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Journal of Clinical Medicine

Hyung-Chul Lee, Soo Bin Yoon, Seong-Mi Yang, Won Ho Kim, Ho-Geol Ryu, Chul-Woo Jung, Kyung-Suk Suh, Kook Hyun Lee
Acute kidney injury (AKI) after liver transplantation has been reported to be associated with increased mortality. Recently, machine learning approaches were reported to have better predictive ability than the classic statistical analysis. We compared the performance of machine learning approaches with that of logistic regression analysis to predict AKI after liver transplantation. We reviewed 1211 patients and preoperative and intraoperative anesthesia and surgery-related variables were obtained. The primary outcome was postoperative AKI defined by acute kidney injury network criteria...
November 8, 2018: Journal of Clinical Medicine
Cho-Kai Wu, Mao-Yuan M Su, Yi-Fan Wu, Juey-Jen Hwang, Lian-Yu Lin
Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by heart failure symptoms and structural change (including fibrosis). The relationship between novel biomarkers and the above components remains unclear. Methods: Seventy-seven HFpEF patients were recruited. All patients underwent echocardiography with tissue doppler imaging, cardiac magnetic resonance imaging (CMRI), and measurement of plasma inflammatory, remodelling, endothelial function, and heart failure biomarker levels...
November 8, 2018: Journal of Clinical Medicine
Benjamin Navet, Jorge William Vargas-Franco, Andrea Gama, Jérome Amiaud, Yongwon Choi, Hideo Yagita, Christopher G Mueller, Françoise Rédini, Dominique Heymann, Beatriz Castaneda, Frédéric Lézot
RANKL signalization is implicated in the morphogenesis of various organs, including the skeleton. Mice invalidated for Rankl present an osteopetrotic phenotype that was less severe than anticipated, depending on RANKL's implication in morphogenesis. The hypothesis of an attenuated phenotype, as a result of compensation during gestation by RANKL of maternal origin, was thus brought into question. In order to answer this question, Rankl null mutant pups from null mutant parents were generated, and the phenotype analyzed...
November 8, 2018: Journal of Clinical Medicine
Kumar Jayant, Isabella Reccia, Francesco Virdis, A M James Shapiro
AIM: The livers from DCD (donation after cardiac death) donations are often envisaged as a possible option to bridge the gap between the availability and increasing demand of organs for liver transplantation. However, DCD livers possess a heightened risk for complications and represent a formidable management challenge. The aim of this study was to evaluate the effects of thrombolytic flush in DCD liver transplantation. METHODS: An extensive search of the literature database was made on MEDLINE, EMBASE, Cochrane, Crossref, Scopus databases, and clinical trial registry on 20 September 2018 to assess the role of thrombolytic tissue plasminogen activator (tPA) flush in DCD liver transplantation...
November 8, 2018: Journal of Clinical Medicine
Hideya Yamazaki, Koji Masui, Gen Suzuki, Satoaki Nakamura, Norihiro Aibe, Daisuke Shimizu, Tatsuyuki Nishikawa, Haruumi Okabe, Ken Yoshida, Tadayuki Kotsuma, Eiichi Tanaka, Keisuke Otani, Yasuo Yoshioka, Kazuhiko Ogawa
We compared radiotherapy outcomes between 241 elderly patients aged ≥75 years and 867 younger controls (age <75 years) with clinically localized prostate cancer. The elderly group showed an equivalent actuarial seven-year biochemical failure-free survival rate (7y-bNED) (94.9%) to the younger control group (96.4%, p = 0.593). The incidence of late genitourinary (GU) and gastrointestinal (GI) toxicities grade ≥2 was also similar between the elderly and younger cohorts, while no grade ≥4 adverse events occurred...
November 8, 2018: Journal of Clinical Medicine
Ivana Acimovic, Marwan M Refaat, Adrien Moreau, Anton Salykin, Steve Reiken, Yvonne Sleiman, Monia Souidi, Jan Přibyl, Andrey V Kajava, Sylvain Richard, Jonathan T Lu, Philippe Chevalier, Petr Skládal, Petr Dvořak, Vladimir Rotrekl, Andrew R Marks, Melvin M Scheinman, Alain Lacampagne, Albano C Meli
BACKGROUND: Sarcoplasmic reticulum Ca2+ leak and post-translational modifications under stress have been implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly lethal inherited arrhythmogenic disorder. Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease modeling. OBJECTIVE: The aims were to obtain functional hiPSC-derived cardiomyocytes from a CPVT patient harboring a novel ryanodine receptor (RyR2) mutation and model the syndrome, drug responses and investigate the molecular mechanisms associated to the CPVT syndrome...
