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Epilepsia

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https://www.readbyqxmd.com/read/28084641/malformation-risk-of-antiepileptic-drug-exposure-during-pregnancy-in-women-with-epilepsy-results-from-a-pregnancy-registry-in-south-india
#1
Sanjeev V Thomas, Manna Jose, Srividya Divakaran, Prabhakaran Sankara Sarma
OBJECTIVE: Kerala Registry of Epilepsy and Pregnancy had been prospectively evaluating the reproductive issues of women with epilepsy since April 1998. This analysis aimed to estimate the relative risk of major congenital malformations (MCM) to the registrants. METHODS: All pregnancies with known outcome in this register until December 2013 were included. Malformation status was evaluated by antenatal ultrasonography, physical examination at birth, echocardiography, and abdomen ultrasonography at 3 months of age and a final review at 1 year of age...
January 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28084639/bursts-of-seizures-in-long-term-recordings-of-human-focal-epilepsy
#2
Philippa J Karoly, Ewan S Nurse, Dean R Freestone, Hoameng Ung, Mark J Cook, Ray Boston
OBJECTIVE: We report on temporally clustered seizures detected from continuous long-term ambulatory human electroencephalographic data. The objective was to investigate short-term seizure clustering, which we have termed bursting, and consider implications for patient care, seizure prediction, and evaluating therapies. METHODS: Chronic ambulatory intracranial electroencephalography (EEG) data collected for the purpose of seizure prediction were annotated to identify seizure events...
January 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28084635/de-novo-scn1a-pathogenic-variants-in-the-gefs-spectrum-not-always-a-familial-syndrome
#3
Kenneth A Myers, Rosemary Burgess, Zaid Afawi, John A Damiano, Samuel F Berkovic, Michael S Hildebrand, Ingrid E Scheffer
Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome characterized by heterogeneous phenotypes ranging from mild disorders such as febrile seizures to epileptic encephalopathies (EEs) such as Dravet syndrome (DS). Although DS often occurs with de novo SCN1A pathogenic variants, milder GEFS+ spectrum phenotypes are associated with inherited pathogenic variants. We identified seven cases with non-EE GEFS+ phenotypes and de novo SCN1A pathogenic variants, including a monozygotic twin pair...
January 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28084627/carvacrol-after-status-epilepticus-se-prevents-recurrent-se-early-seizures-cell-death-and-cognitive-decline
#4
Aytakin Khalil, Stjepana Kovac, Gareth Morris, Matthew C Walker
OBJECTIVE: Carvacrol is a naturally occurring monoterpenic phenol that has been suggested to have an action at transient receptor potential cation subfamily M7 (TRPM7) channels, γ-aminobutyric acid (GABAA receptors, and sodium channels, and has been shown to be antiinflammatory. Carvacrol is neuroprotective in models of cerebral ischemia in vivo and in vitro, probably through its action at TRPM7 channels. We therefore aimed to determine the effect of carvacrol on status epilepticus (SE), chronic epilepsy, cell death, and post-SE cognitive decline...
January 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28079250/use-of-the-ketogenic-diet-in-the-neonatal-intensive-care-unit-safety-and-tolerability
#5
Lindsey Thompson, Erin Fecske, Mohammad Salim, Ara Hall
Drug-resistant epilepsy poses a challenge in neonatal patients, especially those in the neonatal intensive care unit (NICU), who have various secondary comorbidities. We present results of four children with a history of drug-resistant epilepsy for whom a ketogenic diet was initiated and used in the NICU. A nonfasting induction into ketosis over 1-2 weeks was utilized, with gradual increases in the ketogenic ratio every 2-3 days. Data were collected retrospectively from a database, which included medical history, daily progress notes, relevant laboratory data, and imaging and diagnostic information...
