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Epilepsia

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https://www.readbyqxmd.com/read/29034463/statin-treatment-may-lower-the-risk-of-postradiation-epilepsy-in-patients-with-nasopharyngeal-carcinoma
#1
Xiaoming Rong, Jing Yin, Hongxuan Wang, Xiaoni Zhang, Ying Peng
OBJECTIVE: This study aimed to clarify the effect of statins on preventing the risk of postradiation epilepsy. METHODS: We performed a retrospective analysis of neurological nasopharyngeal carcinoma patients with a history of radiotherapy. Patients with a history of epilepsy before radiation and those who received prophylactically antiepileptic treatment were excluded. The demographic and clinical data of these patients were collected through chart review. We used Kaplan-Meier analysis (log-rank test) to examine the effect of statins on epilepsy-free survival...
October 16, 2017: Epilepsia
https://www.readbyqxmd.com/read/29034451/cortical-light-scattering-during-interictal-epileptic-spikes-in-frontal-lobe-epilepsy-in-children-a-fast-optical-signal-and-electroencephalographic-study
#2
Mana Manoochehri, Mahdi Mahmoudzadeh, Emilie Bourel-Ponchel, Fabrice Wallois
OBJECTIVE: Interictal epileptic spikes (IES) represent a signature of the transient synchronous and excessive discharge of a large ensemble of cortical heterogeneous neurons. Epilepsy cannot be reduced to a hypersynchronous activation of neurons whose functioning is impaired, resulting on electroencephalogram (EEG) in epileptic seizures or IES. The complex pathophysiological mechanisms require a global approach to the interactions between neural synaptic and nonsynaptic, vascular, and metabolic systems...
October 16, 2017: Epilepsia
https://www.readbyqxmd.com/read/29027197/the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-new-users-of-antiepileptic-drugs
#3
Noel Frey, Michael Bodmer, Andreas Bircher, Stephan Rüegg, Susan S Jick, Christoph R Meier, Julia Spoendlin
OBJECTIVE: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. METHODS: In a matched case-control study of 480 previously validated SJS/TEN cases (1995-2013) we used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs), and calculated absolute risks of SJS/TEN within separate cohorts of new users of 28 AEDs...
October 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/29023667/postnatal-reduction-of-tuberous-sclerosis-complex-1-expression-in-astrocytes-and-neurons-causes-seizures-in-an-age-dependent-manner
#4
Jia Zou, Bo Zhang, David H Gutmann, Michael Wong
OBJECTIVE: Epilepsy is one of the most prominent symptoms of tuberous sclerosis complex (TSC), a genetic disorder, and may be related to developmental defects resulting from impaired TSC1 or TSC2 gene function in astrocytes and neurons. Inactivation of the Tsc1 gene driven by a glial-fibrillary acidic protein (GFAP) promoter during embryonic brain development leads to widespread pathologic effects on astrocytes and neurons, culminating in severe, progressive epilepsy in mice (Tsc1(GFAP)(-Cre) mice)...
October 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28994113/rates-and-predictors-of-success-and-failure-in-repeat-epilepsy-surgery-a-meta-analysis-and-systematic-review
#5
Max O Krucoff, Alvin Y Chan, Stephen C Harward, Shervin Rahimpour, John D Rolston, Carrie Muh, Dario J Englot
OBJECTIVE: Medically refractory epilepsy is a debilitating disorder that is particularly challenging to treat in patients who have already failed a surgical resection. Evidence regarding outcomes of further epilepsy surgery is limited to small case series and reviews. Therefore, our group performed the first quantitative meta-analysis of the literature from the past 30 years to assess for rates and predictors of successful reoperations. METHODS: A PubMed search was conducted for studies reporting outcomes of repeat epilepsy surgery...
