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Journal of Microencapsulation

Ya-Ling Su, Chien-Yu Lin, Shih-Jiuan Chiu, Teh-Min Hu
A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, Rhodamine 6G (R6G) loaded colloidal particles were prepared and characterized in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20-80%, R6G exhibited near 100% efficiency...
August 8, 2018: Journal of Microencapsulation
Elena García Esteban, María José Cózar-Bernal, Antonio M Rabasco Álvarez, María Luisa González-Rodríguez
The aim of this study was to evaluate the stability of levodopa liposomes co-loaded with three different antioxidants (curcumin, ascorbic acid, and superoxide dismutase (SOD)). For this purpose, multilamellar liposomes were prepared. Curcumin was added into the lipid bilayer while ascorbic acid and SOD were placed into the aqueous phase. The influence of preparation technique and surface charge were also investigated. Vesicles were characterised and free radical scavenging potential was determined. From stability study, ascorbic acid showed better stabilising effect...
July 22, 2018: Journal of Microencapsulation
Preeti G Karade, Namdeo R Jadhav
An objective of the present study was to prepare colon specific microspheres of Curcumin (CUR) containing Ascorbic acid (AA) for improved oral bioavailability. 32 factorial design was used to optimize Chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimized CSMS were coated with Eudragit S-100, for delivery to colon. In vitro drug release, in vivo pharmacokinetics and organ distribution studies were performed in Albino wistar rats. Stabilization of CUR in alkaline pH was successfully guarded by AA to the extent 98...
July 16, 2018: Journal of Microencapsulation
Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Sadiq Umar, Farhan Jalees Ahmad
BACKGROUND: Irinotecan (IRN) (CPT-11) is a camptothecin derivative with low oral bioavailability due to active efflux by intestinal P-glycoprotein (p-gp) receptors. Hence, no oral formulation is marketed for IRN till date and its oral ingestion continues to remain a challenge. AIM OF STUDY: The study aims to develop a nanoformulation i.e. Chitosan (CS)-coated-IRN-loaded-poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) (CS-IRN-PLGA-NPs)in order to enhance oral bioavailability of IRN...
July 9, 2018: Journal of Microencapsulation
Mariangela de Burgos M de Azevedo, Vitor H S de Melo, Carlos Roberto J Soares, Douglas M Miyamoto, Ricardo A Katayama, Peterson L Squair, Caio H N Barros, Ljubica Tasic
Biodegradable polymers containing radioactive isotopes such as Holmium 166 (166 Ho) have potential applications as beta particle emitters in tumour tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Poly(d,l-lactic acid), PDLLA, was used to encapsulate holmium acetylacetonate (HoAcAc) using an emulsion solvent extraction/evaporation technique...
May 2018: Journal of Microencapsulation
J Marto, L F Gouveia, L M Gonçalves, H M Ribeiro, A J Almeida
Pharmaceutical research has been focused on developing improved delivery systems while exploring new ways of using approved excipients. The present work investigated the potential of starch nanocapsules (StNC) as a topical delivery platform for hydrophilic antimicrobial drugs using minocycline hydrochloride (MH) as a model drug. Thus, a quality by design approach was used to assess the role of different factors that affect the main pharmaceutical properties of StNC prepared using an emulsification-solvent evaporation method...
June 11, 2018: Journal of Microencapsulation
Pankaj Kumar Kathle, Nivedita Gautam, Karthikeyan Kesavan
The objective of this study was to evaluate the potential of chitosan-gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by Fourier-transform infra-red (FT-IR), differential scanning colorimetric (DSC), and X-ray diffraction (XRD) to investigate any interaction between drug and excipients. Physicochemical parameters, in vitro drug release and release kinetic were studied...
May 2018: Journal of Microencapsulation
Elahehnaz Parhizkar, Marzieh Rashedinia, Maryam Karimi, Shohreh Alipour
Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert® software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. This formulation released about 90% vitamin C within 2 h and showed higher (1...
May 2018: Journal of Microencapsulation
Zhen Jiao, Xiudong Wang, Yuting Yin, Jingxin Xia, Yanan Mei
Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138 nm and 249 nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip...
May 2018: Journal of Microencapsulation
Jianfeng Hu, Xiaotong Zhang, Jinqing Qu
There is lack of understanding on controlling of mechanical properties of moisture-curing PU/MF microcapsules which limited its further application. PU/MF microcapsules containing a core of isophorone diisocyanate (IPDI) were prepared with different chain extenders, polyetheramine D400, H2 O, triethylenetetramine and polyetheramine (PEA) D230 by following a two-step synthesis method in this study. Fourier transform infra-red (FTIR) spectroscopy, Malvern particle sizing, scanning electron microscopy (SEM), and transmission electron microscopy (TEM)...
