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Journal of Neurogastroenterology and Motility

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https://www.readbyqxmd.com/read/28192648/mapping-of-brain-activations-to-rectal-balloon-distension-stimuli-in-male-patients-with-irritable-bowel-syndrome-using-functional-magnetic-resonance-imaging
#1
Anupam Guleria, Arun Karyampudi, Rajan Singh, Chunni L Khetrapal, Abhai Verma, Uday C Ghoshal, Dinesh Kumar
Background/Aims: Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among male. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared...
February 14, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28192647/a-double-blind-randomized-multicenter-clinical-trial-investigating-the-efficacy-and-safety-of-esomeprazole-single-therapy-versus-mosapride-and-esomeprazole-combined-therapy-in-patients-with-esophageal-reflux-disease
#2
Ju Yup Lee, Sung Kook Kim, Kwang Bum Cho, Kyung Sik Park, Joong Goo Kwon, Jin Tae Jung, Eun Young Kim, Byung Ik Jang, Si Hyung Lee
Background/Aims: We aimed to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rate according to the Los Angeles classification for esomeprazole alone and esomeprazole plus mosapride. Methods: A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at week 4 and 8...
February 13, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28163260/central-and-peripheral-effects-of-transcutaneous-acupuncture-treatment-for-nausea-in-patients-with-diabetic-gastroparesis
#3
Irene Sarosiek, Gengqing Song, Yan Sun, Hugo Sandoval, Stephen Sands, Jiande Chen, Richard W McCallum
Background/Aims: Nausea, an unpleasant symptom of diabetic gastroparesis (DMGP), has been reported to be alleviated by needleless transcutaneous electrical acupuncture (TEA). Our study was designed to utilize electroencephalography (EEG) and electrogastrography (EGG) recordings to investigate the central and peripheral responses of TEA in the treatment of nausea in DMGP patients. Methods: Eleven DMGP subjects underwent simultaneous EEG and EGG testing while grading the severity of nausea following 30-minute intervals of: (1) baseline, (2) visual stimulation (VS) to provoke more nausea, (3) active VS together with TEA, and (4) TEA alone, and a final 15-minute recording without any intervention...
February 5, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28163259/effects-of-age-on-esophageal-motility-use-of-high-resolution-esophageal-impedance-manometry
#4
Young Kwang Shim, Nayoung Kim, Yo Han Park, Jong-Chan Lee, Jihee Sung, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Background/Aims: Disturbances of esophageal motility have been reported to be more frequent in aged population. However, the physiology of disturbances in esophageal motility during aging is unclear. The aim of this study was to evaluate the effects of age on the esophageal motility using high-resolution esophageal impedance manometry (HRIM). Methods: Esophageal motor function of 268 subjects were measured using HRIM in 3 age groups, < 40 years (n = 32), 40-65 years (n = 185), and > 65 years (n = 62)...
February 5, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28147345/taste-and-smell-disturbances-in-patients-with-gastroparesis-and-gastroesophageal-reflux-disease
#5
Alisha Kabadi, Mohammed Saadi, Ron Schey, Henry P Parkman
Background/Aims: Patients with gastroparesis and gastroesophageal reflux disease (GERD) often report decreased enjoyment when eating. Some patients remark that food does not smell or taste the same. To determine if taste and/or smell disturbances are present in patients with gastroparesis and/or GERD and relate these to gastrointestinal symptom severity. Methods: Patients with gastroparesis and/or GERD completed questionnaires evaluating taste and smell (Taste and Smell Survey [TSS]), Patient Assessment of Upper Gastrointestinal Symptom Severity Index (PAGI-SYM), and demographics...
February 1, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28147346/foods-inducing-typical-gastroesophageal-reflux-disease-symptoms-in-korea
#6
Jung Wan Choe, Moon Kyung Joo, Hyo Jung Kim, Beom Jae Lee, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Jae Seon Kim, Kwan Soo Byun, Young-Tae Bak
Background/Aims: Several specific foods are known to precipitate gastroesophageal reflux disease (GERD) symptoms and GERD patients are usually advised to avoid such foods. However, foods consumed daily are quite variable according to regions, cultures, etc. This study was done to elucidate the food items which induce typical GERD symptoms in Korean patients. Methods: One hundred and twenty-six Korean patients with weekly typical GERD symptoms were asked to mark all food items that induced typical GERD symptoms from a list containing 152 typical foods consumed daily in Korea...
