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Journal of Neurogastroenterology and Motility

Tadayuki Oshima, Hiroto Miwa
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by cytochrome P450 polymorphisms, unsatisfactory effects at night, and instability in acidic conditions. Alternative formulations of conventional PPIs have been developed to overcome these problems; however, these drugs have only introduced small advantages for controlling acid secretion compared to conventional PPIs...
May 9, 2018: Journal of Neurogastroenterology and Motility
Ryo Katsumata, Manabu Ishii, Suni Lee, Yukiko Handa, Takahisa Murao, Minoru Fujita, Hiroshi Matsumoto, Takemi Otsuki, Akiko Shiotani
Background/Aims: Food interaction, including food hypersensitivity, plays a key role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). Since only a few studies have been reported about the relationship between food hypersensitivity and IBS-D, we elucidate the prevalence of serological food hypersensitivity in patients with IBS-D and the characteristics of gastrointestinal symptoms and serum cytokine profiles in patients with IBS-D and serological food hypersensitivity...
May 9, 2018: Journal of Neurogastroenterology and Motility
Mengdi Jia, Xiaofang Lu, Luqing Zhao, Zhengfang Wang, Shengsheng Zhang
Background/Aims: This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. Methods: IBS-D model rats were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). In in vivo experiments, the model rats were randomly divided into 5 groups: NMS + RS, FLCWK (low dose, middle dose, and high dose), and pinaverium bromide...
April 30, 2018: Journal of Neurogastroenterology and Motility
Fanny Giron, Eamonn M M Quigley
The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract - the gut microbiota. As our understanding of the role of the microbiota in health and human disease increases so to do efforts to prevent and treat disease through the modulation of the microbiota. Several strategies are available to us and range from time honored approaches, such as antibiotics and probiotics, to changes in diet, the administration of prebiotics as food supplements and fecal microbiota transplantation...
April 24, 2018: Journal of Neurogastroenterology and Motility
Jun Xiao
No abstract text is available yet for this article.
April 30, 2018: Journal of Neurogastroenterology and Motility
Frederick W Woodley
No abstract text is available yet for this article.
April 30, 2018: Journal of Neurogastroenterology and Motility
Yang Won Min, Eun-Ju Ko, Jeong Hwan Kim, Ji Yeon Lee, Hee Cheol Kim, Woo Yong Lee, Poong-Lyul Rhee
Background/Aims: Although bisacodyl is a widely administered laxative, its underlying mechanism of action remains generally unknown. This study focuses on investigating the effects of bisacodyl on the human colon muscle contraction, and elucidating its mechanism of action. Methods: Sigmoid colon muscle strips (20 longitudinal and 18 circular muscles) were obtained from 20 subjects who underwent colectomy for colon cancer. Isometric force measurements were calculated in response to electrical field stimulation (EFS, 0...
April 30, 2018: Journal of Neurogastroenterology and Motility
Eric D Shah, Christopher V Almario, Brennan M R Spiegel, William D Chey
Background/Aims: We evaluated the distribution of lower and upper gastrointestinal (GI) symptoms among individuals with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in a nationwide survey. Methods: Individuals (≥ 18 years of age) were identified from a nationwide sample of > 70 000 United States adults. Participants completed the National Institutes of Health GI Patient Reported Outcomes Measurement Information System (NIH GI-PROMIS) questionnaire...
April 30, 2018: Journal of Neurogastroenterology and Motility
Ashkan Farhadi, Dwaine Banton, Laurie Keefer
Background/Aims: There is a close relationship between the mind and gut in the pathogenesis of functional bowel disorders. Common psychological disturbances such as depression and anxiety are not uncommon in those with irritable bowel syndrome (IBS). There is little research investigating the role of positive psychology and gastrointestinal (GI) conditions. In this pilot study we investigated the well-being attributes in those with and without IBS. Methods: We used an anonymous online survey and recruited 416 study subjects using social media as the main method of recruitment...
April 30, 2018: Journal of Neurogastroenterology and Motility
Seung Young Kim, Rok Seon Choung, Seung Ku Lee, Jung Wan Choe, Sung Woo Jung, Jong Jin Hyun, Ja Seol Koo, Sang Woo Lee, Chol Shin
Background/Aims: Sleep impairment is a common complaint among patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). This study aimed to evaluate the prevalence of sleep impairment in FD or IBS patients, and to determine whether IBS-FD overlap induced more sleep disturbance than FD or IBS alone. Methods: A population-based cohort in South Korea including 2251 subjects was asked about gastrointestinal symptoms including IBS and dyspepsia-related symptoms...
April 30, 2018: Journal of Neurogastroenterology and Motility
Yanwen Chen, Ruifeng Wang, Bo Hou, Feng Feng, Xiucai Fang, Liming Zhu, Xiaohong Sun, Zhifeng Wang, Meiyun Ke
Background/Aims: Functional dyspepsia (FD) remains a great clinical challenge since the FD subtypes, defined by Rome III classification, still have heterogeneous pathogenesis. Previous studies have shown notable differences in visceral sensation processing in the CNS in FD compared to healthy subjects (HS). However, the role of CNS in the pathogenesis of each FD subtype has not been recognized. Methods: Twenty-eight FD patients, including 10 epigastric pain syndrome (EPS), 9 postprandial distress syndrome (PDS), and 9 mixed-type, and 10 HS, were enrolled...
