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Journal of Neurogastroenterology and Motility

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https://www.readbyqxmd.com/read/28774159/comparison-of-changes-in-the-interstitial-cells-of-cajal-and-neuronal-nitric-oxide-synthase-positive-neuronal-cells-with-aging-between-the-ascending-and-descending-colon-of-f344-rats
#1
Sun Min Lee, Nayoung Kim, Hyun Jin Jo, Ji Hyun Park, Ryoung Hee Nam, Hye Seung Lee, Hyun Jin Kim, Moon Young Lee, Yong Sung Kim, Dong Ho Lee
Background/Aims: Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide synthase (nNOS) with regard to age-related changes between the ascending colon (AC) and descending colon (DC) in 6-, 31-, and 74-week old and 2-year old male Fischer-344 rats. Methods: The amount of fecal pellet and the bead expulsion times were measured...
August 4, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28774158/regulation-of-intracellular-calcium-by-endoplasmic-reticulum-proteins-in-small-intestinal-interstitial-cells-of-cajal
#2
Chan Guk Park, Mei Jin Wu, Chansik Hong, Ju Yeon Jo, Han Yi Jiao, Hyun Park, Jae Yeoul Jun, Seok Choi
Background/Aims: We investigated the role of representative endoplasmic reticulum proteins, stromal interaction molecule 1 (STIM1), and store-operated calcium entry-associated regulatory factor (SARAF) in pacemaker activity in cultured interstitial cells of Cajal (ICCs) isolated from mouse small intestine. Methods: The whole-cell patch clamp technique applied for intracellular calcium ions ([Ca(2+)]i) analysis with STIM1 or SARAF overexpressed cultured ICCs from mouse small intestine...
August 4, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28750491/severe-delayed-gastric-emptying-induces-non-acid-reflux-up-to-proximal-esophagus-in-neurologically-impaired-patients
#3
Shinji Ishii, Suguru Fukahori, Kimio Asagiri, Yoshiaki Tanaka, Nobuyuki Saikusa, Naoki Hashizume, Motomu Yoshida, Daisuke Masui, Naoko Komatsuzaki, Naruki Higashidate, Saki Sakamoto, Tomohiro Kurahachi, Shiori Tsuruhisa, Hirotomo Nakahara, Minoru Yagi
Background/Aims: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and (13)C-acetate breath test ((13)C-ABT) analyses. Methods: (13)C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD...
July 28, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28738452/prediction-of-delayed-colonic-transit-using-bristol-stool-form-and-stool-frequency-in-eastern-constipated-patients-a-difference-from-the-west
#4
Veeravich Jaruvongvanich, Tanisa Patcharatrakul, Sutep Gonlachanvit
Background/Aims: The correlation between the Bristol stool form scale (BSFS) and colonic transit time (CTT) has been reported in Western populations. Our study aims to study the relationship between BSFS, stool frequency, and CTT in Eastern patients with chronic constipation. Methods: A total of 144 chronic primary constipation patients underwent colonic transit study by using radio-opaque markers, anorectal manometry, and balloon expulsion test. Stool diary including stool forms and frequency was recorded...
July 21, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28738451/psychiatric-comorbidity-in-patients-with-irritable-bowel-syndrome-at-a-tertiary-care-center-in-northern-india
#5
Yuman Kawoos, Zaid A Wani, Showkat A Kadla, Irfan A Shah, Arshad Hussain, M Maqbool Dar, Mushtaq A Margoob, Kouser Sideeq
Background/Aims: Irritable bowel syndrome (IBS) is a chronic psycho-physiological disorder. It is considered to be the most common functional gastrointestinal disorder, and about 50.0-90.0% of IBS patients have associated psychiatric comorbidity. We aimed to study psychiatric comorbidities in patients with IBS visiting a tertiary care center. Methods: This was a cross-sectional case-control study conducted over a duration of one and a half years from January 2014 to July 2015...
July 21, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28571122/detecting-the-non-physiological-surgically-tailored-ileocolic-anastomosis-using-the-wireless-motility-capsule-a-pre-and-post-operative-prospective-within-subject-trial
#6
Yngve Thorsen, Bojan V Stimec, Jens M Nesgaard, Dejan Ignjatovic
Background/Aims: Wireless motility capsule (WMC) detects the ileocolic junction (ICJ) in most non-operated patients. We find no data concerning this examination in patients where the ileocolic valve is replaced by a per definition incompetent, surgically created ICJ. We wanted to see if WMC could detect the ICJ after a right colectomy and assess the competency. Methods: Prospective cohort study using a within-subject design to eliminate subject-subject variability...
June 1, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28554984/the-effect-of-deoxycholic-acid-on-secretion-and-motility-in-the-rat-and-guinea-pig-large-intestine
#7
Nam Hee Kim, Jung Ho Park, Jae-Soon Park, Yeun-Ho Joung
Background/Aims: Bile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon and coordination of bowel movements in the guinea pig colon. Methods: The short-circuit current from the mucosal strip of the proximal and distal rat colon was compared under control conditions after induction of secretion with deoxycholic acid (DCA) as well as after inhibition of secretion with indomethacin, 1,2-bis (o-aminophenoxy) ethane-N, N,N',N'-tetra-acetic acid (an intracellular calcium chelator; BAPTA), and tetrodotoxin (TTX) using an Ussing chamber...
May 29, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672434/effects-of-age-on-esophageal-motility-use-of-high-resolution-esophageal-impedance-manometry
#8
Young Kwang Shim, Nayoung Kim, Yo Han Park, Jong-Chan Lee, Jihee Sung, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
The data "268" in the Abstract should have been written as "279" and the data "277" in the Materials and Methods should have been written as "279."
