journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Nephrology

journal
https://www.readbyqxmd.com/read/29602402/introduction-systems-biology-of-kidney-disease
#1
EDITORIAL
Kumar Sharma, Katalin Susztak, Subramaniam Pennathur
No abstract text is available yet for this article.
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602401/contributory-role-of-gut-microbiota-and-their-metabolites-toward-cardiovascular-complications-in-chronic-kidney-disease
#2
REVIEW
Daniel Y Li, W H Wilson Tang
The gut microbiome recently has emerged as a novel risk factor that impacts health and disease. Our gut microbiota can function as an endocrine organ through its unique ability to metabolize various dietary precursors, and can fuel the systemic inflammation observed in chronic disease. This is especially important in the setting of chronic kidney disease, in which microbial metabolism can contribute directly to accumulation of circulating toxins that then can alter and shift the balance of microbiota composition and downstream functions...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602400/targeting-glucosylceramide-synthesis-in-the-treatment-of-rare-and-common-renal-disease
#3
REVIEW
James A Shayman
Sphingolipids, including ceramides, glycosphingolipids, sphingomyelin, and sphingosine-1-phosphate, have been recognized as important molecules that regulate critical cellular functions. Although originally studied in the context of lysosomal storage diseases, the roles of these compounds in more common disorders involving metabolism, vascular disease, and aberrant growth has been the focus of recent studies, including in disorders that affect the kidneys. These efforts have led to new insights into Fabry disease, a classic disorder of lysosomal function that results in renal failure as well as in more common renal diseases including diabetic nephropathy and polycystic kidney disease...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602399/metabolomics-and-metabolic-reprogramming-in-kidney-cancer
#4
REVIEW
Robert H Weiss
Kidney cancer, or renal cell carcinoma (RCC), is a disease of increasing incidence that commonly is seen in the general practice of nephrology. Despite this state of affairs, this fascinating and highly morbid disease frequently is under-represented, or even absent, from the curriculum of nephrologists in training and generally is underemphasized in national nephrology meetings, both scientific as well as clinical. Although classic concepts in cancer research in general had led to the concept that cancer is a disease resulting from mutations in the control of growth-regulating pathways, reinforced by the discovery of oncogenes, more contemporary research, particularly in kidney cancer, has uncovered changes in metabolic pathways mediated by those same genes that control tumor energetics and biosynthesis...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602398/genome-wide-association-studies-of-metabolite-concentrations-mgwas-relevance-for-nephrology
#5
REVIEW
Anna Köttgen, Johannes Raffler, Peggy Sekula, Gabi Kastenmüller
Metabolites are small molecules that are intermediates or products of metabolism, many of which are freely filtered by the kidneys. In addition, the kidneys have a central role in metabolite anabolism and catabolism, as well as in active metabolite reabsorption and/or secretion during tubular passage. This review article illustrates how the coupling of genomics and metabolomics in genome-wide association analyses of metabolites can be used to illuminate mechanisms underlying human metabolism, with a special focus on insights relevant to nephrology...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602397/a-systems-level-view-of-renal-metabolomics
#6
REVIEW
Eugene P Rhee
The measurement of select circulating metabolites such as creatinine, glucose, and cholesterol are integral to clinical medicine, with implications for diagnosis, prognosis, and treatment. Metabolomics studies in nephrology research seek to build on this paradigm, with the goal to identify novel markers and causal participants in the pathogenesis of kidney disease and its complications. This article reviews three themes pertinent to this goal. Each is rooted in long-established principles of human physiology, with recent updates enabled by metabolomics and other tools...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602396/lipidomics-and-biomarker-discovery-in-kidney-disease
#7
REVIEW
Farsad Afshinnia, Thekkelnaycke M Rajendiran, Stefanie Wernisch, Tanu Soni, Adil Jadoon, Alla Karnovsky, George Michailidis, Subramaniam Pennathur
