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Potential health risks of sound abatement material in positive airway pressure devices for sleep breathing disorders: a summary of studies to date.
Sleep & Breathing 2022 December 16
PURPOSE: The potential carcinogenic and airway irritation risks of polyester-based polyurethane (PE-PUR) contained in sound-absorbing foam in positive airway pressure (PAP) devices have raised many concerns. We summarize the currently available studies to assess the potential health risks of PE-PUR.
METHODS: We searched Pubmed and Web of Science for studies on the safety of PAP devices containing PE-PUF and performed a systematic analysis of the cancer risk.
RESULTS: PE-PUR did not increase the cancer risk (OR: 1.08, 95% CI: 0.99-1.17, I2 = 0%). Patients in the group of PE-PUR devices had increased airway irritation, and they had higher rates of using short-acting beta-agonists and oral corticosteroids (SABA: 9.4% vs. 8.8%, p = 0.047; OCS: 19.7% vs. 17.3%, p < 0.001).
CONCLUSION: The application of PE-PUF can increase airway irritation, but there is no evidence for its potential carcinogenicity.
METHODS: We searched Pubmed and Web of Science for studies on the safety of PAP devices containing PE-PUF and performed a systematic analysis of the cancer risk.
RESULTS: PE-PUR did not increase the cancer risk (OR: 1.08, 95% CI: 0.99-1.17, I2 = 0%). Patients in the group of PE-PUR devices had increased airway irritation, and they had higher rates of using short-acting beta-agonists and oral corticosteroids (SABA: 9.4% vs. 8.8%, p = 0.047; OCS: 19.7% vs. 17.3%, p < 0.001).
CONCLUSION: The application of PE-PUF can increase airway irritation, but there is no evidence for its potential carcinogenicity.
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