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Sleep & Breathing, Schlaf & Atmung

Qingshi Chen, Guofu Lin, Jiefeng Huang, Gongping Chen, Xiaoyun Huang, Qichang Lin
PURPOSE: Long non-coding RNAs (lncRNAs) are a recently identified class of regulatory molecules involved in the regulation of numerous biological processes, but their functions in a rat model of chronic intermittent hypoxia (CIH) remain largely unknown. Therefore, for further investigation, we aimed to explore lncRNA expression profiles and reveal their potential functional roles in rat models of CIH. METHODS: We used a well-established CIH rat model and conducted lncRNA microarray experiments on the heart samples of rats with CIH and under normoxia control...
December 7, 2018: Sleep & Breathing, Schlaf & Atmung
Anders Broström, A H Pakpour, P Nilsen, B Fridlund, M Ulander
BACKGROUND: Continuous positive airway treatment (CPAP) is the recommended treatment for patients with obstructive sleep apnea (OSA). Outcome measures often focus on clinical and/or self-rated variables related to the medical condition. However, a brief validated instrument focusing on the whole life situation (i.e., ethos) suitable for clinical practice is missing. The aim of this study was to investigate factorial structure, categorical functioning of the response scale, and differential item functioning across sub-populations of the Ethos Brief Index (EBI) among patients with obstructive sleep apnea (OSA) before and after initiation of continuous positive airway pressure (CPAP)...
December 6, 2018: Sleep & Breathing, Schlaf & Atmung
Jens Spiesshoefer, Maximilian Spieker, Simon Klose, Stefanie Keymel, Matthias Boentert, Stefan Krüger, Patrick Horn, Malte Kelm, Ralf Westenfeld
PURPOSE: This study tested the hypothesis that a reduction of pulmonary congestion achieved by a reduction of mitral regurgitation (MR) severity in heart failure (HF) patients is associated with reduced event lengths of sleep-disordered breathing (SDB). METHODS: We prospectively enrolled 20 consecutive HF patients who underwent MitraClip implantation. Patients underwent cardiorespiratory polygraphic recording prior to and after percutaneous mitral valve repair (PMVR)...
December 6, 2018: Sleep & Breathing, Schlaf & Atmung
Dhirendra Paudel, Qiuyan Lin, Caiping Yan, Shuai Liu, Bin Zhang
PURPOSE: We report a case with symptoms and signs of obstructive sleep apnea (OSA), depression, and narcolepsy. Polysomnographic (PSG) and multiple sleep latency test (MSLT) findings, clinical characteristics, and diagnostic challenges in this case are discussed. METHODS: A 23-year-old single male presented with excessive daytime sleepiness, low mood, lack of energy, and snoring for 3 years. In addition, he reported excessive weight gain, lack of interest in work, partial loss of muscle tone during excitations, and sleep attacks during work and driving...
December 6, 2018: Sleep & Breathing, Schlaf & Atmung
Matej Delakorda, Nina Ovsenik
PURPOSE: Despite a broad range of diagnostic methods, identifying the site of obstruction in the upper respiratory tract in patients with obstructive sleep apnea is not always simple and straightforward. With regard to this problem, we present our observations about the specific shape of the epiglottis in patients with obstruction at the level of the tongue base and/or epiglottis. METHODS: One hundred and forty consecutive drug-induced sleep endoscopy (DISE) video recordings of patients with polygraphy-verified obstructive sleep apnea were analyzed by three independent observers...
November 30, 2018: Sleep & Breathing, Schlaf & Atmung
Yoshito Mizoguchi, Jun-Ichi Oyama, Yoshiomi Imamura, Koichi Node, Akira Monji
No abstract text is available yet for this article.
November 29, 2018: Sleep & Breathing, Schlaf & Atmung
Nattapong Jaimchariyatam, Kunyalak Na-Rungsri, Somkanya Tungsanga, Somrat Lertmaharit, Vitool Lohsoonthorn, Surachart Totienchai
PURPOSE: Preeclampsia-eclampsia remains one of the leading causes of maternal and perinatal morbidity and mortality. Emerging evidence suggests that obstructive sleep apnea (OSA), which has been linked to hypertension in the general population, may play role in hypertensive disorders in pregnancy, including preeclampsia-eclampsia. However, little research has been conducted in Asia (no data in Thailand) on the effects of OSA on preeclampsia-eclampsia. We aimed to examine the association between OSA and preeclampsia-eclampsia among Thai pregnant women...
