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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

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https://www.readbyqxmd.com/read/30410377/associations-between-eating-habits-and-glycemic-control-and-obesity-in-japanese-workers-with-type-2-diabetes-mellitus
#1
Maki Gouda, Miyuki Matsukawa, Hiroaki Iijima
Purpose: To investigate the impact of poor eating habits on glycemic and metabolic control, we analyzed the associations between eating behaviors and HbA1c and body mass index (BMI) in Japanese workers with type 2 diabetes mellitus (T2DM). Subjects and methods: The Japan Medical Data Center database of workers' medical health insurance claims was used to identify individuals with T2DM who were receiving antidiabetic medication between April 2012 and March 2015 (the primary analysis population)...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30410376/quick-guide-to-type-2-diabetes-self-management-education-creating-an-interdisciplinary-diabetes-management-team
#2
Brittannie Chester, Wayne G Stanely, Thangiah Geetha
Type 2 diabetes is a chronic disease that requires several daily self-management decisions and complex care activities. Clinical management of diabetes and teaching patients diabetes self-management skills are necessary for optimal type 2 diabetes control. Diabetes self-management education (DSME) and support require time and resources. While there is a plethora of education material for health care professionals to use, very few guides compile the information in a practical way to relay the information to the patient...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30410375/to-fast-or-not-to-fast-during-the-month-of-ramadan-a-comprehensive-survey-on-religious-beliefs-and-practices-among-moroccan-diabetic-patients
#3
Eisa Al-Balhan, Hicham Khabbache, Abdelhadi Laaziz, Ali Watfa, Abdelkader Mhamdi, Giovanni Del Puente, Nicola Luigi Bragazzi
Background: Diabetes represents a major public health concern. According to the International Diabetes Federation, about 8%-9% of the population have diabetes, and rates are even higher among Muslim communities. Despite the risks, about half (43%) with type 1 diabetes and most (86%) of those with type 2 diabetes fast during Ramadan. However, there is a dearth of information concerning the determinants that drive diabetic people to fast. Therefore, the present study was designed to fill this gap in knowledge...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30349340/effects-of-caralluma-russeliana-stem-extract-on-some-physiological-parameters-in-streptozotocin-induced-diabetic-male-rats
#4
Talal A Zari, Mesfer A Al-Thebaiti
Purpose: The aim of this study was to investigate the effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin induced diabetes in male Wistar rats after 8 weeks. Materials and methods: The experimental rats were randomly assigned into four groups. Rats of group 1 were normal controls. Rats of group 2 were diabetic controls. Rats of group 3 were diabetic rats treated with C. russeliana stem extract. Rats of group 4 were non-diabetic rats, subjected to C...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30349339/plasma-stearoyl-coa-desaturase-activity-indices-and-bile-acid-concentrations-after-a-low-fat-meal-association-with-a-genetic-variant-in-the-fto-gene
#5
Gudrun Valgerdur Skuladottir, Harpa Oskarsdottir, Claudia Pisanu, Marcus Sjödin, Johan Lindberg, Jessica Mwinyi, Helgi Birgir Schiöth
Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. We investigated the association between the polymorphic expression of the fat mass and obesity-associated ( FTO ) gene and its relationship with SCD activity indices and primary BA concentrations after a low-fat meal. Subjects and methods: Blood plasma samples were collected from 56 young (20-36 years) healthy subjects with different rs9939609 FTO genotypes...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30323641/can-reducing-sitting-time-in-the-university-setting-improve-the-cardiometabolic-health-of-college-students
#6
Karrie M Butler, Joyce S Ramos, Christina A Buchanan, Lance C Dalleck
Purpose: The high prevalence of metabolic syndrome (MetS), prediabetes, and increased risk of cardiovascular diseases linked with prolonged sitting has created a need to identify options to limit sedentary behaviors. A potentially simple approach to achieve this goal in the university setting is to provide students the option to stand during courses rather than sit. The purpose of the present study was to examine the effects of standing in the college classroom setting on cardiometabolic risk factors in a cohort of college students...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30323640/urinary-tgf-%C3%AE-1-was-not-independently-associated-with-renal-function-in-diabetes-mellitus
#7
Rani Sauriasari, Mia Yuliana Pratiwi
Background: Several clinical studies have shown increased level of urinary TGF-β1 in diabetic nephropathy patients and its correlation with urine albumin-to-creatinine ratio (UACR), but other studies showed different results. Because of this contradiction, this study aims to analyze the correlation between urinary TGF-β1 concentration and UACR, and also estimated glomerular filtration rate (eGFR) in type 2 diabetes mellitus (DM) patients by controlling some confounding factors. Methods: This was a cross-sectional study, and the samples were obtained using consecutive sampling technique...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30323639/erratum-factors-associated-with-adherence-to-diabetes-care-recommendations-among-children-and-adolescents-with-type-1-diabetes-a-facility-based-study-in-two-urban-diabetes-clinics-in-uganda-corrigendum
#8
(no author information available yet)
[This corrects the article on p. 93 in vol. 11, PMID: 29636626.].
