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Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology

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https://www.readbyqxmd.com/read/30007210/splenectomy-had-no-significant-impact-on-lipid-metabolism-and-atherogenesis-in-apoe-deficient-mice-fed-on-a-severe-atherogenic-diet
#1
Ying Zhang, Xiangbo An, Qiuyue Lin, Jie Bai, Feng Wang, Jiawei Liao
BACKGROUND: For a long time, our major understanding of the spleen is to function as a blood filter for the removal of aged erythrocytes and circulating microorganisms. Splenectomy, therefore, has been widely performed in case of trauma and a variety of hematologic disorders. Although some studies have indicated an increased rate of developing hyperlipidemia and atherosclerotic cardiovascular diseases in splenectomized patients, our recognition of the splenic regulation on lipid metabolism and atherogenesis is still lacking...
June 23, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005394/mesothelial-monocytic-incidental-cardiac-excrescences-mice-report-of-a-case-and-review-of-literature-with-focus-on-pathogenesis
#2
Ilaria Girolami, Albino Eccher, Eliana Gilioli, Luca Novelli, Gioia Di Stefano, Matteo Brunelli, Luca Cima
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a benign lesion composed of histiocytes and mesothelial cells, usually found during cardiac surgery. To date, no more than 50 cases are reported in literature, and pathogenesis is still unclear even if different theories have been proposed. Here we report a case of MICE encountered during aortic valve replacement with typical histological features and extensive immunohistochemical investigation. To date, little information is available about the pathogenesis of MICE...
June 10, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005395/candida-parapsilosis-endocarditis-in-an-intravenous-drug-abuser-an-autopsy-report
#3
Manoj Gopal Madakshira, Amanjit Bal, ShivaPrakash, Manish Rathi, Rajesh Vijayvergiya
Candida parapsilosis is a rare cause of endocarditis, which is seen to affect the native valves in patients who are known intravenous drug abusers or following contamination during surgery for prosthetic valves. We discuss a unique constellation of autopsy findings in a 35-year-old chronic opium abuser who presented with left-sided weakness followed by low-grade fever. He was diagnosed to have C. parapsilosis native valve endocarditis with septic emboli involving the myocardial vessels, left middle cerebral artery, spleen, and common iliac artery...
June 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005393/intramural-capillary-hemangioma-of-gallbladder-artery-age-related-or-treatment-induced-change
#4
LETTER
Adriana Handra-Luca
No abstract text is available yet for this article.
June 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005392/pathological-evidence-of-adrenergic-cardiac-denervation-in-a-patient-with-congestive-heart-failure
#5
Domenico Acanfora, Gerardo Casucci, Marco Matteo Ciccone, Pietro Scicchitano, Tommaso Lonobile, Luigi Chiariello, Roberto Maestri, Claudio Pedone, Vincenzo Provitera, Maria Nolano, Raffaele Antonelli Incalzi
No abstract text is available yet for this article.
June 5, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29909096/aortic-valve-replacement-for-aortic-regurgitation-associated-with-osteogenesis-imperfecta
#6
Keito Suzuki, Akira Sezai, Satoshi Unosawa, Hiroyuki Hao, Masashi Tanaka
No abstract text is available yet for this article.
May 24, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29906520/achromobacter-endocarditis-in-native-cardiac-valves-an-autopsy-case-report-and-review-of-the-literature
#7
Rong Xia, Caitlin Otto, Jianying Zeng, Amir Momeni-Boroujeni, Joshua Kagan, Katharine Meleney, Jenny Libien
No abstract text is available yet for this article.
May 22, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005391/coronary-pathology-of-inherited-generalized-arterial-calcification-of-infancy-a-case-report
#8
Duccio Federici, Sho Torii, Matteo Ciuffreda, Lorenzo Galletti, Luca Lorini, Ezio Bonanomi, Andrea Gianatti, Maria Iascone, Joohyung Park, Liang Guo, Maria E Romero, Frank D Kolodgie, Giulio Guagliumi, Renu Virmani
Generalized arterial calcification of infancy (GACI), or idiopathic infantile arterial calcification, is a rare autosomal-recessive disease recognized aAs an inherited disorder characterized by severe pathologic calcification of large- and medium-sized arteries accompanied by smooth muscle cell (SMC) hyperplasia leading to vascular obstruction [1]. The prognosis is extremely poor, with 85% of affected infants dying within the first 6 months of life. Loss-of-function mutations in the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) gene is recognized as the main defect associated with GACI [1]...
