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Journal of Clinical Medicine

Celine S Lehmann, Tobias Hofmann, Ulf Elbelt, Matthias Rose, Christoph U Correll, Andreas Stengel, Verena Haas
Increased physical activity (PA) affects outcomes in patients with anorexia nervosa (AN). To objectively assess PA patterns of hospitalized AN patients in comparison with healthy, outpatient controls (HC), and to analyze the effect of PA on Body Mass Index (BMI) change in patients with AN, we measured PA in 50 female patients with AN (median age = 25 years, range = 18⁻52 years; mean BMI = 14.4 ± 2.0 kg/m²) at the initiation of inpatient treatment and in 30 female healthy controls (median age = 26 years, range = 19⁻53 years; mean BMI = 21...
September 18, 2018: Journal of Clinical Medicine
Irene Dogliotti, Daniela Drandi, Elisa Genuardi, Simone Ferrero
The clearance of malignant clonal cells significantly correlates with clinical outcomes in many hematologic malignancies. Accurate and high throughput tools for minimal residual disease (MRD) detection are needed to overcome some drawbacks of standard molecular techniques; such novel tools have allowed for higher sensitivity analyses and more precise stratification of patients, based on molecular response to therapy. In this review, we depict the recently introduced digital PCR and next-generation sequencing technologies, describing their current application for MRD monitoring in lymphoproliferative disorders...
September 18, 2018: Journal of Clinical Medicine
Kristina Bojanić, Ines Bilić Ćurčić, Lucija Kuna, Tomislav Kizivat, Robert Smolic, Nikola Raguž Lučić, Kristina Kralik, Vatroslav Šerić, Gordana Ivanac, Sandra Tucak-Zorić, Aleksandar Včev, Martina Smolić
AIM: To determine the levels of Wnt inhibitors in patients treated with aromatase inhibitors (AIs) prior to therapy and to investigate their association with bone mineral density (BMD) and lifestyle parameters. METHODS: 137 breast cancer patients were divided into a group treated with 1 mg of anastrozole and a group w/o anastrozole therapy. Serum concentrations of sclerostin and dickkopf1 (DKK1) were measured by ELISA. BMD was measured by dual-energy X-ray absorptiometry (DXA)...
September 17, 2018: Journal of Clinical Medicine
Tao-Min Huang, Vin-Cent Wu, Yu-Feng Lin, Jian-Jhong Wang, Chih-Chung Shiao, Likwang Chen, Shih-Chieh Jeff Chueh, Eric Chueh, Shao-Yu Yang, Tai-Shuan Lai, Shuei-Liong Lin, Tzong-Shinn Chu, Kwan-Dun Wu
Although statin treatment is recommended for patients with chronic kidney disease (CKD) stages I⁻IV, its potential benefits have not been reported in advanced CKD patients. Non-diabetic patients with advanced CKD (pre-dialysis patients, estimated glomerular filtration rate <15 mL/min/1.73 m²) were enrolled from a National Health Insurance Research Database with a population of 23 million. Statin users and non-users were matched using propensity scoring and analyzed using Cox proportional hazards models, taking mortality as a competing risk with subsequent end-stage renal disease (ESRD) and statin doses as time-dependent variables...
September 17, 2018: Journal of Clinical Medicine
GianLuca Colussi, Francesca Zuttion, Bruno Bais, Pierluigi Dolso, Mariarosaria Valente, Gian Luigi Gigli, Daniele Gasparini, Massimo Sponza, Cristiana Catena, Leonardo A Sechi, Alessandro Cavarape
Carotid artery stenting (CAS) is a minimal invasive procedure used to resolve carotid occlusion that can be affected by peri-procedural complications. Statin use before CAS has shown to reduce peri-procedural risk and improve survival, though time-dependent cofactors that influence mortality has not been considered. The aim of this study was to evaluate long-term survival of patients who undergo CAS considering new occurred major adverse cardiovascular event (MACE) as time-dependent cofactor. In this study, 171 high cardiovascular risk patients (age 72 ± 8 years, 125 males) were enrolled after CAS procedure and were followed for a median of 8...
September 17, 2018: Journal of Clinical Medicine
Jung-Hee Ryu, Jin-Woo Park, Francis Sahngun Nahm, Young-Tae Jeon, Ah-Young Oh, Hak Jong Lee, Jin-Hee Kim, Sung-Hee Han
The use of gamification in healthcare has been gaining popularity. This prospective, randomized, clinical trial was designed to evaluate whether gamification of the preoperative process-via virtual reality (VR) gaming that provides a vivid, immersive and realistic experience-could reduce preoperative anxiety in children. Seventy children scheduled for elective surgery under general anesthesia were randomly divided into either the control or gamification group. Children in the control group received conventional education regarding the preoperative process, whereas those in the gamification group played a 5 min VR game experiencing the preoperative experience...
