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Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology

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https://www.readbyqxmd.com/read/30223140/myocardial-rupture-after-small-acute-myocardial-infarction-in-the-absence-of-coronary-artery-disease
#1
Christopher P Roth, Morad Qarmali, Silvio H Litovsky, Brigitta C Brott
A 73-year-old woman with a past medical history of hypertension suffered a cardiac arrest. After successful resuscitation, she was hypotensive and tachycardic and the ECG showed ST elevation in the inferior and lateral precordial leads. Coronary angiography did not show evidence of obstructive coronary artery disease. A bedside echocardiogram demonstrated a large pericardial effusion with signs of cardiac tamponade. The echocardiogram and subsequent aortic root angiography did not reveal evidence of dissection...
August 25, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30195228/mir-143-and-mir-145-promote-hypoxia-induced-proliferation-and-migration-of-pulmonary-arterial-smooth-muscle-cells-through-regulating-abca1-expression
#2
Yuxia Yue, Zhiyong Zhang, Lei Zhang, Songhu Chen, Yilin Guo, Yan Hong
BACKGROUND: Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) play an important role in the occurrence and development of pulmonary arterial hypertension (PAH). miR-143/145 was reported to be up-regulated in the animal models and PAH patients, and deletion of miR-143/145 cluster prevented the development of hypoxia-induced pulmonary hypertension, but its underlying mechanism has not been elucidated. METHODS: qRT-PCR and Western blot were performed to detect the expressions of miR-143/145 and ATP-binding cassette transporter A1 (ABCA1) in PAH patients and PASMCs under hypoxic conditions...
August 23, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30121471/tuberculous-myocarditis-on-autopsy-a-rare-underdiagnosed-entity
#3
Sanjay Kumar, Namita Bhutani, Sant Prakash Kataria, Rajeev Sen
No abstract text is available yet for this article.
August 10, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30172777/histone-demethylase-jarid1b-regulates-proliferation-and-migration-of-pulmonary-arterial-smooth-muscle-cells-in-mice-with-chronic-hypoxia-induced-pulmonary-hypertension-via-nuclear-factor-kappa-b-nfkb
#4
Yuanshi Li, Sining Liu, Yihong Zhang, Qianping Gao, Weiju Sun, Lu Fu, Junxian Cao
Chronic hypoxia-induced pulmonary hypertension (PH) is a disorder that is characterized by increased pulmonary arterial pressure resulting from lung diseases or shortage of oxygen in the body. Excess proliferation of pulmonary vascular cells such as pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) plays a critical role in the pathogenesis of PH. Recent evidence indicates that, in addition to genetic predisposition and environmental factors, epigenetic mechanisms play a pivotal role in etiology of PH...
August 3, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30121003/three-dimensional-histologic-reconstruction-of-remnant-functional-accessory-atrioventricular-myocardial-connections-in-a-case-of-wolff-parkinson-white-syndrome
#5
Taka-Aki Matsuyama, Ryo Haraguchi, Junko Nakashima, Kengo Kusano, Hatsue Ishibashi-Ueda
Myocardial bundles working as accessory pathways in Wolff-Parkinson-White (WPW) syndrome are generally tiny tissues, so elucidating the culprit histology of atrioventricular (AV) myocardial connections requires careful serial sectioning of the AV junction. We performed a postmortem examination of accessory AV myocardial connections in an 84-year-old man who died from pneumonia 20 years after surgical cryoablation for WPW syndrome. Three-dimensional reconstruction images of serial histologic sections revealed accessory AV connections between the atrial and ventricular myocardium in the vicinity of the cryoablation scar...
