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Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance.
INTRODUCTION: To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7.
METHODS: The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR.
RESULTS: The area of spleen fibrosis in the model group was significantly larger than that in the control group ( p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group ( p < 0.01).
CONCLUSIONS: CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.
METHODS: The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR.
RESULTS: The area of spleen fibrosis in the model group was significantly larger than that in the control group ( p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group ( p < 0.01).
CONCLUSIONS: CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.
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