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672433/the-increased-level-of-depression-and-anxiety-in-irritable-bowel-syndrome-patients-compared-with-healthy-controls-systematic-review-and-meta-analysis
#9
REVIEW
Changhyun Lee, Eunyoung Doo, Ji Min Choi, Seung-Ho Jang, Han-Seung Ryu, Ju Yup Lee, Jung Hwan Oh, Jung Ho Park, Yong Sung Kim
Background/Aims: Irritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. Methods: We searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; sub-group analyses were conducted according to IBS-subtypes...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672432/pros-and-cons-while-looking-through-an-asian-window-on-the-rome-iv-criteria-for-irritable-bowel-syndrome-pros
#10
REVIEW
Uday C Ghoshal
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Instead of considering functional gastrointestinal disorders (FGIDs) to be largely psychogenic, Rome IV suggested the importance of the gut over brain ("disorders of gut-brain interaction" not "brain-gut interaction")...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672431/the-application-of-the-rome-iv-criteria-to-functional-esophagogastroduodenal-disorders-in-asia
#11
REVIEW
Hidekazu Suzuki
The Rome criteria were amended as Rome IV. For functional esophageal disorders, the exclusion criteria have been more specifically revised based on further understanding of other esophageal disorders, including eosinophilic esophagitis and spastic and hypercontractile motor disorders. Another revised point is the more restrictive definition of gastroesophageal reflux disease, indicating that sensitivity to a physiological reflux burden may be placed more firmly within the functional group. For functional dyspepsia (FD), only minor changes were introduced, mainly to improve specificity...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672430/the-implication-of-gastric-dysmotility-in-the-pathophysiology-of-functional-dyspepsia
#12
EDITORIAL
Yang Won Min
No abstract text is available yet for this article.
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672429/regional-food-causing-symptoms-of-gastroesophageal-reflux-disease
#13
EDITORIAL
Jung Ho Park
No abstract text is available yet for this article.
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28586765/lipid-laden-macrophages-in-respiratory-disease
#14
LETTER
Laura R Sadofsky, Yvette A Hayman, Simon P Hart, Alyn H Morice
No abstract text is available yet for this article.
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28578564/balloon-expulsion-test-does-not-seem-to-be-useful-for-screening-or-exclusion-of-dyssynergic-defecation-as-a-single-test
#15
Jooyoung Lee, Kyoung Sup Hong, Joo Sung Kim, Hyun Chae Jung
Background/Aims: Balloon expulsion test (BET) is regarded as a screening tool of dyssynergic defecation (DD). However, some patients with normal BET results may be treated effectively by biofeedback training. This study aims to validate BET as a single screening test. Methods: Two hundred and thirty-two patients who were diagnosed with functional constipation or irritable bowel syndrome with constipation who underwent anorectal manometry (ARM) and BET at Seoul National University Hospital were enrolled...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28565730/gallbladder-volume-indicated-for-gallbladder-dysmotility
#16
LETTER
Linlin Liu, Bing Wu, Jianlin Lv
No abstract text is available yet for this article.
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28551943/targeting-histamine-receptors-in-irritable-bowel-syndrome-a-critical-appraisal
#17
REVIEW
Adam Fabisiak, Jakub Włodarczyk, Natalia Fabisiak, Martin Storr, Jakub Fichna
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28480684/effects-of-cognitive-behavior-therapy-on-heart-rate-variability-in-young-females-with-constipation-predominant-irritable-bowel-syndrome-a-parallel-group-trial
#18
Aelee Jang, Sun-Kyung Hwang, Nikhil S Padhye, Janet C Meininger
Background/Aims: The relation between heart rate variability (HRV) as non-invasive biomarkers of autonomic function and cognitive behavior therapy (CBT) as non-pharmacological treatments has rarely been examined in patients with constipation-predominant irritable bowel syndrome (IBS-C). The purpose of this study is to evaluate the efficacy of an 8-week CBT intervention on HRV and IBS symptoms, and the correlation of changes in HRV with changes in IBS symptoms among young female nursing students with IBS-C...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28478662/the-degree-of-disease-knowledge-in-patients-with-gastroesophageal-reflux-disease-a-multi-center-prospective-study-in-korea
#19
In Du Jeong, Moo In Park, Sung Eun Kim, Beom Jin Kim, Sang Wook Kim, Jie-Hyun Kim, Hye Young Sung, Tae-Hoon Oh, Yeon Soo Kim
Background/Aims: Patient education has been shown to be beneficial in several diseases. To properly educate patients with gastroesophageal reflux disease (GERD), it is necessary to understand how much they already know about their disease. However, no study has examined the degree of disease knowledge in Korean patients with GERD. Therefore, we conducted this study to assess the degree of knowledge in such patients. Methods: This multicenter prospective study was conducted from January 2014 to January 2015...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28460516/neuroendocrine-dysregulation-in-irritable-bowel-syndrome-patients-a-pilot-study
#20
Cristina Stasi, Massimo Bellini, Dario Gambaccini, Emiliano Duranti, Nicola de Bortoli, Bernardo Fani, Eleonora Albano, Salvatore Russo, Isabella Sudano, Giacomo Laffi, Stefano Taddei, Santino Marchi, Rosa Maria Bruno
Background/Aims: Irritable bowel syndrome (IBS) is a multifactorial disorder, involving dysregulation of brain-gut axis. Our aim was to evaluate the neuroendocrine activity in IBS. Methods: Thirty IBS and 30 healthy volunteers were enrolled. Psychological symptoms were evaluated by questionnaires. Urinary 5-hydroxyindoleacetic acid, plasma serotonin (5-hydroxytryptamine, 5-HT), endothelin, and neuropeptide Y (NPY), and plasma and urinary cortisol levels were evaluated...
July 30, 2017: Journal of Neurogastroenterology and Motility
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