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Subclinical Maternal Autoimmune Disease Leading to Congenital High Degree Atrioventricular Block: Case Report and Review of the Literature.
Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology 2024 March 19
Maternal autoimmune disease is the most common cause of congenital heart block (CHB), a rare illness characterized by fibrosis and calcification of the fetal atrioventricular (AV) node due to maternal autoantibodies anti-SSA/Ro and anti-SSB/La. We report the full autopsy and clinical information on a female neonate with high degree AV block and calcification in the AV node, atrial approaches to the AV node, and both right and left bundle branches, born to a 27-year-old female with subclinical autoimmune disease.
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