Technological advances in mass spectrometry-based lipidomic platforms have provided the opportunity for comprehensive profiling of lipids in biological samples and shown alterations in the lipidome that occur in metabolic disorders. A lipidomic approach serves as a powerful tool for biomarker discovery and gaining insight to molecular mechanisms of disease, especially when integrated with other -omics platforms (ie, transcriptomics, proteomics, and metabolomics) in the context of systems biology. In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, sample preparation, biomarker identification and quantification, and data processing and analysis, as well as crucial considerations in clinical applications...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602395/the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-coactivator-1%C3%AE-pgc-1%C3%AE-in-kidney-disease
#8
REVIEW
Szu-Yuan Li, Katalin Susztak
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key transcriptional regulator of mitochondrial biogenesis and function. Several recent studies have evaluated the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal tubule cells mostly depend on mitochondrial fatty acid oxidation for energy generation. A decrease in PGC-1α expression and fatty acid oxidation is commonly observed in patient samples and mouse models with acute and chronic kidney disease...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602394/the-warburg-effect-in-diabetic-kidney-disease
#9
REVIEW
Guanshi Zhang, Manjula Darshi, Kumar Sharma
Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in diabetic patients. Defining risk factors for DKD using a reductionist approach has proven challenging. Integrative omics-based systems biology tools have shed new insights in our understanding of DKD and have provided several key breakthroughs for identifying novel predictive and diagnostic biomarkers. In this review, we highlight the role of the Warburg effect in DKD and potential regulating factors such as sphingomyelin, fumarate, and pyruvate kinase muscle isozyme M2 in shifting glucose flux from complete oxidation in mitochondria to the glycolytic pathway and its principal branches...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29602393/mitochondrial-dysfunction-and-signaling-in-diabetic-kidney-disease-oxidative-stress-and-beyond
#10
REVIEW
Nicole Bernadette Flemming, Linda Alba Gallo, Josephine Maree Forbes
The kidneys are highly metabolic organs that produce vast quantities of adenosine triphosphate via oxidative phosphorylation and, as such, contain many mitochondria. Although mitochondrial reactive oxygen species are involved in many physiological processes in the kidneys, there is a plethora of evidence to suggest that excessive production may be a pathologic mediator of many chronic kidney diseases, including diabetic kidney disease. Despite this, results from clinical testing of antioxidant therapies have been generally underwhelming...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291764/translating-knowledge-into-therapy-for-acute-kidney-injury
#11
REVIEW
Mark de Caestecker, Raymond Harris
No therapies have been shown to improve outcomes in patients with acute kidney injury (AKI). Given the high morbidity and mortality associated with AKI this represents an important unmet medical need. A common feature of all of the therapeutic development efforts for AKI is that none were driven by target selection or preclinical modeling that was based primarily on human data. This is important when considering a heterogeneous and dynamic condition such as AKI, in which in the absence of more accurate molecular classifications, clinical cohorts are likely to include patients with different types of injury at different stages in the injury and repair continuum...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291763/proteomics-and-metabolomics-for-aki-diagnosis
#12
REVIEW
David Marx, Jochen Metzger, Martin Pejchinovski, Ryan Bruce Gil, Maria Frantzi, Agnieszka Latosinska, Iwona Belczacka, Silke Sophie Heinzmann, Holger Husi, Jerome Zoidakis, Matthias Klingele, Stefan Herget-Rosenthal
Acute kidney injury (AKI) is a severe and frequent condition in hospitalized patients. Currently, no efficient therapy of AKI is available. Therefore, efforts focus on early prevention and potentially early initiation of renal replacement therapy to improve the outcome in AKI. The detection of AKI in hospitalized patients implies the need for early, accurate, robust, and easily accessible biomarkers of AKI evolution and outcome prediction because only a narrow window exists to implement the earlier-described measures...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291762/advances-in-renal-cell-imaging
#13
REVIEW
Georgina Gyarmati, Hiroyuki Kadoya, Ju-Young Moon, James L Burford, Nariman Ahmadi, Inderbir S Gill, Young-Kwon Hong, Bálint Dér, János Peti-Peterdi