January 31, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28096522/control-of-food-intake-by-gastrointestinal-peptides-mechanisms-of-action-and-possible-modulation-in-the-treatment-of-obesity
#7
REVIEW
Philip Prinz, Andreas Stengel
This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative-physical activity and pharmacotherapy-treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways...
January 17, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28044052/the-relationship-of-the-post-reflux-swallow-induced-peristaltic-wave-index-and-esophageal-baseline-impedance-with-gastroesophageal-reflux-disease-symptoms
#8
Young Kyu Cho, Joon Seong Lee, Tae Hee Lee, Su Jin Hong, Sang Joon Park, Seong Ran Jeon, Hyun Gun Kim, Jin-Oh Kim
Background/Aims: The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with reflux symptoms is not known. We aimed to evaluate the correlations of the PSPW index and esophageal BI with gastroesophageal reflux disease (GERD) symptoms. Methods: We performed a retrospective review of multichannel intraluminal impedance and pH (MII-pH) tracings in patients with suspected GERD...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28044051/maturation-phenotype-of-peripheral-blood-monocyte-macrophage-after-stimulation-with-lipopolysaccharides-in-irritable-bowel-syndrome
#9
Oscar A Rodríguez-Fandiño, Joselín Hernández-Ruiz, Yolanda López-Vidal, Luis Charúa-Guindic, Galileo Escobedo, Max J Schmulson
Background/Aims: Abnormal immune regulation and increased intestinal permeability augmenting the passage of bacterial molecules that can activate immune cells, such as monocytes/macrophages, have been reported in irritable bowel syndrome (IBS). To compare the maturation phenotype of monocytes/macrophages (CD14+) from IBS patients and controls in the presence or absence of E. coli lipopolysaccharides (LPS), in vitro. Methods: Mononuclear cells were isolated from peripheral blood of 20 Rome II-IBS patients and 19 controls and cultured with or without LPS for 72 hours...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28044050/piezo2-a-candidate-biomarker-for-visceral-hypersensitivity-in-irritable-bowel-syndrome
#10
Tao Bai, Ying Li, Jing Xia, Yudong Jiang, Lei Zhang, Huan Wang, Wei Qian, Jun Song, Xiaohua Hou
Background/Aim: Currently, there exists no biomarker for visceral hypersensitivity in Irritable Bowel Syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test the expressions of Piezo1 and Piezo2 proteins in the intestinal epithelial cells from different intestinal segments and to explore the correlation between Piezo proteins expression and visceral pain threshold...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28013295/emerging-roles-of-the-endolumenal-functional-lumen-imaging-probe-endoflip-in-gastrointestinal-motility-disorders
#11
REVIEW
Rona Marie A Lawenko, Yeong Yeh Lee
Gastrointestinal sphincters play a vital role in gut function and motility by separating the gut into functional segments. Traditionally, function of sphincters including the esophagogastric junction is studied using endoscopy and manometry. However, due to its dynamic biomechanical properties, data on distensibility and compliance may provide a more accurate representation of the sphincter function. The endolumenal functional lumen imaging probe (EndoFLIP) system uses a multi-detector impedance planimetry system to provide data on tissue distensibility and geometric changes in the sphincter as measured through resistance to volumetric distention with real-time images...
