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Archives of Medical Science: AMS

Ebru Golcuk, Kivanc Yalin, Cansu Selcan Akdeniz, Erhan Teker, Başak Teker, Veysel Sabri Hancer, Ibrahim Altun, Murat Sezer, Reyhan Diz Kucukkaya, Aytac Oncul
Introduction: Glycoprotein Ibα (GPIbα) receptor is the chief molecule responsible for initial platelet adhesion to the subendothelium. A thymidine to cytosine single nucleotide substitution at position -5 from the ATG start codon characterizes the Kozak sequence polymorphism. The Kozak sequence polymorphism may increase the surface expression of GPIbα and contribute to thrombogenesis. We evaluated the allele frequencies of GPIbα Kozak sequence polymorphism in the Turkish population and examined the relationship between GPIbα Kozak sequence polymorphism and early-onset acute coronary syndrome (ACS)...
June 2018: Archives of Medical Science: AMS
Lei Yang, Wei Qin, Wenli Hu
No abstract text is available yet for this article.
June 2018: Archives of Medical Science: AMS
Jolanta Malyszko, Teresa Dryl-Rydzynska, Wojciech Marcinkowski, Tomasz Prystacki, Jacek S Malyszko
No abstract text is available yet for this article.
June 2018: Archives of Medical Science: AMS
Atsushi Tanaka, Patrick S C Leung, Howard A Young, M Eric Gershwin
No abstract text is available yet for this article.
June 2018: Archives of Medical Science: AMS
Aleksandra Matuszyk, Piotr Ceranowicz, Zygmunt Warzecha, Jakub Cieszkowski, Krystyna Gałązka, Joanna Bonior, Jolanta Jaworek, Peter Christopher Konturek, Krzysztof Gil, Artur Dembiński
Introduction: Obestatin is a 23-amino acid peptide derived from proghrelin, a common prohormone for ghrelin and obestatin. Previous studies have shown that obestatin exhibits some protective and therapeutic effects in the pancreas and stomach. The aim of this study was to examine the effect of pretreatment with obestatin on the development of acetic acid-induced colitis. Material and methods: Studies were performed on Wistar rats. Before induction of colitis, rats were treated intraperitoneally with saline or obestatin, administered twice at a dose of 4, 8 or 16 nmol/kg/dose...
June 2018: Archives of Medical Science: AMS
Marta Kapałczyńska, Tomasz Kolenda, Weronika Przybyła, Maria Zajączkowska, Anna Teresiak, Violetta Filas, Matthew Ibbs, Renata Bliźniak, Łukasz Łuczewski, Katarzyna Lamperska
Cell culture is a widely used in vitro tool for improving our understanding of cell biology, tissue morphology, and mechanisms of diseases, drug action, protein production and the development of tissue engineering. Most research regarding cancer biology is based on experiments using two-dimensional (2D) cell cultures in vitro . However, 2D cultures have many limitations, such as the disturbance of interactions between the cellular and extracellular environments, changes in cell morphology, polarity, and method of division...
June 2018: Archives of Medical Science: AMS
Marta Michalska-Kasiczak, Agata Bielecka-Dabrowa, Stephan von Haehling, Stefan D Anker, Jacek Rysz, Maciej Banach
The prevalence of heart failure with preserved ejection fraction (HFpEF) is steadily increasing. Its diagnosis remains difficult and controversial and relies mostly on non-invasive echocardiographic detection of left ventricular diastolic dysfunction and elevated filling pressures. The large phenotypic heterogeneity of HFpEF from pathophysiologic al underpinnings to clinical manifestations presents a major obstacle to the development of new therapies targeted towards specific HF phenotypes. Recent studies suggest that natriuretic peptides have the potential to improve the diagnosis of early HFpEF, but they still have significant limitations, and the cut-off points for diagnosis and prognosis in HFpEF remain open to debate...
June 2018: Archives of Medical Science: AMS
Katarzyna Kotfis, Małgorzata Zegan-Barańska, Marta Strzelbicka, Krzysztof Safranow, Maciej Żukowski, E Wesley Ely
Introduction: Pain in the critically ill affects nearly 50% of patients. In patients unable to self-report pain, behavioural scales are used. The aim of this study was to validate the Polish version of the Critical Care Pain Observation Tool (CPOT). Material and methods: The prospective observational cohort study included patients observed during non-nociceptive and nociceptive procedures, at rest, during the intervention, and 15 min after each intervention. Assessments included self-report by patients and CPOT assessment carried out by two blinded observers...
