journal
MENU ▼
Read by QxMD icon Read
search

Journal of Clinical Medicine

journal
https://www.readbyqxmd.com/read/29320468/clinical-remission-of-cutaneous-squamous-cell-carcinoma-of-the-auricle-with-cetuximab-and-nivolumab
#1
Alessandra Chen, Nabilah Ali, Peter Boasberg, Allen S Ho
Cutaneous squamous cell carcinomas (SCC) affecting the regions of the head and neck can be challenging to resect surgically and refractory to chemotherapy or radiation therapy. Consequently; the treatment of squamous cell carcinomas of the skin is a focus of current research. One such advancement is immunotherapy. Herein we describe clinical remission of invasive, poorly differentiated squamous cell carcinoma of the pre-auricular region with external auditory canal involvement using cetuximab, an epidermal growth factor receptor (EGFR) antibody; and nivolumab, a programmed death receptor-1 (PD-1) antibody...
January 10, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29315259/the-evolving-treatment-of-peripheral-arterial-disease-through-guideline-directed-recommendations
#2
REVIEW
Ramez Morcos, Boshra Louka, Andrew Tseng, Sanjay Misra, Robert McBane, Heidi Esser, Fadi Shamoun
Peripheral arterial disease (PAD) refers to partial or complete occlusion of one or more non-coronary arteries that leads to compromised blood flow and ischemia. Numerous processes are involved in arterial stenosis, however, atherosclerosis remains the most common etiology. PAD constitutes a major health economic problem, and it is estimated that over 200 million people around the world suffer from PAD, with at least 20% having some degree of claudication. The purpose of this review is to compare and contrast the guidelines on PAD published in 2005, 2011 and 2016 in terms of new recommendations and level of evidence for practicing clinicians...
January 9, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29300345/folfirinox-chemotherapy-in-metastatic-pancreatic-cancer-a-systematic-review-and-meta-analysis-of-retrospective-and-phase-ii-studies
#3
Stephane Thibodeau, Ioannis A Voutsadakis
The introduction of the FOLFIRINOX regimen within the last decade marked the first progress in the clinical field of metastatic pancreatic cancer which had not seen any improvements in treatment availability for several years. In a phase III randomized clinical trial, FOLFIRINOX showed superior efficacy compared to the previous standard treatment of gemcitabine monotherapy. Nevertheless, it is unknown whether the superior results observed in this single phase III clinical trial can be translated more broadly to clinical practice...
January 4, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29301380/the-gut-brain-axis-and-the-microbiome-clues-to-pathophysiology-and-opportunities-for-novel-management-strategies-in-irritable-bowel-syndrome-ibs
#4
REVIEW
Eamonn M M Quigley
Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anywhere from the external environment to the contents of the gut lumen and from the enteric neuromuscular apparatus and the gut immune system to the central nervous system. Consequently, the paradigm of the gut-brain axis, which includes the participation of these various factors, has proven a useful model to assist clinicians and patients alike in understanding the genesis of symptoms in IBS...
January 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29301333/experimental-models-of-irritable-bowel-syndrome-and-the-role-of-the-enteric-neurotransmission
#5
REVIEW
Maria Giuliana Vannucchi, Stefano Evangelista
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pathogenesis of IBS is only partially understood, a main role has been attributed to psychosocial stress of different origin. Animal models such as neonatal maternal separation, water avoidance stress and wrap restraint stress have been developed as psychosocial stressors in the attempt to reproduce the IBS symptomatology and identify the cellular mechanisms responsible for the disease...
January 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29301307/association-of-maternal-factors-with-perinatal-complications-in-pregnancies-complicated-with-diabetes-a-single-center-retrospective-analysis
#6
Sho Endo, Yoshifumi Saisho, Kei Miyakoshi, Daigo Ochiai, Tadashi Matsumoto, Yoshinaga Kawano, Masanori Mitsuishi, Junichiro Irie, Masami Tanaka, Shu Meguro, Mamoru Tanaka, Hiroshi Itoh
OBJECTIVE: The aim of this study was to clarify the association of maternal factors with perinatal complications in pregnancies complicated with type 1 (T1D) or type 2 diabetes (T2D). METHODS: We conducted a retrospective chart review and enrolled 26 Japanese pregnant women with diabetes who received perinatal care at our hospital between 2008 and 2015. Perinatal complications were defined as one or more of the following: miscarriage, fetal death, fetal dysfunction, fetal structural anomaly, small-for-gestational age, large-for-gestational age (LGA), premature birth, neonatal hypoglycemia, pregnancy-induced hypertension (PIH), deterioration of maternal kidney function, and urgent Caesarean section (CS)...
