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Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology

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https://www.readbyqxmd.com/read/29778910/a-case-of-vascular-ehlers-danlos-syndrome-with-a-cardiomyopathy-and-multi-system-involvement
#1
Nick Si Rui Lan, Michael Fietz, Nicholas Pachter, Vincent Paul, David Playford
Ehlers-Danlos Syndrome comprises a heterogeneous group of heritable connective tissue disorders resulting from various gene mutations. We present an unusual case of vascular Ehlers-Danlos Syndrome with distinctive physical characteristics and a cardiomyopathy with features suggesting isolated left ventricular non-compaction. The cardiac features represent the first report of a cardiomyopathy associated with a mutation in the COL3A1 gene. This case also illustrates the multi-system nature of Ehlers-Danlos Syndrome and the complexity of managing patients with the vascular subtype...
April 24, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29772448/molecular-and-cellular-insights-into-the-pathogenesis-of-coronary-artery-ectasia
#2
REVIEW
Selcuk Ozturk, Ertan Yetkin, Johannes Waltenberger
Coronary artery ectasia describes a local or diffuse dilatation of the epicardial coronary arteries. This review summarizes the molecular and cellular mechanisms involved in the pathogenesis of coronary artery ectasia. Better identification of the pathophysiologic steps will shed light into the clinical significance and may have direct implications for the management strategies of this disease. Additionally, understanding the underlying etiology may help to improve treatment modalities specific to coronary artery ectasia...
April 16, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29747049/thromboembolic-findings-in-patients-with-heart-failure-at-autopsy
#3
Isabella Sales de Macedo, Layara Fernanda Lipari Dinardi, Thiago Vicente Pereira, Lyna Kyria Rodrigues de Almeida, Thaisa Silveira Barbosa, Luiz Alberto Benvenuti, Silvia Moreira Ayub-Ferreira, Edimar Alcides Bocchi, Victor Sarli Issa
BACKGROUND: The risk of thromboembolic events is increased in patients with heart failure (HF); however, few studies have reported thromboembolic findings in HF patients who have undergone autopsy. METHODS AND RESULTS: We reviewed 1457 autopsies (January 2000/July 2006) and selected 595 patients with HF. We studied the occurrence of thromboembolic events in patients' autopsy reports. Mean age was 61.8±15.9 years; 376 (63.2%) were men and 219 (36.8%) women; left ventricular ejection fraction was 42...
April 13, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29730526/reasons-for-missing-noncompaction-in-myopathies-and-vice-versa
#4
Josef Finsterer, Claudia Stöllberger
No abstract text is available yet for this article.
April 12, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29747050/long-non-coding-rna-chrf-facilitates-cardiac-hypertrophy-through-regulating-akt3-via-mir-93
#5
Yang Wo, Jie Guo, Peihui Li, Hongxia Yang, Jinshan Wo
BACKGROUND: Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been demonstrated as central mediators in cardiac hypertrophy responses. LncRNA cardiac hypertrophy related factor (CHRF) has been reported to be implicated in cardiac hypertrophy. However, the underlying mechanisms of CHRF have not been thoroughly elucidated. METHODS: Expressions of CHRF and microRNA-93 (miR-93) in heart tissues and cardiomyocytes were detected by RT-qPCR assay...
April 11, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29729633/thrombospondin-4-mediates-cardiovascular-remodelling-in-angiotensin-ii-induced-hypertension
#6
Teresa Palao, Lejla Medzikovic, Catarina Rippe, Shaynah Wanga, Claudia Al-Mardini, Angela van Weert, Judith de Vos, Nicole N van der Wel, Henk A van Veen, Ed T van Bavel, Karl Swärd, Vivian de Waard, Erik Ntp Bakker
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4-/- ) mice. We reported increased heart weight, as well as the occurrence of aortic aneurysms in the Ang II-treated Thbs4-/- animals...
April 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29727769/lymphocyte-and-monocyte-subpopulations-in-severe-aortic-stenosis-at-the-time-of-surgical-intervention
#7
Piotr Mazur, Aleksandra Mielimonka, Joanna Natorska, Ewa Wypasek, Bogusław Gawęda, Dorota Sobczyk, Przemysław Kapusta, Krzysztof Piotr Malinowski, Bogusław Kapelak
INTRODUCTION: Aortic stenosis (AS) is the most common acquired valvular heart disease in adults. Immune system involvement becomes evident during AS development. We sought to investigate the role of different circulating lymphocyte and monocyte subpopulations, with focus on CD4+ CD8+ and natural killer T (NKT) cells, in AS. MATERIAL AND METHODS: Blood samples and aortic valves were obtained from patients undergoing elective aortic valve surgery. Valves were dissected and underwent genetic analyses and calcium content assessment...