June 2018: Archives of Medical Science: AMS
David Rodriguez Sanz, Francisco Unda Solano, Daniel López López, Irene Sanz Corbalan, Carlos Romero Morales, Cesar Calvo Lobo
Introduction: Oral ibuprofen (OI) and median nerve neural mobilization (MNNM) are first line treatments for patients who suffer cervicobrachial pain (CP). OI may produce side effects which are not tolerated by all subjects who suffer CP, whereas MNNM has no known side effects. Therefore, the aim of this study was to assess the effectiveness of both treatments (OI vs. MNNM) in CP. Material and methods: This investigation was a blinded parallel randomized clinical trial (NCT02593721)...
June 2018: Archives of Medical Science: AMS
Robert Gałązkowski, Michał M Farkowski, Daniel Rabczenko, Marta Marciniak-Emmons, Tomasz Darocha, Dariusz Timler, Maciej Sterliński
Introduction: The Revised Trauma Score (RTS) accurately identifies trauma patients at high risk of adverse events or death. Less is known about its usefulness in the general population and non-trauma recipients of Helicopter Emergency Medical Service (HEMS). The RTS is a simple tool and omits a lot of other data obtained during clinical evaluation. The aim was to assess the role of the RTS to identify patients at risk of major complications (death, cardiopulmonary resuscitation, defibrillation, intubation) in the general population of HEMS patients...
June 2018: Archives of Medical Science: AMS
Elżbieta Jabłonowska, Piotr Pulik, Anna Kalinowska, Jacek Gąsiorowski, Miłosz Parczewski, Monika Bociąga-Jasik, Elżbieta Mularska, Łukasz Pulik, Ewa Siwak, Kamila Wójcik
Introduction: The aim of the study was to present the experience of Polish centers regarding dual therapy based on the integrase inhibitor raltegravir (RAL) and ritonavir-boosted protease inhibitors (PI/r) for treating treatment-naïve and -experienced HIV-infected patients. Material and methods: The paper concerns a retrospective multicenter study. The medical databases of six main Polish HIV centers from January 2009 to December 2014 were analyzed for the use of combined antiretroviral treatment consisting of RAL + PI/r...
June 2018: Archives of Medical Science: AMS
Selcuk Selcuk, Bulent Emre Bilgic, Cetin Kilicci, Mehmet Kucukbas, Cetin Cam, Huseyin Tayfun Kutlu, Ates Karateke
Introduction: This study aims to compare the association between the most commonly used ovarian responsiveness markers - age, anti-Müllerian hormone levels (AMH), antral follicle count (AFC), ovarian sensitivity index (OSI), and ovarian response prediction index (ORPI) - and ovarian responsiveness to gonadotropin stimulation in assisted reproductive technology (ART) cycles. Material and methods: Patients who underwent intracytoplasmic sperm injection treatment using either a gonadotropin releasing hormone (GnRH) antagonist or agonist protocol were enrolled in the study...
June 2018: Archives of Medical Science: AMS
Ahter Tanay Tayyar, Ahmet Tayyar, Tolga Atakul, Cigdem Abide Yayla, Cetin Kilicci, Ahmet Eser, Resul Karakus, Dilsat Herkiloglu, Cevat Rifat Cundubey, Mehmet Tayyar
Introduction: The aim of this study is to compare first- and second-trimester Down syndrome biochemical screening markers in intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies. Material and methods: This observational case-control study was conducted at Health Sciences University Zeynep Kamil Maternity and Children's Health Training and Research Hospital and the Department of Obstetrics and Gynecology at Erciyes University Medical Faculty during 2016-2017...
June 2018: Archives of Medical Science: AMS
Anna Fijałkowska, Ewa Szczerba, Grzegorz Szewczyk, Anna Budaj-Fidecka, Janusz Burakowski, Bożena Sobkowicz, Alicja Nowowiejska-Wiewióra, Grzegorz Opolski, Adam Torbicki, Marcin Kurzyna
Introduction: Pulmonary embolism (PE) is a leading cause of mortality in pregnancy and a great diagnostic challenge. Deviations from the recommended diagnostic pathway in suspected PE contribute to greater mortality in the general population. The deviations from the guidelines of the European Society of Cardiology (ESC) for diagnosis of PE were analyzed, with particular emphasis on pregnant women with suspected PE. Material and methods: ZATPOL is a prospective national registry including data of all patients with suspected PE admitted to 86 Polish cardiology departments between January 2007 and September 2008...