January 2, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29301273/irritable-bowel-syndrome-patient-provider-interaction-and-patient-education
#7
REVIEW
Albena Halpert
The Patient-Provider (P-P) relationship is the foundation of medical practice. The quality of this relationship is essential, particularly for the management of chronic illness such as Irritable Bowel Syndrome (IBS), since it correlates with disease improvement. A significant aspect of fostering the P-P relationship is providing effective patient-centered education about IBS. An effective education empowers the patients to achieve the main therapeutic goals: to reduce symptoms and improve quality of life. METHOD: A literature search of PubMed was conducted using the terms "Irritable Bowel syndrome", "Patient Physician Relationship", "Patient Provider Relationship", and "Patient Physician interaction"...
January 2, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29295565/prevalence-of-idiopathic-cyclic-edema-in-women-with-lower-limb-lymphedema
#8
Jose Maria Pereira de Godoy, Henrique Jose Pereira de Godoy, Lívia Maria Pereira de Godoy, Maria de Fatima Guerreiro Godoy
Cyclic edema is a clinical condition in women that leads to fluid retention in the orthostatic position. The aim of the present study was to evaluate the prevalence of idiopathic cyclic edema in women with lower limb lymphedema. The prevalence of idiopathic cyclic edema was evaluated in a retrospective study of 100 consecutive female patients submitted to leg lymphedema treatment at the Clínica Godoy. The diagnosis of lymphedema was clinical, based on patient history and a physical examination. Patients with clinical stage II lymphedema were included in the study with those in stages I and III being excluded...
December 25, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29271928/epithelial-mesenchymal-transition-in-embryonic-development-tissue-repair-and-cancer-a-comprehensive-overview
#9
REVIEW
Do Hyung Kim, Tiaosi Xing, Zhibin Yang, Ronald Dudek, Qun Lu, Yan-Hua Chen
The epithelial mesenchymal transition (EMT) plays a central role in both normal physiological events (e.g., embryonic development) and abnormal pathological events (e.g., tumor formation and metastasis). The processes that occur in embryonic development are often reactivated under pathological conditions such as oncogenesis. Therefore, defining the regulatory networks (both gene and protein levels) involved in the EMT during embryonic development will be fundamental in understanding the regulatory networks involved in tumor development, as well as metastasis...
December 22, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29231893/hypertrophic-cardiomyopathy-past-present-and-future
#10
REVIEW
Alphonsus C Liew, Vassilios S Vassiliou, Robert Cooper, Claire E Raphael
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with a prevalence of 1 in 500 in the general population. Since the first pathological case series at post mortem in 1957, we have come a long way in its understanding, diagnosis and management. Here, we will describe the history of our understanding of HCM including the initial disease findings, diagnostic methods and treatment options. We will review the current guidelines for the diagnosis and management of HCM, current gaps in the evidence base and discuss the new and promising developments in this field...
December 12, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29215577/acute-encephalitis-in-an-adult-with-diffuse-large-b-cell-lymphoma-with-secondary-involvement-of-the-central-nervous-system-infectious-or-non-infectious-etiology
#11
Surinder S Moonga, Kenneth Liang, Burke A Cunha
Both infectious and non-infectious etiologies of acute encephalitis have been described, as well as their specific presentations, diagnostic tests, and therapies. Classic findings of acute encephalitis include altered mental status, fever, and new lesions on neuroimaging or electroencephalogram (EEG). We report an interesting case of a 61-year-old male with a history of diffuse large B-cell lymphoma with secondary involvement of the central nervous system (SCNS-DLBCL). He presented with acute encephalitis: altered mental status, fever, leukocytosis, neuropsychiatric symptoms, multiple unchanged brain lesions on computed tomography scan of the head, and EEG showed mild to moderate diffuse slowing with low-moderate polymorphic delta and theta activity...
December 7, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29211048/imaging-characteristics-of-malignant-sinonasal-tumors
#12
REVIEW
Masaya Kawaguchi, Hiroki Kato, Hiroyuki Tomita, Keisuke Mizuta, Mitsuhiro Aoki, Akira Hara, Masayuki Matsuo
Malignancies of the nasal cavity and paranasal sinuses account for 1% of all malignancies and 3% of malignancies of the upper aerodigestive tract. In the sinonasal tract, nearly half of all malignancies arise in the nasal cavity, whereas most of the remaining malignancies arise in the maxillary or ethmoid sinus. Squamous cell carcinoma is the most common histological subtype of malignant tumors occurring in this area, followed by other epithelial carcinomas, lymphomas, and malignant soft tissue tumors. Although many of these tumors present with nonspecific symptoms, each tumor exhibits characteristic imaging features...
