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Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology

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https://www.readbyqxmd.com/read/30419478/endomyocardial-fibrosis-and-myocardial-infarction-leading-to-diastolic-and-systolic-dysfunction-requiring-transplantation
#1
Monica De Gaspari, Giuseppe Toscano, Lorenzo Bagozzi, Marco Metra, Carlo Lombardi, Stefania Rizzo, Annalisa Angelini, Martina Perazzolo Marra, Gino Gerosa, Cristina Basso
Endomyocardial fibrosis (EMF) is an endemic disease in tropical areas, characterized by restrictive physiology due to endocardial fibrous thickening of the ventricular chambers. We report the case of a 25-year-old man of African origin who presented with end-stage heart failure due to both diastolic and systolic dysfunction and extensive endocavitary thrombosis as proven by echocardiography and cardiac magnetic resonance. EMF diagnosis was confirmed by endomyocardial biopsy and the patient had eventually cardiac transplantation...
October 31, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30428421/morphology-and-mechanisms-of-a-novel-absorbable-polymeric-conduit-in-the-pulmonary-circulation-of-sheep
#2
Marieke Brugmans, Aurélie Serrero, Martijn Cox, Oleg Svanidze, Frederick J Schoen
BACKGROUND: Right ventricular outflow tract (RVOT) conduits used in children with congenital heart disease often degenerate rapidly or develop other complications, and they do not grow with the patient. This leads to multiple surgeries until adult-sized conduits can be implanted. We report experimental in vivo experience with an entirely synthetic absorbable graft, designed to be replaced by tissue in-vivo by host cells, in a process termed Endogenous Tissue Restoration (ETR), and to grow commensurate with somatic growth...
October 25, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30419479/expression-of-tenascin-c-in-cardiovascular-lesions-of-kawasaki-disease
#3
Yuki Yokouchi, Toshiaki Oharaseki, Yasunori Enomoto, Wakana Sato, Kyoko Imanaka-Yoshida, Kei Takahashi
BACKGROUND/OBJECTIVE: To examine tenascin C (TN-C) expression in coronary artery lesions (CALs) and myocardial lesions (MLs) in Kawasaki disease (KD). METHODS AND RESULTS: Twenty-five KD autopsy cases (post-KD-onset range of 6 days to 17 years) were examined in this study. Time-course analysis based on the disease day was performed of the histological findings for the CALs and MLs, as well as the localization and intensity of expression of TN-C. TN-C expression was observed to coincide with the areas where inflammatory cell infiltration was present in both coronary arteries and myocardium during the acute stage of KD, and the intensity of its expression correlated with the degree of inflammation...
October 24, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30359839/renal-cystic-disease-in-the-fbn1-c1039g-marfan-mouse-is-associated-with-enhanced-aortic-aneurysm-formation
#4
Stijntje Hibender, Shaynah Wanga, Ingeborg van der Made, Mariska Vos, Barbara Jm Mulder, Ron Balm, Carlie Jm de Vries, Vivian de Waard
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1), resulting in aortic aneurysm formation and dissections. Interestingly, variable aortopathy is observed even within MFS families with the same mutation. Thus, additional risk factors determine disease severity. Here, we describe a case of a 2-month-old Fbn1C1039G/+ MFS mouse with extreme aortic dilatation and increased vascular inflammation, when compared to MFS siblings, which coincided with unilateral renal cystic disease...
October 16, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30399527/pathological-correlates-of-brain-arterial-calcifications
#5
Steven D Shapiro, James Goldman, Susan Morgello, Lawrence Honig, Mitchell S V Elkind, Randolph S Marshall, Jay P Mohr, Jose Gutierrez
BACKGROUND: In clinical practice, calcifications seen on computed tomographic studies within the large brain arteries are often referred to as a surrogate marker for cholesterol-mediated atherosclerosis. However, limited data exist to support the association between calcification and atherosclerosis. In this study, we examined if intracranial arterial calcifications were associated with cholesterol-mediated intracranial large artery atherosclerosis (ILAA) within the arteries of the circle of Willis in an autopsy-based sample...
October 12, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30342321/coronary-artery-myointimal-dysplasia-in-patients-with-pheochromocytoma-possible-causal-relationship-pathophysiology-and-clinical-implication-with-reference-to-takotsubo-cardiomyopathy-and-spontaneous-coronary-dissection
#6
Louis Tsun Cheung Chow, Maria Bernadette Che Ying Chow
Myocardial damage in catecholamine cardiomyopathy, characterized by patchy myocyte necrosis commonly with contraction band appearances, interstitial fibrosis, and varying degrees of inflammatory infiltrates, has been well documented. However, coronary vascular pathology has not been recognized. Autopsy of a 43-year-old housewife who died of acute apical anteroseptal myocardial infarction revealed the incidental finding of a left adrenal pheochromocytoma. The epicardial and intramyocardial median- and small-sized coronary arteries exhibited myointimal dysplasia in the form of fibroblastic proliferation in the intima and media, resulting in thickened dysplastic vessels with marked luminal narrowing, occasionally leading to near-total occlusion...
