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Journal of Clinical Medicine

Meng-Yu Wu, Ling-Chi Lee, Yu-Long Chen, Yung-Hsiang Yeh, Chia-Jung Li, Giou-Teng Yiang
Emphysematous pyelonephritis is a rare but life-threatening infection characterized by an accumulation of gas in the renal parenchyma. A high mortality rate was reported, and timely administration of broad-spectrum antibiotics for enteric gram-negative bacilli, such as Escherichia coli , Enterobacter , and Klebsiella pneumoniae , was recommended for improving the clinical outcome. Computed tomography is a useful tool for identifying gas accumulation within the perirenal space. Abdominal ultrasound and abdominal plain film are alternative options with lower accuracy rates...
July 14, 2018: Journal of Clinical Medicine
Ines Pombeiro, Sven H Loosen, Sanchari Roy, Florian Schueller, Lukas Niewenhuisen, Mark Luedde, Mihael Vucur, Frank Tacke, Marcel Binnebösel, Wenzel Schoening, Christian Trautwein, Tom Luedde, Ulf Peter Neumann, Christoph Roderburg
The tumor necrosis factor⁻related weak inducer of apoptosis (TWEAK) belongs to the tumor necrosis factor ligand superfamily, which was shown to play an important role in inflammatory and malignant gastrointestinal diseases, including colitis or colorectal cancer. However, in contrast to other members of the TNF ligand superfamily, its role as a biomarker in pancreatic cancer is currently unknown. We analyzed serum levels of A proliferation-inducing ligand (APRIL) and TWEAK in 134 patients with pancreatic cancer...
July 13, 2018: Journal of Clinical Medicine
Vladimir Zugic, Natasa Mujovic, Sanja Hromis, Jelena Jankovic, Mirjana Drvenica, Aleksandra Perovic, Ivan Kopitovic, Aleksandra Ilic, Dejan Nikolic
BACKGROUND: The aim of this study was to establish whether non-atopic patients with cough variant asthma (CVA) have different pattern of response to direct bronchoconstrictors than non-atopic patients with classic asthma (CA). METHOD: A total of 170 patients of both sexes with stable CVA and CA were screened for the study and 153 were included. Patients with proven atopy were not included and 17 patients with worsening of their condition or with verified bronchial obstruction during screening were excluded...
July 12, 2018: Journal of Clinical Medicine
Ruicong Zhi, Ghada Zamzmi Dmitry Zamzmi, Dmitry Goldgof, Terri Ashmeade, Yu Sun
Infants' early exposure to painful procedures can have negative short and long-term effects on cognitive, neurological, and brain development. However, infants cannot express their subjective pain experience, as they do not communicate in any language. Facial expression is the most specific pain indicator, which has been effectively employed for automatic pain recognition. In this paper, dynamic pain facial expression representation and fusion scheme for automatic pain assessment in infants is proposed by combining temporal appearance facial features and temporal geometric facial features...
July 11, 2018: Journal of Clinical Medicine
Kentaro Inamura, Yutaka Takazawa, Yosuke Inoue, Yusuke Yokouchi, Maki Kobayashi, Akio Saiura, Tomoko Shibutani, Yuichi Ishikawa
B7-H3 (CD276), a member of the family of immune modulators, orchestrates antitumor immunity. To date, only small-sized studies have examined the association of B7-H3 expression with survival in pancreatic cancer, yielding inconclusive results. We evaluated tumor B7-H3 expression in 150 consecutive patients with pancreatic ductal adenocarcinoma using immunohistochemistry. B7-H3 expression was positive (≥10% tumor cells) in 99 of 150 (66%) cases of pancreatic cancer. We classified the tumors into four groups depending on B7-H3 expression (negative, low, intermediate, and high) and found that higher B7-H3 expression was independently associated with lower disease-free survival (DFS; for high vs...
July 10, 2018: Journal of Clinical Medicine
Hodaka Yamada, Shunsuke Funazaki, Daisuke Suzuki, Rika Saikawa, Masashi Yoshida, Masafumi Kakei, San-E Ishikawa, Yoshiyuki Morisita, Kazuo Hara
Urinary calcium excretion is not known to predict progression of renal dysfunction in patients with type 2 diabetes mellitus. This study aimed to investigate associations between urinary calcium excretion and progression of estimated glomerular filtration rate (eGFR) in type 2 diabetic patients. This study was a retrospective, single-center, observational cohort study. We enrolled a total of 89 patients with type 2 diabetes mellitus and the average follow-up period was 7.2 ± 1.0 years. We divided patients into two groups based on the median of annual decline in the slope of eGFR, then defined the over-median population as the progressed group and under-median population as the non-progressed group...