July 27, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30103083/a-novel-mutation-of-dystrophin-in-a-becker-muscular-dystrophy-family-with-severe-cardiac-involvement-from-genetics-to-clinicopathology
#6
Liang Chen, Jie Ren, Xiao Chen, Kai Chen, Man Rao, Ningning Zhang, Wenhua Yu, Jiangping Song
BACKGROUND: Dystrophin gene defects are the pathogenic molecular basis of Becker muscular dystrophy (BMD), characterised by skeletal myopathy and cardiomyopathy. Because of the broad phenotype spectrum, it was difficult to use the traditional diagnostic method to achieve an early accurate diagnosis of BMD-associated cardiomyopathy. METHODS: We applied an in-house gene panel testing and a gene-filtering strategy to investigate the genetic defect in a four-generation family with 73 members...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30100494/in-memoriam-hugh-h-mcallister-jr-m-d
#7
EDITORIAL
L Maximilian Buja
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30056298/cd39-and-cd73-in-the-aortic-valve-biochemical-and-immunohistochemical-analysis-in-valve-cell-populations-and-its-changes-in-valve-mineralization
#8
Ewa Kaniewska-Bednarczuk, Barbara Kutryb-Zajac, Padmini Sarathchandra, Iwona Pelikant-Malecka, Alicja Sielicka, Izabela Piotrowska, Ewa M Slominska, Adrian H Chester, Magdi H Yacoub, Ryszard T Smolenski
BACKGROUND: The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis, and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ectonucleotidases, mainly ectonucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5'nucleotidase (CD73, e5NT). OBJECTIVE AND METHODS: We investigated the localization of CD39 and CD73 proteins in human noncalcified and calcified aortic valves using immunohistochemistry together with analysis of NTPDases and e5NT activities in aortic valve homogenates by analysis of substrate into product conversion by high-performance liquid chromatography...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30014985/method-for-preclinical-pathology-evaluation-and-analysis-of-cardiovascular-implantable-electronic-device-implant-sites
#9
Staci L Jessen, Maureen T O'Brien, Trevor W Lancon, Harrison R Smith, Leslie L Suarez, Matthew D Wilcox, Matthew Miller, Brad R Weeks, Fred J Clubb
Cardiovascular implantable electronic devices (CIEDs) typically incorporate leads that directly contact the endocardium. Post-explant pathology evaluation of formalin-fixed CIED lead implant sites and downstream organs (i.e., lungs) can provide useful safety data to the US Food and Drug Administration; however, current regulatory guidelines do not mandate how the safety data are collected. In this paper, we outline a protocol for preclinical pathology evaluation of leads associated with CIEDs, which includes formalin fixation of the heart and lungs, gross evaluation, and qualitative and quantitative histologic evaluation...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30014984/consensus-documents-past-present-and-future
#10
EDITORIAL
Michael A Seidman
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30007210/splenectomy-had-no-significant-impact-on-lipid-metabolism-and-atherogenesis-in-apoe-deficient-mice-fed-on-a-severe-atherogenic-diet
#11
Ying Zhang, Xiangbo An, Qiuyue Lin, Jie Bai, Feng Wang, Jiawei Liao
BACKGROUND: For a long time, our major understanding of the spleen is to function as a blood filter for the removal of aged erythrocytes and circulating microorganisms. Splenectomy, therefore, has been widely performed in case of trauma and a variety of hematologic disorders. Although some studies have indicated an increased rate of developing hyperlipidemia and atherosclerotic cardiovascular diseases in splenectomized patients, our recognition of the splenic regulation on lipid metabolism and atherogenesis is still lacking...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005395/candida-parapsilosis-endocarditis-in-an-intravenous-drug-abuser-an-autopsy-report
#12
Manoj Gopal Madakshira, Amanjit Bal, ShivaPrakash, Manish Rathi, Rajesh Vijayvergiya