January 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28067423/current-standards-of-neuropsychological-assessment-in-epilepsy-surgery-centers-across-europe
#6
Viola Lara Vogt, Marja Äikiä, Antonio Del Barrio, Paul Boon, Csaba Borbély, Ema Bran, Kees Braun, Evelien Carette, Maria Clark, Judith Helen Cross, Petia Dimova, Daniel Fabo, Nikolaos Foroglou, Stefano Francione, Anna Gersamia, Antonio Gil-Nagel, Alla Guekht, Sue Harrison, Hrvoje Hecimovic, Einar Heminghyt, Edouard Hirsch, Alena Javurkova, Reetta Kälviäinen, Nicole Kavan, Anna Kelemen, Vasilios K Kimiskidis, Margarita Kirschner, Catherine Kleitz, Teia Kobulashvili, Mary H Kosmidis, Selin Yagci Kurtish, Mathieu Lesourd, Sofia Ljunggren, Morten Ingvar Lossius, Kristina Malmgren, Ruta Mameniskiené, Patricia Martin-Sanfilippo, Petr Marusic, Marijke Miatton, Çiğdem Özkara, Federica Pelle, Guido Rubboli, Sarah Rudebeck, Philippe Ryvlin, Monique van Schooneveld, Elisabeth Schmid, Pia-Magdalena Schmidt, Margitta Seeck, Bernhard J Steinhoff, Sara Shavel-Jessop, Oana Tarta-Arsene, Eugen Trinka, Gerd Viggedal, Anne-Sophie Wendling, Juri-Alexander Witt, Christoph Helmstaedter
We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of "E-PILEPSY" (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup...
January 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28064446/depression-screening-tools-in-persons-with-epilepsy-a-systematic-review-of-validated-tools
#7
REVIEW
Stephanie J Gill, Sara Lukmanji, Kirsten M Fiest, Scott B Patten, Samuel Wiebe, Nathalie Jetté
OBJECTIVE: Depression affects approximately 25% of epilepsy patients. However, the optimal tool to screen for depression in epilepsy has not been definitively established. The purpose of this study was to systematically review the literature on the validity of depression-screening tools in epilepsy. METHODS: MEDLINE, EMBASE, and PsycINFO were searched until April 4, 2016 with no restriction on dates. Abstract, full-text review and data abstraction were conducted in duplicate...
January 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28035782/wonoep-appraisal-biomarkers-of-epilepsy-associated-comorbidities
#8
REVIEW
Teresa Ravizza, Filiz Y Onat, Amy R Brooks-Kayal, Antoine Depaulis, Aristea S Galanopoulou, Andrey Mazarati, Adam L Numis, Raman Sankar, Alon Friedman
Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such comorbidities do not exist. They may share pathogenetic mechanisms with epileptogenesis/ictogenesis, and as such are an unmet clinical need. The objectives of the subgroup on biomarkers of comorbidities at the XIII Workshop on the Neurobiology of Epilepsy (WONOEP) were to present the state-of-the-art recent research findings in the field that highlighting potential biomarkers for comorbidities in epilepsy...
December 30, 2016: Epilepsia
https://www.readbyqxmd.com/read/28012175/clinical-implications-of-scn1a-missense-and-truncation-variants-in-a-large-japanese-cohort-with-dravet-syndrome
#9
Atsushi Ishii, Joseph C Watkins, Debbie Chen, Shinichi Hirose, Michael F Hammer
OBJECTIVE: Two major classes of SCN1A variants are associated with Dravet syndrome (DS): those that result in haploinsufficiency (truncating) and those that result in an amino acid substitution (missense). The aim of this retrospective study was to describe the first large cohort of Japanese patients with SCN1A mutation-positive DS (n = 285), and investigate the relationship between variant (type and position) and clinical expression and response to treatment. METHODS: We sequenced all exons and intron-exon boundaries of SCN1A in our cohort, investigated differences in the distribution of truncating and missense variants, tested for associations between variant type and phenotype, and compared these patterns with those of cohorts with milder epilepsy and healthy individuals...
