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Journal of Neurogastroenterology and Motility

Anlong Yuan, Peng Li, Li Wang, Bibo Zhong, Bin Bai, Xiaoyu Huang, Jiguang Kou
No abstract text is available yet for this article.
June 29, 2018: Journal of Neurogastroenterology and Motility
Sung Eun Kim, Nayoung Kim, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Kwangwoo Nam, Hyeon Ju Kim, Hyun Joo Song, Young-Eun Joo, Dae-Seong Myung, Ji-Hyun Seo, Hyun Jin Jo, Seon Mie Kim, Seon Hee Lim, Hyun Jin Kim, Gwang Ho Baik, Sang Hyeon Choi, Suck Chei Choi
Background/Aims: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study was to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea. Methods: A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with Rome III criteria, and Helicobacter pylori serology (IgG)...
June 23, 2018: Journal of Neurogastroenterology and Motility
Adrienne Lenhart, Courtney Ferch, Michael Shaw, William D Chey
Background/Aims: Dietary therapy is increasingly used to manage gastrointestinal (GI) symptoms in patients with irritable bowel syndrome (IBS). We aim to gauge United States gastroenterologists' perceptions of dietary therapies for IBS. Methods: We distributed a 22-question survey to members of the American College of Gastroenterology. The survey was developed by gastroenterologists and survey methodologists. We collected information pertaining to demographics, providers' interpretation of their patients' views on dietary therapy, and gastroenterologists' perceptions on dietary therapy, and nutritional counseling in IBS...
June 8, 2018: Journal of Neurogastroenterology and Motility
Cosimo Alex Leo, Emanuel Cavazzoni, Gregory P Thomas, Jonathan Hodgkison, Jamie Murphy, Carolynne J Vaizey
Background/Aims: The Anopress device is a new portable manometry system. The aim of this study is to formulate normative data using this new device by recording the anorectal function of asymptomatic subjects. Patient comfort was also assessed. Methods: Anorectal function was assessed in asymptomatic volunteers using the Anopress. All volunteers were examined in a standardized way in accordance with the study protocol. Normative values for the Anopress were obtained from the recorded data and patient comfort was assessed using a visual analogue scale...
June 7, 2018: Journal of Neurogastroenterology and Motility
Yeong Yeh Lee, Askin Erdogan, Siegfried Yu, Annie Dewitt, Satish S C Rao
Background/Aims: Whether high-resolution anorectal pressure topography (HRPT), having better fidelity and spatio-temporal resolution is comparable to waveform manometry (WM) in the diagnosis and characterization of defecatory disorders (DD) is not known. Methods: Patients with chronic constipation (Rome III) were evaluated for DD with HRPT and WM during bearing-down "on-bed" without inflated rectal balloon and "on-commode (toilet)" with 60-mL inflated rectal balloon...
June 7, 2018: Journal of Neurogastroenterology and Motility
Fatemeh Dolatabadi, Amir H Abdolghaffari, Mohammad H Farzaei, Maryam Baeeri, Fatemeh S Ziarani, Majid Eslami, Mohammad Abdollahi, Roja Rahimi
Background/Aims: The aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of irritable bowel syndrome (IBS) and the possible role of nitric oxide. Methods: Two individual models of IBS were induced in male Wistar-albino rats. In the acetic acid model, the animals were exposed to rectal distension and abdominal withdrawal reflex, and the defecation patterns were determined...
June 4, 2018: Journal of Neurogastroenterology and Motility
Tadayuki Oshima, Hiroto Miwa
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by cytochrome P450 polymorphisms, unsatisfactory effects at night, and instability in acidic conditions. Alternative formulations of conventional PPIs have been developed to overcome these problems; however, these drugs have only introduced small advantages for controlling acid secretion compared to conventional PPIs...
May 9, 2018: Journal of Neurogastroenterology and Motility
Ryo Katsumata, Manabu Ishii, Suni Lee, Yukiko Handa, Takahisa Murao, Minoru Fujita, Hiroshi Matsumoto, Takemi Otsuki, Akiko Shiotani
Background/Aims: Food interaction, including food hypersensitivity, plays a key role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). Since only a few studies have been reported about the relationship between food hypersensitivity and IBS-D, we elucidate the prevalence of serological food hypersensitivity in patients with IBS-D and the characteristics of gastrointestinal symptoms and serum cytokine profiles in patients with IBS-D and serological food hypersensitivity...
May 9, 2018: Journal of Neurogastroenterology and Motility
Fanny Giron, Eamonn M M Quigley
The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract - the gut microbiota. As our understanding of the role of the microbiota in health and human disease increases so to do efforts to prevent and treat disease through the modulation of the microbiota. Several strategies are available to us and range from time honored approaches, such as antibiotics and probiotics, to changes in diet, the administration of prebiotics as food supplements and fecal microbiota transplantation...
April 24, 2018: Journal of Neurogastroenterology and Motility
Ji Hyun Kim, Sung Eun Kim, Yu Kyung Cho, Chul-Hyun Lim, Moo In Park, Jin Won Hwang, Jae-Sik Jang, Minkyung Oh
The figure 6 should have been presented as follows.
July 30, 2018: Journal of Neurogastroenterology and Motility
Esperanza Martos Vizcaino, Fernando Canga Rodriguez-Valcárcel, Constanza Ciriza de Los Ríos
No abstract text is available yet for this article.
