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Anesthesiology

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https://www.readbyqxmd.com/read/28437360/dna-hydroxymethylation-by-ten-eleven-translocation-methylcytosine-dioxygenase-1-and-3-regulates-nociceptive-sensitization-in-a-chronic-inflammatory-pain-model
#1
Zhiqiang Pan, Zhou-Ya Xue, Guo-Fang Li, Meng-Lan Sun, Ming Zhang, Ling-Yun Hao, Qian-Qian Tang, Li-Jiao Zhu, Jun-Li Cao
BACKGROUND: Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. METHODS: The global levels of 5-hydroxymethylcytosine and ten-eleven translocation methylcytosine dioxygenase were measured in spinal cords in mice treated with complete Freund's adjuvant...
April 24, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28430694/iron-loading-exaggerates-the-inflammatory-response-to-the-toll-like-receptor-4-ligand-lipopolysaccharide-by-altering-mitochondrial-homeostasis
#2
Konrad Hoeft, Donald B Bloch, Jan A Graw, Rajeev Malhotra, Fumito Ichinose, Aranya Bagchi
BACKGROUND: Perioperative and critically ill patients are often exposed to iron (in the form of parenteral-iron administration or blood transfusion) and inflammatory stimuli, but the effects of iron loading on the inflammatory response are unclear. Recent data suggest that mitochondrial reactive oxygen species have an important role in the innate immune response and that increased mitochondrial reactive oxygen species production is a result of dysfunctional mitochondria. We tested the hypothesis that increased intracellular iron potentiates lipopolysaccharide-induced inflammation by increasing mitochondrial reactive oxygen species levels...
April 21, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28422819/gnaq-tt-695-694-gc-polymorphism-is-associated-with-increased-gq-expression-vascular-reactivity-and-myocardial-injury-after-coronary-artery-bypass-surgery
#3
Ulrich H Frey, Stefanie Klenke, Anna Mitchell, Tim Knüfermann, Heinz Jakob, Matthias Thielmann, Winfried Siffert, Jürgen Peters
BACKGROUND: Angiotensin II receptor type 1-mediated activation of the α-subunit of the heterotrimeric Gq protein evokes increased vasoconstriction and may promote hypertrophy-induced myocardial damage. The authors recently identified a TT(-695/-694)GC polymorphism in the human Gq promoter, the GC allele being associated with an increased prevalence of cardiac hypertrophy. In this article, the authors tested whether the TT(-695/-694)GC polymorphism is associated with differences in (1) myocardial Gq protein expression, (2) vascular reactivity, and (3) myocardial damage after coronary artery bypass grafting...
April 19, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28422818/inhibition-of-metabotropic-glutamate-receptor-subtype-1-alters-the-excitability-of-the-commissural-pyramidal-neuron-in-the-rat-anterior-cingulate-cortex-after-chronic-constriction-injury-to-the-sciatic-nerve
#4
Shi-Hao Gao, Lin-Lin Shen, Hui-Zhong Wen, Yan-Dong Zhao, Huai-Zhen Ruan
BACKGROUND: Inhibition of the metabotropic glutamate receptor subtype 1 in the anterior cingulate cortex has an analgesic effect during sustained nociceptive hypersensitivity. However, the specific changes in different subtypes of anterior cingulate cortex layer 5 pyramidal neurons, as well as the distinct effect of metabotropic glutamate receptor subtype 1 inhibition on different neuronal subtypes, have not been well studied. METHODS: Retrograde labeling combined with immunofluorescence, whole cell clamp recording, and behavioral tests combined with RNA interference were performed in a rat model of chronic constriction injury to the sciatic nerve...
April 19, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28410273/up-regulation-of-intracellular-calcium-handling-underlies-the-recovery-of-endotoxemic-cardiomyopathy-in-mice
#5
Justin C Morse, Joanne Huang, Natasha Khona, Edward J Miller, Deborah A Siwik, Wilson S Colucci, Ion A Hobai
BACKGROUND: In surviving patients, sepsis-induced cardiomyopathy is spontaneously reversible. In the absence of any experimental data, it is generally thought that cardiac recovery in sepsis simply follows the remission of systemic inflammation. Here the authors aimed to identify the myocardial mechanisms underlying cardiac recovery in endotoxemic mice. METHODS: Male C57BL/6 mice were challenged with lipopolysaccharide (7 μg/g, intraperitoneally) and followed for 12 days...
