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Archives of Medical Science: AMS

Agnieszka Kolasa-Wołosiuk, Kamila Misiakiewicz-Has, Irena Baranowska-Bosiacka, Izabela Gutowska, Maciej Tarnowski, Marta Tkacz, Barbara Wiszniewska
Introduction: Hormone-dependent events that occur throughout the first wave of spermatogenesis, such as cellular communication within seminiferous epithelium during early postnatal testis maturation, are important for adult male fertility. Any changes in the T/DHT ratio in male progeny born from females fertilized by finasteride-treated male rats can result in impairment of testicular physiology. The aim of the study was to verify whether finasteride has a transgenerational effect on the expression of connexin 43 (Cx43), a gap junction protein in testes of the F1 generation...
October 2018: Archives of Medical Science: AMS
Hayri Kertmen, Erhan Celikoglu, Ozden Caglar Ozturk, Bora Gürer, Huseyin Bozkurt, Mehmet Ali Kanat, Ata Turker Arikok, Berrin Imge Erguder, Mustafa Fevzi Sargon, Zeki Sekerci
Introduction: Tetracosactide is an engineered peptide that applies the same biological impacts as the endogenous adrenocorticotropic hormone. Previous studies indicated that tetracosactide has anti-inflammatory, antioxidant and neurotrophic activity. In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury. Material and methods: Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide)...
October 2018: Archives of Medical Science: AMS
Enas Ahmed Mohamed, Hussien H Kassem
Introduction: The cardiotoxicity of doxorubicin is incompletely understood. We investigated the prophylactic effect of nebivolol on doxorubicin-induced cardiac toxicity. Material and methods: Thirty rats were divided into a control group, doxorubicin-treated group and nebivolol + doxorubicin-treated group. The specimens were examined using H + E and Masson's trichrome, caspase 3, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and tumor necrosis factor factor-α (TNF-α)...
October 2018: Archives of Medical Science: AMS
Anna Augustynowicz, Aleksandra I Czerw, Andrzej Deptała
Introduction: In developed countries, malignant tumours are the second most common cause of death after cardiovascular diseases. The estimates made by epidemiologists indicate that the incidence and death rate for malignant tumours all over the world, Poland included, will probably grow in the decades to come, specifically among patients who are over 65. The aim of the study was to evaluate how local government units address the health needs of citizens on the basis of an analysis of health policy programmes concerning malignant tumours completed in Poland in 2009-2014...
October 2018: Archives of Medical Science: AMS
Jinlei Zhang, Aixing Pan, Li Zhou, Jingyi Yu, Xiao Zhang
Introduction: This study was conducted to compare the clinical effects of unilateral pedicle screw fixation and interbody fusion with PEEK cage (UPSFC) and standalone expandable fusion cage (SAEFC) on unilateral lumbar disc herniation. Material and methods: From September 2011 to July 2014, a respective investigation was performed on 130 lumbar disc herniation patients treated with SAEFC or UPSFC. The hospital stay, operating time, blood loss, Japanese orthopaedic association scores (JOA), and visual analogue score (VAS) in the two groups were compared using Student's t -test...
October 2018: Archives of Medical Science: AMS
Joerg Arnholdt, Yama Kamawal, Boris Michael Holzapfel, Axel Ripp, Maximilian Rudert, Andre Friedrich Steinert
Introduction: The goals of successful bi-compartmental knee arthroplasty are to achieve correct fit and positioning of the implant, while appropriately correcting the mechanical alignment of the leg after surgery. As these requirements are not always reliably fulfilled using off-the-shelf implant systems, newer approaches for bi-compartmental resurfacing have been explored. Material and methods: In this article we report the radiographic results of 30 patients with anteromedial osteoarthritis (OA) who were treated with a novel patient-specific fixed-bearing bi-compartmental knee resurfacing system using custom-made implants and instruments...
October 2018: Archives of Medical Science: AMS
Petra Belohlavkova, Filip Vrbacky, Jaroslava Voglova, Zdenek Racil, Daniela Zackova, Katerina Hrochova, Jana Malakova, Jiri Mayer, Pavel Zak
Introduction: Imatinib mesylate is the drug of choice for patients with chronic myeloid leukemia (CML). Imatinib pharmacokinetics is affected by a number of transport proteins and enzymes. Material and methods: In the present study we evaluated the association of eight polymorphisms in the seven genes CYP3A5*3 (rs776746), CYP3A4*1 (rs2740574), CYP2C9*3 (rs1057910), SLC22A1 (rs683369), ABCB1 (rs1045642, rs1128503), ABCG2 (rs2231142) and ABCC2 (rs717620) with imatinib plasma level and achieving an optimal clinical response in 112 CML patients (53 men and 59 women)...