November 8, 2018: Journal of Clinical Medicine
Valentin Benzing, Mirko Schmidt
Exergaming, or active video gaming, has become an emerging trend in fitness, education and health sectors. It is defined as digital games that require bodily movements to play, stimulating an active gaming experience to function as a form of physical activity (PA). Since exergaming is becoming more popular, claims have been made on the usefulness of exergaming. It has, for example, been entitled as being "the future of fitness" by the American College of Sports Medicine, promoting PA and health in children and adolescents...
November 8, 2018: Journal of Clinical Medicine
Maria Gabriela O Fernandes, Vanessa F Santos, Natália Martins, Maria C Sucena, Madalena M Passos, Maria Manuel Marques, Adriana M Magalhães, António Bugalho
BACKGROUND: Different anesthetic protocols may influence endobronchial ultrasound-guided needle aspiration (EBUS-TBNA) outcomes, patient comfort, and even safety. In this study, two anesthesia techniques were assessed and compared for EBUS-TBNA. METHODS: A prospective, multicenter study was carried out. Patients were allocated to Group 1 (general anesthesia with neuromuscular blockade and controlled ventilation) and Group 2 (intravenous sedation). EBUS-TBNA accuracy was the primary outcome...
November 8, 2018: Journal of Clinical Medicine
Sofia Salta, Sandra P Nunes, Mário Fontes-Sousa, Paula Lopes, Micaela Freitas, Margarida Caldas, Luís Antunes, Fernando Castro, Pedro Antunes, Susana Palma de Sousa, Rui Henrique, Carmen Jerónimo
BACKGROUND: Breast cancer (BrC) is the most frequent neoplasm in women. New biomarkers, including aberrant DNA methylation, may improve BrC management. Herein, we evaluated the detection and prognostic performance of seven genes' promoter methylation ( APC , BRCA1 , CCND2 , FOXA1 , PSAT1 , RASSF1A and SCGB3A1 ). METHODS: Methylation levels were assessed in primary BrC tissues by quantitative methylation-specific polymerase chain reaction (QMSP) and in circulating cell-free DNA (ccfDNA) by multiplex QMSP from two independent cohorts of patients (Cohort #1, n = 137; and Cohort #2, n = 44)...
November 7, 2018: Journal of Clinical Medicine
Sophia Subat, Kentaro Inamura, Hironori Ninomiya, Hiroko Nagano, Sakae Okumura, Yuichi Ishikawa
The EGFR gene was one of the first molecules to be selected for targeted gene therapy. EGFR -mutated lung adenocarcinoma, which is responsive to EGFR inhibitors, is characterized by a distinct oncogenic pathway in which unique microRNA (miRNA)⁻mRNA interactions have been observed. However, little information is available about the miRNA⁻mRNA regulatory network involved. Both miRNA and mRNA expression profiles were investigated using microarrays in 155 surgically resected specimens of lung adenocarcinoma with a known EGFR mutation status (52 mutated and 103 wild-type cases)...
November 6, 2018: Journal of Clinical Medicine
Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet
Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate of patients and to identify contributing factors leading to mortality of SCLS in cancer. We searched MEDLINE (inception to July 2018) and of 4612 articles, we identified 62 case reports on SCLS associated with cancer or cancer-related drugs in a total of 53 articles...
November 6, 2018: Journal of Clinical Medicine
Yuanyuan Li, Fan Yu, Lina Niu, Wei Hu, Yong Long, Franklin R Tay, Jihua Chen
The relationship between bruxism and tooth wear is contentious in the literature. The pathophysiological processes of tooth wear may be complicated by the relationship between bruxism and gastroesophageal reflux disease (GERD). The objective of this study was to evaluate the associations among bruxism, GERD, and tooth wear. Two complementary studies were performed: a case-control study to verify the linkage between GERD and bruxism and a cross-sectional study on the same cohort to establish the connection between GERD and tooth wear in bruxism patients...
November 6, 2018: Journal of Clinical Medicine
Kuan-Ju Lai, Chew-Teng Kor, Yao-Peng Hsieh
Background: The results have been inconsistent with regards to the impact of uric acid (UA) on clinical outcomes both in the general population and in patients with chronic kidney disease. The aim of this study was to study the influence of serum UA levels on mortality in patients undergoing continuous ambulatory peritoneal dialysis. Methods: Data on 492 patients from a single peritoneal dialysis unit were retrospectively analyzed. The mean age of the patients was 53.5 ± 15.3 years, with 52% being female ( n = 255)...
