Instant Protection Spray for Anti-Infection And Accelerated Healing of Empyrosis.

Distinct from common injuries, deep burns often require a chronic recovery cycle for healing and long-term antibiotic treatment to prevent infection. The presence of drug-resistant bacteria has caused antibiotics to no longer be perfect, and continuous drug use can easily lead to repeated infection and even death. Inspired by how wild animals chew plants to prevent wound infection, probiotic extracts with a structure similar to the tailspike of phage were obtained from L. casei and combined with different flavones to design a series of nonantibiotic bactericides. These novel antibacterial agents were combined with a rapid gelation spray with a novel cross-angle layout to form an instant protection spray (IPS) and provide a physical and anti-infectious barrier for burns within 30 s. This IPS was able to sterilize 100.00% and 96.14% of multidrug-resistant Staphylococcus aureus (MRSA) in vitro and in vivo, respectively. In addition, it was found to effectively reduce inflammation in MRSA-infected burns in rats and promote tissue healing. This article is protected by copyright. All rights reserved.