December 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/28012173/trpc3-channels-play-a-critical-role-in-the-theta-component-of-pilocarpine-induced-status-epilepticus-in-mice
#10
Kevin D Phelan, U Thaung Shwe, Michael A Cozart, Hong Wu, Matthew M Mock, Joel Abramowitz, Lutz Birnbaumer, Fang Zheng
OBJECTIVE: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE)...
December 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/28012164/verbal-memory-after-temporal-lobe-epilepsy-surgery-in-children-do-only-mesial-structures-matter
#11
Nicole Law, Mony Benifla, James Rutka, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed regarding verbal memory outcome after left temporal lobectomy in children, and there are few studies comparing verbal memory change after lateral versus mesial temporal lobe resections. We compared verbal memory outcome associated with sparing or including the mesial structures in children who underwent left or right temporal lobe resection. We also investigated predictors of postsurgical verbal memory change. METHODS: We retrospectively assessed verbal memory change approximately 1 year after unilateral temporal lobe epilepsy surgery using a list learning task...
December 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/28012162/evidence-for-a-differential-interaction-of-brivaracetam-and-levetiracetam-with-the-synaptic-vesicle-2a-protein
#12
Martyn D Wood, Michel Gillard
OBJECTIVE: Brivaracetam (BRV) and levetiracetam (LEV) are effective antiepileptic drugs that bind selectively to the synaptic vesicle 2A (SV2A) protein. However, BRV differs from LEV in that it exhibits more potent and complete seizure suppression in animal models including in amygdala-kindled mice, where BRV afforded nearly complete seizure suppression. This raises the possibility that aside from potency differences, BRV and LEV may interact differently with the SV2A protein, which is not apparent in radioligand-binding competition studies...
December 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/27988967/time-to-onset-of-sustained-%C3%A2-50-responder-status-in-patients-with-focal-partial-onset-seizures-in-three-phase-iii-studies-of-adjunctive-brivaracetam-treatment
#13
Pavel Klein, Martin E Johnson, Jimmy Schiemann, John Whitesides
Time to onset of sustained ≥50% responder status (SRS) was assessed for the pooled patient population receiving brivaracetam (BRV) 50, 100, or 200 mg/day or placebo in three randomized phase III studies (NCT00464269, NCT00490035, and NCT01261325). Patients were aged ≥16 years with well-characterized focal (partial-onset) seizures (FS) uncontrolled by 1-2 concomitant antiepileptic drugs. After an 8-week baseline period, patients received study drug without up-titration for a 12-week (84-day) treatment period...
December 18, 2016: Epilepsia
https://www.readbyqxmd.com/read/27988965/ictal-asystole-a-systematic-review
#14
Dalma Tényi, Csilla Gyimesi, Péter Kupó, Réka Horváth, Beáta Bóné, Péter Barsi, Norbert Kovács, Tamás Simor, Zsuzsa Siegler, László Környei, András Fogarasi, József Janszky
OBJECTIVE: To comprehensively analyze ictal asystole (IA) on a large number of subjects. METHODS: We performed a systematic review of case report studies of patients diagnosed with IA (1983-2016). Each included case was characterized with respect to patient history, IA seizure characteristics, diagnostic workup, and therapy. In addition, comparative analyses were also carried out: two alignments were developed based on the delay between epilepsy onset and IA onset ("new-onset" if <1 year, "late-onset" if ≥1 year) and asystole duration (asystole was "very prolonged" if lasted >30 s)...
December 18, 2016: Epilepsia
https://www.readbyqxmd.com/read/27988935/perampanel-effects-in-the-wag-rij-rat-model-of-epileptogenesis-absence-epilepsy-and-comorbid-depressive-like-behavior
#15
Rita Citraro, Antonio Leo, Valentina Franco, Roberto Marchiselli, Emilio Perucca, Giovambattista De Sarro, Emilio Russo
OBJECTIVE: Perampanel (PER), a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonist, exhibits broad-spectrum anticonvulsant activity in several seizure models, but its potential disease-modifying effects have not been investigated. Because of the relevance of AMPA receptors in epileptogenesis and psychiatric comorbidities, we studied the effects of PER in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and depressive-like comorbidity...