October 2018: Archives of Medical Science: AMS
Ufuk Cobanoglu, Ozgur Kemik, Sebahattin Celik, Fuat Sayir
Introduction: The effective control of malignant pleural effusion (MPE) is of paramount importance in the treatment of patients with disseminated cancer. In this study, we compared two different approaches (early pleurodesis versus late pleurodesis) to MPE. Material and methods: Patients (188 cases) whose primary tumor type was known and who were confirmed to have MPE, were included in the study and were separated into two groups. One group consisted of patients who were asymptomatic and who underwent early phase pleurodesis (group I, n = 79)...
October 2018: Archives of Medical Science: AMS
Servet Altay, Altan Onat, Günay Can, Eyyup Tusun, Barış Şimşek, Adnan Kaya
Introduction: The aim of the study was to evaluate whether serum thyroid-stimulating hormone (TSH) within the normal range in euthyroid subjects (having normal free triiodothyronine (fT3) and thyroxine (fT4)) is related to the risk of overall mortality or a composite endpoint of death and nonfatal events. Material and methods: In 614 middle-aged adult hospital screenees, free of uncontrolled diabetes at baseline, the association of sex-specific TSH tertiles with death was prospectively assessed using Cox regression, with the composite endpoint assessed using logistic regression in adjusted analyses, stratified by gender...
October 2018: Archives of Medical Science: AMS
Mieszko Kozikowski, Jan Powroźnik, Wojciech Malewski, Szymon Kawecki, Sebastian Piotrowicz, Wojciech Michalak, Łukasz Nyk, Magdalena Gola, Jakub Dobruch
Introduction: We aimed to evaluate the diagnostic performance of 3.0-T multiparametric magnetic resonance imaging (mpMRI) in preoperative staging of prostate cancer (PCa) and its influence on the extent of resection during endoscopic radical prostatectomy (ERP) among cancer risk groups. Material and methods: The data of 154 patients with PCa in whom mpMRI was performed prior to ERP between 2011 and 2015 were included. The initial decision whether to perform neurovascular bundle (NVB) sparing surgery was based on EAU guidelines...
October 2018: Archives of Medical Science: AMS
Heng Fan, Yu Zhao, Min Sun, Jian-Hua Zhu
Introduction: The aim of the study was to confirm whether higher levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and N-acetyl-β-D-glucosaminidase (NAG) are associated with mortality risk scores in severe septic patients with acute kidney injury (AKI). Material and methods: A prospective observational study was performed in an adult critical care unit. A total of 135 patients were included. The levels of urinary NGAL, KIM-1 and NAG were compared between patients with acute physiology and chronic health evaluation (APACHE II) score > 25 (group A, n = 31) and APACHE II score ≤ 25 (group B, n = 104)...
October 2018: Archives of Medical Science: AMS
Shaoyun Wu, Dubo Chen, Xun Zeng, Junmin Wen, Chuzhi Zhou, Ke Xiao, Peng Hu, Weixin Chen
Introduction: Present study was to evaluate whether increased arterial stiffness was associated with target organ damage in pre-hypertensive subjects. Material and methods: Pre-hypertensive subjects enrolled and echocardiography was used to evaluate left ventricular hypertrophy (LVH) and the first morning urine was collected to evaluate albumin and creatinine ratio (ALB/Cr ratio). Carotid-femoral pulse wave velocity (cf-PWV) was measured. Results: A total of 420 subjects were recruited and mean age was 42...
October 2018: Archives of Medical Science: AMS
Armando Totomoch-Serra, Maria de Lourdes Muñoz, Juan Burgueño, Maria Cristina Revilla-Monsalve, Alvaro Diaz-Badillo
Introduction: Genetic variants have been replicated for association with type 2 diabetes mellitus (T2D) and many of them with diabetes-related traits. Because T2D is highly prevalent in Mexico, this study aimed to test the association of CDKN2A/B , PPARGC1A , VEGFA , SIRT1 and UCP2 gene polymorphisms (rs10811661, rs8192678, rs2010963, rs7896005 and rs659366 respectively) with metabolic traits in 415 unrelated Mexican mestizos with T2D under three models of inheritance. Material and methods: A total of 415 unrelated Mexican mestizos were genotyped by TaqMan assays...