April 14, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28410272/management-of-severe-bleeding-in-patients-treated-with-direct-oral-anticoagulants-an-observational-registry-analysis
#6
Pierre Albaladejo, Charles-Marc Samama, Pierre Sié, Sophie Kauffmann, Vincent Mémier, Pierre Suchon, Alain Viallon, Jean Stéphane David, Yves Gruel, Lorenn Bellamy, Emmanuel de Maistre, Pauline Romegoux, Sophie Thoret, Gilles Pernod, Jean-Luc Bosson
BACKGROUND: The use of prothrombin complex concentrates and the role of plasma concentration of anticoagulants in the management of bleeding in patients treated with direct oral anticoagulants are still debated. Our aim was to describe management strategies and outcomes of severe bleeding events in patients treated with direct oral anticoagulants. METHODS: We performed a prospective cohort study of 732 patients treated with dabigatran, rivaroxaban, or apixaban hospitalized for severe bleeding, included prospectively in the registry from June 2013 to November 2015...
April 14, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28398933/video-laryngoscopy-for-intubation-after-smoke-inhalation
#7
Bianca M Conti, L Yvette Fouché-Weber, Justin E Richards, Thomas Grissom
No abstract text is available yet for this article.
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28398932/brachial-arterial-pressure-monitoring-during-cardiac-surgery-rarely-causes-complications
#8
Asha Singh, Bobby Bahadorani, Brett J Wakefield, Natalya Makarova, Priya A Kumar, Michael Zhen-Yu Tong, Daniel I Sessler, Andra E Duncan
BACKGROUND: Brachial arterial catheters better estimate aortic pressure than radial arterial catheters but are used infrequently because complications in a major artery without collateral flow are potentially serious. However, the extent to which brachial artery cannulation promotes complications remains unknown. The authors thus evaluated a large cohort of cardiac surgical patients to estimate the incidence of related serious complications. METHODS: The institutional Society of Thoracic Surgeons Adult Cardiac Surgery Database and Perioperative Health Documentation System Registry of the Cleveland Clinic were used to identify patients who had brachial artery cannulation between 2007 and 2015...
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28398927/triggering-receptor-expressed-on-myeloid-cells-2-a-novel-regulator-of-immunocyte-phenotypes-confers-neuroprotection-by-relieving-neuroinflammation
#9
Qian Zhai, Feng Li, Xiyao Chen, Ji Jia, Sisi Sun, Dandan Zhou, Lei Ma, Tao Jiang, Fuhai Bai, Lize Xiong, Qiang Wang
BACKGROUND: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. METHODS: Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days after reperfusion, the effects of activation and suppression of triggering receptor expressed on myeloid cells 2 on immunocyte phenotypes (n = 5), neurobehavioral scores (n = 7), infarct volumes (n = 8), and neuronal apoptosis (n = 7) were analyzed...
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28394769/in-memoriam-jean-mantz-1960-to-2017
#10
Bruno Riou
No abstract text is available yet for this article.
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28383325/effectiveness-of-written-and-oral-specialty-certification-examinations-to-predict-actions-against-the-medical-licenses-of-anesthesiologists
#11
Yan Zhou, Huaping Sun, Deborah J Culley, Aaron Young, Ann E Harman, David O Warner
BACKGROUND: The American Board of Anesthesiology administers written and oral examinations for its primary certification. This retrospective cohort study tested the hypothesis that the risk of a disciplinary action against a physician's medical license is lower in those who pass both examinations than those who pass only the written examination. METHODS: Physicians who entered anesthesiology training from 1971 to 2011 were followed up to 2014. License actions were ascertained via the Disciplinary Action Notification Service of the Federation of State Medical Boards...
April 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28383324/cerebral-autoregulation-oriented-therapy-at-the-bedside-a-comprehensive-review
#12
Lucia Rivera-Lara, Andres Zorrilla-Vaca, Romergryko G Geocadin, Ryan J Healy, Wendy Ziai, Marek A Mirski
This comprehensive review summarizes the evidence regarding use of cerebral autoregulation-directed therapy at the bedside and provides an evaluation of its impact on optimizing cerebral perfusion and associated functional outcomes. Multiple studies in adults and several in children have shown the feasibility of individualizing mean arterial blood pressure and cerebral perfusion pressure goals by using cerebral autoregulation monitoring to calculate optimal levels. Nine of these studies examined the association between cerebral perfusion pressure or mean arterial blood pressure being above or below their optimal levels and functional outcomes...
