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Journal of Clinical Medicine

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https://www.readbyqxmd.com/read/28333078/telemedicine-applications-in-pediatric-retinal-disease
#1
REVIEW
Akhilesh S Pathipati, Darius M Moshfeghi
Teleophthalmology is a developing field that presents diverse opportunities. One of its most successful applications to date has been in pediatric retinal disease, particularly in screening for retinopathy of prematurity (ROP). Many studies have shown that using telemedicine for ROP screening allows a remote ophthalmologist to identify abnormal findings and implement early interventions. Here, we review the literature on uses of telemedicine in pediatric retinal disease and consider future applications.
March 23, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28335525/the-history-of-clotting-factor-concentrates-pharmacokinetics
#2
REVIEW
Massimo Morfini
Clotting factor concentrates (CFCs) underwent tremendous modifications during the last forty years. Plasma-derived concentrates made the replacement therapy feasible not only in the hospital but also at patients' home by on-demand or prophylactic regimen. Virucidal methods, implemented soon after hepatitis and AIDS outbreak, and purification by Mabs made the plasma-derived concentrates safer and purer. CFCs were considered equivalent to the other drugs and general rules and methods of pharmacokinetics (PK) were applied to their study...
March 20, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28335488/italian-registry-of-congenital-bleeding-disorders
#3
Adele Giampaolo, Francesca Abbonizio, Romano Arcieri, Hamisa Jane Hassan
In Italy, the surveillance of people with bleeding disorders is based on the National Registry of Congenital Coagulopathies (NRCC) managed by the Italian National Institute of Health (Istituto Superiore di Sanità). The NRCC collects epidemiological and therapeutic data from the 54 Hemophilia Treatment Centers, members of the Italian Association of Hemophilia Centres (AICE). The number of people identified with bleeding disorders has increased over the years, with the number rising from approx. 7000 in 2000 to over 11,000 in 2015...
March 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28304333/improving-communication-between-physicians-and-their-patients-through-mindfulness-and-compassion-based-strategies-a-narrative-review
#4
REVIEW
Alberto Amutio-Kareaga, Javier García-Campayo, Luis Carlos Delgado, Daniel Hermosilla, Cristina Martínez-Taboada
Communication between physicians and patients is a key pillar of psychosocial support for enhancing the healing process of patients and for increasing their well-being and quality of life. Physicians and other health professionals might benefit from interventions that increase their self-care, awareness, compassion, and other-focused concern, and reduce the chances of distress and burnout. There is substantial evidence for the contribution of different management strategies to achieve these aims. The goal of this article is to review the potential effect of mindfulness and compassion-based strategies for the improvement of physician-patient interactions...
March 17, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28335442/in-vitro-and-in-vivo-effects-of-gracilaria-verrucosa-extracts-on-osteoclast-differentiation
#5
Kwang-Jin Kim, Yong-Jin Lee, Yun-Ho Hwang, Kyung-Yun Kang, Sung-Tae Yee, Young-Jin Son
Bone remodeling, a physiological process characterized by bone formation by osteoblasts and bone resorption by osteoclasts, is important for the maintenance of healthy bone in adult humans. Osteoclasts play a critical role in bone erosion and osteoporosis and are bone-specific multinucleated cells generated through differentiation of monocyte/macrophage lineage precursors. Receptor activator of NF-κB ligand (RANKL) has been reported to induce osteoclast differentiation. In this study, we explored whether Gracilaria verrucosa extracts (GE) could affect RANKL-mediated osteoclast differentiation...
March 14, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28287425/the-relationship-between-mitochondrial-respiratory-chain-activities-in-muscle-and-metabolites-in-plasma-and-urine-a-retrospective-study
#6
Corinne Alban, Elena Fatale, Abed Joulani, Polina Ilin, Ann Saada
The relationship between 114 cases with decreased enzymatic activities of mitochondrial respiratory chain (MRC) complexes I-V (C I-V) in muscle and metabolites in urine and plasma was retrospectively examined. Less than 35% disclosed abnormal plasma amino acids and acylcarnitines, with elevated alanine and low free carnitine or elevated C4-OH-carnitine as the most common findings, respectively. Abnormal urine organic acids (OA) were detected in 82% of all cases. In CI and CII defects, lactic acid (LA) in combination with other metabolites was the most common finding...
March 10, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28287416/novel-pharmacological-activity-of-artesunate-and-artemisinin-their-potential-as-anti-tubercular-agents
#7
Won Hyung Choi
Tuberculosis is a major infectious disease that globally causes the highest human mortality. From this aspect, this study was carried out to evaluate novel pharmacological activities/effects of artesunate and artemisinin causing anti-tubercular activity/effects against Mycobacterium tuberculosis (Mtb). The anti-Mtb activities/effects of artesunate and artemisinin were evaluated using different anti-Mtb indicator assays, such as the resazurin microtiter assay, the Mycobacteria Growth Indicator Tube (MGIT) 960 system assay, and the Ogawa slant medium assay, as well as in vivo tests...