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30323638/obesity-management-in-prader-willi-syndrome-current-perspectives
#9
REVIEW
Antonino Crinò, Danilo Fintini, Sarah Bocchini, Graziano Grugni
Prader-Willi syndrome (PWS) is a complex multisystem disorder due to the absent expression of the paternally active genes in the PWS critical region on chromosome 15 (15q11.2-q13). The syndrome is considered the most common genetic cause of obesity, occurring in 1:10,000-1:30,000 live births. Its main characteristics include neonatal hypotonia, poor feeding, and lack of appetite in infancy, followed by weight gain, lack of satiety, and uncontrolled appetite, frequently after the age of 2-3 years. The clinical picture includes short stature, multiple endocrine abnormalities (hypogonadism, growth hormone/insulin-like growth factor-I axis dysfunction, hypothyroidism, central adrenal insufficiency), dysmorphic features, scoliosis, osteoporosis, mental retardation, and behavioral and psychiatric problems...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30319281/comprehensive-comparison-of-metap2-tissue-and-cellular-expression-pattern-in-lean-and-obese-rodents
#10
Jing Han, Yang Tang, Mingjian Lu, Haiqing Hua
Background: Methionine aminopeptidase 2 (MetAP2) cleaves the initiator methionine from nascent peptides during translation. In both preclinical and clinical studies, the pharmacological inhibition of MetAP2 in obese subjects results in the suppression of food intake and body weight loss. However, the mechanism of action of body weight loss caused by MetAP2 inhibition remains to be elucidated, and the sites of action by pharmacological MetAP2 inhibition remain unknown. Methods: In the present study, a comprehensive analysis of the MetAP2 expression pattern in mice was performed...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30319280/identification-of-key-gene-pathways-and-coexpression-networks-of-islets-in-human-type-2-diabetes
#11
Lu Li, Zongfu Pan, Si Yang, Wenya Shan, Yanyan Yang
Purpose: The number of people with type 2 diabetes (T2D) is growing rapidly worldwide. Islet β-cell dysfunction and failure are the main causes of T2D pathological processes. The aim of this study was to elucidate the underlying pathways and coexpression networks in T2D islets. Materials and methods: We analyzed the differentially expressed genes (DEGs) in the data set GSE41762, which contained 57 nondiabetic and 20 diabetic samples, and developed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30310299/metabolic-syndrome-and-blood-pressure-are-they-related-or-not
#12
COMMENT
Venu Gopal Jonnalagadda, Shravan Kumar Uppulapu
No abstract text is available yet for this article.