April 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28383323/risk-of-epidural-hematoma-after-neuraxial-techniques-in-thrombocytopenic-parturients-a-report-from-the-multicenter-perioperative-outcomes-group
#13
Linden O Lee, Brian T Bateman, Sachin Kheterpal, Thomas T Klumpner, Michelle Housey, Michael F Aziz, Karen W Hand, Mark MacEachern, Christopher G Goodier, Jeffrey Bernstein, Melissa E Bauer, Philip Lirk, Janet Wilczak, Roy Soto, Simon Tom, Germaine Cuff, Daniel A Biggs, Traci Coffman, Leif Saager, Warren J Levy, Michael Godbold, Nathan L Pace, Kevin L Wethington, William C Paganelli, Marcel E Durieux, Karen B Domino, Bala Nair, Jesse M Ehrenfeld, Jonathan P Wanderer, Robert B Schonberger, Joshua Berris, Steven Lins, Peter Coles, Kenneth C Cummings, Kamal Maheshwari, Mitchell F Berman, Christopher Wedeven, John LaGorio, Peter M Fleishut, Terri A Ellis, Susan Molina, Curtis Carl, Bassam Kadry, Wilton A van Klei, Wietze Pasma, Leslie C Jameson, Daniel L Helsten, Michael S Avidan
BACKGROUND: Thrombocytopenia has been considered a relative or even absolute contraindication to neuraxial techniques due to the risk of epidural hematoma. There is limited literature to estimate the risk of epidural hematoma in thrombocytopenic parturients. The authors reviewed a large perioperative database and performed a systematic review to further define the risk of epidural hematoma requiring surgical decompression in this population. METHODS: The authors performed a retrospective cohort study using the Multicenter Perioperative Outcomes Group database to identify thrombocytopenic parturients who received a neuraxial technique and to estimate the risk of epidural hematoma...
April 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28358749/lost-in-translation-the-2016-john-w-severinghaus-lecture-on-translational-research
#14
Daniel I Sessler
No abstract text is available yet for this article.
March 30, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28358748/effect-of-thoracic-epidural-anesthesia-on-ventricular-excitability-in-a-porcine-model
#15
Kimberly Howard-Quijano, Tatsuo Takamiya, Erica A Dale, Kentaro Yamakawa, Wei Zhou, Una Buckley, Aman Mahajan
BACKGROUND: Imbalances in the autonomic nervous system, namely, excessive sympathoexcitation, contribute to ventricular tachyarrhythmias. While thoracic epidural anesthesia clinically suppresses ventricular tachyarrhythmias, its effects on global and regional ventricular electrophysiology and electrical wave stability have not been fully characterized. The authors hypothesized that thoracic epidural anesthesia attenuates myocardial excitability and the proarrhythmic effects of sympathetic hyperactivity...
March 30, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346325/clinical-judgment-is-not-reliable-for-reducing-whole-body-computed-tomography-scanning-after-isolated-high-energy-blunt-trauma
#16
Thomas Mistral, Vivien Brenckmann, Laurence Sanders, Jean-Luc Bosson, Gilbert Ferretti, Frederic Thony, Samuel M Galvagno, Jean-François Payen, Pierre Bouzat
BACKGROUND: The purpose of this study was to test the diagnostic performance of clinical judgment for the prediction of a significant injury with whole-body computed tomography scanning after high-energy trauma. METHODS: The authors conducted an observational prospective study in a single level-I trauma center. Adult patients were included if they had an isolated high-energy injury. Senior trauma leaders were asked to make a clinical judgment regarding the likelihood of a significant injury before performance of a whole-body computed tomography scan...
March 27, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346324/t-wave-alternans-and-long-qt-syndrome
#17
Rebecca S Isserman, Allan F Simpao, Alan Jay Schwartz, Matthew F Pearsall
No abstract text is available yet for this article.
March 27, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346323/isolated-persistent-left-sided-superior-vena-cava
#18
Danielle S Shafiepour, Karim S Ladha, Matteo Parotto, Narinder S Paul, Karen M McRae
No abstract text is available yet for this article.
March 27, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346322/ultrasound-guided-intraarticular-knee-injection
#19
Neda Sadeghi, Amanda Kumar, James Kim, Joshua Dooley
No abstract text is available yet for this article.
March 27, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346321/growth-arrest-and-dna-damage-inducible-protein-45%C3%AE-mediated-dna-demethylation-of-voltage-dependent-t-type-calcium-channel-3-2-subunit-enhances-neuropathic-allodynia-after-nerve-injury-in-rats
#20
Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, An-Sheng Lee, Hsueh-Hsiao Wang, Jen-Kun Cheng, Yat-Pang Chau, Hsien-Yu Peng
BACKGROUND: Growth arrest and DNA-damage-inducible protein 45β reactivates methylation-silenced neural plasticity-associated genes through DNA demethylation. However, growth arrest and DNA-damage-inducible protein 45β-dependent demethylation contributes to neuropathic allodynia-associated spinal plasticity remains unclear. METHODS: Adult male Sprague-Dawley rats (654 out of 659) received a spinal nerve ligation or a sham operation with or without intrathecal application of one of the following: growth arrest and DNA-damage-inducible protein 45β messenger RNA-targeted small interfering RNA, lentiviral vector expressing growth arrest and DNA-damage-inducible protein 45β, Ro 25-6981 (an NR2B-bearing N-methyl-D-aspartate receptor antagonist), or KN-93 (a calmodulin-dependent protein kinase II antagonist) were used for behavioral measurements, Western blotting, immunofluorescence, dot blots, detection of unmodified cytosine enrichment at cytosine-phosphate-guanine site, chromatin immunoprecipitation quantitative polymerase chain reaction analysis, and slice recordings...
March 27, 2017: Anesthesiology
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