April 30, 2018: Journal of Neurogastroenterology and Motility
Donghua Liao, Christian Lottrup, Lotte Fynne, Barry P McMahon, Klaus Krogh, Asbjørn M Drewes, Jingbo Zhao, Hans Gregersen
Background/Aims: Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a scarcity of technology for measuring esophagus movements in the longitudinal (axial) direction. The aim of this study is to develop new analytical tools for dynamic evaluation of the length change and axial movement of the human LES based on the functional luminal imaging probe (FLIP) technology and to present normal signatures for the selected parameters...
April 30, 2018: Journal of Neurogastroenterology and Motility
Ga Hee Kim, Kee Wook Jung, Hwoon-Yong Jung, Kee Don Choi, JungBok Lee, Young Soo Park, So-Woon Kim, Jeong Hoon Lee, Do Hoon Kim, Ji Yong Ahn, Ho June Song, Gin Hyug Lee, Jin-Ho Kim
Background/Aims: The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods: Using an endoscopic database maintained at a tertiary care center, we retrospectively reviewed the biopsy reports regarding 18 399 biopsy specimens collected from all patients who underwent esophagogastroduodenoscopy and esophageal biopsy at this facility between 2006 and 2014...
April 30, 2018: Journal of Neurogastroenterology and Motility
Hironobu Mikami, Norihisa Ishimura, Mayumi Okada, Daisuke Izumi, Eiko Okimoto, Shunji Ishihara, Yoshikazu Kinoshita
Background/Aims: The novel prokinetic drug acotiamide is used for treatment of functional dyspepsia. It is still unclear how acotiamide has effects on esophageal motor function. Esophageal peristalsis and esophagogastric junction (EGJ) compliance has an important role for prevention of esophageal mucosal damage caused by gastroesophageal reflux, however, few studies have analyzed the effects of acotiamide on those former activities and none have investigated its effects on EGJ compliance...
April 30, 2018: Journal of Neurogastroenterology and Motility
Duc T Quach, Trang T Nguyen, Toru Hiyama
Background/Aims: There have been no studies investigating the distribution of abnormal gastroesophageal flap valve (GEFV) among patients with dyspepsia, non-erosive reflux disease (NERD), and reflux esophagitis (RE) in the same set of patients. The aims of this study are to investigate (1) the association between GEFV and gastroesophageal reflux disease questionnaire (GERDQ) score, and (2) the distribution of abnormal GEFV in Vietnamese patients presenting with upper gastrointestinal symptoms...
April 30, 2018: Journal of Neurogastroenterology and Motility
Camille Bazin, Alban Benezech, Marine Alessandrini, Jean-Charles Grimaud, Veronique Vitton
Background/Aims: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett's esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. Methods: A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry...
April 30, 2018: Journal of Neurogastroenterology and Motility
Kyung Ho Song, Hye-Kyung Jung, Hyun Jin Kim, Hoon Sup Koo, Yong Hwan Kwon, Hyun Duk Shin, Hyun Chul Lim, Jeong Eun Shin, Sung Eun Kim, Dae Hyeon Cho, Jeong Hwan Kim, Hyun Jung Kim
In 2011, the Korean Society of Neurogastroenterology and Motility (KSNM) published clinical practice guidelines on the management of irritable bowel syndrome (IBS) based on a systematic review of the literature. The KSNM planned to update the clinical practice guidelines to support primary physicians, reduce the socioeconomic burden of IBS, and reflect advances in the pathophysiology and management of IBS. The present revised version of the guidelines is in continuity with the previous version and targets adults diagnosed with, or suspected to have, IBS...
April 30, 2018: Journal of Neurogastroenterology and Motility
Yoshikazu Kinoshita, Norihisa Ishimura, Shunji Ishihara
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically important adverse effects of PPIs can occur, just as with other drugs, those are not frequently observed during or after administration. Thus, PPIs are regarded as relatively safe and considered to be clinically beneficial. Recently, PPIs have become frequently administered to patients with functional gastrointestinal diseases or primary prevention of drug-related gastroduodenal damage, even though their beneficial effects for those conditions have not been fully confirmed...
April 30, 2018: Journal of Neurogastroenterology and Motility
Hans Gregersen, Kar Man Lo
The gastrointestinal (GI) tract is efficient in transporting ingested material to the site of delivery in healthy subjects. A fine balance exists between peristaltic forces, the mixing and delivery of the contents, and sensory signaling. This fine balance is easily disturbed by diseases. It is mandatory to understand the pathophysiology to enhance our understanding of GI disorders. The inaccessibility and complex nervous innervation, geometry and mechanical function of the GI tract make mechanosensory evaluation difficult...
April 30, 2018: Journal of Neurogastroenterology and Motility
Seung-Ho Jang, Yong Sung Kim
No abstract text is available yet for this article.
April 30, 2018: Journal of Neurogastroenterology and Motility
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