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Sleep & Breathing, Schlaf & Atmung

Fariborz Rezaeitalab, Naghmeh Mokhber, Yalda Ravanshad, Soheila Saberi, Fariba Rezaeetalab
No abstract text is available yet for this article.
August 13, 2018: Sleep & Breathing, Schlaf & Atmung
Yan Zhang, Xiaoli Su, Fangfang Zou, Tengjuan Xu, Pinhua Pan, Chengping Hu
BACKGROUND: Obstructive sleep apnea (OSA)-associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered renal damage. This study aims to investigate the role of toll-like receptor-4 (TLR4) in underlying mechanism involved chronic intermittent hypoxia (CIH)-induced renal damage. METHODS: C57BL/6J mice with normal TLR4 (TLR4 WT) or deficient TLR4 (TLR4 KO) were divided into four groups and exposed to normal air (NA) and CIH: TLR4 WT + NA, TLR4 KO + NA, TLR4 WT + CIH, and TLR4 KO + CIH...
August 11, 2018: Sleep & Breathing, Schlaf & Atmung
Jinzhong Xu, Hui Li, Fan Wang, Zeping Xu, Guohua Li, Cheng Ding, Junnan Wu, Yimin Kang, Hong Li, Heng Xu, Yanlong Liu
OBJECTIVE: Glutamate is an excitatory neurotransmitter in the central nervous system that participates in initiation and maintenance of sleep and wakefulness. The mechanisms involved occur in the brainstem, lateral hypothalamus, and basal forebrain. Our previous study suggested that higher levels of glutamate in cerebrospinal fluid (CSF) contributed to poorer sleep quality. Smoking has been shown to be harmful to sleep quality. In the present study, we recruited non-smokers and heavy smokers and measured the concentration of CSF glutamate in order to investigate the associations among smoking status, sleep quality, and CSF glutamate levels...
August 7, 2018: Sleep & Breathing, Schlaf & Atmung
Josip A Borovac, Zoran Dogas, Daniela Supe-Domic, Tea Galic, Josko Bozic
PURPOSE: Obstructive sleep apnea (OSA) is a complex sleep disorder associated with autonomic and sympathetic dysregulation. To the contrary, catestatin, an endogenous pleiotropic peptide cleaved from chromogranin A, is known for its inhibitory effects on catecholamine release and sympathetic activity. The aims of the study were to determine catestatin serum levels among male OSA patients compared to healthy control subjects and to explore associations of catestatin with anthropometric, polysomnographic, and lipid profile parameters...
August 7, 2018: Sleep & Breathing, Schlaf & Atmung
C Kastoer, L B L Benoist, M Dieltjens, B Torensma, L H de Vries, P E Vonk, M J L Ravesloot, N de Vries
PURPOSE: To compare patient characteristics, upper airway (UA) collapse patterns and treatment outcome in obstructive sleep apnea (OSA) patients, including non-positional OSA patients (NPP) and positional OSA patients (PP), and non-OSA. METHODS: Cohort study of patients screened for OSA in 2012. Polysomnography was performed and UA was evaluated using the VOTE classification during drug-induced sleep endoscopy (DISE). Treatment outcome of MAD and UA surgery was evaluated...
August 1, 2018: Sleep & Breathing, Schlaf & Atmung
Grazia Crescimanno, Francesca Greco, Salvatore Arrisicato, Oreste Marrone
PURPOSE: The study aims to evaluate the performance of autonomic activations as a tool to assess sleep fragmentation and to recognize hypopneas in patients with amyotrophic lateral sclerosis (ALS) under non-invasive mechanical ventilation and secondarily, to evaluate, in patients with the same disease, the relationship between disruption of autonomic nervous system (ANS) activity and the usefulness of the autonomic activations as surrogates of cortical arousals. METHODS: Sixteen ALS patients underwent simultaneous polysomnography and portable cardiorespiratory monitoring (PM)...