June 2018: Archives of Medical Science: AMS
Ahmet Omma, Duygu Tecer, Orhan Kucuksahin, Sevinc Can Sandikci, Fatih Yildiz, Sukran Erten
Introduction: The aim of the study was to investigate whether there is a relationship between the European League Against Rheumatism (EULAR) outcome measures and quality of life (QoL), fatigue, anxiety and depression in patients with pSS and to define determinants which could affect quality of life. Material and methods: The study included 105 pSS patients and 72 age/sex-matched healthy controls (HCs). Cross-sectional clinical data were collected, including the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Assessment of Fatigue (MAF) scale, the Short Form (SF-36), EULAR Sjögren's syndrome disease activity index (ESSDAI) and EULAR Sjögren's syndrome patient reported index (ESSPRI)...
June 2018: Archives of Medical Science: AMS
Mojtaba Ahmadinejad, Seyyed Mohsen Pouryaghobi, Fatemeh Bayat, Ehsan Bolvardi, Niaz Mohammad Jafari Chokan, Babak Masoumi, Koorosh Ahmadi
Introduction: The aim of this study was to evaluate the significance of clinicopathological characteristics of colorectal cancer patients undergoing emergency and elective surgery. Material and methods: In total, 116 tumors from patients treated surgically for colorectal cancer at four hospitals in Tehran between 2008 and 2013 were analyzed in the current study. Results: Our findings revealed that the emergency cases were significantly more likely to have an advanced TNM stage ( p = 0...
June 2018: Archives of Medical Science: AMS
Zhuo Chen, Fanqian Song, Liyao Sun, Chuchu Zhao, Ningning Gao, Ping Liu, Hongyan Ge
Introduction: Here we intended to investigate the changes in corneal endothelial cells and foveal thickness after phacoemulsification surgery on the eyes of diabetic and non-diabetic cataract patients. Material and methods: A total of 120 cataract patients who were scheduled for phacoemulsification surgery and intraocular lens implantation were recruited and divided into 2 categories according to the diagnosis of diabetes mellitus. Changes in integrity, endothelial cell density (ECD), coefficient of variation (CV), percentage of hexagonal cells (PHC), central corneal thickness (CCT), and central foveal thickness (CFT) were all recorded at preoperative day 1 and postoperative day 3, 1 week, 1 month, 3 months and 6 months...
June 2018: Archives of Medical Science: AMS
Krzysztof Hoppe, Krzysztof Schwermer, Anna Kawka, Patrycja Klysz, Ewa Baum, Malgorzata Kaluzna, Dorota Sikorska, Anna Scigacz, Bengt Lindholm, Krzysztof Pawlaczyk, Andrzej Oko
Introduction: Body mass decomposition and hydration state imbalances affect patients on maintenance dialysis. We compared body composition, hydration and nutritional state of patients on peritoneal dialysis (PD) and hemodialysis (HD) based on dialysis vintage (DV). Material and methods: Three hundred and fifty-nine prevalent patients on HD ( n = 301) and PD ( n = 58) were divided into 3 subgroups depending on DV: < 2 years HD ( n = 41) and PD ( n = 28), 2-4 years HD ( n = 111) and PD ( n = 17), > 4 years HD ( n = 149) and PD ( n = 13)...
June 2018: Archives of Medical Science: AMS
Lidia Jureczko, Karolina Dobronska, Marcin Kolacz, Piotr Radziszewski, Piotr Dobronski
Introduction: Percutaneous nephrolithotomy (PNL) is an endoscopic treatment of renal lithiasis. It is usually two-staged: it begins in the lithotomy position for ureteral catheter placement and retrograde pyelography, and subsequently an optimal renal access is obtained in the prone position. Some patients under epidural anesthesia do not tolerate the prone position and the PNL cannot be continued. This may be related to changes occurring within the circulatory system. The aim of this prospective randomized double-blind study was to evaluate the changes of the cardiac index (CI) during PNL...
June 2018: Archives of Medical Science: AMS
Christian Blockhaus, Jan Schmidt, Muhammed Kurt, Lukas Clasen, Patrick Müller, Christoph Brinkmeyer, Malte Kelm, Dong-In Shin, Hisaki Makimoto
Introduction: Ablation of the cavotricuspid isthmus (CTI) in patients with atrial flutter (AFL) and pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) are both common therapies. As the demand for ablative treatments rises, total radiation exposure times of staff increase concomitantly. Here, we report on our first experiences with a new fluoroscopy integrating system (FIS) integrated into a current 3D mapping system (3DMS). Material and methods: The study population consisted of 59 consecutive patients who underwent PVI or CTI ablation (26 and 33 patients with and without FIS respectively)...
June 2018: Archives of Medical Science: AMS
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