November 27, 2018: Sleep & Breathing, Schlaf & Atmung
RuoHan Chen, KePing Chen, Yan Dai, Shu Zhang
BACKGROUND: Pacing patients was revealed with a high prevalence of sleep disorder, but mostly undiagnosed. The pacemaker with transthoracic impedance sensor and novel algorithm could identify sleep apnea (SA) event. This study aimed to evaluate accuracy of pacemaker in sleep apnea diagnosis. METHODS: This is a prospective study which enrolled patients implanted with pacemakers integrated with transthoracic impedance sensor and SA-identified algorithm (AP Scan). All patients underwent a polysomnography (PSG)...
November 24, 2018: Sleep & Breathing, Schlaf & Atmung
Ulla Anttalainen, L Grote, I Fietze, R L Riha, S Ryan, R Staats, J Hedner, T Saaresranta
PURPOSE: The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. METHODS: Cohort of the European Sleep Apnea Database (n = 17,325; 29...
November 22, 2018: Sleep & Breathing, Schlaf & Atmung
Marco Alessandrini, Claudio Liguori, Andrea Viziano, Francesca Izzi, Donatella Capoccia, Alessia Lanzillotta, Fabio Placidi, Nicola Biagio Mercuri, Alessandro Micarelli
PURPOSE: To assess whether vestibulo-ocular reflex (VOR) gain, posturography parameters and related clinical outcomes can improve in OSA patients after 12 months of CPAP treatment, taking into consideration that a certain degree of vestibular dysfunction has been identified in these subjects. METHODS: Vestibular, postural, clinical, and polygraphic parameters were assessed in 32 OSA patients before and after beneficial CPAP treatment by means of video head impulse test (vHIT), static posturography (SP), Dizziness Handicap Inventory (DHI), Epworth Sleepiness Scale (ESS), and Apnea-Hypopnea Index (AHI), respectively, and were compared by means of a "within-subject" ANOVA model and Spearman's rank correlation...
November 19, 2018: Sleep & Breathing, Schlaf & Atmung
Chutintorn Sriphrapradang, Sittichai Pinyopodjanard, Onnicha Suntornlohanakul, Hataikarn Nimitphong, Naricha Chirakalwasan, Sunee Saetang, Thunyarat Anothaisintawee, Nantaporn Siwasaranond, Areesa Manodpitipong, La-Or Chailurkit, Sirimon Reutrakul
PURPOSE: Hypothyroidism is associated with a high frequency of obstructive sleep apnea (OSA). However, the prevalence of OSA in hypothyroid patients is not different from the general population in many reports. The importance of thyroid function screening in sleep-disordered breathing is still controversial. This study aimed to explore the association between thyroid dysfunction and OSA in the adults with prediabetes or diabetes mellitus type 2, who have very high prevalence of OSA. METHODS: OSA was assessed using an in-home monitoring device, WatchPAT200...
November 19, 2018: Sleep & Breathing, Schlaf & Atmung
Hong Jun Jeon, Young Rong Bang, In-Young Yoon
PURPOSE: Obstructive sleep apnea (OSA) is highly prevalent and causes serious cardiovascular complications. Several screening questionnaires for OSA have been introduced, but only few validation studies have been conducted in general population. The aim of the present study was to assess the diagnostic value of three OSA screening questionnaires (Berlin Questionnaire, BQ; STOP-Bang Questionnaire, STOP-B; Four-Variable Screening Tool, Four-V) in a Korean community sample. METHODS: A total of 1148 community-dwelling participants completed the BQ, STOP-B, and Four-V...
November 17, 2018: Sleep & Breathing, Schlaf & Atmung
Eli Van de Perck, Jolien Beyers, Marijke Dieltjens, Sara Op de Beeck, Johan Verbraecken, Paul Van de Heyning, An Boudewyns, Olivier M Vanderveken
PURPOSE: The aim of this study was to report on the successful application of upper airway stimulation (UAS) therapy in an adult Down syndrome (DS) patient with severe obstructive sleep apnea (OSA) and continuous positive airway pressure (CPAP) intolerance. METHODS: Baseline polysomnography (PSG) in a 23-year-old male OSA patient (body mass index (BMI) 24.4 kg/m2 ) revealed an apnea/hypopnea index (AHI) of 61.5 events/h and oxygen desaturation index (ODI) of 39...
November 14, 2018: Sleep & Breathing, Schlaf & Atmung
Siraj Omar Wali, Bahaa Abaalkhail, Faris Alhejaili, S R Pandi-Perumal
PURPOSE: Restless legs syndrome is a movement sleep disorder that may be linked to dopaminergic dysfunction and in which vitamin D may play a role. This 12-week randomized, placebo-controlled trial elucidated the efficacy of vitamin D supplements in decreasing restless legs syndrome symptom severity. METHODS: Thirty-five subjects with restless legs syndrome, diagnosed using the International Restless Legs Syndrome Study Group criteria, were enrolled. The subjects were randomized to orally receive either vitamin D (50,000 IU caplets) or a placebo...