Candida parapsilosis is a rare cause of endocarditis, which is seen to affect the native valves in patients who are known intravenous drug abusers or following contamination during surgery for prosthetic valves. We discuss a unique constellation of autopsy findings in a 35-year-old chronic opium abuser who presented with left-sided weakness followed by low-grade fever. He was diagnosed to have C. parapsilosis native valve endocarditis with septic emboli involving the myocardial vessels, left middle cerebral artery, spleen, and common iliac artery...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005394/mesothelial-monocytic-incidental-cardiac-excrescences-mice-report-of-a-case-and-review-of-literature-with-focus-on-pathogenesis
#13
Ilaria Girolami, Albino Eccher, Eliana Gilioli, Luca Novelli, Gioia Di Stefano, Matteo Brunelli, Luca Cima
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a benign lesion composed of histiocytes and mesothelial cells, usually found during cardiac surgery. To date, no more than 50 cases are reported in literature, and pathogenesis is still unclear even if different theories have been proposed. Here we report a case of MICE encountered during aortic valve replacement with typical histological features and extensive immunohistochemical investigation. To date, little information is available about the pathogenesis of MICE...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005393/intramural-capillary-hemangioma-of-gallbladder-artery-age-related-or-treatment-induced-change
#14
LETTER
Adriana Handra-Luca
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005392/pathological-evidence-of-adrenergic-cardiac-denervation-in-a-patient-with-congestive-heart-failure
#15
Domenico Acanfora, Gerardo Casucci, Marco Matteo Ciccone, Pietro Scicchitano, Tommaso Lonobile, Luigi Chiariello, Roberto Maestri, Claudio Pedone, Vincenzo Provitera, Maria Nolano, Raffaele Antonelli Incalzi
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005391/coronary-pathology-of-inherited-generalized-arterial-calcification-of-infancy-a-case-report
#16
Duccio Federici, Sho Torii, Matteo Ciuffreda, Lorenzo Galletti, Luca Lorini, Ezio Bonanomi, Andrea Gianatti, Maria Iascone, Joohyung Park, Liang Guo, Maria E Romero, Frank D Kolodgie, Giulio Guagliumi, Renu Virmani
Generalized arterial calcification of infancy (GACI), or idiopathic infantile arterial calcification, is a rare autosomal-recessive disease recognized aAs an inherited disorder characterized by severe pathologic calcification of large- and medium-sized arteries accompanied by smooth muscle cell (SMC) hyperplasia leading to vascular obstruction [1]. The prognosis is extremely poor, with 85% of affected infants dying within the first 6 months of life. Loss-of-function mutations in the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) gene is recognized as the main defect associated with GACI [1]...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29909096/aortic-valve-replacement-for-aortic-regurgitation-associated-with-osteogenesis-imperfecta
#17
Keito Suzuki, Akira Sezai, Satoshi Unosawa, Hiroyuki Hao, Masashi Tanaka
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29906520/achromobacter-endocarditis-in-native-cardiac-valves-an-autopsy-case-report-and-review-of-the-literature
#18
Rong Xia, Caitlin Otto, Jianying Zeng, Amir Momeni-Boroujeni, Joshua Kagan, Katharine Meleney, Jenny Libien
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29859507/comparing-fist-size-to-heart-size-is-not-a-viable-technique-to-assess-cardiomegaly
#19
Garyfalia Ampanozi, Eileen Krinke, Patrick Laberke, Wolf Schweitzer, Michael J Thali, Lars C Ebert
PURPOSE: Several medical textbooks state that a human heart is approximately the size of that person's fist. Stating that a heart has the size of the corpse's fist is thought to signify that the heart size is normal. We formulate two hypotheses that are tested in this article. First, we hypothesize that in cases without cardiomegaly, volumes of the hand and the heart are not significantly different. Second, we hypothesize that in cases of cardiomegaly, the heart volume statistically significantly exceeds that of the hand...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29803123/comparing-coronary-artery-fibromuscular-dysplasia-with-coronary-atherosclerosis-from-clinical-to-histopathological-characteristics
#20
Xiumeng Hua, Xiao Chen, Kai Chen, Songqing Lai, Ran Gao, Yiqing Hu, Jiangping Song
No abstract text is available yet for this article.
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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