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Journal of Neurogastroenterology and Motility

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https://www.readbyqxmd.com/read/30347942/overexpression-of-stromal-interaction-molecule-1-store-operated-calcium-entry-associated-regulatory-factor-in-interstitial-cells-of-cajal-in-mouse-jejunum-impairs-pacemaker-activity
#1
LETTER
Jian-Lin Lv, Ning-Yuan Chen, Shang-Ling Pan
No abstract text is available yet for this article.
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347941/microrna-200a-targets-cannabinoid-receptor-1-and-serotonin-transporter-to-increase-visceral-hyperalgesia-in-diarrhea-predominant-irritable-bowel-syndrome-rats
#2
Qiuke Hou, Yongquan Huang, Changrong Zhang, Shuilian Zhu, Peiwu Li, Xinlin Chen, Zhengkun Hou, Fengbin Liu
Background/Aims: MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity in IBS-D remains largely unknown. Methods: We established the IBS-D rat model and evaluated it using the nociceptive visceral hypersensitivity test, myeloperoxidase activity assay, restraint stress-induced defecation, and electromyographic (EMG) activity...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347940/role-of-high-affinity-choline-transporter-1-in-colonic-hypermotility-in-a-rat-model-of-irritable-bowel-syndrome
#3
Meng-Juan Lin, Bao-Ping Yu
Background/Aims: Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1), a determinant of cholinergic signaling capacity, modulates intestinal motility associated with stress-induced IBS. Methods: A rat IBS model was established using chronic water avoidance stress (WAS). Colonic pathological alterations were evaluated histologically and intestinal motility was assessed by intestinal transit time and fecal water content (FWC)...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347939/expression-of-toll-like-receptors-pro-and-anti-inflammatory-cytokines-in-relation-to-gut-microbiota-in-irritable-bowel-syndrome-the-evidence-for-its-micro-organic-basis
#4
Ratnakar Shukla, Ujjala Ghoshal, Prabhat Ranjan, Uday C Ghoshal
Background/Aims: A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their expression in relation to gut microbiota. Methods: Expression of TLRs and cytokines was assessed in 47 IBS patients (Rome III) and 25 controls using quantitative real-time polymerase chain reaction. Immunohistochemistry was further performed to confirm the expression of TLR-4 and TLR-5...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347938/association-between-anxiety-and-depression-and-gastroesophageal-reflux-disease-results-from-a-large-cross-sectional-study
#5
Ji Min Choi, Jong In Yang, Seung Joo Kang, Yoo Min Han, Jooyoung Lee, Changhyun Lee, Su Jin Chung, Dae Hyun Yoon, Boram Park, Yong Sung Kim
Background/Aims: The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each subtype of GERD. Methods: Subjects who underwent esophagogastroduodenoscopy and completed a symptom questionnaire between January 2008 and December 2011 were analyzed. The subjects were classified into the following groups: erosive reflux disease (ERD), non-erosive reflux disease (NERD), asymptomatic erosive esophagitis (AEE), and controls...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347937/development-and-psychometric-assessment-of-a-self-evaluation-questionnaire-for-gastroesophageal-reflux-disease
#6
Hye-Kyung Jung, Myung-Gyu Choi, Myung-Ki Baek, Justin C Y Wu
Background/Aims: There is uncertainty about how to measure outcomes reported by patients in gastroesophageal reflux disease (GERD). This study was conducted to develop an instrument and to determine of the definition of respondent for a patient reported outcomes to assess the efficacy of a treatment used for GERD treatment. Methods: A structural process has developed a self-evaluation questionnaire for GERD (SEQ-GERD); health-related quality of life questionnaire for GERD (GERD-QOL) was translated through cross-cultural validation...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347936/pathophysiology-of-potassium-competitive-acid-blocker-refractory-gastroesophageal-reflux-and-the-potential-of-potassium-competitive-acid-blocker-test
#7
Tatsuhiro Masaoka, Hisako Kameyama, Tsuyoshi Yamane, Yuta Yamamoto, Hiroya Takeuchi, Hidekazu Suzuki, Yuko Kitagawa, Takanori Kanai
Background/Aims: Potassium-competitive acid blockers are expected to be the next generation of drugs for the treatment of diseases caused by gastric acid. In 2015, vonoprazan fumarate, a novel potassium-competitive acid blocker, was approved by the Japanese health insurance system. Since its approval, patients refractory to vonoprazan can be encountered in clinical settings. We designed this study to clarify the pathophysiology of gastroesophageal reflux disease refractory to vonoprazan...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347935/the-changing-epidemiology-of-gastroesophageal-reflux-disease-are-patients-getting-younger
#8
Takahisa Yamasaki, Colin Hemond, Mohamed Eisa, Stephen Ganocy, Ronnie Fass
Background/Aims: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged and older people. Since risk factors for GERD affect a growing number of the adult population, concerns have been raised that increasingly younger people may develop GERD. We aim to determine if the proportion of younger patients has increased among the GERD population...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347934/sex-gender-differences-in-irritable-bowel-syndrome
#9
REVIEW
Young Sun Kim, Nayoung Kim
Because of the sex-gender differences that are shown in a diversity of physiological and psychological factors, it can be speculated that the clinical presentation of symptoms as well as treatment strategies in women and men with irritable bowel syndrome (IBS) may differ. Studies have revealed that IBS is more common in women than men. As for the IBS subtype, IBS with constipation is significantly more prevalent among women than men. Sex hormones and gender differences may play important roles in the pathophysiology of IBS...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347933/do-toll-like-receptors-play-a-new-role-as-a-biomarker-of-irritable-bowel-syndrome
#10
EDITORIAL
Hyun Jin Kim
No abstract text is available yet for this article.