March 10, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28282928/oxidative-stress-a-new-target-for-pancreatic-cancer-prognosis-and-treatment
#8
REVIEW
Javier Martinez-Useros, Weiyao Li, Marticela Cabeza-Morales, Jesus Garcia-Foncillas
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumors, and its incidence is rising worldwide. Survival can be improved when tumors are detected at an early stage; however, this cancer is usually asymptomatic, and the disease only becomes apparent after metastasis. Several risk factors are associated to this disease. Chronic pancreatitis, diabetes, and some infectious disease are the most relevant risk factors. Incidence of PDAC has increased in the last decades. It is hypothesized it could be due to other acquired risk habits, like smoking, high alcohol intake, and obesity...
March 9, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28282848/long-term-vaptan-treatment-of-idiopathic-siadh-in-an-octogenarian
#9
Stefan Büttner, Jürgen Bachmann, Helmut Geiger, Nicholas Obermüller
Hyponatremia is the most common and by far underestimated electrolyte disorder in clinical practice. Especially in elderly patients, treatment of symptomatic hyponatremia is challenging. Herein we describe the case of an octogenarian with recurrent symptomatic hyponatremia due to idiopathic syndrome of inappropriate antidiuretic hormone release (SIADH). Fluid restriction was insufficient to prevent repeated episodes of hyponatremia complicated by falls and coma. After introduction of a low-dose therapy with tolvaptan, serum sodium levels as well as the clinical condition were stable under vaptan therapy, without any relapse for more than six years now...
March 8, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28273876/biochemical-assessment-of-coenzyme-q10-deficiency
#10
REVIEW
Juan Carlos Rodríguez-Aguilera, Ana Belén Cortés, Daniel J M Fernández-Ayala, Plácido Navas
Coenzyme Q10 (CoQ10) deficiency syndrome includes clinically heterogeneous mitochondrial diseases that show a variety of severe and debilitating symptoms. A multiprotein complex encoded by nuclear genes carries out CoQ10 biosynthesis. Mutations in any of these genes are responsible for the primary CoQ10 deficiency, but there are also different conditions that induce secondary CoQ10 deficiency including mitochondrial DNA (mtDNA) depletion and mutations in genes involved in the fatty acid β-oxidation pathway...
March 5, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28257031/portal-vein-embolization-impact-of-chemotherapy-and-genetic-mutations
#11
Amy R Deipolyi, Yu Shrike Zhang, Ali Khademhosseini, Sailendra Naidu, Mitesh Borad, Burcu Sahin, Amit K Mathur, Rahmi Oklu
We characterized the effect of systemic therapy given after portal vein embolization (PVE) and before hepatectomy on hepatic tumor and functional liver remnant (FLR) volumes. All 76 patients who underwent right PVE from 2002-2016 were retrospectively studied. Etiologies included colorectal cancer (n = 44), hepatocellular carcinoma (n = 17), cholangiocarcinoma (n = 10), and other metastases (n = 5). Imaging before and after PVE was assessed. Chart review revealed systemic therapy administration, SNaPshot genetic profiling, and comorbidities...
March 1, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28245555/mitochondrial-modification-techniques-and-ethical-issues
#12
Lucía Gómez-Tatay, José M Hernández-Andreu, Justo Aznar
Current strategies for preventing the transmission of mitochondrial disease to offspring include techniques known as mitochondrial replacement and mitochondrial gene editing. This technology has already been applied in humans on several occasions, and the first baby with donor mitochondria has already been born. However, these techniques raise several ethical concerns, among which is the fact that they entail genetic modification of the germline, as well as presenting safety problems in relation to a possible mismatch between the nuclear and mitochondrial DNA, maternal mitochondrial DNA carryover, and the "reversion" phenomenon...
February 24, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28241471/the-roles-of-histone-demethylase-jmjd3-in-osteoblast-differentiation-and-apoptosis
#13
REVIEW
Di Yang, Bo Yu, Haiyan Sun, Lihong Qiu
Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone 3 lysine 27 (H3K27me3) is observed at the promoters of a wide variety of important genes, especially for mammalian development, and contributes to gene silencing. Demethylase Jumonji domain-containing 3 (Jmjd3) catalyzes the transition of H3K27me3 to H3K27me1, therefore from a repressive to an active status of gene expression. Jmjd3 plays important roles in cell differentiation, inflammation, and tumorigenesis by targeting distinct transcription factors...