July 30, 2018: Journal of Neurogastroenterology and Motility
Philip Abraham, Verima Pereira
No abstract text is available yet for this article.
July 30, 2018: Journal of Neurogastroenterology and Motility
Hyo Jeong Lee, Kee Wook Jung, Sun Ju Chung, Seung-Mo Hong, Juyeon Kim, Jeong Hoon Lee, Sung Wook Hwang, Ho-Sung Ryu, Mi Jung Kim, Ho-Su Lee, Myeongsook Seo, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Hwoon-Yong Jung, Suk-Kyun Yang, Seung-Jae Myung
Background/Aims: α-Synucleinopathy in the brain is the neuropathological hallmark of Parkinson's disease (PD). However, the functional impact of α-synucleinopathy in the enteric nervous system remains unknown. We aim to evaluate the association between gastrointestinal (GI) dysfunction and α-synuclein (αSYN) pathology in the stomach and colon of PD patients and controls, as well as to investigate the association between the αSYN pathology in GI tract and future PD risk. Methods: A total of 35 PD patients and 52 neurologically intact subjects were enrolled in this study...
July 30, 2018: Journal of Neurogastroenterology and Motility
Choong-Kyun Noh, Bong Sun Kim, Gana Hong, Jae Youn Cheong, Kwang Jae Lee
Background/Aims: Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods: Twelve healthy volunteers with age range of 30-42 years provided baseline fecal samples. Subsequently, they took commercially available probiotic capsules (a mixture for Bifidobacterium , Lactobacillus , and Enterococcus ) for 4 weeks...
July 30, 2018: Journal of Neurogastroenterology and Motility
Philip Woodland, Shirley Gabieta-Sonmez, Julieta Arguero, Joanne Ooi, Kenichiro Nakagawa, Esteban Glasinovic, Etsuro Yazaki, Daniel Sifrim
Background/Aims: Single swallow integrated relaxation pressure (IRP) on high-resolution manometry (HRM) does not always accurately predict esophagogastric outflow obstruction on timed barium esophagogram (TBE). Furthermore, neither single swallow IRP or TBE is reliable in predicting symptoms, particularly after treatment with dilatation or myotomy. A 200 mL rapid drink challenge (RDC) has been proposed as an adjunctive test during HRM. This serves as a "stress-test" to the esophagogastric junction, and may yield clinically useful parameters...
July 30, 2018: Journal of Neurogastroenterology and Motility
Takahisa Yamasaki, Toshihiko Tomita, Sumire Mori, Mayu Takimoto, Akio Tamura, Ken Hara, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
Background/Aims: High-resolution esophageal manometry (HREM) is considered to be the gold standard for the diagnosis of achalasia. However, the Japan Esophageal Society recommends that esophagography is also accurate in either diagnosing or excluding the disorder. Accordingly, we compared the efficacy of esophagography and HREM in diagnosing achalasia patients with upper gastrointestinal symptoms. Methods: HREM was performed in 126 patients with dysphagia. The final diagnosis of achalasia was done using HREM...
July 30, 2018: Journal of Neurogastroenterology and Motility
Lawrence F Borges, Vikrant Jagadeesan, Hilary Goldberg, Sravanya Gavini, Wai-Kit Lo, Robert Burakoff, Natan Feldman, Walter W Chan
Background/Aims: Gastroesophageal reflux (GER) is postulated to play a role in idiopathic pulmonary fibrosis (IPF). However, the value of objective GER measures in predicting IPF disease progression is unclear. We aim to evaluate the association between objective GER measures on multichannel intraluminal impedance and pH (MII-pH) testing and development of poor pulmonary outcomes within 1 year in prelung transplant IPF patients. Methods: This was a retrospective cohort study of adults with IPF who underwent pre-lung transplant evaluation with MII-pH off proton pump inhibitors (PPI) at a tertiary care center from June 2008 to November 2015...
July 30, 2018: Journal of Neurogastroenterology and Motility
Michael C Bennett, Amit Patel, Nitin Sainani, Dan Wang, Gregory S Sayuk, C Prakash Gyawali
Background/Aims: Breaks in the peristaltic contour on esophageal high-resolution manometry (HRM) may be associated with bolus retention in the esophagus. We evaluated the relationship between peristaltic breaks and esophageal symptoms, reflux exposure, and symptom outcomes in a prospective patient cohort. Methods: Two hundred and eighteen patients (53.2 ± 0.9 years, 68.3% female) undergoing both pH-impedance testing and HRM over a 5-year period were prospectively evaluated...
July 30, 2018: Journal of Neurogastroenterology and Motility
Hirokazu Fukui, Xin Xu, Hiroto Miwa
Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only short-chain fatty acids produced by microbiota but also gut hormones and inflammatory signaling by enteroendocrine and immune cells under the influence of the microbiota. GI motility is orchestrated by the enteric nervous system and hormonal networks, and disturbance of GI motility plays an important role in the pathophysiology of functional gastrointestinal disorders (FGIDs)...
July 30, 2018: Journal of Neurogastroenterology and Motility
Tae Hee Lee
No abstract text is available yet for this article.
July 30, 2018: Journal of Neurogastroenterology and Motility
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