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Journal of Clinical Medicine

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https://www.readbyqxmd.com/read/29762469/individualised-multimodal-treatment-strategies-for-anaplastic-and-poorly-differentiated-thyroid-cancer
#1
Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch, Pietro Di Fazio
The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter ( NIS ) and radioiodine up-take (RAI-U)...
May 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29757946/role-of-venous-sampling-in-the-diagnosis-of-endocrine-disorders
#2
REVIEW
Ryan W England, Eliza B Geer, Amy R Deipolyi
Venous sampling is the gold standard for localizing abnormal hormone secretion in several endocrine disorders. The most common indication for venous sampling is in the workup of primary aldosteronism, adrenocorticotropic hormone-dependent Cushing's syndrome, and hyperparathyroidism. In experienced hands, venous sampling is safe and accurate. This review discusses the role of venous sampling in the workup of endocrine disease, describing the underlying anatomy and pathophysiology, as an understanding of these concepts is essential for technical and clinical success...
May 14, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29757253/association-of-cardiovascular-health-with-epicardial-adipose-tissue-and-intima-media-thickness-the-kardiovize-study
#3
Jana Hruskova, Andrea Maugeri, Helena Podroužková, Tatiana Štípalová, Juraj Jakubík, Martina Barchitta, Jose R Medina-Inojosa, Martin Homolka, Antonella Agodi, Sarka Kunzova, Ondrej Sochor, Francisco Lopez-Jimenez, Manlio Vinciguerra
Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe...
May 13, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29748483/alexithymia-and-somatosensory-amplification-link-perceived-psychosocial-stress-and-somatic-symptoms-in-outpatients-with-psychosomatic-illness
#4
Mutsuhiro Nakao, Takeaki Takeuchi
BACKGROUND: Psychosomatic patients often complain of a variety of somatic symptoms. We sought to clarify the role of clinical predictors of complaints of somatic symptoms. METHODS: We enrolled 604 patients visiting a psychosomatic outpatient clinic. The outcome was the total number of somatic symptoms, and the candidate clinical predictors were perceived psychosocial stress, alexithymia, somatosensory amplification, adaptation, anxiety, and depression. All participants completed questionnaires assessing the outcome and the predictors...
May 10, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29748480/practice-trends-of-fibrinogen-monitoring-in-thrombolysis
#5
Claire Kaufman, Thomas Kinney, Keith Quencer
There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society of Interventional Radiology, consisting of 23 questions related to practitioner demographics, thrombolysis protocol, and fibrinogen monitoring. There were 455 physician responses; 82% of respondents monitored fibrinogen levels during thrombolysis, of which 97% decreased or stopped tissue plasminogen activator based on the level...
May 10, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29748467/factors-affecting-pregnancy-rate-following-fallopian-tube-recanalization-in-women-with-proximal-fallopian-tube-obstruction
#6
Mamoon H Al-Omari, Nael Obeidat, Mwafiq Elheis, Ruba A Khasawneh, Maha M Gharaibeh
Fallopian tube obstruction is a major cause of female infertility. We aimed to evaluate the factors potentially affecting pregnancy rate following fallopian tube recanalization (FTR) in infertile women with proximal fallopian tube obstruction. Data was retrospectively collected for 61 women (25, primary infertility; 36, secondary infertility) who underwent FTR at our institution. Bivariable and multivariable analyses of clinical pregnancy rates in relation to the following factors were performed: primary vs...
May 10, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29747435/the-use-of-transarterial-approaches-in-peripheral-arteriovenous-malformations-avms
#7
REVIEW
Aditya Khurana, Patrick T Hangge, Hassan Albadawi, M-Grace Knuttinen, Sadeer J Alzubaidi, Sailendra G Naidu, J Scott Kriegshauser, Rahmi Oklu, Brian W Chong
Arteriovenous malformations (AVMs) are a subset of congenital vascular malformations (CVMs). They comprise abnormal connections between arterial and venous circulation; treatment approaches are dependent on the angioarchitecture of the AVM, specifically the number and arrangement of the feeder arteries and outflow veins. Various imaging modalities can be used to diagnose and plan treatment. Here we will review the use of transarterial approaches to treat AVMs.
