Read by QxMD icon Read

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Hanadi Alnageeb, Elamin Abdelgadir, Azza Khalifa, Mohamed Suliman, Subash Chander Gautam, Laurent Layani, Sriganesh Subramaniam, Alaaeldin Bashier
Background: Owing to its impact on weight loss, remission of diabetes mellitus and metabolic syndrome, bariatric surgery has offered hope for grossly obese individuals. In recent years, obesity has increased in the UAE and the use of bariatric surgery has increased in-line with this trend. However, data regarding bariatric surgery outcomes in diabetic Emirati people is scarce. Objective: To evaluate the effect of bariatric surgery in patients with diabetes mellitus...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Susumu Yoshino, Riyo Awa, Yasuo Miyake, Ikuo Fukuhara, Hisao Sato, Toyotada Ashino, Shinpei Tomita, Hiroshige Kuwahara
Purpose: Obesity is a serious problem, which is now a worldwide health problem. Kaempferia parviflora extract (KPE) exhibits anti-obesity effects in animals. However, as no clinical trials have evaluated the anti-obesity effects of KPE in humans, we examined the effects of KPE in reducing abdominal fat in overweight and preobese Japanese subjects. Materials and methods: A 12-week, single-center, randomized, double-blind, placebo-controlled clinical trial was conducted...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Hamza Mohammad Abdulghani, Areej Salman AlRajeh, Budoor Hussain AlSalman, Lulwah Sami AlTurki, Norah Sulaiman AlNajashi, Mohammad Irshad, Khalid Hamad Alharbi, Yazeed Eid AlBalawi, Yazeed A AlSuliman, Tauseef Ahmad
Background: Diabetes mellitus with comorbid complications constitute a major public health problem worldwide. The aim of this study was to evaluate the risk of comorbid complications with glycosylated hemoglobin levels and diabetes duration. Also assessed were patients' diabetic foot-care knowledge and practices. Patients and methods: This was a quasiexperimental study. A total of 360 type 2 diabetes mellitus patients were interviewed at a government health care center in Riyadh, Saudi Arabia...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Chun-Yang Wang, Shu Liu, Xiao-Nv Xie, Zhi-Ying Luo, Li Yang, Zhi-Rong Tan
Introduction: The small peptide transporter 1 (PepT-1) and adipose phospholipase A2 (AdPLA) play a key role in the development of obesity. However, there are no data assessing the impact of PepT-1 ( SLC15A1 ) and AdPLA ( PLA2G16 ) variants on obesity susceptibility. Therefore, we assessed the contribution of 9 single-nucleotide polymorphisms (SNPs) between these two genes on obesity susceptibility in Chinese subjects. Materials and methods: A total of 611 participants were enrolled in the study, and 9 SNPs in the SLC15A1 and PLA2G16 genes were selected...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Sean Wharton, Lilian Raiber, Kristin J Serodio, Jasmine Lee, Rebecca Ag Christensen
Background: The cause of the obesity epidemic is multifactorial, but may, in part, be related to medication-induced weight gain. While clinicians may strive to do their best to select pharmacotherapy(ies) that has the least negative impact on weight, the literature regarding the weight effects of medication is often limited and devoid of alternative therapies. Results: Antipsychotics, antidepressants, antihyperglycemics, antihypertensives and corticosteroids all contain medications that were associated with significant weight gain...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Thilak Priyantha Weerarathna, Herath Mudiyanselage Meththananda Herath, Gayani Liyanage, Miyuru Kavinda Weerarathna, Vidarsha Senadheera
Introduction: Implementation of effective measures to control rising burden of cardiovascular diseases among patients with type 2 diabetes mellitus (T2DM) requires information on the adequacy of control and identification of specific groups with suboptimal control of blood glucose, lipids and blood pressure. Methods: A cross-sectional study of patients with T2DM referred from primary care to a diabetes center was carried out to estimate the proportion of patients achieving the recommended therapeutic targets of four major modifiable cardiovascular risk factors: glycosylated hemoglobin (HbA1c <7%), low-density lipoprotein cholesterol <100 mg/dL, systolic blood pressure (SBP) <130 mmHg and diastolic blood pressure (DBP) <80 mmHg and their associations with age, gender, duration of diabetes and body mass index were studied...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Regina Carmen Espósito, Paulo Jose de Medeiros, Fernando de Souza Silva, Antonio Gouveia Oliveira, Cícero Flávio Soares Aragão, Hugo Alexandre Oliveira Rocha, Sueli Aparecida Moreira, Valéria Soraya de Farias Sales