November 5, 2018: Journal of Clinical Medicine
Giorgina B Piccoli, Elena Zakharova, Rossella Attini, Margarita Ibarra Hernandez, Alejandra Orozco Guillien, Mona Alrukhaimi, Zhi-Hong Liu, Gloria Ashuntantang, Bianca Covella, Gianfranca Cabiddu, Philip Kam Tao Li, Guillermo Garcia-Garcia, Adeera Levin
Pregnancy is possible in all phases of chronic kidney disease (CKD), but its management may be difficult and the outcomes are not the same as in the overall population. The prevalence of CKD in pregnancy is estimated at about 3%, as high as that of pre-eclampsia (PE), a better-acknowledged risk for adverse pregnancy outcomes. When CKD is known, pregnancy should be considered as high risk and followed accordingly; furthermore, since CKD is often asymptomatic, pregnant women should be screened for the presence of CKD, allowing better management of pregnancy, and timely treatment after pregnancy...
November 5, 2018: Journal of Clinical Medicine
Hsin-Hsu Chou, Yuan-Yow Chiou, Yee-Hsuan Chiou, You-Lin Tain, Hsin-Hui Wang, Mei-Ching Yu, Chih-Cheng Hsu, Ching-Yuang Lin
There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescents on chronic dialysis, specifically focused on the risk of various PRDs. The study cohort included children and adolescents with end-stage renal disease (ESRD) (aged < 20 years) who had received dialysis for at least 90 days between 2000 and 2014 and were identified from Taiwan's National Health Insurance medical claims...
November 5, 2018: Journal of Clinical Medicine
Jiyeon Lee, Jihyeon Kim, Seong A Shin, Soowon Park, Dong Hyun Yoon, Hongrae Kim, Yu Kyeong Kim, Min Kyong Moon, Bo Kyung Koo, Jun-Young Lee
BACKGROUND: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. METHODS: We recruited 160 participants (78 with Alzheimer's disease and 82 without Alzheimer's disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline...
November 4, 2018: Journal of Clinical Medicine
Magdalena Pisarska, Natalia Gajewska, Piotr Małczak, Michał Wysocki, Piotr Major, Katarzyna Milian-Ciesielska, Andrzej Budzyński, Michał Pędziwiatr
The aim of our study was to evaluate the implementation and degree of adherence to the Enhanced Recovery after Surgery (ERAS) protocol in a group of 400 patients operated laparoscopically for colorectal cancer, and to assess its impact on the short-term results. The prospective study included patients with histologically confirmed colorectal cancer undergoing elective laparoscopic resection from years 2012 to 2017. For the purpose of further analysis, patients were divided into four groups: 100 consecutive patients were in each group...
November 4, 2018: Journal of Clinical Medicine
Fatemeh Ebrahimi Belil, Fatemeh Alhani, Abbas Ebadi, Anooshirvan Kazemnejad
BACKGROUND: Given the increasing prevalence of chronic illnesses and their complications, supporting and empowering chronically ill patients seems crucial. Self-efficacy is considered as a predictor for empowerment. The purpose of this study to explore of different aspects of self-efficacy among persons with chronic physical conditions based on the Family-Centered Empowerment Model (FCEM). METHODS: this qualitative study is part of a larger study; sequential exploratory mixed-method for designing an instrument for the FCEM was conducted from May 2015 to March 2016 in two university hospitals...
November 3, 2018: Journal of Clinical Medicine
Tzyy-Yue Wong, Wang-Chuan Juang, Chia-Ti Tsai, Ching-Jiunn Tseng, Wen-Hsien Lee, Sheng-Nan Chang, Pei-Wen Cheng
The dynamics of a living body enables organs to experience mechanical stimulation at cellular level. The human cardiomyocytes cell line provides a source for simulating heart dynamics; however, a limited understanding of the mechanical stimulation effect on them has restricted potential applications. Here, we investigated the effect of mechanical stimulation on the cardiac function-associated protein expressions in human cardiomyocytes. Human cardiomyocyte cell line AC16 was subjected to different stresses: 5% mild and 25% aggressive, at 1 Hz for 24 h...
November 2, 2018: Journal of Clinical Medicine
Verdiana Ravarotto, Francesca Simioni, Gianni Carraro, Giovanni Bertoldi, Elisa Pagnin, Lorenzo A Calò
Fabry disease is an X-linked lysosomal storage disease caused by mutations in the GLA gene that lead to a reduction or an absence of the enzyme α-galactosidase A, resulting in the progressive and multisystemic accumulation of globotriaosylceramide. Clinical manifestation varies from mild to severe, depending on the phenotype. The main clinical manifestations are cutaneous (angiokeratomas), neurological (acroparesthesias), gastrointestinal (nausea, diarrhea abdominal pain), renal (proteinuria and kidney failure), cardiovascular (cardiomyopathy and arrhythmias), and cerebrovascular (stroke)...
November 2, 2018: Journal of Clinical Medicine
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