July 24, 2018: Sleep & Breathing, Schlaf & Atmung
Pascal Delsart, Jerome Soquet, Elodie Drumez, Francis Juthier, Seenam Kutoati, Thomas Nganou Koutouzi, Stephanie Fry, Anne Mallart, David Montaigne, Claire Mounier-Vehier
BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increased aortic root size. This association has never been studied in patients with hypertension undergoing continuous positive airway pressure (CPAP) treatment for OSA. METHODS: The 24-h blood pressure (BP) monitoring of 142 hypertensive patients undergoing CPAP treatment for OSA was prospectively documented. Aortic root diameter was assessed by echocardiography. RESULTS: The population included 33...
July 24, 2018: Sleep & Breathing, Schlaf & Atmung
(no author information available yet)
No abstract text is available yet for this article.
July 23, 2018: Sleep & Breathing, Schlaf & Atmung
Surya Prakash Bhatt, Randeep Guleria, Naval K Vikram, A K Gupta
INTRODUCTION: Obstructive sleep apnea (OSA) has been estimated to affect 4-11% of the population and causes systemic inflammation which leads to metabolic syndrome (MS). Non-alcoholic fatty liver disease (NAFLD) is also associated with MS whether NAFLD is an additional risk factor for the systemic inflammation that occurs in OSA is unclear. OBJECTIVE: In this study, we aimed to analyze the association of OSA and NAFLD with MS and systemic inflammation in Asian Indians...
July 22, 2018: Sleep & Breathing, Schlaf & Atmung
Umesh Goswami, Adam Black, Brian Krohn, Wendy Meyers, Conrad Iber
PURPOSE: Upper airway exercises for snoring treatment can be effective but difficult to administer and monitor. We hypothesized that a brief, relatively simple daily upper airway exercise regimen, administered by a smartphone application, would reduce snoring and encourage compliance. METHODS: Targeted vowel sounds causing tongue base movements were incorporated into a voice-controlled smartphone game application. Participants with habitual snoring, apnea hypopnea index (AHI) ≤ 14 events/h, and BMI ≤ 32 kg/m2 were randomly assigned to perform 15 min of daily gameplay (intervention group) or 5 s of daily voice recording (control group) and to audio record their snoring for 2 nights/week for up to 12 weeks...
July 21, 2018: Sleep & Breathing, Schlaf & Atmung
Ch Alexopoulou, M Bolaki, E Akoumianaki, S Erimaki, E Kondili, P Mitsias, D Georgopoulos
PURPOSE: There is limited data regarding the sleep quality in survivors of critical illness, while the time course of the sleep abnormalities observed after ICU discharge is not known. The aim of this study was to assess sleep quality and the time course of sleep abnormalities in survivors of critical illness. METHODS: Eligible survivors of critical illness without hypercapnia and hypoxemia were evaluated within 10 days (1st evaluation, n = 36) and at 6 months after hospital discharge (2nd evaluation, n = 29)...
July 20, 2018: Sleep & Breathing, Schlaf & Atmung
Ghizlane Aarab, Frank Lobbezoo
No abstract text is available yet for this article.
July 19, 2018: Sleep & Breathing, Schlaf & Atmung
Sanjiv Narayan, Priyanka Shivdare, Tharun Niranjan, Kathryn Williams, Jon Freudman, Ruchir Sehra
PURPOSE: Diagnosis of obstructive sleep apnea by the gold-standard of polysomnography (PSG), or by home sleep testing (HST), requires numerous physical connections to the patient which may restrict use of these tools for early screening. We hypothesized that normal and disturbed breathing may be detected by a consumer smartphone without physical connections to the patient using novel algorithms to analyze ambient sound. METHODS: We studied 91 patients undergoing clinically indicated PSG...
July 18, 2018: Sleep & Breathing, Schlaf & Atmung
Trent A Hargens, Ryan A Martin, Courtney L Strosnider, Gabrielle Elam Williams Giersch, Christopher J Womack
PURPOSE: Obesity and obstructive sleep apnea (OSA) are frequent comorbid conditions. The impact of OSA on objectively measured physical activity (PA), independent of obesity, is not clear. The purpose of this study is to examine the effect of OSA on PA measured via accelerometer. METHODS: Overweight-to-obese individuals were recruited and screened for the presence of OSA via portable diagnostic device and divided into an OSA (n = 35) and control group (n = 24)...
