vathaire
Improvements in cancer survival have made the long-term risks from treatments more important, in particular among the children, adolescents and young adults who are more at risk particularly due to a longer life expectancy and a higher sensitivity to treatments. Subsequent malignancies in cancer survivors now constitute 15 to 20% of all cancer diagnoses in the cancer registries. Lots of studies are published to determine risk factors, with some controversial findings. Just data from large cohorts with detailed information on individual treatments and verification of what is called "secondary cancers" can add some knowledge, because their main difficulty is that the number of events for most second cancer sites are low, which impact the statistical results...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30102557/theranostics-in-neuroendocrine-tumours-somatostatin-receptor-imaging-and-therapy
#19
Deborah Pencharz, Gopinath Gnanasegaran, Shaunak Navalkissoor
Theranostics and its principles: pre-treatment selection of patients who are most likely to benefit from treatment by the use of a related, specific diagnostic test are integral to the treatment of patients with neuroendocrine tumours (NETs). This is due to NETs' important, but variable, somatostatin receptor (SSTR) expression, their heterogeneity and variation in site of primary and rate of progression. Only patients whose tumours have sufficient expression of SSTRs will benefit from SSTR-based radionuclide therapy and demonstrating this expression prior to therapy is essential...
September 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29987980/mr-imaging-and-ct-features-of-oncocytic-papilloma-of-the-sinonasal-tract-with-comparison-to-inverted-papilloma
#20
Bentao Yang, Jing Li, Jiyong Dong
OBJECTIVE: To evaluate and compare the imaging feature of sinonasal oncocytic papilloma (OP) with inverted papilloma (IP). METHODS: The CT and MR imaging manifestations of 17 pathology proven sinonasal OPs were reviewed and compared with 17 IPs randomly selected as a control group over the same period. RESULTS: Seventeen sinonasal OPs had unilateral occurrence and 16 of them (94.1%) had a lobulated configuration.The distribution of original sites differed significantly between OPs and IPs (p < 0...
September 12, 2018: British Journal of Radiology
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