October 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/28990169/methylphenidate-cognition-and-epilepsy-a-1-month-open-label-trial
#6
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford J Meador
OBJECTIVE: Cognitive difficulties are common in epilepsy. Beyond reducing seizures and adjusting antiepileptic medications, no well-validated treatment exists in adults. Methylphenidate is used effectively in children with epilepsy and attention-deficit/hyperactivity disorder, but its effects in adults have not been systematically evaluated. We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28990168/automated-analysis-of-seizure-semiology-and-brain-electrical-activity-in-presurgery-evaluation-of-epilepsy-a-focused-survey
#7
REVIEW
David Ahmedt-Aristizabal, Clinton Fookes, Sasha Dionisio, Kien Nguyen, João Paulo S Cunha, Sridha Sridharan
Epilepsy being one of the most prevalent neurological disorders, affecting approximately 50 million people worldwide, and with almost 30-40% of patients experiencing partial epilepsy being nonresponsive to medication, epilepsy surgery is widely accepted as an effective therapeutic option. Presurgical evaluation has advanced significantly using noninvasive techniques based on video monitoring, neuroimaging, and electrophysiological and neuropsychological tests; however, certain clinical settings call for invasive intracranial recordings such as stereoelectroencephalography (SEEG), aiming to accurately map the eloquent brain networks involved during a seizure...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28983921/epileptogenic-networks-in-nodular-heterotopia-a-stereoelectroencephalography-study
#8
Francesca Pizzo, Nicolas Roehri, Hélène Catenoix, Samuel Medina, Aileen McGonigal, Bernard Giusiano, Romain Carron, Didier Scavarda, Karine Ostrowsky, Anne Lepine, Sébastien Boulogne, Julia Scholly, Edouard Hirsch, Sylvain Rheims, Christian-George Bénar, Fabrice Bartolomei
OBJECTIVE: Defining the roles of heterotopic and normotopic cortex in the epileptogenic networks in patients with nodular heterotopia is challenging. To elucidate this issue, we compared heterotopic and normotopic cortex using quantitative signal analysis on stereoelectroencephalography (SEEG) recordings. METHODS: Clinically relevant biomarkers of epileptogenicity during ictal (epileptogenicity index; EI) and interictal recordings (high-frequency oscillation and spike) were evaluated in 19 patients undergoing SEEG...
October 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28983917/influence-of-the-location-and-type-of-epileptogenic-lesion-on-scalp-interictal-epileptiform-discharges-and-high-frequency-oscillations
#9
Carolina Cuello-Oderiz, Nicolas von Ellenrieder, François Dubeau, Jean Gotman
OBJECTIVE: To increase the diagnostic power of scalp electroencephalography (EEG) by investigating whether lesion type and location influence the morphology of interictal epileptic discharges (IEDs) and the likelihood that IEDs and high-frequency oscillations (HFOs) are present. METHODS: We studied EEG activity in epilepsy patients with lesional epilepsy. Lesions were classified by type and by location (region and depth). We marked a maximum of 50 IEDs during deep non-rapid eye movement sleep...
October 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28983902/intractable-seizures-after-a-lengthy-remission-in-childhood-onset-epilepsy
#10
Peter R Camfield, Carol S Camfield
OBJECTIVES: To establish the risk of subsequent intractable epilepsy after ≥2, ≥5, and ≥10 years of remission in childhood-onset epilepsy. METHODS: From the Nova Scotia childhood-onset epilepsy population-based cohort patients with all types of epilepsy were selected with ≥20 years follow-up from seizure onset (incidence cases). Children with childhood absence epilepsy were excluded. The rate of subsequent intractable epilepsy was then studied for patients with ≥5 years remission on or off AED treatment and compared with the rate for those with ≥2 and ≥10 years of remission...
October 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28980702/detection-of-generalized-tonic-clonic-seizures-using-surface-electromyographic-monitoring
#11
Jonathan J Halford, Michael R Sperling, Dileep R Nair, Dennis J Dlugos, William O Tatum, Jay Harvey, Jacqueline A French, John R Pollard, Edward Faught, Katherine H Noe, Thomas R Henry, Gina M Jetter, Octavian V Lie, Lola C Morgan, Michael R Girouard, Damon P Cardenas, Luke E Whitmire, Jose E Cavazos
OBJECTIVE: A prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in the epilepsy monitoring unit (EMU) of an investigational wearable surface electromyographic (sEMG) monitoring system for the detection of generalized tonic-clonic seizures (GTCSs). METHODS: One hundred ninety-nine patients with a history of GTCSs who were admitted to the EMU in 11 level IV epilepsy centers for clinically indicated video-electroencephalographic monitoring also received sEMG monitoring with a wearable device that was worn on the arm over the biceps muscle...