February 23, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28241467/role-of-protein-phosphatase-2a-in-osteoblast-differentiation-and-function
#14
REVIEW
Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Jumpei Teramachi, Kazuhiko Ochiai, Tatsuji Haneji, Akihito Yamamoto
The reversible phosphorylation of proteins plays hugely important roles in a variety of cellular processes, such as differentiation, proliferation, and apoptosis. These processes are strictly controlled by protein kinases (phosphorylation) and phosphatases (de-phosphorylation). Here we provide a brief history of the study of protein phosphorylation, including a summary of different types of protein kinases and phosphatases. One of the most physiologically important serine/threonine phosphatases is PP2A. This review provides a description of the phenotypes of various PP2A transgenic mice and further focuses on the known functions of PP2A in bone formation, including its role in osteoblast differentiation and function...
February 23, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28230726/cvd-and-oxidative-stress
#15
REVIEW
Karla Cervantes Gracia, Daniel Llanas-Cornejo, Holger Husi
Nowadays, it is known that oxidative stress plays at least two roles within the cell, the generation of cellular damage and the involvement in several signaling pathways in its balanced normal state. So far, a substantial amount of time and effort has been expended in the search for a clear link between cardiovascular disease (CVD) and the effects of oxidative stress. Here, we present an overview of the different sources and types of reactive oxygen species in CVD, highlight the relationship between CVD and oxidative stress and discuss the most prominent molecules that play an important role in CVD pathophysiology...
February 20, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28212273/oxidative-stress-in-copd-sources-markers-and-potential-mechanisms
#16
REVIEW
Adam John Anthony McGuinness, Elizabeth Sapey
Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD) and reactive oxygen species (ROS) are able to alter biological molecules, signaling pathways and antioxidant molecule function, many of which have been implicated in the pathogenesis of COPD. However, the involvement of ROS in the development and progression of COPD is not proven. Here, we discuss the sources of ROS, and the defences that have evolved to protect against their harmful effects. We address the role that ROS may have in the development and progression of COPD, as well as current therapeutic attempts at limiting the damage they cause...
February 15, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28208807/telehealth-increasing-access-to-high-quality-care-by-expanding-the-role-of-technology-in-correctional-medicine
#17
REVIEW
Jeremy D Young, Melissa E Badowski
The United States (US) has a large correctional population. However, many incarcerated persons lack access to evidence-based, up-to-date medical care, particularly by subspecialty providers, due to limitations of geography, travel, cost and other resources. The use of telehealth technologies can remove these barriers, increasing access to high quality, multidisciplinary care. Studies have shown that, with telemedicine, timely triage and medical management can be provided across many disciplines, which may lead to improved clinical outcomes and significant cost savings...
February 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28208803/barriers-to-seeking-help-for-skin-cancer-detection-in-rural-australia
#18
Kate M Fennell, Kimberley Martin, Carlene J Wilson, Camilla Trenerry, Greg Sharplin, James Dollman
This study explores rural South Australians' barriers to help-seeking for skin cancer detection. A total of 201 randomly selected rural adults (18-94 years, 66% female) were presented with a skin-cancer-related scenario via telephone and were asked the extent to which various barriers would impede their help-seeking, based on an amended version of the Barriers to Help-Seeking Scale. Older (≥63 years) and less educated participants endorsed barriers more strongly than their younger, more educated counterparts in the following domains; "Concrete barriers and distrust of caregivers", "Emotional control", "Minimising problem and Normalisation", "Need for control and self-reliance" (every domain other than "Privacy")...
February 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28208802/the-effect-of-mitochondrial-supplements-on-mitochondrial-activity-in-children-with-autism-spectrum-disorder
#19
Leanna M Delhey, Ekim Nur Kilinc, Li Yin, John C Slattery, Marie L Tippett, Shannon Rose, Sirish C Bennuri, Stephen G Kahler, Shirish Damle, Agustin Legido, Michael J Goldenthal, Richard E Frye
Treatment for mitochondrial dysfunction is typically guided by expert opinion with a paucity of empirical evidence of the effect of treatment on mitochondrial activity. We examined citrate synthase and Complex I and IV activities using a validated buccal swab method in 127 children with autism spectrum disorder with and without mitochondrial disease, a portion of which were on common mitochondrial supplements. Mixed-model linear regression determined whether specific supplements altered the absolute mitochondrial activity as well as the relationship between the activities of mitochondrial components...
February 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28208800/help-seeking-in-suicidal-situations-paramount-and-yet-challenging-interactions-between-significant-others-of-suicidal-persons-and-health-care-providers
#20
Dolores Angela Castelli Dransart, Sophie Guerry
Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the care received by their loved one, and the interactions and collaboration they experienced with professionals. Most significant others repeatedly sought out support for their loved one and themselves...
February 13, 2017: Journal of Clinical Medicine
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