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Sleep & Breathing, Schlaf & Atmung

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https://www.readbyqxmd.com/read/30324548/4-phenylbutyric-acid-attenuates-endoplasmic-reticulum-stress-mediated-apoptosis-and-protects-the-hepatocytes-from-intermittent-hypoxia-induced-injury
#1
Liu Xin, Wu Fan, Du Tingting, Sun Zuoming, Zhang Qiang
PURPOSE: To investigate the effect of 4-phenylbutyric acid (4-PBA) on intermittent hypoxia (IH)-induced liver cell injury and to clarify the underlying mechanisms. METHODS: L02 cells (normal human liver cells) were cultured in normoxic condition or subjected to intermittent hypoxia for 4, 8, and 12 h. A part of hypoxia-treated L02 cells was applied with 4-PBA 1 h before exposure to hypoxia. The effect of 4-PBA on liver injury, hepatocyte apoptosis, endoplasmic reticulum stress (ERS), and PERK-eIFa2-ATF4-CHOP apoptotic pathway was investigated...
October 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30324547/obstructive-sleep-apnea-and-self-reported-functional-impairment-in-revascularized-patients-with-coronary-artery-disease-in-the-riccadsa-trial
#2
Lynn M Baniak, Eileen R Chasens, Faith S Luyster, Patrick J Strollo, Erik Thunström, Yüksel Peker
PURPOSE: Daytime sleepiness, a frequent symptom of obstructive sleep apnea (OSA), can impact functional status. In patients with coronary artery disease (CAD) and concomitant OSA, the distinction between sleep-related functional impairment from underlying CAD versus OSA is unclear. This study evaluated the impact of OSA on sleep-related functional impairment in patients with CAD and compared the effect of 1-year continuous positive airway pressure (CPAP) use on change in impairment between those with and without excessive daytime sleepiness (EDS) and OSA...
October 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30324546/persistent-sleep-disordered-breathing-after-adenoidectomy-and-or-tonsillectomy-a-long-term-survey-in-a-tertiary-pediatric-hospital
#3
Julia Cohen-Levy, Marie-Claude Quintal, Anthony Abela, Pierre Rompré, Fernanda R Almeida, Nelly Huynh
PURPOSE: To determine the long-term prevalence of persistent sleep disordered breathing (SDB) in children, after adenoidectomy, tonsillectomy or adenotonsillectomy, and to assess the relationship between baseline characteristics and persistent nocturnal symptoms. METHODS: The clinical charts of children operated for adenoidectomy and/or tonsillectomy in a tertiary hospital, between January 2000 and March 2016, were retrospectively reviewed. All patients who had signs of SDB prior to surgery received a six-question validated pediatric questionnaire, the Hierarchic Severity Clinical Scale (HSCS)...
October 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30324545/effect-of-remifentanil-during-drug-induced-sleep-endoscopy-in-patients-with-obstructive-sleep-apnea
#4
Youngsoon Kim, Hyungjun Park, Junoik Shin, Jeong-Hyun Choi, Sung Wook Park, Hee Yong Kang
PURPOSE: During drug-induced sleep endoscopy (DISE) in patients with obstructive sleep apnea, the increased depth of propofol anesthesia is related to the increased collapsibility of the upper airway with dose-dependent. We examined the effect of remifentanil on propofol concentration during DISE. METHODS: In a prospective randomized trial, 56 adult patients were divided into remifentanil-propofol (n = 28) and propofol alone (n = 28) groups. Anesthesia was administered using a target-controlled infusion system...
October 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30315394/alterations-of-the-brain-network-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder-structural-connectivity-analysis
#5
Kang Min Park, Ho-Joon Lee, Byung In Lee, Sung Eun Kim
PURPOSE: To evaluate and compare structural connectivity using graph theoretical analysis in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and healthy subjects. METHODS: Ten consecutive patients with iRBD were recruited from a single tertiary hospital. All patients had normal brain magnetic resonance imaging results on visual inspection. They did not have any other neurological disorder. Control subjects were also enrolled. All subjects underwent three-dimensional volumetric T1-weighted imaging...
