Severity of in vivo corticospinal tract degeneration is associated with survival in amyotrophic lateral sclerosis: a longitudinal, multicohort study.

BACKGROUND: This study sought to evaluate the relationship of progressive corticospinal tract degeneration with survival in patients with amyotrophic lateral sclerosis (ALS).

METHODS: Forty-one ALS patients and forty-two healthy controls were prospectively recruited from the Canadian ALS Neuroimaging Consortium (CALSNIC). MRI scanning and clinical evaluations were performed on participants at three serial visits with four-month intervals. Texture analysis was performed on T1-weighted MRI scans and the texture feature 'autocorrelation' was quantified. Whole brain group-level comparisons were performed between patient subgroups. Linear mixed models were used to evaluate longitudinal progression. Region-of-interest and 3D voxel-wise Cox Proportional-Hazard's regression models were constructed for survival prediction. For all survival analyses, a second independent cohort was used for model validation.

RESULTS: Autocorrelation of the bilateral corticospinal tract (CST) was increased at baseline and progressively increased over time at a faster rate in ALS short survivors. Cox Proportional-Hazard's regression analyses revealed autocorrelation of the CST as a significant predictor of survival at five years follow-up (HR = 1.28, P = 0.005). Similarly, voxel-wise whole-brain survival analyses revealed that increased autocorrelation of the CST was associated with shorter survival. ALS patients stratified by median autocorrelation in the CST had significantly different survival times using Kaplan Meier curve and Log-rank tests (χ2 = 7.402, P = 0.007).

CONCLUSIONS: Severity of cerebral degeneration is associated with survival in ALS. CST degeneration progresses faster in sub-groups of patients with shorter survival. Neuroimaging holds promise as a tool to improve patient management and facilitation of clinical trials.