April 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29729634/new-morphological-classification-of-congenital-quadricuspid-aortic-valve-and-its-histopathologic-features
#8
Ching-Li Cheng, Hsiao-Huang Chang, Wei-Chen Wang, Pei-Jung Huang, Shan-Yang Lin
We report a 52-year-old male patient who had a quadricuspid aortic valve (QAV) associated with aortic regurgitation (AR) and left ventricular hypertrophy (LVH). A new accessory cusp (ACC) with maximum thickness than other cusps was located between right coronary cusp (RCC) and left coronary cusp (LCC). The histopathological features revealed markedly thickened and distorted cusp architecture with fibrosis and/or myxomatous degeneration in both non-coronary cusp (NCC) and ACC. Two equal sizes for larger cusps (RCC and NCC) and two equal sizes for smaller cusps (LCC and ACC) were obtained...
April 6, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29677652/cardiomyocytes-have-mosaic-patterns-of-protein-expression
#9
Tony Y Wang, Dongwong Lee, Karen Fox-Talbot, Dan E Arking, Aravinda Chakravarti, Marc K Halushka
Skeletal myocytes have well-established fast and slow twitch fibers with unique gene and protein specific expression patterns. By immunohistochemical staining, these show a mosaic pattern across myocytes. We hypothesized cardiac myocytes may behave similarly where some proteins are differentially expressed between mature cardiomyocytes. We utilized the tool HPASubC on over 52,000 cardiac images of the Human Protein Atlas to identify differential protein expression patterns by immunohistochemistry across the cardiomyocytes...
March 24, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29660676/cerebrovascular-myocardium-tissue-embolism-a-rare-complication-of-heart-surgery-autopsy-case-report
#10
Jan Hrudka, Jan Hlavička, Marie Claire Šmůlová, Petr Kujal
No abstract text is available yet for this article.
March 18, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29574291/five-chambered-heart-case-of-a-huge-left-atrial-appendage-aneurysm
#11
Mohammad Hassan Nezafati, Hossein Nazari Hayanou, Mahdi Kahrom, Alireza Khooei, Pouya Nezafati
Aneurysmal enlargement of the left atrial appendage is an extremely rare pathology and can predispose to adverse events, including cardiac arrest, respiratory distress, arrhythmia, heart failure, systemic thromboembolism, or rupture. It is usually diagnosed incidentally or after the occurrence of atrial tachyarrhythmias or thrombotic events in the second to fourth decades of life. We describe a rare case of a symptomatic giant congenital left atrial appendage aneurysm (LAAA) in a 26-year-old man presenting with neurologic event, in whom surgical resection of the aneurysm was successfully performed...
March 6, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29550703/coxiella-burnetii-endocarditis-on-bioprosthetic-aortic-valve-with-peripheral-arterial-embolism
#12
Anne-Laure Faucon, Jean-Luc Mainardi, Oana Zamfir, Hervé Gorka, Patrick Bruneval, André Pruna
Acute limb ischemia related to Coxiella burnetii endocarditis is rare. We report an original case of a 68-year-old man hospitalized for recurrent acute left limb ischemia in a context of atrial flutter, which revealed C. burnetii endocarditis. This case illustrates that even if embolic events are uncommon, septic embolisms must be systematically searched for in case of C. burnetii endocarditis. Conversely, extensive etiologic explorations must be performed in case of systemic embolism. New molecular techniques represent a major step forward in infective endocarditis diagnosis...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29539583/increased-calcific-aortic-valve-disease-in-response-to-a-diabetogenic-procalcific-diet-in-the-ldlr-apob-100-100-mouse-model
#13
Marta Scatena, Melissa F Jackson, Mei Y Speer, Elizabeth M Leaf, Mary C Wallingford, Cecilia M Giachelli
OBJECTIVE: Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis (AS) and cardiac insufficiency. Patients with type II diabetes mellitus (T2DM) are at heightened risk for CAVD, and their valves have greater calcification than nondiabetic valves. No drugs to prevent or treat CAVD exist, and animal models that might help identify therapeutic targets are sorely lacking. To develop an animal model mimicking the structural and functional features of CAVD in people with T2DM, we tested a diabetogenic, procalcific diet and its effect on the incidence and severity of CAVD and AS in the, LDLr-/- ApoB100/100 mouse model...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29525729/immunophenotypic-analysis-of-the-chronological-events-of-tissue-repair-in-aortic-medial-dissections
#14
