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Journal of Neurogastroenterology and Motility

Kee Wook Jung, Myeognsook Seo, Young Hwan Cho, Young-Ok Park, So-Yoon Yoon, Jungbok Lee, Dong-Hoon Yang, In Ja Yoon, So Young Seo, Hyo Jeong Lee, Sang Hyoung Park, Kyung Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung
Background/Aims: Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT). Methods: Patients diagnosed with IBS and asymptomatic control individuals were prospectively enrolled in the study...
February 13, 2018: Journal of Neurogastroenterology and Motility
Viet Q Tran, Tania Mahler, Patrick Bontems, Dinh Q Truong, Annie Robert, Philippe Goyens, Henri Steyaert
Background/Aims: Although many advances in the management of Hirschsprung's disease have recently been achieved, postoperative outcomes of these patients remain difficult in a non-negligible number of cases. Therefore, this study aims at investigating characteristics of anorectal manometry and its relationship with postoperative outcomes during long-term follow-up in Hirschsprung patients. Methods: Patients over 4 years of age operated on for Hirschsprung's disease were interviewed to complete detailed questionnaires on bowel function...
November 25, 2017: Journal of Neurogastroenterology and Motility
Carlos Teruel, María Jesús de Higes, Patricia Luengo, Eduardo Lobo
No abstract text is available yet for this article.
January 30, 2018: Journal of Neurogastroenterology and Motility
Yoo Jin Lee, Zahid Hussain, Cheal Wung Huh, Young Ju Lee, Hyojin Park
Background/Aims: Postoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are lacking. We aim to correlate the recovery time of postoperative dysmotility with that of inflammation and mucosal permeability. Methods: An experimental POI model of guinea pig was used. Contractile activity of the circular muscle of the stomach, jejunum, ileum, and proximal colon was measured through a tissue bath study...
January 30, 2018: Journal of Neurogastroenterology and Motility
Afifa Ait-Belgnaoui, Isabelle Payard, Claire Rolland, Cherryl Harkat, Viorica Braniste, Vassillia Théodorou, Thomas A Tompkins
Background/Aims: Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) prevents chronic stress-mediated brain function abnormalities by attenuating the HPA axis response. Here, we compared the effect between different probiotic treatments on the perception of visceral pain during colorectal distension (CRD) following a chronic stress and the consequences to the activity of the HPA axis...
January 30, 2018: Journal of Neurogastroenterology and Motility
Jakob L Poulsen, Esben B Mark, Christina Brock, Jens B Frøkjær, Klaus Krogh, Asbjørn M Drewes
Background/Aims: Opioid-induced constipation (OIC) is the most common gastrointestinal (GI) side effect to opioid treatment. Opioid receptor antagonists against OIC have been introduced, but their efficacy has not been directly compared to conventional laxatives. Our aim was to compare symptoms and objective parameters of gut function in an experimental model of OIC during treatment with the opioid antagonist naloxone and oxycodone in prolonged-release (PR) formulation versus oxycodone plus macrogol 3350...
January 30, 2018: Journal of Neurogastroenterology and Motility
Jiaofen Nan, Liangliang Zhang, Qiqiang Chen, Nannan Zong, Peiyong Zhang, Xing Ji, Shaohui Ma, Yuchen Zhang, Wei Huang, Zhongzhou Du, Yongquan Xia, Ming Zhang
Background/Aims: The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. Methods: The voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics...
January 30, 2018: Journal of Neurogastroenterology and Motility
Christopher M Dussik, Maryam Hockley, Aleksandra Grozić, Ichiro Kaneko, Lin Zhang, Marya S Sabir, Jin Park, Jie Wang, Cheryl A Nickerson, Steven H Yale, Christopher J Rall, Amy E Foxx-Orenstein, Connie M Borror, Todd R Sandrin, Peter W Jurutka
Background/Aims: Irritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other conditions. A more direct manner to identify IBS is needed to reduce healthcare costs and the time required for accurate diagnosis. The overarching objective of this work is to identify gene expression-based biological signatures and biomarkers of IBS. Methods: Gene transcripts from 24 tissue biopsy samples were hybridized to microarrays for gene expression profiling...
January 30, 2018: Journal of Neurogastroenterology and Motility
Yukari Tanaka, Motoyori Kanazawa, Olafur S Palsson, Miranda A Van Tilburg, Lisa M Gangarosa, Shin Fukudo, Douglas A Drossman, William E Whitehead
Background/Aims: The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms. Methods: One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal...
January 30, 2018: Journal of Neurogastroenterology and Motility
Hsing-Feng Lee, Pei-Yi Liu, Yen-Po Wang, Chia-Fen Tsai, Full-Young Chang, Ching-Liang Lu
Background/Aims: Both sexual and physical abuse history have been reported to be associated with irritable bowel syndrome (IBS) in Western countries. The impact of abuse history in IBS patients in Asia remains unclear. We aim to determine the prevalence of abuse history, its associated psychological profiles, and sleep problems among IBS patients in Taiwan. Methods: In total, 194 Rome III-defined IBS patients were invited to participate. Age- and sex- matched healthy carriers of chronic hepatitis B or hepatitis C without chronic abdominal symptoms were identified as disease-controls...
