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Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype.
Journal of Neurogastroenterology and Motility 2024 January 31
BACKGROUND/AIMS: Eating is the major synchronizer of gastrointestinal motility and secretions. The present study aims to evaluate the interplay between self-perceived constipation severity (CS) and colonic response to eating in constipated patients according to the phenotype.
METHODS: We included 387 consecutive outpatients complaining of Rome IV chronic idiopathic constipation. Likert scales for CS, abdominal pain severity, bloating severity, depression and anxiety assessment, total and segmental colonic transit time (CTT), and colonic transit response to eating (CTRE) were performed in all patients.
RESULTS: Of the 387 patients included (49.7 ± 16.4 years), 320 (83%) were female, 203 had irritable bowel syndrome with constipation (IBS-C), 184 as functional constipation (FC), and 283 had defecation disorders (DD). The female gender was characterized by increased bloating severity ( P = 0.011) and decreased Bristol stool form ( P = 0.002). In IBS-C and FC patients, CS was related with bloating severity ( P < 0.001 in both groups) and total CTT ( P = 0.007 in IBS-constipation, P = 0.040 in FC). In IBS-C patients, CS was also associated with abdominal pain severity ( P = 0.003) and Bristol stool form ( P = 0.004). In contrast, in FC, CS was only related to left CTRE ( P = 0.006), and in patients with DD, CS was associated with total CTT ( P < 0.001) and left CTRE ( P = 0.002).
CONCLUSION: Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.
METHODS: We included 387 consecutive outpatients complaining of Rome IV chronic idiopathic constipation. Likert scales for CS, abdominal pain severity, bloating severity, depression and anxiety assessment, total and segmental colonic transit time (CTT), and colonic transit response to eating (CTRE) were performed in all patients.
RESULTS: Of the 387 patients included (49.7 ± 16.4 years), 320 (83%) were female, 203 had irritable bowel syndrome with constipation (IBS-C), 184 as functional constipation (FC), and 283 had defecation disorders (DD). The female gender was characterized by increased bloating severity ( P = 0.011) and decreased Bristol stool form ( P = 0.002). In IBS-C and FC patients, CS was related with bloating severity ( P < 0.001 in both groups) and total CTT ( P = 0.007 in IBS-constipation, P = 0.040 in FC). In IBS-C patients, CS was also associated with abdominal pain severity ( P = 0.003) and Bristol stool form ( P = 0.004). In contrast, in FC, CS was only related to left CTRE ( P = 0.006), and in patients with DD, CS was associated with total CTT ( P < 0.001) and left CTRE ( P = 0.002).
CONCLUSION: Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.
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