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Differentially expressed transcripts study during pregnancy and postpartum anestrus of yak ( Bos grunniens ).
Animal Biotechnology 2023 September 7
Background: Yak is the main livestock species in the plateau area, and its reproductive performance is low, usually two years or three years. A very few of yaks recover within a certain period of time after delivery and smoothly enter the next estrous cycle, while most of them enter the postpartum anestrus and show no estrus performance. However, the key biological factors and influencing mechanisms that cause postpartum anestrus in yaks are not clear. Objective: To study the expression of differential transcripts in ovaries of yak during pregnancy and postpartum anestrus. Methods: Each three yaks in pregnancy and anestrus under natural grazing conditions in Haiyan County, Qinghai Province were selected and slaughtered, and their ovaries were collected and sent to Biomarker Technologies. Oxford Nanopore Technologies single-molecule real-time electrical signal sequencing technology was used to perform full-length transcriptome sequencing. Astalavista software was used to identify the types of alternative splicing events in yak estrus and pregnancy, and TAPIS pipeline was used to identify alternative polyadenylation. Results: The results showed that there were 1751 differentially expressed transcripts (DETs) between pregnancy and anestrus in yak, of which 808 were upregulated and 943 were downregulated. GO analysis showed that the biological processes of DETs were mainly reproductive, reproductive and rhythmic processes. KEGG analysis showed that the DET cell junction-related adhesion junction protein ( β-catenin ) and amino terminal kinase ( JNK ) were involved in FAs (local adhesion). Phosphatidylinositol-3-kinase ( PI3K ) is involved in the PI3K/AKT/mTOR signaling pathway. Circadian rhythm output cycle failure ( Clock ) and brain and muscle tissue aromatic hydrocarbon receptor nuclear transporter-like protein 1 ( Bmal1 ) are involved in circadian rhythm signaling pathway. Conclusion: This study found that β-catenin, JNK , PI3K , Clock and Bmal1 were closely related to postpartum anestrus in yak.
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