July 18, 2018: Sleep & Breathing, Schlaf & Atmung
Xiandong Gu, Wei Yang, Xuming Luo, Xiongbiao Wang, Jihong Tang, Zhuying Cai
PURPOSE: Obstructive sleep apnea (OSA) is induced by obstruction of the upper airway, which can raise multiple health risks. This study is designed to reveal the key genes involved in OSA. METHODS: GSE38792 was extracted from Gene Expression Omnibus database, including ten visceral adipose tissues from OSA patients and eight visceral adipose tissues from normal controls. Differential expression analysis was conducted using limma package, and then the functions of the differentially expressed genes (DEGs) were analyzed using DAVID database, followed by protein-protein interaction (PPI) network, and integrated regulatory network analysis was performed using Cytoscape software...
July 10, 2018: Sleep & Breathing, Schlaf & Atmung
Zeng-Hong Wu, Xiu-Ping Yang, Xun Niu, Xi-Yue Xiao, Xiong Chen
BACKGROUND: Obstructive sleep apnea hypopnea syndrome (OSAHS) means apnea and hypopnea caused by partial or complete obstruction of upper airway collapse during sleep. Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for OSAHS. AIM: A meta-analysis was performed to identify the association between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease...
July 9, 2018: Sleep & Breathing, Schlaf & Atmung
Chien-Hua Chen, Cheng-Li Lin, Chung-Y Hsu, Chia-Hung Kao
PURPOSE: To assess the association between obstructive sleep apnea (OSA) and gallstones. METHODS: We identified 3827 patients aged ≥ 20 years with OSA between 2000 and 2010 from the Longitudinal Health Insurance Research Database 2000 (LHID2000) as the study cohort. The beneficiaries without OSA were randomly selected and propensity-matched with the study cohort in a 1:1 ratio according to age; sex; occupation; urbanization; comorbidities of hypothyroidism, hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, chronic obstructive pulmonary disease (COPD), obesity, inflammatory bowel disease, stroke, coronary artery disease (CAD), hepatitis B virus, and hepatitis C virus; and the index year...
July 7, 2018: Sleep & Breathing, Schlaf & Atmung
Chitra Lal, Gary Hardiman, Suchit Kumbhare, Charlie Strange
PURPOSE: There are currently no biomarkers that are associated with cognitive impairment (CI) in patients with obstructive sleep apnea syndrome (OSAS). This pilot study performed an exploratory plasma proteomic analysis to discover potential biomarkers and explore proteomic pathways that differentiate OSAS subjects with and without CI. METHODS: Participants were selected from a cohort of women within 5 years of menopause not on hormone replacement therapy between the ages of 45-60 years...
July 2, 2018: Sleep & Breathing, Schlaf & Atmung
Yanhong Zhang, Yuanyuan Lin, Jianwu Zhang, Li Li, Xinxin Liu, Tianhe Wang, Zhenzhong Gao
PURPOSE: Diabetes and sleep disorders are public health threats worldwide, but the potential association between them is still unclear. METHODS: We conducted a community-based cross-sectional study including 5078 participants (2665, 52.5% male) to determine the association between insomnia and diabetes mellitus prevalence. RESULTS: In patients with type 2 diabetes mellitus (T2DM) and nondiabetic controls, the prevalence of insomnia was 20...
June 30, 2018: Sleep & Breathing, Schlaf & Atmung
Bing Yang, Yongwei Wang, Fangfang Cui, Ting Huang, Peijia Sheng, Ting Shi, Chan Huang, Yajia Lan, Yi-Na Huang
PURPOSE: Insomnia has become one of the foremost health concerns among workers. Despite a significant number of epidemiological studies have reported on the correlation between insomnia and job stress, comprehensive evidence remains insufficient. Therefore, this research seeks to provide evidence with greater reliability, through summarizing relevant contemporary literature via a meta-analysis. METHODS: Literature from across Europe and Asia that was of both a prospective and cross-sectional design was included, if well-controlled odds ratios were available...
June 29, 2018: Sleep & Breathing, Schlaf & Atmung
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