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Seminars in Nephrology

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https://www.readbyqxmd.com/read/27987550/back-to-the-future-paving-the-way-for-the-next-generation-of-renal-therapeutics
#1
REVIEW
Louis Brenner
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987549/genetics-of-diabetic-kidney-disease
#2
EDITORIAL
Jose C Florez
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987548/genetics-of-kidney-diseases
#3
EDITORIAL
Friedhelm Hildebrandt
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987547/genetics-of-familial-fsgs
#4
EDITORIAL
Martin Pollak
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987546/tales-of-personalized-cancer-treatment
#5
EDITORIAL
George Demetri
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987545/podocyte-targeted-treatment-for-proteinuric-kidney-disease
#6
EDITORIAL
Peter Mundel
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987544/clinical-trials-in-fsgs-past-challenges-and-new-trial-designs
#7
EDITORIAL
Deb Gipson
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987543/personalized-comments-on-challenges-and-opportunities-in-kidney-disease-therapeutics-the-glom-next-symposium
#8
EDITORIAL
Anna Greka, Deb Gibson, Peter Mundel, George Demetri, Friedhelm Hildebrandt, Martin Pollak, Jose Florez
In the face of ever-increasing incidence and prevalence of kidney disease worldwide, the unmet need for new treatments is unprecedented. Precision medicine is defined as the use of modern technologies to identify mechanisms of diseases in individual patients, and thus deploy treatment using tailored, targeted approaches, in the hopes of avoiding unnecessary toxicities and complications. Is there a place for kidney disease therapeutics in this space? If so, what is required to make significant progress toward precision nephrology? To answer these critical questions, we present a series of personalized comments corresponding to the responses offered to these very questions during the Inaugural Glom-NExT Symposium held at Harvard Medical School on October 23, 2014, a national meeting focused exclusively on kidney disease therapeutics...
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987542/an-introduction-to-the-glom-next-inaugural-symposium-toward-precision-medicine-in-nephrology
#9
EDITORIAL
Anna Greka
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987541/developing-treatments-for-chronic-kidney-disease-in-the-21st-century
#10
REVIEW
Matthew D Breyer, Katalin Susztak
Chronic kidney disease (CKD) is a lethal and rapidly increasing burden on society. Despite this, there are relatively few therapies in development for the treatment of CKD. Several recent costly phase 3 trials have failed to provide improved renal outcomes, diminishing interest in pharmaceutical investment. Furthermore, poor patient, physician, and payer awareness of CKD as a diagnosis has contributed to slow trial enrollment and successful implementation of these trials. Nevertheless, several therapeutics remain in development for the treatment of CKD, including mineralocorticoid-receptor antagonists, sodium/glucose cotransporter 2 inhibitors, anti-inflammatory drugs, and drugs that mitigate oxidative injury...
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27987540/introduction-toward-precision-medicines-for-kidney-disease
#11
EDITORIAL
Anna Greka
No abstract text is available yet for this article.
November 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772627/not-the-usual-viral-suspects-parvovirus-b19-west-nile-virus-and-human-t-cell-lymphotrophic-virus-infections-after-kidney-transplantation
#12
REVIEW
Raymund R Razonable
Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. In this review article, the epidemiology, clinical manifestations, diagnosis and treatment of less common viruses are discussed in the setting of kidney transplantation...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772626/respiratory-viruses-influenza-rsv-and-adenovirus-in-kidney-transplantation
#13
REVIEW
Dana J Hawkinson, Michael G Ison
Although advances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, respiratory viruses continue to be a common cause of morbidity and mortality in immunocompromised populations. We describe the clinical manifestations, diagnosis and treatment options for influenza, respiratory syncytial virus and adenovirus infection in the kidney transplant population.
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772625/human-immunodeficiency-virus-in-kidney-transplantation
#14
REVIEW
Kathleen O Degnan, Emily A Blumberg
Patients infected with human immunodeficiency virus (HIV) are living longer, healthier lives on highly active antiretroviral therapy and, as a result, interest in kidney transplantation for HIV-infected patients with end-stage renal disease has increased. HIV is no longer considered a contraindication to solid-organ transplantation and the number of kidney transplants performed in HIV-infected patients each year is increasing steadily. HIV-infected kidney transplant recipients have had excellent outcomes overall, but there are still significant challenges, including high rates of acute rejection, drug-drug interactions, and poor outcomes in patients co-infected with hepatitis C virus...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772624/human-papillomavirus-in-kidney-transplant-recipients
#15
REVIEW
Peter V Chin-Hong
Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772623/hepatitis-viruses-in-kidney-transplantation
#16
REVIEW
Kiran Gajurel, Jack T Stapleton
Hepatitis viruses are named for their primary clinical illness, inflammation of the liver. Currently, six types of viruses are designated hepatitis viruses (A, B, C, D, E, and G), although only five of these cause hepatitis. Hepatitis viruses are composed of RNA and DNA viruses from different families and with different virologic properties, some of which typically cause acute hepatitis while others cause acute and chronic hepatitis. In addition to their role in liver disease, members of this group of viruses may cause a variety of pathologic changes in the kidney and other organs, and chronic infection may lead to cirrhosis in addition to raising a variety of important issues in the management of kidney transplant recipients...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772622/bk-and-other-polyomaviruses-in-kidney-transplantation
#17
REVIEW
Jennifer Trofe-Clark, Deirdre Sawinski
For more than 40 years, polyomaviruses (BK virus and JC virus) have been known to cause disease in human beings. Recently, 11 new polyomaviruses were discovered. However, the majority of these viruses are rare in renal transplant recipients and BK and JC viruses remain the most important polyomaviruses to impact this population. BK virus presents as BK virus nephropathy and has, in rare instances, been associated with hemorrhagic cystitis or ureteral strictures. JC virus can cause progressive multifocal leukoencephalopathy or nephropathy in this population as well, but is uncommon...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772621/oncogenic-%C3%AE-herpesviruses-ebv-and-hhv8-in-kidney-transplantation
#18
REVIEW
Jade Le
Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. EBV is associated with post-transplantation lymphoproliferative disorder (PTLD), with increased risk in EBV-seronegative patients on intensified immunosuppression. Human herpesvirus-8 is associated with Kaposi's sarcoma (KS), with an increased risk in certain patient populations. Diagnosis of PTLD and KS relies on tissue biopsy. The mainstay of therapy for both PTLD and Kaposi's sarcoma is a reduction of immunosuppression, and in the case of PTLD, consideration of rituximab...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772620/cytomegalovirus-and-other-%C3%AE-herpesviruses
#19
REVIEW
Carlos A Q Santos
Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27772619/%C3%AE-herpes-virus-infections-among-renal-transplant-recipients
#20
REVIEW
Cybele Lara Abad, Raymund R Razonable
The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease...
September 2016: Seminars in Nephrology
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