September 17, 2018: Journal of Clinical Medicine
Sherif T S Hassan, Kateřina Berchová-Bímová, Miroslava Šudomová, Milan Malaník, Karel Šmejkal, Kannan R R Rengasamy
Thymus bovei Benth. (TB) is an important plant in the traditional medicine of the Mediterranean region. This study investigates the health-promoting properties of TB essential oil (TB-EO) for its possible use in clinical practice with regards to its cytotoxic, anti-herpes simplex virus type 2 (HSV-2), and antihypertensive (through inhibition of human angiotensin-converting enzyme; ACE) properties. The phytochemical profile of EO (99.9%) was analyzed by Gas Chromatography with Flame-Ionization Detection (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS)...
September 15, 2018: Journal of Clinical Medicine
Su Hwan Lee, Yeojun Yun, Soo Jung Kim, Eun-Ju Lee, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim, Han-Na Kim, Jin Hwa Lee
There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never ( n = 288), former ( n = 267), and current smokers ( n = 203). Among the three groups, there was no difference in alpha diversity, however, Jaccard-based beta diversity showed significant difference ( p = 0...
September 14, 2018: Journal of Clinical Medicine
Roger J W Truscott, Michael G Friedrich
Recent discoveries may change the way that multiple sclerosis (MS) is viewed, particularly with regard to the reasons for the untoward immune response. The fact that myelin proteins are long-lived, and that by the time we are adults, they are extensively degraded, alters our perspective on the reasons for the onset of autoimmunity and the origin of MS. For example, myelin basic protein (MBP) from every human brain past the age of 20 years, is so greatly modified, that it is effectively a different protein from the one that was laid down in childhood...
September 14, 2018: Journal of Clinical Medicine
Sylvia L Asa, Shereen Ezzat, Ozgur Mete
Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the sympathetic and parasympathetic nervous systems. They are most commonly identified in the head and neck, being most frequent in the carotid body, followed by jugulotympanic paraganglia, vagal nerve and ganglion nodosum, as well as laryngeal paraganglia. Abdominal sites include the well-known urinary bladder tumors that originate in the Organ of Zuckerkandl. However, other unusual sites of origin include peri-adrenal, para-aortic, inter-aortocaval, and paracaval retroperitoneal sites, as well as tumors in organs where they may not be expected in the differential diagnosis of neuroendocrine neoplasms, such as thyroid, parathyroid, pituitary, gut, pancreas, liver, mesentery, lung, heart and mediastinum...
September 13, 2018: Journal of Clinical Medicine
Feng-Tzu Chen, Jennifer L Etnier, Chih-Han Wu, Yu-Min Cho, Tsung-Min Hung, Yu-Kai Chang
This study aimed to determine the dose-response relationship between exercise duration and task switching in older adults. Acute moderate intensity aerobic exercise for 20 min resulted in shorter response times than control and 10-min sessions in the heterogeneous, non-switch, and switch conditions, but not in the homogeneous condition. Additionally, linear and cubic trends between exercise duration and global switching performance as well as local switching performance were revealed with faster times being predicted by longer duration exercise; however, the cubic relationship resulted in performance following the 45-min session being not significantly different from the other three sessions...
September 13, 2018: Journal of Clinical Medicine
Shiuh-Tsuen Huang, Chun-Yi Wu, Nan-Yao Lee, Chien-Wei Cheng, Meei-Ju Yang, Yi-An Hung, Tak-Wah Wong, Ji-Yuan Liang
The adaptability of bacterial resistance to antibiotics contributes to its high efficiency during evolution. Tetracycline (TC) is a broad-spectrum antimicrobial agent. Chromatographic analyses and mass spectrometry were used to study the effects of the light illumination of a 462 nm light-emitting diode (LED) on the conformational changes of TC in a phosphate buffer solution (PBS, pH 7.8). Especially, the inactivation of superoxide anion radicals (O₂•- ) and Escherichia coli ( E. coli ), including that of a multidrug-resistant E...
September 12, 2018: Journal of Clinical Medicine
Meng-Hsuen Hsieh, Li-Min Sun, Cheng-Li Lin, Meng-Ju Hsieh, Kyle Sun, Chung-Y Hsu, An-Kuo Chou, Chia-Hung Kao
OBJECTIVES: Observational studies suggested that patients with type 2 diabetes mellitus (T2DM) presented a higher risk of developing colorectal cancer (CRC). The current study aims to create a deep neural network (DNN) to predict the onset of CRC for patients with T2DM. METHODS: We employed the national health insurance database of Taiwan to create predictive models for detecting an increased risk of subsequent CRC development in T2DM patients in Taiwan. We identified a total of 1,349,640 patients between 2000 and 2012 with newly diagnosed T2DM...
September 12, 2018: Journal of Clinical Medicine
Akihito Kazuno, Daisuke Maki, Ippei Yamato, Nobuyuki Nakajima, Hiroya Seta, Shuichi Soeda, Soji Ozawa, Yoshiyasu Uchiyama, Tetsuro Tamaki
Hybrid transplantation of skeletal muscle-derived multipotent stem cells (Sk-MSCs) and bioabsorbable polyglyconate (PGA) felt was studied as a novel regeneration therapy for the transected recurrent laryngeal nerve (RLN). Sk-MSCs were isolated from green fluorescence protein transgenic mice and then expanded and transplanted with PGA felt for the hybrid transplantation (HY group) into the RLN transected mouse model. Transplantation of culture medium (M group) and PGA + medium (PGA group) were examined as controls...
