Evaluating the Utility of Traditional Bowel Dose Constraints when Treating Abdominal and Pelvic Sarcomas with Preoperative Radiation Therapy.

PURPOSE/OBJECTIVE(S): Abdominopelvic soft tissue sarcomas (AP-STS) are selectively treated with preoperative radiation therapy (RT) followed by surgery. Due to their rarity, most bowel dose constraints are extrapolated from dosimetric studies for other abdominal or pelvic malignancies where concurrent chemotherapy is often given in addition to RT. We sought to investigate associations between dosimetric bowel constraints and the risk for developing acute and long-term toxicities in patients who received preoperative RT for AP-STS.

MATERIALS/METHODS: We performed a retrospective review of patients treated at a tertiary cancer center for non-metastatic AP-STS between 2005 and 2020. Dosimetric parameters for the "bowel bag" organ at risk structure were extracted for each patient. Chi-Square or Fisher's Exact Test, where appropriate, was utilized to compare the proportion of patients who exceeded constraints to the bowel bag contour as per the consensus RT retroperitoneal sarcoma guidelines, and the development of acute and long-term toxicities.

RESULTS: We identified 39 patients with available dosimetric data. The median follow-up was 34 months (IQR 20-47). Approximately half of the tumors were located in the pelvis (n = 20, 51%), and the majority were treated with IMRT/VMAT (n = 35, 90%). 31 patients (80%) presented with de novo disease, and 20% (n = 8) were recurrent presentations but had not received prior RT. The most common histology was leiomyosarcoma (n = 15, 38%), followed by de-differentiated liposarcoma (n = 8, 21%). The median bowel max dose (defined as D0.1cc) was 5309cGy [IQR 5262-5830]. Thirteen patients (33%) exceeded the volumetric V15 Gy <830cm3 bowel bag constraint, and 18 (46%) exceeded the V45 Gy ≤ 195cm3 bowel bag constraint. Overall, 17 patients (44%) had acute grade 1 diarrhea, and 11 (28%) had grade 1-2 nausea. Five patients (13%) had long-term radiation-related toxicities, including 1 patient who developed an enterocutaneous fistula. There was no association between exceeding V15 Gy>830 cm3 (p = 0.31) or V45 Gy≥195cm3 (p = 0.65) bowel bag constraints and developing a long-term RT toxicity. Similarly, exceeding V15 Gy>830 cm3 or V45 Gy≥195cm3 did not lead to increased risks of developing acute diarrhea, nausea, or any other acute RT toxicity (all p>0.05).

CONCLUSION: Traditional volumetric bowel bag dose constraints are frequently exceeded given the large size of AP-STS at presentation and thus the large RT target volumes. Despite a significant proportion of patients exceeding these constraints, these data suggest that RT is overall well-tolerated, and the risk of developing toxicities does not correlate with traditional bowel bag volumetric constraints. There are ongoing efforts to substantially expand this cohort for further investigation into the relationship between dosimetric data and bowel toxicities in order to identify more predictive bowel constraints that can be used during treatment planning of AP-STS.