May 18, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29859507/comparing-fist-size-to-heart-size-is-not-a-viable-technique-to-assess-cardiomegaly
#9
Garyfalia Ampanozi, Eileen Krinke, Patrick Laberke, Wolf Schweitzer, Michael J Thali, Lars C Ebert
PURPOSE: Several medical textbooks state that a human heart is approximately the size of that person's fist. Stating that a heart has the size of the corpse's fist is thought to signify that the heart size is normal. We formulate two hypotheses that are tested in this article. First, we hypothesize that in cases without cardiomegaly, volumes of the hand and the heart are not significantly different. Second, we hypothesize that in cases of cardiomegaly, the heart volume statistically significantly exceeds that of the hand...
May 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29803123/comparing-coronary-artery-fibromuscular-dysplasia-with-coronary-atherosclerosis-from-clinical-to-histopathological-characteristics
#10
Xiumeng Hua, Xiao Chen, Kai Chen, Songqing Lai, Ran Gao, Yiqing Hu, Jiangping Song
No abstract text is available yet for this article.
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29800929/late-diagnosis-of-mucopolysaccharidosis-type-ivb-and-successful-aortic-valve-replacement-in-a-60-year-old-female-patient
#11
Gabriela Dostalova, Zuzana Hlubocka, Jaroslav Lindner, Helena Hulkova, Helena Poupetova, Hana Vlaskova, Jakub Sikora, Ales Linhart, Jiri Zeman, Martin Magner
Mucopolysaccharidosis type IVB (MPS IVB) is a very rare lysosomal storage disorder characterized by skeletal dysplasia, hearing disorder, and cardiac valvular disease. Herein, we report an extremely rare manifestation of MPS IVB in a 60-year-old female patient who underwent a successful aortic valve replacement. The patient presented with mild coarse facial features, short stature, mild dyspnea, sternal protrusion, mild lumbar hyperlordosis, and waddling gait owing to bilateral femoral head necroses and bilateral arthrosis of the knees...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29778910/a-case-of-vascular-ehlers-danlos-syndrome-with-a-cardiomyopathy-and-multi-system-involvement
#12
Nick Si Rui Lan, Michael Fietz, Nicholas Pachter, Vincent Paul, David Playford
Ehlers-Danlos Syndrome comprises a heterogeneous group of heritable connective tissue disorders resulting from various gene mutations. We present an unusual case of vascular Ehlers-Danlos Syndrome with distinctive physical characteristics and a cardiomyopathy with features suggesting isolated left ventricular non-compaction. The cardiac features represent the first report of a cardiomyopathy associated with a mutation in the COL3A1 gene. This case also illustrates the multi-system nature of Ehlers-Danlos Syndrome and the complexity of managing patients with the vascular subtype...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29772448/molecular-and-cellular-insights-into-the-pathogenesis-of-coronary-artery-ectasia
#13
REVIEW
Selcuk Ozturk, Ertan Yetkin, Johannes Waltenberger
Coronary artery ectasia describes a local or diffuse dilatation of the epicardial coronary arteries. This review summarizes the molecular and cellular mechanisms involved in the pathogenesis of coronary artery ectasia. Better identification of the pathophysiologic steps will shed light into the clinical significance and may have direct implications for the management strategies of this disease. Additionally, understanding the underlying etiology may help to improve treatment modalities specific to coronary artery ectasia...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29747050/long-non-coding-rna-chrf-facilitates-cardiac-hypertrophy-through-regulating-akt3-via-mir-93
#14
Yang Wo, Jie Guo, Peihui Li, Hongxia Yang, Jinshan Wo
BACKGROUND: Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been demonstrated as central mediators in cardiac hypertrophy responses. LncRNA cardiac hypertrophy related factor (CHRF) has been reported to be implicated in cardiac hypertrophy. However, the underlying mechanisms of CHRF have not been thoroughly elucidated. METHODS: Expressions of CHRF and microRNA-93 (miR-93) in heart tissues and cardiomyocytes were detected by RT-qPCR assay...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29747049/thromboembolic-findings-in-patients-with-heart-failure-at-autopsy
#15
Isabella Sales de Macedo, Layara Fernanda Lipari Dinardi, Thiago Vicente Pereira, Lyna Kyria Rodrigues de Almeida, Thaisa Silveira Barbosa, Luiz Alberto Benvenuti, Silvia Moreira Ayub-Ferreira, Edimar Alcides Bocchi, Victor Sarli Issa
BACKGROUND: The risk of thromboembolic events is increased in patients with heart failure (HF); however, few studies have reported thromboembolic findings in HF patients who have undergone autopsy. METHODS AND RESULTS: We reviewed 1457 autopsies (January 2000/July 2006) and selected 595 patients with HF. We studied the occurrence of thromboembolic events in patients' autopsy reports. Mean age was 61.8±15.9 years; 376 (63.2%) were men and 219 (36.8%) women; left ventricular ejection fraction was 42...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29730526/reasons-for-missing-noncompaction-in-myopathies-and-vice-versa
#16
Josef Finsterer, Claudia Stöllberger
No abstract text is available yet for this article.