September 12, 2018: Journal of Clinical Medicine
Behzad Memari, Niloofar Moghiseh, Farnaz Mohammadian, Mahsa Ghajarzadeh, Hadi Ghoreishian
Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are considered important complications of pre-eclampsia. This study was conducted to determine the association of pre-eclampsia with non-alcoholic fatty liver disease and the association of pre-eclampsia with bilateral intima⁻media thickness (IMT; right and left), separately. Twenty-one pregnant women with pre-eclampsia and 21 normal pregnant women were enrolled in the present study. The right and left intima⁻media thicknesses of carotid arteries were evaluated using Doppler sonography...
September 12, 2018: Journal of Clinical Medicine
Ying-Ying Chen, Vin-Cent Wu, Wei-Chieh Huang, Yu-Chang Yeh, Mai-Szu Wu, Chiu-Ching Huang, Kwan-Dun Wu, Ji-Tseng Fang, Chih-Jen Wu
(1) Background: Norepinephrine (NE) is the first-line vasoactive agent used in septic shock patients; however, the effect of norepinephrine on dialysis-required septic acute kidney injury (AKI-D) patients is uncertain. (2) Methods: To evaluate the impact of NE on 90-day mortality and renal recovery in septic AKI-D patients, we enrolled patients in intensive care units from 30 hospitals in Taiwan. (3) Results: 372 patients were enrolled and were divided into norepinephrine users and non-users. After adjustment by Inverse probability of treatment weighted (IPTW), there was no significant difference of baseline comorbidities between the two groups...
September 12, 2018: Journal of Clinical Medicine
Letizia Lorusso, Monica Salerno, Francesco Sessa, Daniela Nicolosi, Lucia Longhitano, Carla Loreto, Marco Carotenuto, Antonietta Messina, Vincenzo Monda, Ines Villano, Giuseppe Cibelli, Anna Valenzano, Marcellino Monda, Paolo Murabito, Maria Pina Mollica, Giovanni Messina, Andrea Viggiano
The term "pain threshold" refers to the measurement of the intensity of a physical stimulus that evokes pain. To estimate the pain threshold, a mechanical or electrical stimulus with increasing intensity is usually applied until the subject under evaluation refers to a pain sensation. This study aims to evaluate the autoalgometric pain threshold as a perfect technique to determine the effects of stimulation rate in relation to both gender and the site of stimulation. In this experimental model, pressure algometry was applied: the subject under evaluation pushed a finger against a small round metal tip, producing and at the same time controlling the intensity of the noxious stimulus...
September 12, 2018: Journal of Clinical Medicine
Martin Langeskov-Christensen, Søren Eskildsen, Egon Stenager, Henrik Boye Jensen, Helle Hvilsted Nielsen, Thor Petersen, Lars Grøndahl Hvid, Päivi Hämäläinen, Lisbet Marstrand, Ulrik Dalgas
(1) Background: Cognitive impairment is highly prevalent in multiple sclerosis (MS). Staying physically fit may be associated with preservation of cognitive performance in persons with MS (pwMS); (2) Objective: To investigate the association between aerobic capacity and the cognitive domains of information processing, learning and memory, and verbal fluency as well as single and composite z-scores of the Brief Repeatable Battery of Neuropsychological tests (BRBNT) in pwMS; (3) Methods: All subjects first performed the BRBNT and then a maximal oxygen consumption (VO₂-max) test on a bicycle ergometer as a measure of aerobic capacity...
September 11, 2018: Journal of Clinical Medicine
Luis M Pérez-Belmonte, Juan J Gómez-Doblas, Mercedes Millán-Gómez, María D López-Carmona, Ricardo Guijarro-Merino, Fernando Carrasco-Chinchilla, Eduardo de Teresa-Galván, Manuel Jiménez-Navarro, M Rosa Bernal-López, Ricardo Gómez-Huelgas
The use of noninsulin antihyperglycaemic drugs in the hospital setting has not yet been fully described. This observational study compared the efficacy and safety of the standard basal-bolus insulin regimen versus a dipeptidyl peptidase-4 inhibitor (linagliptin) plus basal insulin in medicine department inpatients in real-world clinical practice. We retrospectively enrolled non-critically ill patients with type 2 diabetes with mild to moderate hyperglycaemia and no injectable treatments at home who were treated with a hospital antihyperglycaemic regimen (basal-bolus insulin, or linagliptin-basal insulin) between January 2016 and December 2017...
September 11, 2018: Journal of Clinical Medicine
Hasthi U Dissanayake, Rowena L McMullan, Yang Kong, Ian D Caterson, David S Celermajer, Melinda Phang, Camille Raynes-Greenow, Jaimie W Polson, Adrienne Gordon, Michael R Skilton
Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thickening, cardiac autonomic control, and cardiac structure/function differ in newborns with high or low body fatness compared to those with average body fatness. 189 healthy singleton term born neonates were recruited and stratified by body fat percentiles (sex and gestation-specific)...
September 11, 2018: Journal of Clinical Medicine
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