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30310298/inadequate-identification-of-fatty-liver-disease-obesity-and-metabolic-syndrome-by-family-physicians
#13
Mahmud Mahamid, Tawfik Khoury, Hana Amara, Mahmoud Siadi, Jabaren Mohamed, Amir Mari, Rafea Shalabi, Hisham Sholy, Wiliam Nseir
Background: Nonalcoholic fatty liver disease (NAFLD) is an emerging condition and is constituted as a vital public health epidemic globally. This study evaluated the process of identification and documentation of NAFLD and metabolic syndrome in correlation with those diagnosed with obesity. Methods: Participants included 352 patients older than 18 years who were diagnosed with fatty liver disease. We performed a cross-sectional study between August 2016 and September 2017...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30310297/decompression-nerve-surgery-for-diabetic-neuropathy-a-structured-review-of-published-clinical-trials
#14
REVIEW
James W Albers, Ryan Jacobson
Aim: To assess lower extremity decompression nerve surgery (DNS) to treat the consequences of diabetic distal symmetric peripheral neuropathy (DPN). Research design and methods: MEDLINE, PubMed, and related registries were searched through December 2017 to identify randomized, quasi-randomized or observational trials that evaluated the efficacy of lower extremity DNS on pain relief (primary outcome) or other secondary outcomes. Observational studies were included, given investigators' reluctance to use sham surgery controls...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30288074/developmental-origins-of-health-and-disease-a-new-approach-for-the-identification-of-adults-who-suffered-undernutrition-in-early-life
#15
Haroldo da Silva Ferreira, Antonio Fernando Silva Xavier Junior, Monica Lopes Assunção, Tainá Cardoso Caminha Uchôa, Abel Barbosa Lira-Neto, Ricardo Paulino Nakano
Background: Undernutrition in early life (UELife) is a condition associated with greater occurrence of chronic diseases in adulthood. Some studies on this relationship have used short stature as indicator of UELife. However, other non-nutritional factors can also determine short stature. Depending on the severity of UELife, the human body reacts primarily compromising weight and length gain, but prioritizing brain growth, resulting in disproportionate individuals. Based on this premise, this study aimed to validate a new anthropometric indicator of UELife...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30288073/obesity-and-nonalcoholic-fatty-liver-disease-current-perspectives
#16
REVIEW
Raiya Sarwar, Nicholas Pierce, Sean Koppe
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease due to an increase in the prevalence of obesity. The development of NASH leads to an increase in morbidity and mortality. While the first line of treatment is lifestyle modifications, including dietary changes and increased physical activity, there are no approved pharmacological treatment agents for NAFLD and NASH currently. Due to its complex pathophysiology, different pathways are under investigation for drug development with the focus on metabolic pathways, inflammation, and slowing or reversing fibrosis...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30288072/assessment-of-sleep-quality-and-its-predictors-among-patients-with-diabetes-in-jazan-saudi-arabia
#17
Abdulaziz Darraj, Mohamed Salih Mahfouz, Abdullah Alsabaani, Mubarack Sani, Anwar Alameer
Background: Poor sleep quality is common among patients with diabetes. It is associated with negative physical, psychological, and functional consequences. However, the implicated risk factors of poor sleep quality remain uncertain. Objectives: This study aimed to determine the prevalence of poor sleep quality among patients with diabetes and to investigate the factors associated with the poor sleep quality. Patients and methods: An analytical cross-sectional study of 307 diabetic patients in Jazan, Saudi Arabia was conducted in 2018...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30288071/alterations-in-the-gene-expression-of-drug-and-arachidonic-acid-metabolizing-cyp450-in-the-livers-of-controlled-and-uncontrolled-insulin-dependent-diabetic-mice
#18
Yazun Bashir Jarrar, Luay Al-Essa, Abdulhasib Kilani, Mariam Hasan, Walid Al-Qerem
Background: Diabetic patients have lower capacity to metabolize drugs in comparison to normal people. Therefore, the present study aimed to investigate the alterations in gene expression of drug and arachidonic acid metabolizing cytochrome p450s (cyp450s) in the livers of controlled (CDM) and uncontrolled (UDM) insulin-dependent diabetic mice. Methods: Balb/c mice were treated with single dose of streptozocin (240 mg/kg) to induce diabetes and compared with control group, which was treated with citric buffer (pH =4...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30271186/nutrition-therapy-for-type-2-diabetes-confirmed-efficacy-on-individualized-management
#19
COMMENT
Feng-Xian Wei, Xue-Ping Qi
No abstract text is available yet for this article.
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30233224/challenging-obesity-diabetes-and-addiction-the-potential-of-lorcaserin-extended-release
#20
REVIEW
Ryan T Hurt, Manpreet S Mundi, Jon O Ebbert
Obesity is a global epidemic that is a leading cause of preventable death. In addition to lifestyle modification, there are numerous obesity treatments for clinicians to consider, including medications. Lorcaserin immediate release/extended release (IR/XR) is a US Food and Drug Administration approved medication for overweight and obese patients to be used with lifestyle modifications. Lorcaserin is thought to reduce weight by targeting the serotonin (5HT2c ) system to induce satiety. Lorcaserin IR has been shown to be effective in reducing weight in overweight (body mass index [BMI] > 27 kg/m2 ) and obese (BMI > 30 kg/m2 ) participants in three large Phase III trials...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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