May 9, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29738505/preschoolers-technology-assessed-physical-activity-and-cognitive-function-a-cross-sectional-study
#8
Minghui Quan, Hanbin Zhang, Jiayi Zhang, Tang Zhou, Jinming Zhang, Guanggao Zhao, Hui Fang, Shunli Sun, Ru Wang, Peijie Chen
Early childhood is a critical period for development of cognitive function, but research on the association between physical activity and cognitive function in preschool children is limited and inconclusive. This study aimed to examine the association between technology-assessed physical activity and cognitive function in preschool children. A cross-sectional analysis of baseline data from the Physical Activity and Cognitive Development Study was conducted in Shanghai, China. Physical activity was measured with accelerometers for 7 consecutive days, and cognitive functions were assessed using the Chinese version of Wechsler Young Children Scale of Intelligence (C-WYCSI)...
May 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29738433/degree-of-left-renal-vein-compression-predicts-nutcracker-syndrome
#9
Patrick T Hangge, Nikhil Gupta, Aditya Khurana, Keith B Quencer, Hassan Albadawi, Sadeer J Alzubaidi, M-Grace Knuttinen, Sailendra G Naidu, Rahmi Oklu
Nutcracker syndrome (NS) refers to symptomatic compression of the left renal vein (LRV) between the abdominal aorta and superior mesenteric artery with potential symptoms including hematuria, proteinuria, left flank pain, and renal venous hypertension. No consensus diagnostic criteria exist to guide endovascular treatment. We aimed to evaluate the specificity of LRV compression to NS symptoms through a retrospective study including 33 NS and 103 control patients. The size of the patent lumen at point of compression and normal portions of the LRV were measured for all patients...
May 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29735915/influence-of-the-self-perception-of-old-age-on-the-effect-of-a-healthy-aging-program
#10
Víctor Manuel Mendoza-Núñez, Elia Sarmiento-Salmorán, Regulo Marín-Cortés, María de la Luz Martínez-Maldonado, Mirna Ruiz-Ramos
It has been shown that health programs are useful for the prevention and control of chronic diseases in community-dwelling older people; however, a negative self-perception of old age could have an effect on the results. Therefore, our aim was to evaluate the effect of a healthy aging program linked to self-perception of old age in Mexican community-dwelling older people. A pre-test/post-test single-group design study was conducted in a convenience sample of 64 older people who undertook the entire healthy aging program workshop (five months’ duration)...
May 7, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29735907/the-frequency-of-mefv-gene-mutations-and-genotypes-in-sanliurfa-province-south-eastern-region-of-turkey-after-the-syrian-civil-war-by-using-next-generation-sequencing-and-report-of-a-novel-exon-4-mutation-i423t
#11
Evren Gumus
BACKGROUND: Familial Mediterranean Fever (FMF) is a genetic disorder characterized by recurrent episodes of fever and abdominal pain. Mutations in the Mediterranean fever (MEFV) gene are localized on the p arm of chromosome 16. Over 333 MEFV sequence variants have been identified so far in FMF patients, which occur mostly in the 2nd and 10th exons of the gene. METHODS: In this study, 296 unrelated patients with clinical suspicion of FMF, which were admitted during January⁻December 2017, were retrospectively reviewed to identify the frequency of MEFV gene mutations by using next generation sequencing...
May 7, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29734770/evaluation-of-the-effect-of-oral-pyridostigmine-on-the-ileus-after-abdominal-surgery-a-blinded-randomized-clinical-trial
#12
Abdulbaset Maleknejad, Alireza Khazaei, Salehoddin Bouya
Postoperative ileus is one of the most important and common complications after abdominal surgery. This single-blind randomized clinical trial study was conducted with the aim of evaluating the effect of oral pyridostigmine (60 mg) on the duration and frequency of response to the treatment of ileus after abdominal surgery on 40 patients in two 20-subject groups of oral pyridostigmine (interventional) and starch (control) in 2015. All 40 people completed the study process and entered the final analysis. In the oral Pyridostigmin group (60 mg) the mean response time for the disposal of gas and stool were 5...
May 6, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29751567/the-gender-impact-on-morphogenetic-variability-in-coronary-artery-disease-a-preliminary-study
#13
Radmila Karan, Biljana Obrenovic-Kircanski, Suzana Cvjeticanin, Natasa Kovacevic-Kostic, Milos Velinovic, Vladimir Milicevic, Milica Vranes-Stoimirov, Dejan Nikolic
We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2...
May 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29751511/the-relationship-between-sleep-problems-neurobiological-alterations-core-symptoms-of-autism-spectrum-disorder-and-psychiatric-comorbidities
#14
REVIEW
Luigi Mazzone, Valentina Postorino, Martina Siracusano, Assia Riccioni, Paolo Curatolo
Children with Autism Spectrum Disorder (ASD) are at an increased risk for sleep disturbances, and studies indicate that between 50 and 80% of children with ASD experience sleep problems. These problems increase parental stress and adversely affect family quality of life. Studies have also suggested that sleep disturbances may increase behavioral problems in this clinical population. Although understanding the causes of sleep disorders in ASD is a clinical priority, the causal relationship between these two conditions remains unclear...