December 23, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28049864/irritable-bowel-syndrome-and-nickel-allergy-what-is-the-role-of-the-low-nickel-diet
#12
Angela Rizzi, Eleonora Nucera, Lucrezia Laterza, Eleonora Gaetani, Venanzio Valenza, Giuseppe M Corbo, Riccardo Inchingolo, Alessandro Buonomo, Domenico Schiavino, Antonio Gasbarrini
Background/Aims: Irritable bowel syndrome (IBS) is characterized by chronic abdominal pain or discomfort accompanied by abnormal bowel movements. In sensitized subjects, ingested nickel (Ni) may induce gastrointestinal symptoms similar to IBS, in addition to typical systemic cutaneous lesions (systemic nickel allergy syndrome [SNAS]). A low nickel diet could improve the systemic manifestations. We evaluated prevalence of nickel allergy in IBS and effects of low Ni diet on (1) gastrointestinal symptoms control, (2) intestinal barrier function, (3) quality of life, and (4) psychological status of patients with IBS and Ni-sensitized patients...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28049863/the-effect-of-acute-stress-on-esophageal-motility-and-gastroesophageal-reflux-in-healthy-humans
#13
Hong Sub Lee, Chung Kyun Noh, Kwang Jae Lee
Background/Aims: Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. Methods: A total of 10 (M:F = 8:2, median age 34 years-old) healthy volunteers without any recurrent gastrointestinal symptoms participated in this study. They underwent esophageal high-resolution manometry with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28049862/therapeutic-modulation-of-gut-microbiota-in-functional-bowel-disorders
#14
REVIEW
Hyo Jeong Lee, Jong Kyoung Choi, Han Seung Ryu, Chang Hwan Choi, Eun Hee Kang, Kyung Sik Park, Yang Won Min, Kyoung Sup Hong
Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28049861/colonic-slow-transit-can-cause-changes-in-the-gut-environment-observed-in-the-elderly
#15
EDITORIAL
Seong-Eun Kim
No abstract text is available yet for this article.
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28049860/why-should-we-contemplate-on-gender-difference-in-functional-gastrointestinal-disorders
#16
EDITORIAL
Jaehoon Jahng, Yong Sung Kim
No abstract text is available yet for this article.
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27832682/effect-of-da-9701-a-novel-prokinetic-agent-on-post-operative-ileus-in-rats
#17
Sang Pyo Lee, Oh Young Lee, Kang Nyeong Lee, Hang Lak Lee, Ho Soon Choi, Byung Chul Yoon, Dae Won Jun
Background/Aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM)...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27829577/chronic-early-life-stress-in-rat-pups-alters-basal-corticosterone-intestinal-permeability-and-fecal-microbiota-at-weaning-influence-of-sex
#18
Nabila Moussaoui, Jonathan P Jacobs, Muriel Larauche, Mandy Biraud, Mulugeta Million, Emeran Mayer, Yvette Taché
Background/Aims: Wistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier at PND10 and a visceral hypersensitivity at adulthood. Little is known about the impact of early life stress on the offspring before adulthood and the influence of sex. We investigated whether male and female rats previously exposed to LNS displays at weaning altered corticosterone, intestinal permeability, and microbiota...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27817184/biomarkers-of-irritable-bowel-syndrome
#19
REVIEW
Jae Hak Kim, Eugenia Lin, Mark Pimentel
Traditionally, irritable bowel syndrome (IBS) has not been regarded as an organic disease, and the pathophysiology of IBS is heterogeneous. Currently, the diagnosis of IBS is based upon the Rome diagnostic criteria. The performance of these criteria is only modest in predicting IBS, and moreover their validation is lacking. Additionally, as functional symptoms are common in the general population, healthy controls or volunteers are difficult to define and there is currently no definition of "normal" in the Rome criteria...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27771944/is-gastroesophageal-reflux-disease-and-achalasia-coincident-or-not
#20
REVIEW
Da Hyun Jung, Hyojin Park
Achalasia and gastroesophageal reflux disease (GERD) are on opposite ends of the spectrum of lower esophageal sphincter dysfunction. Heartburn is the main symptom of GERD. However, heartburn and regurgitation are frequently observed in patients who have achalasia. The diagnosis of achalasia might be delayed because these symptoms are misinterpreted as gastroesophageal reflux. Here, we reviewed the clinical characteristics of patients with the erroneous diagnosis of GERD who actually had untreated achalasia.
January 30, 2017: Journal of Neurogastroenterology and Motility
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