November 14, 2018: Sleep & Breathing, Schlaf & Atmung
Chunfang Zou, Weiwei Sheng, De Huai, Juan Cao, Mei Su, Ding Ning, Rong Xue, Yanli Wang, Mao Huang, Xilong Zhang
PURPOSE: Our study aims to compare the difference in clinical efficacy between auto-trilevel positive airway pressure (auto-trilevel PAP) ventilator and conventional fixed bilevel positive airway pressure (BiPAP) ventilator for obesity hypoventilation syndrome (OHS) patients with coexisting moderate or severe obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Twenty-three OHS patients with moderate or severe OSAHS enrolled between January 2015 and September 2017 underwent ventilation by three different modes of positive airway pressure (PAP) for 8 h per night...
November 13, 2018: Sleep & Breathing, Schlaf & Atmung
Jie Ren, Meng Jin, Zhen-Xi You, Miao Luo, Yin Han, Guang-Cai Li, Hui-Guo Liu
BACKGROUND: Hepatic steatosis that occasionally results in nonalcoholic steatohepatitis (NASH) is related to obstructive sleep apnea (OSA). Many studies have shown that autophagy exerts protective effects on liver damage caused by various diseases and melatonin exhibits hepatoprotective properties. However, the mechanisms of liver injury induced by chronic intermittent hypoxia (CIH) and the effect of melatonin on the regulation of liver injury remain unclear. PURPOSE: This study was aimed to evaluate the role of CIH in steatohepatitis progression and the regulatory function of melatonin on fatty liver sensitivity to CIH injury, mainly focusing on autophagy signaling...
November 8, 2018: Sleep & Breathing, Schlaf & Atmung
Xin Peng, Nan Liu, XiaoXia Zhang, XinYu Bao, YiXian Xie, JunXuan Huang, PeiXi Wang, QingFeng Du
PURPOSE: The aim of this study was to explore associations between objectively assessed physical fitness levels and sleep quality in community-dwelling elderly people in South China. METHODS: One thousand one hundred thirty-six (504 males and 632 females) community-dwelling adults aged ≥ 50 years old in Dongguan City, South China, were included in the cross-sectional study. All the participants were asked to complete all prepared multi-instrument questionnaire, including the Pittsburgh Sleep Quality Index (Chinese version), for the assessment of the sleep quality and information regarding socio-demographic characteristics, lifestyle, and physical health data...
November 6, 2018: Sleep & Breathing, Schlaf & Atmung
Nashwa Wahba, Syed Sayeeduddin, Montserrat Diaz-Abad, Steven M Scharf
INTRODUCTION: Traditionally, evaluation of obstructive sleep apnea (OSA) has consisted of a diagnostic polysomnogram (PSG), followed by a continuous positive pressure (CPAP) titration. However, to reduce costs, many third-party payers mandate performance of split-night studies (SPL), combining diagnostic and CPAP titration testing. We ascertained the utility of performing SPL for diagnosis and treatment of OSA. METHODS: We reviewed the PSG records of 200 patients suspected of having OSA...
November 5, 2018: Sleep & Breathing, Schlaf & Atmung
Marie Bruyneel, Flora Veltri, Kris Poppe
BACKGROUND: Hypothyroidism can directly cause obstructive sleep apnea (OSA) but may also contribute to it through its impact on the metabolic syndrome. The purpose of this study was to establish the prevalence of known and newly diagnosed overt and subclinical hypothyroidism (SCH) among patients with OSA. METHODS: We prospectively included all consecutive moderate or severe OSA patients referred for CPAP therapy. A fasting blood sample was collected to determine thyroid-stimulating hormone (TSH) and free T4 (FT4) levels...
October 27, 2018: Sleep & Breathing, Schlaf & Atmung
Haibo Ding, Jie-Feng Huang, Han-Sheng Xie, Bi-Ying Wang, Ting Lin, Jian-Ming Zhao, Qi-Chang Lin
PURPOSE: Growing evidence has revealed that nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes. This study aimed to assess the association between glycometabolism and NAFLD in patients with obstructive sleep apnea (OSA). METHODS: Patients with suspected OSA were enrolled consecutively and then underwent polysomnography, liver ultrasound, and biochemical measurements. Logistic regressions were used to identify factors associated with NAFLD...
October 22, 2018: Sleep & Breathing, Schlaf & Atmung
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