December 6, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29206194/adipose-derived-stem-cells-for-corneal-wound-healing-after-laser-induced-corneal-lesions-in-mice
#13
Marco Zeppieri, Maria Letizia Salvetat, Antonio Beltrami, Daniela Cesselli, Rossella Russo, Ignacio Alcalde, Jesús Merayo-Lloves, Paolo Brusini, Pier Camillo Parodi
The aim of our study was to assess the clinical effectiveness of topical adipose derived stem cell (ADSC) treatment in laser induced corneal wounds in mice by comparing epithelial repair, inflammation, and histological analysis between treatment arms. Corneal lesions were performed on both eyes of 40 mice by laser induced photorefractive keratectomy. All eyes were treated with topical azythromycin bid for three days. Mice were divided in three treatment groups (n = 20), which included: control, stem cells and basic serum; which received topical treatment three times daily for five consecutive days...
December 5, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29189747/neurological-and-sleep-disturbances-in-bronchiectasis
#14
REVIEW
Chun Seng Phua, Tissa Wijeratne, Conroy Wong, Lata Jayaram
Bronchiectasis unrelated to cystic fibrosis is a chronic lung disease that is increasingly recognised worldwide. While other common chronic lung conditions such as chronic obstructive lung disease have been associated with cardiovascular disease, there is a paucity of data on the relationship between bronchiectasis and cardiovascular risks such as stroke and sleep disturbance. Furthermore, it is unclear whether other neuropsychological aspects are affected, such as cognition, cerebral infection, anxiety and depression...
November 30, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29186064/airway-mucus-and-asthma-the-role-of-muc5ac-and-muc5b
#15
REVIEW
Luke R Bonser, David J Erle
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction-a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma, and recent work sheds light on their contribution to asthma pathogenesis...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29186062/viral-oncology-molecular-biology-and-pathogenesis
#16
REVIEW
Uyen Ngoc Mui, Christopher T Haley, Stephen K Tyring
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world's population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV)...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29186054/implementing-a-psychotherapy-service-for-medically-unexplained-symptoms-in-a-primary-care-setting
#17
Angela Cooper, Allan Abbass, Joel Town
Medically unexplained symptoms (MUS) are known to be costly, complex to manage and inadequately addressed in primary care settings. In many cases, there are unresolved psychological and emotional processes underlying these symptoms, leaving traditional medical approaches insufficient. This paper details the implementation of an evidence-based, emotion-focused psychotherapy service for MUS across two family medicine clinics. The theory and evidence-base for using Intensive Short-Term Dynamic Psychotherapy (ISTDP) with MUS is presented along with the key service components of assessment, treatment, education and research...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29186029/muc1-the-first-respiratory-mucin-with-an-anti-inflammatory-function
#18
REVIEW
Kosuke Kato, Erik P Lillehoj, Wenju Lu, Kwang Chul Kim
MUC1 is a membrane-bound mucin expressed on the apical surfaces of most mucosal epithelial cells. In normal lung epithelia, MUC1 is a binding site for Pseudomonas aeruginosa, an opportunistic human pathogen of great clinical importance. It has now been established that MUC1 also serves an anti-inflammatory role in the airways that is initiated late in the course of a bacterial infection and is mediated through inhibition of Toll-like receptor (TLR) signaling. MUC1 expression was initially shown to interfere with TLR5 signaling in response to P...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29186896/the-impact-of-the-brain-derived-neurotrophic-factor-gene-on-trauma-and-spatial-processing
#19
Jessica K Miller, Siné McDougall, Sarah Thomas, Jan Wiener
The influence of genes and the environment on the development of Post-Traumatic Stress Disorder (PTSD) continues to motivate neuropsychological research, with one consistent focus being the Brain-Derived Neurotrophic Factor (BDNF) gene, given its impact on the integrity of the hippocampal memory system. Research into human navigation also considers the BDNF gene in relation to hippocampal dependent spatial processing. This speculative paper brings together trauma and spatial processing for the first time and presents exploratory research into their interactions with BDNF...
November 27, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29165342/knee-and-ankle-arthroplasty-in-hemophilia
#20
REVIEW
Luigi Piero Solimeno, Gianluigi Pasta
Today, major surgical procedures can be safely performed in hemophilic patients with chronic arthropathy, using available factor concentrates. In this setting, total knee replacement is considered the "gold standard", while the use of total ankle replacement is still debated. Indeed, the unsatisfactory results obtained with the previous available design of implants did not raise enthusiasm as knee or hip replacement. Recently, the introduction of new implant designs and better reported outcomes have renewed the interest in total ankle replacement in people with hemophilia...
November 22, 2017: Journal of Clinical Medicine
journal
journal
48579
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"