October 5, 2017: Epilepsia
https://www.readbyqxmd.com/read/28980315/multicenter-clinical-assessment-of-improved-wearable-multimodal-convulsive-seizure-detectors
#12
Francesco Onorati, Giulia Regalia, Chiara Caborni, Matteo Migliorini, Daniel Bender, Ming-Zher Poh, Cherise Frazier, Eliana Kovitch Thropp, Elizabeth D Mynatt, Jonathan Bidwell, Roberto Mai, W Curt LaFrance, Andrew S Blum, Daniel Friedman, Tobias Loddenkemper, Fatemeh Mohammadpour-Touserkani, Claus Reinsberger, Simone Tognetti, Rosalind W Picard
OBJECTIVE: New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive and automated, and provide false alarm rates (FARs) bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors. METHODS: Hand-annotated video-electroencephalographic seizure events were collected from 69 patients at six clinical sites. Three different wristbands were used to record electrodermal activity (EDA) and accelerometer (ACM) signals, obtaining 5,928 h of data, including 55 convulsive epileptic seizures (six focal tonic-clonic seizures and 49 focal to bilateral tonic-clonic seizures) from 22 patients...
October 4, 2017: Epilepsia
https://www.readbyqxmd.com/read/28961316/reduced-infancy-and-childhood-epilepsy-following-hypothermia-treated-neonatal-encephalopathy
#13
Xun Liu, Sally Jary, Frances Cowan, Marianne Thoresen
OBJECTIVE: To investigate what proportion of a regional cohort of cooled infants with neonatal encephalopathy develop epilepsy (determined by the International League Against Epilepsy [ILAE] definition and the number of antiepileptic drugs [AEDs]) up to 8 years of age. METHODS: From 2006-2013, 151 infants with perinatal asphyxia underwent 72 h cooling. Clinical and amplitude-integrated electroencepalography (aEEG) with single-channel EEG-verified neonatal seizures were treated with AEDs...
September 29, 2017: Epilepsia
https://www.readbyqxmd.com/read/28960284/potential-years-lost-and-life-expectancy-in-adults-with-newly-diagnosed-epilepsy
#14
Claudia A Granbichler, Georg Zimmermann, Willi Oberaigner, Giorgi Kuchukhidze, Jean-Pierre Ndayisaba, Alexandra Taylor, Gerhard Luef, Arne C Bathke, Eugen Trinka
OBJECTIVE: Studies using relative measures, such as standardized mortality ratios, have shown that patients with epilepsy have an increased mortality. Reports on more direct and absolute measure such as life expectancy are sparse. We report potential years lost and how life expectancy has changed over 40 years in a cohort of patients with newly diagnosed epilepsy. METHODS: We analyzed life expectancy in a cohort of adult patients diagnosed with definite epilepsy between 1970 and 2010...
September 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/28960286/standardization-procedure-for-plasma-biomarker-analysis-in-rat-models-of-epileptogenesis-focus-on-circulating-micrornas
#15
REVIEW
Erwin A van Vliet, Noora Puhakka, James D Mills, Prashant K Srivastava, Michael R Johnson, Paolo Roncon, Shalini Das Gupta, Jenni Karttunen, Michele Simonato, Katarzyna Lukasiuk, Jan A Gorter, Eleonora Aronica, Asla Pitkänen
The World Health Organization estimates that globally 2.4 million people are diagnosed with epilepsy each year. In nearly 30% of these cases, epilepsy cannot be properly controlled by antiepileptic drugs. More importantly, treatments to prevent or modify epileptogenesis do not exist. Therefore, novel therapies are urgently needed. In this respect, it is important to identify which patients will develop epilepsy and which individually tailored treatment is needed. However, currently, we have no tools to identify the patients at risk, and diagnosis of epileptogenesis remains as a major unmet medical need, which relates to lack of diagnostic biomarkers for epileptogenesis...