Background: Metabolic syndrome (MetS) is an aggregation of risk factors associated with increased incidence of cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality. Information on MetS prevalence is scarce in the northeast region, Brazil. This study aims to estimate the prevalence of MetS according to different diagnostic criteria in a community sample of men during the November Blue Campaign living in the metropolitan area of Natal, Rio Grande do Norte, Brazil. Methods: This is a cross-sectional study on 500 men aged 40 years or older invited by the Blue November Campaign of 2015, an awareness program aimed at the prevention of male diseases...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Nadia Zghoul, Nada Alam-Eldin, Ivan Tong Mak, Burton Silver, William B Weglicki
Purpose: In this clinical trial, we assessed the efficacy of magnesium (Mg) supplementation in hypomagnesemic type 2 diabetes patients in restoring serum and intracellular Mg levels. The study had two coprimary end points: the change in serum and intracellular Mg level between baseline and after 3 months of supplementation. We compared the efficacy with regard to lowering hemoglobin A1c (HbA1c), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and 8-isoprostane as secondary end points...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Jaya Prasad Tripathy
Background: Diabetes, hyperglycemia, and their complications are a growing problem in India. However, no comprehensive picture of this disease burden has yet been presented to date. Methods: I used aggregate data from the Global Burden of Disease 2016 to describe the burden of diabetes and its risk factors, chronic kidney disease (CKD) due to diabetes, and diseases caused by high fasting plasma glucose from 1990 to 2016 in India. Results: Deaths due to diabetes accounted for 3...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Fariba Nasirian, Masoumeh Dadkhah, Nasrollah Moradi-Kor, Zia Obeidavi
Objectives: Lipid peroxidation and hyperglycemia are common signs for diabetes. Natural antioxidants such as Spirulina platensis microalgae (SPM) may prevent lipid peroxidation and hyperglycemia. This study aimed to evaluate the effects of SPM on antioxidant and anti-inflammatory in diabetic rats. Materials and methods: Sixty-four rats were divided into eight groups (n=8) and orally treated with 0, 10, 20 and 30 mg/kg body weight of SPM extract. Experimental groups included diabetic rats fed with 0 (DC), 10, 20 and 30 mg/kg SPM...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Ana López-de-Andrés, José Luis Del Barrio, Valentín Hernández-Barrera, Javier de Miguel-Díez, Isabel Jimenez-Trujillo, María Angeles Martinez-Huedo, Rodrigo Jimenez-García
Aims: To investigate the association between migraine and diabetes mellitus while controlling for several socio-demographic characteristics, comorbidities, and lifestyle variables. We also aimed to identify which of these variables are associated with migraine among diabetics. Patients and methods: We conducted a cross-sectional study using data taken from the European Health Interview Surveys for Spain conducted in 2009/10 (n=22,188) and 2014 (n=22,842). We selected those subjects ≥40 years of age...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Weifeng Huang, Liangliang Yao, Xiao He, Lei Wang, Mingxi Li, Youxin Yang, Chunpeng Wan
Background: To investigate hypoglycemic activity and elucidate the active composition of the fruit blueberry ( Vaccinium corymbosum ). Methods: Methanol extracts of blueberry (MEB) were separated using a D101 macroporous resin column to yield quinic acid derivative (Fr.1)- and flavonoid (Fr.2)-rich fractions. The effects of the blueberry extracts on mRNA expression of GLUT-2 (glucose transporter type 2) and PPARγ (peroxisome proliferator-activated receptor-γ), as well as on the activities of PPRE (peroxisome proliferator response element) and NF-κB were analyzed in LO2 normal liver cells...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Rodi Courie, Martin Gaillard, Panagiotis Lainas, Boris Hansel, Sylvie Naveau, Ibrahim Dagher, Hadrien Tranchart
Background: The Paleolithic diet, a diet devoid of food-processing procedure, seems to produce a greater decrease in weight compared to healthy reference diets but its limited food choices make it difficult to implement in our modern times where refined food is dominant. Objective: To evaluate the effects of a 2-year diet that excludes only six refined foodstuffs implicated in obesity. Professional contact was kept minimal to approximate the approach used by most dieters...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Lina Darwish, Erika Beroncal, Ma Veronica Sison, Walter Swardfager
Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Tiago Tomazini Gonçalves, Carolina M Lazaro, Fernanda G De Mateo, Marcela Cb Campos, Jackeline Gb Mezencio, Mario A Claudino, Patrícia de O Carvalho, R Clinton Webb, Fernanda Bm Priviero
Objective: The aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD). Methods: After weaning, male Wistar rats were fed with an HFD plus fructose for 12 weeks and started receiving oral antioxidant supplementation and/or physical training after the fourth week of diet for eight further weeks...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Nawaf J Shatnawi, Nabil A Al-Zoubi, Hassan M Hawamdeh, Yousef S Khader, Khaled Garaibeh, Hussein A Heis
Purpose: This study was conducted to determine the risk factors of major lower extremity amputations in type 2 diabetic patients referred for hospital care with diabetic foot syndrome. Patients and methods: This retrospective study involved 225 type 2 diabetic patients referred for management of diabetic foot syndrome at King Abdullah University Hospital in the period between January 2014 and December 2015. A structured customized diabetic foot data collection form with diabetic foot characteristics chart was used for documentation of relevant information, which checks for age, sex, body mass index, smoking, duration of diabetes, diabetic control therapy, associated hypertension, cardiac diseases, stroke, chronic renal impairment, renal replacement therapy (hem-dialysis), and history of diabetes-related complication in both feet prior to the study period...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Kalyana Chakravarthy Bairapareddy, Arun G Maiya, Padma Kumar, Krishnananda Nayak, Vasudeva Guddattu, Vidya Nayak
Background: Epicardial adipose tissue thickness (EATT) measured by echocardiography is a reliable indicator of visceral adipose tissue in the body and metabolic syndrome. The objective of this work was to study the effect of 12-week aerobic exercise training on echocardiographic epicardial adipose tissue thickness (EEATT), body composition and other metabolic parameters in asymptomatic overweight adults. Methods: A total of 170 overweight and mild obese individuals were randomly allocated to 12-week aerobic exercise program (intervention group) or no supervised exercise (control group)...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Valzimeire do Nascimento de Oliveira, Abelardo Barbosa Moreira Lima-Neto, Maurício Fraga van Tilburg, Ana Cristina de Oliveira Monteiro-Moreira, Marina Duarte Pinto Lobo, Davide Rondina, Virgínia Oliveira Fernandes, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro, Maria Izabel Florindo Guedes
Purpose: Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved in the development of DM1. Thus, the aim of this study was to investigate the differential expression of serum proteins in patients with DM1...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Gaoxiong Yang, Rui Yan, Huanjun Tong, Jitai Zhang, Bin Chen, Xiangyang Xue, Jue Wang, Maoping Chu, Shengwei Jin, Ming Li
Background: The neutrophil-lymphocyte ratio (NLR) has been considered as an inflammatory marker in various disorders, but it is not clear whether the NLR is also elevated with hidden diabetes (HD), which is normal in fasting blood glucose (FBG) but abnormal in the oral glucose tolerance test (OGTT). Materials and methods: An HD animal model for 27 days and an animal model with oscillating glucose (OG) for 7 days were applied on adult female Sprague-Dawley rats. OGTT, leukogram analysis, histology, and immunohistochemistry were carried out...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Anwar E Ahmed, Wala R Alanazi, Rayan A Ahmed, Wijdan AlJohi, Doaa A AlBuraikan, Budor A AlRasheed, Bashayr I ALMuqbil, Ali A Al-Zahrani, Zeyad M Yousef, Hamdan Al-Jahdali
Background: Although the frequency of surgical weight loss interventions has increased in Saudi Arabia, literature describing the clinical outcomes of bariatric surgery in Saudi Arabia is limited. This study aimed to assess whether weight loss intervention improves hemoglobin A1c (HbA1c) in obese patients and to identify its associated factors. Patients and methods: A retrospective study was carried out on 318 patients with obesity class 1 or higher (body mass index [BMI] ≥ 30 kg/m2 ) who underwent laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass at King Abdulaziz Medical City in Riyadh, Saudi Arabia, between January 1, 2001 and March 31, 2017...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"