We have located open access text paper links.
The clinical impact of sample storage at -20°C on renin reference intervals and aldosterone-renin ratio calculations.
Journal of Clinical Endocrinology and Metabolism 2024 January 31
Cryoactivation was known to occur in whole blood and plasma samples when kept between +4 and -5°C leading to falsely high renin concentrations. In 2022 it has been clearly shown that cryoactivation can also occur in samples stored at -20°C.Based on these new findings here we discuss how this can influence the clinical diagnosis of patients. First, we show that storage of renin plasma samples can affect the renin measurements and thereby the aldosterone-to-renin ratio (ARR) calculation, which might explain the high intra-individual variability in ARR also recently demonstrated. Second, we discuss the existing studies on the establishment of renin reference intervals and noted the lack of attention given to this recently revealed preanalytical conditions. Our literature review of the reference intervals for renin suggest that cryoactivation might have influence the published data.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app