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30347932/it-is-time-to-meet-the-challenges-of-the-changing-epidemiology-of-gastroesophageal-reflux-disease
#11
EDITORIAL
Gwang Ha Kim
No abstract text is available yet for this article.
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30180307/quantitative-analysis-of-distribution-of-the-gastrointestinal-tract-eosinophils-in-childhood-functional-abdominal-pain-disorders
#12
Eun Hye Lee, Hye Ran Yang, Hye Seung Lee
Background/Aims: Although functional abdominal pain disorders (FAPDs) are common in children, the accurate pathogenesis of FAPDs is not known yet. Micro-inflammation, particularly tissue eosinophilia of gastrointestinal (GI) tract, has been suggested as the pathophysiology observed in several GI disorders. We aimed to evaluate eosinophilic infiltration throughout the entire GI tract in children with FAPDs, compared to those with inflammatory bowel diseases (IBD) and to normal reference values...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30153722/cultural-factors-influencing-functional-gastrointestinal-disorders-in-the-east
#13
REVIEW
Kee-Huat Chuah, Sanjiv Mahadeva
Culture forms an integral aspect of environmental factors which influences disease presentation and clinical outcomes in functionalgastrointestinal disorders (FGIDs). In this review, the role of culture in FGIDs in the East is briefly explored with regards to symptompresentation and diagnostic issues, lifestyle and cultural habits, epidemiology, and healthcare seeking behavior. In both functionaldyspepsia and irritable bowel syndrome, symptom presentation and disease sub-typing in Asians are known to differ from their Western counterparts, possibly relating to cultural dietary practices and from cultural perception of symptoms...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30153721/-aloe-vera-is-effective-and-safe-in-short-term-treatment-of-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#14
REVIEW
Seung Wook Hong, Jaeyoung Chun, Sunmin Park, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
Background/Aims: To evaluate the efficacy and safety of Aloe vera (AV) in patients with irritable bowel syndrome (IBS). Methods: We searched the MEDLINE, EMBASE, and Cochrane databases for studies dated between 1st January 1960 and 30th December 2017. Eligible randomized controlled trials (RCTs) compared AV to placebo in patients with IBS. The primary outcome was standardized mean difference of the change in severity of IBS symptoms as measured by patient-rated scales...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30122029/improving-high-resolution-impedance-manometry-using-novel-viscous-and-super-viscous-substrates-in-the-supine-and-upright-positions-a-pilot-study
#15
Uni Wong, Erik B Person, Donald O Castell, Erik von Rosenvinge, Jean-Pierre Raufman, Guofeng Xie
Background/Aims: Swallows with viscous or solid boluses in different body positions alter esophageal manometry patterns. Limitations of previous studies include lack of standardized viscous substrates and the need for chewing prior to swallowing solid boluses. We hypothesize that high-resolution impedance manometry (HRiM) using standardized viscous and super-viscous swallows in supine and upright positions improves sensitivity for detecting esophageal motility abnormalities when compared with traditional saline swallows...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30114898/the-effect-of-trimebutine-on-the-overlap-syndrome-model-of-guinea-pigs
#16
Zahid Hussain, Da Hyun Jung, Young Ju Lee, Hyojin Park
Background/Aims: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods: Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30041284/understanding-neurogastroenterology-from-neuroimaging-perspective-a-comprehensive-review-of-functional-and-structural-brain-imaging-in-functional-gastrointestinal-disorders
#17
REVIEW
Michiko Kano, Patrick Dupont, Qasim Aziz, Shin Fukudo
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29955019/to-understand-the-modulatory-effect-of-probiotics-on-irritable-bowel-syndrome
#18
LETTER
Anlong Yuan, Peng Li, Li Wang, Bibo Zhong, Bin Bai, Xiaoyu Huang, Jiguang Kou
No abstract text is available yet for this article.
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29938463/prevalence-and-risk-factors-of-functional-dyspepsia-in-health-check-up-population-a-nationwide-multicenter-prospective-study
#19
Sung Eun Kim, Nayoung Kim, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Kwangwoo Nam, Hyeon Ju Kim, Hyun Joo Song, Young-Eun Joo, Dae-Seong Myung, Ji-Hyun Seo, Hyun Jin Jo, Seon Mie Kim, Seon Hee Lim, Hyun Jin Kim, Gwang Ho Baik, Sang Hyeon Choi, Suck Chei Choi
Background/Aims: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea. Methods: A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with the Rome III criteria, and Helicobacter pylori serology (IgG)...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29969864/factors-determining-the-inter-observer-variability-and-diagnostic-accuracy-of-high-resolution-manometry-for-esophageal-motility-disorders
#20
Ji Hyun Kim, Sung Eun Kim, Yu Kyung Cho, Chul-Hyun Lim, Moo In Park, Jin Won Hwang, Jae-Sik Jang, Minkyung Oh
The figure 6 should have been presented as follows.
July 30, 2018: Journal of Neurogastroenterology and Motility
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