October 12, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30311184/obesity-modulates-the-association-between-sleep-apnea-treatment-and-chi3l1-levels-but-not-chit1-activity-in-moderate-to-severe-osa-an-observational-study
#6
Unnur Dilja Teitsdottir, Erna Sif Arnardottir, Erla Bjornsdottir, Thorarinn Gislason, Petur Henry Petersen
PURPOSE: The inflammatory markers chitinase-3-like protein 1 (CHI3L1) and chitotriosidase (CHIT1) have both been associated with cardiovascular complications. The aim of this preliminary observational study was to assess the roles and interaction of obstructive sleep apnea (OSA) severity and body mass index (BMI) with plasma CHI3L1 levels and CHIT1 activity in patients with moderate to severe OSA. The second aim was to assess the roles and interaction of positive airway pressure (PAP) treatment and BMI on the expression of the same proteins...
October 11, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30311183/addition-of-frontal-eeg-to-adult-home-sleep-apnea-testing-does-a-more-accurate-determination-of-sleep-time-make-a-difference
#7
Matthew P Light, Thalia N Casimire, Catherine Chua, Viachaslau Koushyk, Omar E Burschtin, Indu Ayappa, David M Rapoport
RATIONALE: Home sleep apnea testing (HSAT) typically does not include electroencephalogram (EEG) monitoring for sleep assessment. In patients with insomnia and low sleep efficiency, overestimation of the sleep period can result from absence of EEG, which will reduce sleep disordered breathing (SDB) indices and may lead to a false-negative result. OBJECTIVE: To validate a single channel frontal EEG for scoring sleep versus wake against full EEG during polysomnography, and then to examine the utility of adding this single channel EEG to standard HSAT to prevent false-negative results...
October 11, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30302659/the-use-of-mandibular-advancement-devices-in-obstructive-sleep-apnea-a-proven-and-effective-therapy
#8
LETTER
Caetano Petrella, Milton Maluly, Monica L Andersen, Sergio Tufik
No abstract text is available yet for this article.
October 9, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30293099/laryngopharyngeal-motor-dysfunction-and-obstructive-sleep-apnea-in-parkinson-s-disease
#9
Christianne Martins Corrêa Silva Bahia, João Santos Pereira, Agnaldo José Lopes
PURPOSE: Obstructive sleep apnea (OSA) is a common sleep disorder in Parkinson's disease (PD), but the relationship between these two conditions remains uncertain. Upper airway (UA) dysfunction in PD is well documented in some patients and is believed to be a reflex of the motor involvement of laryngopharyngeal muscles. The aim of this study is to determine whether UA dysfunction and laryngopharyngeal motor dysfunction (LMD) are involved in the obstructive phenomenon of OSA in PD. METHODS: Forty-eight PD patients underwent polysomnography for OSA diagnosis, functional evaluation of the UA by spirometry and a clinical protocol for analysis of laryngopharyngeal muscles and physical examination...
October 6, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30284702/the-use-of-mandibular-advancement-devices-in-obstructive-sleep-apnea-a-proven-and-effective-therapy
#10
LETTER
Sylvan Mintz
No abstract text is available yet for this article.
October 4, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30284175/oxidative-stress-does-not-contribute-to-the-release-of-proinflammatory-cytokines-through-activating-the-nod-like-receptor-protein-3-inflammasome-in-patients-with-obstructive-sleep-apnoea
#11
Tingyu Tang, Qingdong Huang, Juan Liu, Xiaoxi Zhou, Jianzong Du, Haiyan Wu, Zhijun Li
PURPOSE: The study was conducted to test the hypothesis that oxidative stress leads to the release of proinflammatory cytokines by activating the Nod-like receptor protein (NLRP)3 inflammasome in patients with obstructive sleep apnoea (OSA). METHODS: The study recruited 247 participants who were divided into cases and healthy control groups. OSA patients were subdivided into four subgroups according to sex, blood pressure, body mass index (BMI), and severity of disease...
October 3, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30276710/the-role-of-drug-induced-sleep-endoscopy-predicting-and-guiding-upper-airway-surgery-for-adult-osa-patients
#12
Yan Wang, Chuanyu Sun, Xinhua Cui, Ying Guo, Qirong Wang, Hui Liang
PURPOSE: Obstructive sleep apnea (OSA) is a common sleep disorder that can be corrected with upper airway surgery. Prior to surgery, drug-induced sleep endoscopy (DISE) is routinely used to evaluate obstruction sites and severity. Evidence suggests that the findings of DISE may relate to the final surgical outcome. Therefore, we evaluated the ability of drug-induced sleep endoscopy to predict the final effect of upper airway surgery and potentially to guide surgical treatment decision-making...