October 11, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30343188/a-case-of-biopsy-proven-eosinophilic-myocarditis-related-to-tetanus-toxoid-immunization
#7
Hiroyuki Yamamoto, Toru Hashimoto, Keiko Ohta-Ogo, Hatuse Ishibashi-Ueda, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Tomoki Yokochi
Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. A systemic high-dose corticosteroid treatment had a dramatic beneficial effect on hemodynamic instability and resulted in complete recovery...
October 9, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30342320/infrasound-induces-coronary-perivascular-fibrosis-in-rats
#8
Ana Lousinha, Maria João R Oliveira, Gonçalo Borrecho, José Brito, Pedro Oliveira, António Oliveira de Carvalho, Diamantino Freitas, Artur P Águas, Eduardo Antunes
BACKGROUND: Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound (<20 Hz), whose effects on the heart are unknown. We evaluated the morphological changes induced by IFS in rat coronaries in the presence and absence of dexamethasone...
October 9, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30399526/thrombus-on-the-inflow-cannula-of-the-heartware-hvad-an-update
#9
Carolyn H Glass, Alexander Christakis, Gregory A Fishbein, Jaclyn C Watkins, Kyle C Strickland, Richard N Mitchell, Robert F Padera
BACKGROUND: The HeartWare HVAD (Medtronic, Minneapolis, MN) is a continuous-flow left ventricular assist device (LVAD) approved by the FDA in 2012 as a bridge to transplant in patients with end-stage left ventricular heart failure. The current inflow cannula has a smooth outer surface near the inflow edge and a sintered collar of titanium microspheres near the pump. A previous case series of HVAD patients bridged to transplant revealed thrombus on the outer surface of the inflow cannula in 8 of 8 patients, predominantly at the smooth-sintered interface, that was associated with a clinical stroke rate of 12...
September 15, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30282064/phenotypic-variations-in-carriers-of-predicted-protein-truncating-genetic-variants-in-mybpc3-an-autopsy-based-case-series
#10
Nori Williams, Robert Marion, Thomas V McDonald, Dawei Wang, Bo Zhou, Lucy S Eng, Sung Yon Um, Ying Lin, Kevin Ruiter, Lisa Rojas, Barbara A Sampson, Yingying Tang
Our aim is to characterize predicted protein-truncating variants (PTVs) in MYBPC3, the gene most commonly associated with hypertrophic cardiomyopathy (HCM), found in a series of autopsied HCM cases after sudden unexpected cardiac death. All cases underwent death scene investigation, gross and microscopic autopsies, toxicological testing, a review of medical records, and a molecular analysis of 95 cardiac genes. We found four pathogenic PTVs in MYBPC3 among male decedents. All variants were previously submitted to ClinVar without phenotype details...
September 13, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30223140/myocardial-rupture-after-small-acute-myocardial-infarction-in-the-absence-of-coronary-artery-disease
#11
Christopher P Roth, Morad Qarmali, Silvio H Litovsky, Brigitta C Brott
A 73-year-old woman with a past medical history of hypertension suffered a cardiac arrest. After successful resuscitation, she was hypotensive and tachycardic and the ECG showed ST elevation in the inferior and lateral precordial leads. Coronary angiography did not show evidence of obstructive coronary artery disease. A bedside echocardiogram demonstrated a large pericardial effusion with signs of cardiac tamponade. The echocardiogram and subsequent aortic root angiography did not reveal evidence of dissection...
August 25, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30195228/mir-143-and-mir-145-promote-hypoxia-induced-proliferation-and-migration-of-pulmonary-arterial-smooth-muscle-cells-through-regulating-abca1-expression
#12
Yuxia Yue, Zhiyong Zhang, Lei Zhang, Songhu Chen, Yilin Guo, Yan Hong
BACKGROUND: Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) play an important role in the occurrence and development of pulmonary arterial hypertension (PAH). miR-143/145 was reported to be up-regulated in the animal models and PAH patients, and deletion of miR-143/145 cluster prevented the development of hypoxia-induced pulmonary hypertension, but its underlying mechanism has not been elucidated. METHODS: qRT-PCR and Western blot were performed to detect the expressions of miR-143/145 and ATP-binding cassette transporter A1 (ABCA1) in PAH patients and PASMCs under hypoxic conditions...