December 18, 2016: Epilepsia
https://www.readbyqxmd.com/read/27935031/interictal-epileptiform-discharges-impair-word-recall-in-multiple-brain-areas
#16
Peter C Horak, Stephen Meisenhelter, Yinchen Song, Markus E Testorf, Michael J Kahana, Weston D Viles, Krzysztof A Bujarski, Andrew C Connolly, Ashlee A Robbins, Michael R Sperling, Ashwini D Sharan, Gregory A Worrell, Laura R Miller, Robert E Gross, Kathryn A Davis, David W Roberts, Bradley Lega, Sameer A Sheth, Kareem A Zaghloul, Joel M Stein, Sandhitsu R Das, Daniel S Rizzuto, Barbara C Jobst
OBJECTIVES: Interictal epileptiform discharges (IEDs) have been linked to memory impairment, but the spatial and temporal dynamics of this relationship remain elusive. In the present study, we aim to systematically characterize the brain areas and times at which IEDs affect memory. METHODS: Eighty epilepsy patients participated in a delayed free recall task while undergoing intracranial electroencephalography (EEG) monitoring. We analyzed the locations and timing of IEDs relative to the behavioral data in order to measure their effects on memory...
December 9, 2016: Epilepsia
https://www.readbyqxmd.com/read/27888513/decreased-allopregnanolone-levels-in-cerebrospinal-fluid-obtained-during-status-epilepticus
#17
Stefano Meletti, Chiara Lucchi, Giulia Monti, Giada Giovannini, Roberta Bedin, Tommaso Trenti, Cecilia Rustichelli, Giuseppe Biagini
Neuroactive steroids are increasingly considered as relevant modulators of neuronal activity. Especially allopregnanolone (AP) and pregnenolone sulfate (PS) have been shown to possess, respectively, anticonvulsant or proconvulsant properties. In view of the potential role of these steroids, we aimed at evaluating AP and PS levels in cerebrospinal fluid (CSF) and blood samples obtained from patients with status epilepticus (SE). To this purpose, we enrolled 41 patients affected by SE and 41 subjects investigated for nonepileptic neurologic disorders...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27888502/a-novel-c132-134del-mutation-in-unverricht-lundborg-disease-and-the-review-of-literature-of-heterozygous-compound-patients
#18
Giovanni Assenza, Antonella Benvenga, Elena Gennaro, Mario Tombini, Chiara Campana, Federica Assenza, Giovanni Di Pino, Vincenzo Di Lazzaro
Unverricht-Lundborg disease or progressive myoclonic epilepsy type 1 (EPM1) is an autosomal recessive disease caused by mutation of the cystatin B gene (CSTB), located on chromosome 21q22.3. The most common mutation is an expansion of unstable dodecamer repetition (CCCCGCCCCGCG), whereas other types of mutations are rare. Among these, heterozygous compound mutations are described to induce a more severe phenotype than that of homozygous dodecameric repetition. We report two siblings affected by heterozygous compound mutations carrying a novel mutation of the deletion of three nucleotides in exon 2 of the gene in position 132-134 of the coding sequence (c...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27883181/workshop-on-neurobiology-of-epilepsy-appraisal-imaging-biomarkers-in-epilepsy
#19
REVIEW
Erwin A van Vliet, Stefanie Dedeurwaerdere, Andrew J Cole, Alon Friedman, Matthias J Koepp, Heidrun Potschka, Riikka Immonen, Asla Pitkänen, Paolo Federico
Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy...
November 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/28064461/international-summer-school-for-neuropathology-and-epilepsy-surgery-in-chengdu-china-august-29-september-1-2016
#20
LETTER
Jinmei Li, Ingmar Blumcke
No abstract text is available yet for this article.
January 2017: Epilepsia
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