October 2018: Archives of Medical Science: AMS
Hoda Atwa, Khaled Gad, Hala Hagrasy, Amany Elkelany, Mona Azzam, Nouran Bayoumi, Ayman Gobarah, Hassan Shora
Introduction: There is a 3-fold higher prevalence of cardiovascular complications in patients with type 1 diabetes. The aim was to assess the relationship between subclinical atherosclerosis and visceral fat and fatty liver in diabetic adolescents. Material and methods: The study was performed on 110 adolescents with type 1 diabetes (T1D) attending the Pediatric Diabetes Clinic of the University Hospital, Ismailia, Egypt. Their mean age was 14.2 ±0.7 years with a mean duration of diabetes 6 ±0...
October 2018: Archives of Medical Science: AMS
Yubao Cui, Lili Yu, Feixiang Teng, Nan Wang, Ying Zhou, Chengbo Zhang, Li Yang
Introduction: Specific immunotherapy is critical for alleviating symptoms associated with house dust mite allergy, such as asthma and rhinitis. However, this approach relies on crude extracts, which are often not of sufficient quality or purity and are not standardized. The use of recombinant allergens may enable safer, more effective treatment. Material and methods: Using our previously constructed plasmids pET28a(+)-Der f 1, pET28a(+)-Der f 2 and pET28b(+)-Der f 4 as templates, the gene fragments coding for the allergens Der f 1, Der f 2 and Der f 4, respectively, of the dust mite Dermatophagoides farinae were amplified by PCR...
October 2018: Archives of Medical Science: AMS
Duygu Yasar Sirin, Numan Karaarslan
Introduction: The aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II ( COL2A1 ), hypoxia-inducible factor 1-α ( HIF-1 α), and chondroadherin ( CHAD ) gene expression in osteoarthritic chondrocytes. Material and methods: Standard primary chondrocyte cultures were prepared using osteochondral tissues that were surgically obtained from 6 patients with gonarthrosis. Cell morphology was evaluated using an inverted microscope, and cell death and proliferation were determined through MTT analysis, which was confirmed by AO/PI staining and statistically evaluated...
October 2018: Archives of Medical Science: AMS
Man Yang, Lingxiu Zhang, Xiufeng Wang, Yanjun Zhou, Sun Wu
Introduction: Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play vital roles in multiple myeloma (MM) development and progression. However, the underlying mechanism of PVT1 in MM remains unclear. Material and methods: QRT-PCR was used to detect the expression of PVT1 and miR-203a in MM samples and cell lines. The effects of PVT1 on MM cell proliferation and apoptosis were determined by CCK8 assay and flow cytometer assay, respectively. Bioinformatics methods were used to identify the downstream target miRNAs of PVT1...
October 2018: Archives of Medical Science: AMS
Xinquan Wu, Weibo Chen, Huihua Cai, Jun Hu, Baoqiang Wu, Yong Jiang, Xuemin Chen, Donglin Sun, Yong An
Introduction: Pancreatic cancer is a highly lethal malignancy with high invasion metastasis, which is difficult to diagnose and treat. MicroRNA-216b (miR-216b) plays an important role in many types of tumors. In this study, we explore how miR-216b affected human pancreatic cancer cell development by targeting KRAS . Material and methods: Expression level of miR-216b and KRAS in tissue samples and cells were detected by RT-PCR and western blot. Immunohistochemical assay analysed the expressions of KRAS protein in tumor and adjacent tissues...
October 2018: Archives of Medical Science: AMS
Zhengxiang Luo, Junchen Pan, Yi Ding, Yan-Song Zhang, Yanjun Zeng
Introduction: Gliomas are the most frequent primary tumors in the human brain. Recent studies have identified a class of long noncoding RNAs, named lncRNAs, which were reported to participate in regulating the development of various diseases, including gliomas. In our previous studies, we found that lncRNA UBE2CP3-001 was overexpressed in gliomas but not in normal tissue. However, the molecular functions of UBE2CP3-001 in glioma are largely unknown. Material and methods: The presence of UBE2CP3-001 in U87 cells, glioma tissues and normal brain tissues was detected by real-time RT-PCR...
October 2018: Archives of Medical Science: AMS
Wenxian Wang, Zhengbo Song, Yiping Zhang
Introduction: To analyze the appropriate treatment methods or timing to use epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and brain radiation treatment (RT) for symptomatic and asymptomatic brain metastases (BM) in patients with EGFR mutation non-small cell lung cancer (NSCLC). Material and methods: We retrospectively studied patients diagnosed with EGFR gene mutated NSCLC who developed brain metastasis between June 2006 and December 2015 at Zhejiang Cancer Hospital...
October 2018: Archives of Medical Science: AMS
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