July 10, 2018: Journal of Clinical Medicine
Munekazu Yamakuchi, Teruto Hashiguchi
Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entire body. In most mammalian systems, the capacity of endothelial cells to divide is limited and endothelial cells are prone to be senescent. Aging of ECs and resultant endothelial dysfunction lead to a variety of vascular diseases such as atherosclerosis, diabetes mellites, hypertension, and ischemic injury. However, the mechanism by which ECs get old and become senescent and the impact of endothelial senescence on the vascular function are not fully understood...
July 10, 2018: Journal of Clinical Medicine
Dong Hyun Yoon, Jun-Young Lee, Seong A Shin, Yu Kyeong Kim, Wook Song
BACKGROUND: Cognitive frailty and impairment are phenotypically and pathophysiologically correlated with physical frailty. We examined associations between accumulation of amyloid-β in the brain as a brain imaging biomarker and phenotypes of physical frailty (weight loss, weakness, exhaustion, slowness, low physical activity) in older adults with mild cognitive impairment (MCI) and cognitive frailty. METHODS: Cross-sectional associations between brain amyloid-β accumulation measured with 11 C-Pittsburgh compound B (PiB)-positron emission tomography (PET) and physical frailty were examined in 48 elderly participants (mean age: 75...
July 9, 2018: Journal of Clinical Medicine
Rosagemma Ciliberti, Matteo Gulino, Valentina Gazzaniga, Fabio Gallo, Valerio Gaetano Vellone, Francesco De Stefano, Pierluigi Santi, Ilaria Baldelli
Post mortem body donation (PMBD) for medical training and research plays a key role in medical-surgical education. The aim of this study is to evaluate Italian medical students’ awareness and attitudes regarding this practice. A questionnaire was sent to 1781 Italian medical students (MS). A total of 472 MS responded: 406 (92.91%) had a strongly positive attitude to PMBD, while 31 (7.09%) were not in favor. The majority of subjects were Catholic (56.36%), while 185 and 21 subjects, said that they did not hold any religious beliefs, or were of other religions, respectively...
July 9, 2018: Journal of Clinical Medicine
Yun Kyung Jeon, Myung Jun Shin, Cheol Min Kim, Byeong-Ju Lee, Sang Hun Kim, Da Som Chae, Jong-Hwan Park, Yong Seok So, Hyuntae Park, Chang Hyung Lee, Byoung Chul Kim, Jae Hyeok Chang, Yong Beom Shin, In Joo Kim
We explored whether a mechanically-assisted squat exercise improved muscle mass, muscle function, and pulmonary function in elderly women with or without sarcopenia. In total, 76 community-dwelling elderly subjects (>60 years of age) were screened. We ultimately included 30 subjects who completed more than 80% of the six-week course of mechanically-assisted squat exercises (three days per week, 30 min per day). We measured body composition, lung function, knee extensor strength, hand grip strength, and the 3-min walk distance (3MWD) before and after the exercise program...
July 5, 2018: Journal of Clinical Medicine
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Yuri Yamamoto, Akira Kuwahara, Minoru Irahara
It is known that metabolic disturbances suppress reproductive functions in females. The mechanisms underlying metabolic and nutritional effects on reproductive functions have been established based on a large body of clinical and experimental data. From the 1980s to 1990s, it was revealed that disrupted gonadotropin-releasing hormone (GnRH) secretion is the main cause of reproductive impairments in metabolic and nutritional disorders. From the late 1990s to early 2000s, it was demonstrated that, in addition to their primary functions, some appetite- or metabolism-regulating factors affect GnRH secretion...
July 5, 2018: Journal of Clinical Medicine
Heidi Buchele Harris, Weiyun Chen
BACKGROUND: This study examined the effects of a 4-week technology-enhanced physical activity (PA) interventions on students’ real-time daily PA and aerobic fitness levels. METHODS: 116 fifth-graders were assigned to one intervention group ( n = 31) participating in daily physical activity engaging the brain with Fitbit Challenge (PAEB-C), another intervention group ( n = 29) wearing Fitbits only (Fitbit-O) daily, five days per week, or the comparison group ( n = 56)...
June 29, 2018: Journal of Clinical Medicine
Anmol Cheema, Saira Chaughtai, Usman Mazahir, Manimala Roy, Mohammad A Hossain
Foreign body granulomatosis has many etiologies, including the injection of oral medications intravenously. The insoluble filler materials that are used in the medications can lodge in pulmonary arterioles and capillaries, which can trigger foreign body giant cell reaction, chronic inflammation, thrombosis, and fibrosis, resulting in pulmonary hypertension, progressive shortness of breath, and, potentially, fatal conditions. On imaging, this may present with multiple miliary mottling’s/nodules. The use of a bronchoscopy with biopsy can be an excellent way to establish a diagnosis in appropriate clinical settings...