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29729634/new-morphological-classification-of-congenital-quadricuspid-aortic-valve-and-its-histopathologic-features
#17
Ching-Li Cheng, Hsiao-Huang Chang, Wei-Chen Wang, Pei-Jung Huang, Shan-Yang Lin
We report a 52-year-old male patient who had a quadricuspid aortic valve (QAV) associated with aortic regurgitation (AR) and left ventricular hypertrophy (LVH). A new accessory cusp (ACC) with maximum thickness than other cusps was located between right coronary cusp (RCC) and left coronary cusp (LCC). The histopathological features revealed markedly thickened and distorted cusp architecture with fibrosis and/or myxomatous degeneration in both non-coronary cusp (NCC) and ACC. Two equal sizes for larger cusps (RCC and NCC) and two equal sizes for smaller cusps (LCC and ACC) were obtained...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29729633/thrombospondin-4-mediates-cardiovascular-remodelling-in-angiotensin-ii-induced-hypertension
#18
Teresa Palao, Lejla Medzikovic, Catarina Rippe, Shaynah Wanga, Claudia Al-Mardini, Angela van Weert, Judith de Vos, Nicole N van der Wel, Henk A van Veen, Ed T van Bavel, Karl Swärd, Vivian de Waard, Erik Ntp Bakker
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4-/- ) mice. We reported increased heart weight, as well as the occurrence of aortic aneurysms in the Ang II-treated Thbs4-/- animals...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29727769/lymphocyte-and-monocyte-subpopulations-in-severe-aortic-stenosis-at-the-time-of-surgical-intervention
#19
Piotr Mazur, Aleksandra Mielimonka, Joanna Natorska, Ewa Wypasek, Bogusław Gawęda, Dorota Sobczyk, Przemysław Kapusta, Krzysztof Piotr Malinowski, Bogusław Kapelak
INTRODUCTION: Aortic stenosis (AS) is the most common acquired valvular heart disease in adults. Immune system involvement becomes evident during AS development. We sought to investigate the role of different circulating lymphocyte and monocyte subpopulations, with focus on CD4+ CD8+ and natural killer T (NKT) cells, in AS. MATERIAL AND METHODS: Blood samples and aortic valves were obtained from patients undergoing elective aortic valve surgery. Valves were dissected and underwent genetic analyses and calcium content assessment...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29677652/cardiomyocytes-have-mosaic-patterns-of-protein-expression
#20
Tony Y Wang, Dongwon Lee, Karen Fox-Talbot, Dan E Arking, Aravinda Chakravarti, Marc K Halushka
Skeletal myocytes have well-established fast and slow twitch fibers with unique gene and protein specific expression patterns. By immunohistochemical staining, these show a mosaic pattern across myocytes. We hypothesized cardiac myocytes may behave similarly where some proteins are differentially expressed between mature cardiomyocytes. We utilized the tool HPASubC on over 52,000 cardiac images of the Human Protein Atlas to identify differential protein expression patterns by immunohistochemistry across the cardiomyocytes...
May 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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