October 1, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30264356/weight-gain-may-affect-mandibular-advancement-device-therapy-in-patients-with-obstructive-sleep-apnea-a-retrospective-study
#13
Tiina-Riitta Vuorjoki-Ranta, Ghizlane Aarab, Frank Lobbezoo, Henri Tuomilehto, Jari Ahlberg
PURPOSE: The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD). METHODS: As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study...
September 27, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30255484/the-prevalence-of-obstructive-sleep-apnea-and-its-association-with-pregnancy-related-health-outcomes-a-systematic-review-and-meta-analysis
#14
REVIEW
Lina Liu, Guang Su, Shuling Wang, Bingqian Zhu
PURPOSE: Obstructive sleep apnea (OSA) is common during pregnancy. Nevertheless, prevalence estimates of OSA have varied widely due to variabilities in the assessment methods. This meta-analysis aimed to examine the prevalence of objectively assessed OSA and its association with pregnancy-related health outcomes in pregnant women. METHODS: This review was developed following the PRISMA guideline. A systematic search was conducted in major electronic databases to identify studies conducted from inception to January 2018...
September 25, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30238284/association-between-obstructive-sleep-apnea-syndrome-and-waist-to-height-ratio
#15
Yasemin Unal, Dilek Aslan Ozturk, Kursad Tosun, Gulnihal Kutlu
PURPOSE: Obesity is among the known risk factors for obstructive sleep apnea syndrome (OSAS). In this study, our aim was to investigate the correlation of waist-to-height ratio, an indicator of central obesity, with presence and severity of OSAS; to compare the use of this ratio with the use of waist circumference and body mass index (BMI); and to determine OSAS-related cutoff values. METHODS: The patient records were retrospectively analyzed for whom a polysomnography was conducted at our sleep...
September 20, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30232681/rem-obstructive-sleep-apnea-risk-for-adverse-health-outcomes-and-novel-treatments
#16
REVIEW
Andrew W Varga, Babak Mokhlesi
Rapid eye movement (REM) sleep was discovered nearly 60 years ago. This stage of sleep accounts for approximately a quarter of total sleep time in healthy adults, and it is mostly concentrated in the second half of the sleep period. The majority of research on REM sleep has focused on neurocognition. More recently, however, there has been a growing interest in understanding whether obstructive sleep apnea (OSA) during the two main stages of sleep (REM and non-REM sleep) leads to different cardiometabolic and neurocognitive risk...
September 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30232680/obstructive-sleep-apnea-in-pregnancy-performance-of-a-rapid-screening-tool
#17
Bilgay Izci Balserak, Bingqian Zhu, Michael A Grandner, Nicholas Jackson, Grace W Pien
PURPOSE: The Sleep Apnea Symptom Score (SASS) has been commonly used to assess obstructive sleep apnea (OSA). The aim of this study was to examine the psychometric properties of the SASS and the predictive value of SASS incorporating bedpartner-reported information in identifying OSA in pregnant women. METHODS: A cohort of healthy pregnant women completed the SASS and Pittsburgh Sleep Quality Index. Participants underwent overnight laboratory polysomnography (PSG) monitoring...
September 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30225628/sleep-quality-in-survivors-of-critical-illness-practical-shortcomings-resolved
#18
LETTER
M Bolaki, Ch Alexopoulou, D Georgopoulos
No abstract text is available yet for this article.
September 17, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30219962/telmisartan-attenuates-kidney-apoptosis-and-autophagy-related-protein-expression-levels-in-an-intermittent-hypoxia-mouse-model
#19
Xiao-Bin Zhang, Jing-Huang Cai, Yu-Yun Yang, Yi-Ming Zeng, Hui-Qing Zeng, Miao Wang, Xiao Cheng, Xiongbiao Luo, Henry Chidozie Ewurum
PURPOSE: Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a mouse model of OSA. MATERIALS AND METHODS: Mice were randomly allocated to normoxia, CIH, and CIH+telmisartan groups (n = 12 in each group). The CIH exposure duration was 12 weeks...
September 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30219961/sleep-quality-in-survivors-of-critical-illness-practical-shortcomings-unresolved
#20
LETTER
Mohamad F El-Khatib, Antonio M Esquinas
No abstract text is available yet for this article.
September 15, 2018: Sleep & Breathing, Schlaf & Atmung
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