September 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28960283/a-randomized-prospective-pilot-trial-of-web-delivered-epilepsy-stigma-reduction-communications-in-young-adults
#16
Martha Sajatovic, Lynn K Herrmann, Jamie R Van Doren, Curtis Tatsuoka, Elisabeth Welter, Adam T Perzynski, Ashley Bukach, Kelley Needham, Hongyan Liu, Anne T Berg
OBJECTIVE: Epilepsy is a common neurological condition that is often associated with stigmatizing attitudes and negative stereotypes among the general public. This randomized controlled trial (RCT) tested two new communication approaches targeting epilepsy stigma versus an education-alone approach. METHODS: Two brief stigma-reduction videos were developed, informed by community stakeholder input; one highlighted role competency in people with epilepsy; the other highlighted social inclusion of people with epilepsy...
September 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28960278/remission-of-encephalopathy-with-status-epilepticus-eses-during-sleep-renormalizes-regulation-of-slow-wave-sleep
#17
Bigna K Bölsterli, Elena Gardella, Elena Pavlidis, Flavia M Wehrle, Carlo A Tassinari, Reto Huber, Guido Rubboli
OBJECTIVE: In previous studies, we showed an altered overnight decrease of non-rapid-eye-movement (NREM) sleep slow waves in children with encephalopathy related to status epilepticus during sleep (ESES). Here, we test the hypothesis that these alterations renormalize after remission of ESES. Because overnight decrease of slow waves has been linked to brain recovery and cognition, we investigate whether cognitive outcome is related to overnight changes of slow waves. METHODS: We performed a retrospective analysis of longitudinal overnight electroencephalography (EEG) in 10 patients with idiopathic ESES...
September 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28949013/seizures-syndromes-and-etiologies-in-childhood-epilepsy-the-international-league-against-epilepsy-1981-1989-and-2017-classifications-used-in-a-population-based-cohort
#18
Kari Modalsli Aaberg, Pål Surén, Camilla Lund Søraas, Inger Johanne Bakken, Morten I Lossius, Camilla Stoltenberg, Richard Chin
OBJECTIVE: The study provides updated information about the distribution of seizures, epilepsies, and etiologies of epilepsy in the general child population, and compares the old and new classification systems from the International League Against Epilepsy (ILAE). METHODS: The study platform was the Norwegian Mother and Child Cohort Study. Cases of epilepsy were identified through registry linkages and sequential parental questionnaires. Epilepsy diagnoses were validated using a standardized protocol, and seizures, epilepsies, and etiologies were classified according to the old (ILAE 1981/1989) and new (ILAE 2017) classifications...
September 26, 2017: Epilepsia
https://www.readbyqxmd.com/read/28948998/bimodal-coupling-of-ripples-and-slower-oscillations-during-sleep-in-patients-with-focal-epilepsy
#19
Inkyung Song, Iren Orosz, Inna Chervoneva, Zachary J Waldman, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Noriko Salamon, Richard Gorniak, Sandra Dewar, Anatol Bragin, Jerome Engel, Michael R Sperling, Richard Staba, Shennan A Weiss
OBJECTIVE: Differentiating pathologic and physiologic high-frequency oscillations (HFOs) is challenging. In patients with focal epilepsy, HFOs occur during the transitional periods between the up and down state of slow waves. The preferred phase angles of this form of phase-event amplitude coupling are bimodally distributed, and the ripples (80-150 Hz) that occur during the up-down transition more often occur in the seizure-onset zone (SOZ). We investigated if bimodal ripple coupling was also evident for faster sleep oscillations, and could identify the SOZ...
September 26, 2017: Epilepsia
https://www.readbyqxmd.com/read/28948997/emotional-well-being-in-children-with-epilepsy-family-factors-as-mediators-and-moderators
#20
Shane W Goodwin, Piotr Wilk, M Karen Campbell, Kathy N Speechley
OBJECTIVE: Our objective was to examine the relationships of factors associated with children's emotional well-being 2 years after diagnosis, and to examine if these relationships are mediated or moderated by family factors. METHODS: Data came from a multicenter prospective cohort study of children with newly diagnosed epilepsy from across Canada (Health-Related Quality of Life in Children with Epilepsy Study; HERQULES, n = 373). Emotional well-being was assessed using the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55)...
September 26, 2017: Epilepsia
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