June 29, 2018: Journal of Clinical Medicine
Anna E B McLean, David J Barnes, Lauren K Troy
The role of the respiratory physician in diagnosing lung cancer has increased in complexity over the last 20 years. Adenocarcinoma is now the prevailing histopathological sub-type of non-small cell lung cancer (NSCLC) resulting in more peripheral cancers. Conventional bronchoscopy is often not sufficient to obtain adequate tissue samples for diagnosis. Radiologically guided transthoracic biopsy is a sensitive alternative, but carries significant risks. These limitations have driven the development of complimentary bronchoscopic navigation techniques for peripheral tumour localisation and sampling...
June 29, 2018: Journal of Clinical Medicine
Milan Savic, Suzana Cvjeticanin, Milica Lazovic, Ljubica Nikcevic, Dejan Nikolic
In this study, we evaluated and compared the morphogenetic variability and the degree of recessive homozygosity in patients with manifested ischemic stroke compared to healthy controls. We have evaluated 120 patients with manifested ischemic stroke, of which 64 did not have hypertension and 56 have hypertension. For comparison, we additionally tested 194 healthy individuals without manifested ischemic stroke (controls). For the estimation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs...
June 26, 2018: Journal of Clinical Medicine
Faruk Pehlivanlı, Oktay Aydin, Gökhan Karaca, Gülçin Aydin, Tuba Devrim, Huri Bulut, Bülent Bakar, Çağatay Erden Daphan
BACKGROUND: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. METHODS: Forty eight male Wistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created...
June 25, 2018: Journal of Clinical Medicine
Füsun Şahin, Ayşe Feyza Aslan
We seek to define inflammatory markers, lipid and protein profiles that may aid in distinguishing lung cancer cases from those who are healthy and to determine the relationships between these levels and cancer stage and cell type. Lung cancer patients ( n = 140, Group 1) and healthy cases ( n = 50, Group 2) were enrolled. We retrieved platelet, platelet-associated markers (plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW)), neutrophil/lymphocyte ratio-NLR, platelet/lymphocyte ratio-PLR, lipids (total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides), proteins (total protein (TP) and albumin), and C-reactive protein (CRP) from electronic records and compared the data from lung cancer patients with those from healthy controls...
June 25, 2018: Journal of Clinical Medicine
Elham Rahmani, Samad Akbarzadeh, Ainaz Broomand, Fatemeh Torabi, Niloofar Motamed, Marzieh Zohrabi
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproduction age and a major cause of anovulatory infertility. Insulin resistance plays an important role in the development and durability of this disorder. ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain...
June 22, 2018: Journal of Clinical Medicine
Xuan Yang, Ronald Domalaon, Yinfeng Lyu, George G Zhanel, Frank Schweizer
In this study, we examined the in vitro effect of tobramycin-efflux pump inhibitor (TOB-EPI) conjugates in combinations with fluoroquinolones, rifampicin and fosfomycin on the growth of multi-drug resistant (MDR) and extremely-drug resistant (XDR) Pseudomonas aeruginosa . The TOB-EPI conjugates include tobramycin covalently linked to 1-(1-naphthylmethyl)-piperazine (NMP) ( 1 ), paroxetine (PAR) ( 2 ) and a dibasic peptide analogue of MC-04,124 (DBP) ( 3 ). Potent synergism was found for combinations of TOB-NMP ( 1 ), TOB-PAR ( 2 ) or TOB-DBP ( 3 ) with either fluoroquinolones (moxifloxacin, ciprofloxacin), rifampicin or fosfomycin against a panel of multidrug-resistant/extensively drug-resistant (MDR/XDR) P...
June 22, 2018: Journal of Clinical Medicine
Ali Siddiqui, Paul D Loprinzi
Previous experimental work suggests that acute exercise may positively influence the accurate recall of past episodic events. However, few studies have examined whether acute exercise also reduces the number of false episodic memories. We evaluated this paradigm in conjunction with an examination of the temporal effects of acute exercise, which have previously been shown to play an important role in subserving episodic memory function. Twenty young adults participated in three experimental visits, including a non-exercise control visit, a visit involving an acute bout (20 min) of moderate-intensity exercise occurring prior to the memory task, and a visit involving an acute bout of exercise occurring during the encoding of the memory task...
June 21, 2018: Journal of Clinical Medicine
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