A great variety of cell imaging technologies are used routinely every day for the investigation of kidney cell types in applications ranging from basic science research to drug development and pharmacology, clinical nephrology, and pathology. Quantitative visualization of the identity, density, and fate of both resident and nonresident cells in the kidney, and imaging-based analysis of their altered function, (patho)biology, metabolism, and signaling in disease conditions, can help to better define pathomechanism-based disease subgroups, identify critical cells and structures that play a role in the pathogenesis, critically needed biomarkers of disease progression, and cell and molecular pathways as targets for novel therapies...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291761/precision-medicine-for-acute-kidney-injury-aki-redefining-aki-by-agnostic-kidney-tissue-interrogation-and-genetics
#14
REVIEW
Krzysztof Kiryluk, Andrew S Bomback, Yim-Ling Cheng, Katherine Xu, Pablo G Camara, Raul Rabadan, Peter A Sims, Jonathan Barasch
Acute kidney injury (AKI) currently is diagnosed by a temporal trend of a single blood analyte: serum creatinine. This measurement is neither sensitive nor specific to kidney injury or its protean forms. Newer biomarkers, neutrophil gelatinase-associated lipocalin (NGAL, Lipocalin 2, Siderocalin), or kidney injury molecule-1 (KIM-1, Hepatitis A Virus Cellular Receptor 1), accelerate the diagnosis of AKI as well as prospectively distinguish rapidly reversible from prolonged causes of serum creatinine increase...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291760/bringing-renal-biopsy-interpretation-into-the-molecular-age-with-single-cell-rna-sequencing
#15
REVIEW
Andrew F Malone, Haojia Wu, Benjamin D Humphreys
The renal biopsy provides critical diagnostic and prognostic information to clinicians including cases of acute kidney injury, chronic kidney disease, and allograft dysfunction. Today, biopsy specimens are read using a combination of light microscopy, electron microscopy, and indirect immunofluorescence, with a limited number of antibodies. These techniques all were perfected decades ago with only incremental changes since then. By contrast, recent advances in single-cell genomics are transforming scientists' ability to characterize cells...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291759/phenotyping-of-acute-kidney-injury-beyond-serum-creatinine
#16
REVIEW
Dennis G Moledina, Chirag R Parikh
Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291758/pathologic-perspectives-on-acute-tubular-injury-assessment-in-the-kidney-biopsy
#17
REVIEW
Gilbert W Moeckel
The molecular mechanisms in acute tubular injury (ATI) are complex and enigmatic. Moreover, we currently lack validated tissue injury markers that can be integrated into the kidney biopsy analysis to guide nephrologists in their patient's management of AKI. Although recognizing the ATI lesion by light microscopy is fairly straightforward, the staging of tubular lesions in the context of clinical time course and etiologic mechanism currently is not adapted to the renal pathology practice. To the clinician, the exact time point when an ischemic or toxic injury has occurred often is not known and cannot be discerned from the review of the biopsy sample...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291757/expanding-the-role-for-kidney-biopsies-in-acute-kidney-injury
#18
REVIEW
Sushrut S Waikar, Gearoid M McMahon
Acute kidney injury (AKI) is a highly heterogeneous, common, and potentially devastating condition associated with markedly increased hospital length of stay, cost, mortality, and morbidity. Expanding the role for kidney biopsies in AKI may offer fresh insights into disease heterogeneity, molecular mechanisms, and therapeutic targets. A number of challenges face investigators and clinicians considering research biopsies in AKI: ensuring patient safety, ensuring the ethical conduct of research studies, and maximizing the scientific yield of the kidney tissue obtained...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29291756/introduction-understanding-human-aki
#19
EDITORIAL
Lloyd G Cantley
No abstract text is available yet for this article.
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29110763/clinical-genetic-testing-for-apol1-are-we-there-yet
#20
REVIEW
Bessie A Young, Stephanie Malia Fullerton, James G Wilson, Kerri Cavanaugh, Erika Blacksher, Clarence Spigner, Jonathan Himmelfarb, Wylie Burke
End-stage renal disease (ESRD) disproportionately affects African Americans, who are two to four times more likely than European Americans to develop ESRD. Two independent variants of the apolipoprotein L1 (APOL1) gene, G1 and G2, have been associated with a 7- to 10-fold greater risk of developing nondiabetic ESRD in African Americans. Those who inherit two risk variants (G1/G1, G2/G2, or G1/G2) are also more likely to develop ESRD at a younger age and to have progression of chronic kidney disease. Currently, it is not known what proportion of persons with high-risk genotypes will develop ESRD in the general population, the exact mechanism of injury for APOL1-related risk, its relation to environmental exposures, or whether patients with comorbid conditions are more likely to develop ESRD...
November 2017: Seminars in Nephrology
journal
journal
28249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"