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Engineering biosafe Cisplatin loaded Nanostructured Lipid Carrier: Optimization, Synthesis, Pharmacokinetics and Biodistribution.
Journal of Microencapsulation 2022 November 4
AIM: Low aqueous solubility, adverse effects of Cisplatin includes hepatotoxicity and nephrotoxicity necessitates development of nanoparticulate drug delivery. The study pertains to development of CisNLC (Cisplatin loaded Nanostructured Lipid Carrier) by ultrasonication.
METHODS: Physical characterization includes particle-size, zeta-potential, TEM, SEM-EDX, DSC. Its ex-vivo biocompatibility, pharmacokinetics and biodistribution along with acute toxicity induced oxidative stress in Balb/c mice were evaluated.
RESULTS: The mean particle diameter of CisNLC was observed to be 141.5 ± 3.86 nm with zeta potential of -41.5 ± 1.62 mV. In-vitro release studies at pH 7.4 and 5.8 showed burst release following a sustained release pattern post-72 hrs. CisNLC showed anticancer efficacy against PA-1. Negligible ex-vivo hemolysis indicated bio-compatibility. Improved pharmacokinetics of CisNLC was observed. Acute toxicity and oxidative stress evaluation proved negligible toxicity by CisNLC.
CONCLUSION: The formulated CisNLC had a good physical stability, biocompatible, indicated enhanced circulation and caused negligible toxicity on liver and kidney as compared to pure Cis.
METHODS: Physical characterization includes particle-size, zeta-potential, TEM, SEM-EDX, DSC. Its ex-vivo biocompatibility, pharmacokinetics and biodistribution along with acute toxicity induced oxidative stress in Balb/c mice were evaluated.
RESULTS: The mean particle diameter of CisNLC was observed to be 141.5 ± 3.86 nm with zeta potential of -41.5 ± 1.62 mV. In-vitro release studies at pH 7.4 and 5.8 showed burst release following a sustained release pattern post-72 hrs. CisNLC showed anticancer efficacy against PA-1. Negligible ex-vivo hemolysis indicated bio-compatibility. Improved pharmacokinetics of CisNLC was observed. Acute toxicity and oxidative stress evaluation proved negligible toxicity by CisNLC.
CONCLUSION: The formulated CisNLC had a good physical stability, biocompatible, indicated enhanced circulation and caused negligible toxicity on liver and kidney as compared to pure Cis.
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