January 30, 2018: Journal of Neurogastroenterology and Motility
Ji Hyun Kim, Sung Eun Kim, Yu Kyung Cho, Chul-Hyun Lim, Moo In Park, Jin Won Hwang, Jae-Sik Jang, Minkyung Oh
Background/Aims: Although high-resolution manometry (HRM) has the advantage of visual intuitiveness, its diagnostic validity remains under debate. The aim of this study was to evaluate the diagnostic accuracy of HRM for esophageal motility disorders. Methods: Six staff members and 8 trainees were recruited for the study. In total, 40 patients enrolled in manometry studies at 3 institutes were selected. Captured images of 10 representative swallows and a single swallow in analyzing mode in both high-resolution pressure topography (HRPT) and conventional line tracing formats were provided with calculated metrics...
January 30, 2018: Journal of Neurogastroenterology and Motility
Oana Belei, Laura Olariu, Andreea Dobrescu, Tamara Marcovici, Otilia Marginean
Background/Aims: Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the gastric acid barrier and may cause diarrhea. The aim of this study is to evaluate the prevalence of small intestinal bacterial overgrowth assessed by glucose hydrogen breath test among children that received 12 weeks of PPI with or without probiotics ( Lactobacillus reuteri DSM 17938) associated, compared to controls...
January 30, 2018: Journal of Neurogastroenterology and Motility
Arun T Nair, Vadivelan Ramachandran, Nanjan M Joghee, Shanish Antony, Gopalakrishnan Ramalingam
Recent investigations suggest that gut microbiota affects the brain activity through the microbiota-gut-brain axis under both physiological and pathological disease conditions like Parkinson's disease. Further dopamine synthesis in the brain is induced by dopamine producing enzymes that are controlled by gut microbiota via the microbiota-gut-brain axis. Also alpha synuclein deposition and the associated neurodegeneration in the enteric nervous system that increase intestinal permeability, oxidative stress, and local inflammation, accounts for constipation in Parkinson's disease patients...
January 30, 2018: Journal of Neurogastroenterology and Motility
Judith S Moore, Peter R Gibson, Rebecca E Burgell
The concept of therapeutic percutaneous neuromodulation has, until recently, been limited by the ability to penetrate deeply enough to stimulate internal organs. By utilizing 2 medium frequency, slightly out of phase electrical currents passing diagonally through the abdomen, a third, low frequency current is created at the point of bisection. This interferential current appears to stimulate nerve fibers in the target organs and may have a therapeutic action. The aim of the study is to review the use of transcutaneous interferential electrical stimulation with a focus on its application in gastroenterology, particularly in motility disorders...
January 30, 2018: Journal of Neurogastroenterology and Motility
Beverley Greenwood-Van Meerveld, Anthony C Johnson
Evidence suggests that long-term stress facilitates visceral pain through sensitization of pain pathways and promotes chronic visceral pain disorders such as the irritable bowel syndrome (IBS). This review will describe the importance of stress in exacerbating IBS-induced abdominal pain. Additionally, we will briefly review our understanding of the activation of the hypothalamic-pituitary-adrenal axis by both chronic adult stress and following early life stress in the pathogenesis of IBS. The review will focus on the glucocorticoid receptor and corticotropin-releasing hormone-mediated mechanisms in the amygdala involved in stress-induced visceral hypersensitivity...
January 30, 2018: Journal of Neurogastroenterology and Motility
Uday C Ghoshal
No abstract text is available yet for this article.
January 30, 2018: Journal of Neurogastroenterology and Motility
Kyoungwon Jung, Moo In Park
No abstract text is available yet for this article.
January 30, 2018: Journal of Neurogastroenterology and Motility
Chenxi Xie, Daniel Sifrim, Yuwen Li, Minhu Chen, Yinglian Xiao
Background/Aims: Esophageal baseline impedance, which is decreased in gastroesophageal reflux disease (GERD) patients, is related to the severity of acid reflux and the integrity of the esophageal mucosa. The study aims to compare the baseline impedance and the dilated intercellular spaces (DIS) within patients with typical reflux symptoms and to evaluate the correlation of baseline impedance with DIS, esophageal acid exposure, as well as the efficacy of proton pump inhibitor (PPI) treatment...
November 21, 2017: Journal of Neurogastroenterology and Motility
Jae Yoon Chung, Jong Seol Park, Yong Sung Kim
No abstract text is available yet for this article.
October 30, 2017: Journal of Neurogastroenterology and Motility
Hong Sub Lee, Kwang Jae Lee
Background/Aims: The role of dietary factors in the pathogenesis of irritable bowel syndrome (IBS) is still unclear. The aim of this study was to compare IgG4 levels to common food antigens between patients with IBS and healthy controls. Methods: Thirty-two patients diagnosed as IBS according to the Rome III criteria (12 diarrhea subgroup; 20 non-diarrhea subgroup) and 32 sex and age-matched healthy controls participated in the study. Serum IgG4 titers to 90 common foods were measured in each subject...
October 30, 2017: Journal of Neurogastroenterology and Motility
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