Silvia D Visonà, Onno J de Boer, Claire Mackaaij, Hans H de Boer, Kartika R Pertiwi, Ruben W de Winter, Antonio Osculati, Allard C van der Wal
Acute medial dissection of aorta can occur in the context of a sudden and unexpected death. For medico-legal reasons it is important to estimate as accurately the histological age of dissections. We evaluated the additional value of a systematic application of immunohistochemistry, compared with conventional histology only, in determining chronological steps of injury and repair. Thirty two paraffin embedded specimens of aortic dissection were retrospectively allocated to one of four defined stages: acute (I), subacute (II), early organizing (III) and scarring (IV) using Hematoxylin and Eosin and Elastica van Gieson stained sections...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29525728/papillary-muscles-of-right-ventricle-morphological-variations-and-its-clinical-relevance
#15
Anubha Saha, Sanchita Roy
INTRODUCTION: Papillary muscle plays an important role in stabilizing the position of the tricuspid valve. Several pathologies can result in anatomical and functional abnormalities of the papillary muscles. The aim of the study is to deliberate the morphometry of papillary muscles in tricuspid valve and to analyze with the eminent research works previously done. MATERIALS AND METHODS: The study was carried out in 52 formalin-fixed adult apparently normal cadaveric hearts belonging to either sex obtained from the Department of Anatomy...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29525727/endomyocardial-biopsy-in-differential-diagnosis-between-arrhythmogenic-right-ventricular-cardiomyopathy-and-dilated-cardiomyopathy-an-in-vitro-simulated-study
#16
Mangyuan Wang, Kai Chen, Xiao Chen, Liang Chen, Jiangping Song, ShengShou Hu
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy (DCM), despite being two dramatically different entities, have overlapping phenotypes. As it is easy to misdiagnose between ARVC and DCM, there is a need to establish a new differential diagnostic parameter to differentiate the two. We investigated the utility of endomyocardial biopsy (EMB) for the differential diagnosis, and our study had three aims. The first was to verify the EMB high diagnostic efficacy. The second was to investigate the EMB perforation risk at the right ventricle (RV) free wall of end-stage ARVC...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29474941/blocking-wnt5a-signaling-decreases-cd36-expression-and-foam-cell-formation-in-atherosclerosis
#17
Ian Ackers, Candice Szymanski, K Jordan Duckett, Leslie A Consitt, Mitchell J Silver, Ramiro Malgor
BACKGROUND AND AIMS: Wnt5a is a highly studied member of the Wnt family and recently has been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown. Foam cell development is a critical process to atherosclerotic plaque formation. In the present study, we investigated the role of noncanonical Wnt5a signaling in the development of foam cells. METHODS: Human carotid atherosclerotic tissue and THP-1-derived macrophages were used to investigate the contribution of Wnt5a signaling in the formation of foam cells...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29459347/rare-device-landing-zone-ruptures-after-transcatheter-aortic-valve-implantation-tavi
#18
Jan Willem van Rijswijk, Adriaan O Kraaijeveld, Michiel Voskuil, Pieter R Stella, Aryan Vink
No abstract text is available yet for this article.
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29433109/pathogenesis-of-aortic-wall-complications-in-marfan-syndrome
#19
Nimrat Grewal, Adriana C Gittenberger-de Groot
BACKGROUND: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as distinct pathways of clinical relevance, we compared the histopathological substrates of aortic pathology. PATIENT AND METHODS: Ascending aortic wall specimen were divided in five groups: BAV (n=36) and TAV (n=23) without and with dilation and non-dilated MFS (n=8)...
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29414433/il-6-expression-is-correlated-with-increased-t-cell-proliferation-and-survival-in-the-arterial-wall-in-giant-cell-arteritis
#20
Sukhbir Manku, Wendy Wong, Zongshu Luo, Michael A Seidman, Zainab Alabdurubalnabi, Kevin Rey, Winnie Enns, J Antonio Avina-Zubieta, Kamran Shojania, Jonathan C Choy
Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in its treatment. We examined the relationship between levels of IL-6 expression and immunological processes that control the expansion of T cells in GCA-positive temporal artery biopsies. CD4 T cells accumulated in clusters within the media and deep intima of all GCA lesions...
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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