August 23, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30103083/a-novel-mutation-of-dystrophin-in-a-becker-muscular-dystrophy-family-with-severe-cardiac-involvement-from-genetics-to-clinicopathology
#13
Liang Chen, Jie Ren, Xiao Chen, Kai Chen, Man Rao, Ningning Zhang, Wenhua Yu, Jiangping Song
BACKGROUND: Dystrophin gene defects are the pathogenic molecular basis of Becker muscular dystrophy (BMD), characterised by skeletal myopathy and cardiomyopathy. Because of the broad phenotype spectrum, it was difficult to use the traditional diagnostic method to achieve an early accurate diagnosis of BMD-associated cardiomyopathy. METHODS: We applied an in-house gene panel testing and a gene-filtering strategy to investigate the genetic defect in a four-generation family with 73 members...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30100494/in-memoriam-hugh-h-mcallister-jr-m-d
#14
EDITORIAL
L Maximilian Buja
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30056298/cd39-and-cd73-in-the-aortic-valve-biochemical-and-immunohistochemical-analysis-in-valve-cell-populations-and-its-changes-in-valve-mineralization
#15
Ewa Kaniewska-Bednarczuk, Barbara Kutryb-Zajac, Padmini Sarathchandra, Iwona Pelikant-Malecka, Alicja Sielicka, Izabela Piotrowska, Ewa M Slominska, Adrian H Chester, Magdi H Yacoub, Ryszard T Smolenski
BACKGROUND: The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis, and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ectonucleotidases, mainly ectonucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5'nucleotidase (CD73, e5NT). OBJECTIVE AND METHODS: We investigated the localization of CD39 and CD73 proteins in human noncalcified and calcified aortic valves using immunohistochemistry together with analysis of NTPDases and e5NT activities in aortic valve homogenates by analysis of substrate into product conversion by high-performance liquid chromatography...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30014985/method-for-preclinical-pathology-evaluation-and-analysis-of-cardiovascular-implantable-electronic-device-implant-sites
#16
Staci L Jessen, Maureen T O'Brien, Trevor W Lancon, Harrison R Smith, Leslie L Suarez, Matthew D Wilcox, Matthew Miller, Brad R Weeks, Fred J Clubb
Cardiovascular implantable electronic devices (CIEDs) typically incorporate leads that directly contact the endocardium. Post-explant pathology evaluation of formalin-fixed CIED lead implant sites and downstream organs (i.e., lungs) can provide useful safety data to the US Food and Drug Administration; however, current regulatory guidelines do not mandate how the safety data are collected. In this paper, we outline a protocol for preclinical pathology evaluation of leads associated with CIEDs, which includes formalin fixation of the heart and lungs, gross evaluation, and qualitative and quantitative histologic evaluation...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30014984/consensus-documents-past-present-and-future
#17
EDITORIAL
Michael A Seidman
No abstract text is available yet for this article.
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30007210/splenectomy-had-no-significant-impact-on-lipid-metabolism-and-atherogenesis-in-apoe-deficient-mice-fed-on-a-severe-atherogenic-diet
#18
Ying Zhang, Xiangbo An, Qiuyue Lin, Jie Bai, Feng Wang, Jiawei Liao
BACKGROUND: For a long time, our major understanding of the spleen is to function as a blood filter for the removal of aged erythrocytes and circulating microorganisms. Splenectomy, therefore, has been widely performed in case of trauma and a variety of hematologic disorders. Although some studies have indicated an increased rate of developing hyperlipidemia and atherosclerotic cardiovascular diseases in splenectomized patients, our recognition of the splenic regulation on lipid metabolism and atherogenesis is still lacking...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005395/candida-parapsilosis-endocarditis-in-an-intravenous-drug-abuser-an-autopsy-report
#19
Manoj Gopal Madakshira, Amanjit Bal, ShivaPrakash, Manish Rathi, Rajesh Vijayvergiya
Candida parapsilosis is a rare cause of endocarditis, which is seen to affect the native valves in patients who are known intravenous drug abusers or following contamination during surgery for prosthetic valves. We discuss a unique constellation of autopsy findings in a 35-year-old chronic opium abuser who presented with left-sided weakness followed by low-grade fever. He was diagnosed to have C. parapsilosis native valve endocarditis with septic emboli involving the myocardial vessels, left middle cerebral artery, spleen, and common iliac artery...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30005394/mesothelial-monocytic-incidental-cardiac-excrescences-mice-report-of-a-case-and-review-of-literature-with-focus-on-pathogenesis
#20
Ilaria Girolami, Albino Eccher, Eliana Gilioli, Luca Novelli, Gioia Di Stefano, Matteo Brunelli, Luca Cima
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a benign lesion composed of histiocytes and mesothelial cells, usually found during cardiac surgery. To date, no more than 50 cases are reported in literature, and pathogenesis is still unclear even if different theories have been proposed. Here we report a case of MICE encountered during aortic valve replacement with typical histological features and extensive immunohistochemical investigation. To date, little information is available about the pathogenesis of MICE...
September 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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