May 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29724061/gastrodoudenal-embolization-indications-technical-pearls-and-outcomes
#15
REVIEW
Gokhan Kuyumcu, Igor Latich, Rulon L Hardman, Gabriel C Fine, Rahmi Oklu, Keith B Quencer
The gastroduodenal artery (GDA) is frequently embolized in cases of upper GI bleed that has failed endoscopic therapy. Additionally, it may be done for GDA pseudoaneurysms or as an adjunctive procedure prior to Yttrim-90 (Y90) treatment of hepatic tumors. This clinical review will summarize anatomy and embryology of the GDA, indications, outcomes and complications of GDA embolization.
May 2, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29724038/reliability-of-using-motion-sensors-to-measure-children-s-physical-activity-levels-in-exergaming
#16
Nan Zeng, Xingyuan Gao, Yuanlong Liu, Jung Eun Lee, Zan Gao
OBJECTIVES: This study examined the reliability of two objective measurement tools in assessing children’s physical activity (PA) levels in an exergaming setting. METHODS: A total of 377 children (190 girls, Mage = 8.39, SD = 1.55) attended the 30-min exergaming class every other day for 18 weeks. Children’s PA levels were concurrently measured by NL-1000 pedometer and ActiGraph GT3X accelerometer, while children’s steps per min and time engaged in sedentary, light, and moderate-to-vigorous PA were estimated, respectively...
May 2, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29723997/lower-limb-function-in-elderly-korean-adults-is-related-to-cognitive-function
#17
A-Sol Kim, Hae-Jin Ko
Patients with cognitive impairment have decreased lower limb function. Therefore, we aimed to investigate the relationship between lower limb function and cognitive disorders to determine whether lower limb function can be screened to identify cognitive decline. Using Korean National Health Insurance Service-National Sample Cohort database data, we assessed the cognitive and lower limb functioning of 66-year-olds who underwent national health screening between 2010 and 2014. Cognitive function was assessed via a questionnaire...
May 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29723992/micrornas-in-smoking-related-carcinogenesis-biomarkers-functions-and-therapy
#18
REVIEW
Tomomi Fujii, Keiji Shimada, Tokiko Nakai, Chiho Ohbayashi
Long-term heavy cigarette smoking is a well-known high-risk factor for carcinogenesis in various organs such as the head and neck, lungs, and urinary bladder. Furthermore, cigarette smoking can systemically accelerate aging, and as the result, promoting carcinogenesis via changing the host microenvironment. Various inflammatory factors, hormones, and chemical mediators induced by smoking mediate carcinoma-related molecules and induce carcinogenesis. MicroRNAs (miRNAs) are a family of short noncoding RNA molecules that bind to mRNAs and inhibit their expression...
May 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29723987/long-term-statin-administration-does-not-affect-warfarin-time-in-therapeutic-range-in-australia-or-singapore
#19
Nijole Bernaitis, Chi Keong Ching, Siew Chong Teo, Tony Badrick, Andrew K Davey, Julia Crilly, Shailendra Anoopkumar-Dukie
BACKGROUND: Warfarin requires ongoing monitoring of the International Normalised Ratio (INR). This is because numerous factors influence the response, including drug interactions with commonly-prescribed medications, such as statins. The administration of statins with warfarin may change INR; however, there is limited information regarding the effects on warfarin control as measured by time in therapeutic range (TTR). Statins may also alter bleeds with warfarin, but there are conflicting reports demonstrating both increased and decreased bleeds, and limited data on diverse ethnic populations...
May 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29723977/body-mass-total-body-fat-percentage-and-visceral-fat-level-predict-insulin-resistance-better-than-waist-circumference-and-body-mass-index-in-healthy-young-male-adults-in-indonesia
#20
Liong Boy Kurniawan, Uleng Bahrun, Mochammad Hatta, Mansyur Arif
The incidence of obesity which leads to insulin resistance (IR) and metabolic disorder is increasing in developing countries, including Indonesia. Male adults have a higher risk of abdominal obesity than females. This is associated with cardiometabolic disorders. Several anthropometric measurements have been proposed to predict IR. The aim of this study was to investigate whether body mass, body mass index (BMI), waist circumference (WC), body fat percentage (BF) or visceral fat level (VF) could become a better predictor of IR in healthy young male adults...
May 1, 2018: Journal of Clinical Medicine
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