May 2018: Journal of Microencapsulation
Sonia Pandey, S M Vijayendra Swamy, Arti Gupta, Akshay Koli, Swagat Patel, Furqan Maulvi, Bhavin Vyas
PURPOSE: To optimise the Eudragit/Surelease® -coated pH-sensitive pellets for controlled and target drug delivery to the colon tissue and to avoid frequent high dosing and associated side effects which restrict its use in the colorectal-cancer therapy. METHODS: The pellets were prepared using extrusion-spheronisation technique. Box-Behnken and 32 full factorial designs were applied to optimise the process parameters [extruder sieve size, spheroniser-speed, and spheroniser-time] and the coating levels [%w/v of Eudragit S100/Eudragit-L100 and Surelease® ], respectively, to achieve the smooth optimised size pellets with sustained drug delivery without prior drug release in upper gastrointestinal tract (GIT)...
May 2018: Journal of Microencapsulation
Guoqing Zhang, Fanyue Meng, Zhen Guo, Tao Guo, Hui Peng, Jian Xiao, Botao Liu, Vikaramjeet Singh, Shuangying Gui, Peter York, Wei Qian, Li Wu, Jiwen Zhang
γ-Cyclodextrin metal-organic frameworks (γ-CD-MOFs) are highly porous and bio-friendly novel materials formed by γ-CD as an organic ligand and potassium ion as an inorganic metal centre. The aim of this study was to enhance the stability of vitamin A palmitate (VAP) using γ-CD-MOFs as the carrier. Herein, γ-CD-MOFs displayed VAP microencapsulating capacity of 9.77 ± 0.24% with molar ratio as nMOFs :nVAP  = 3.2:1.0. It was important to find that the improved stability of VAP microencapsulated by γ-CD-MOFs without addition of any antioxidant(s) was better than that of the best available reference product in the market, with 1...
May 2018: Journal of Microencapsulation
Lijiang Chen, Jinfeng Zhang, Jinghong Rong, Yu Liu, Jinhua Zhao, Qingguo Cui, Xin Wang, Xiao Liang, Hao Pan, Hongsheng Liu
Rhein (RH) have many bioactivities, but the application was limited of its poor solubility. The present study aimed to establish an efficient method for the synthesis of rhein amide derivatives (RAD) to increase the solubility and anti-tumor activity. RAD exhibited stronger anti-tumor activity than RH in MTT assay. The solubility and oil/water partition coefficient results indicated that rhein-phenylalanine and rhein-isoleucine have better absorption effect, which was consolidated in pharmacokinetic study. Then, rhein-phenylalanine and rhein-isoleucine were prepared into nanocrystals via the precipitation-high pressure homogenization method...
April 23, 2018: Journal of Microencapsulation
Alexandra Moschona, Maria Liakopoulou-Kyriakides
Grapes (Vitis vinifera) are produced in large amounts worldwide and mostly are used for winemaking. Their untreated wastes are rich in valuable secondary metabolites, such as phenolics. Thus, in this study, white and red wine wastes (Malagouzia and Syrah variety) were investigated for their added value phenolics, which were analysed by high performance liquid chromatography (HPLC) and electrospray ionisation-mass spectrometry (ESI/MS) and subsequently encapsulated in several polymers. Extracts from all wastes gave high amounts of total phenolics (13 ± 2...
May 2018: Journal of Microencapsulation
Lulu Wang, Yingying Ma, Yu Gu, Yangyang Liu, Juan Zhao, Beibei Yan, Yancai Wang
Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nanosuspension and quercetin (QUE) nanosuspension was evaluated. D-α-tocopheryl polyethylene glycol succinate (TPGS) and folate-modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) were selected as functional stabilisers formulated nanosuspension which were prepared by anti-solvent precipitation method...
May 2018: Journal of Microencapsulation
Ankita Sharma, Navneet Kaur, Saurabh Sharma, Amit Sharma, M S Rathore, Kumar Ajay, Neeraj Mishra
The aim of the present study is to develop embelin-loaded guar gum microparticles through emulsification technique. The in vitro release of the optimised formulation was found to be 88.5 ± 3.8% in 24 h, has exhibited remarkably sustain and delayed the release of embelin at a specific site. Embelin-loaded microparticles showed average particle size of 12.9 ± 0.75 µm. The statistical analysis was carried out by one-way ANOVA followed by comparison test of Bonferroni. P values < 0.05 were considered as significant...
March 2018: Journal of Microencapsulation
Jitendrakumar Patel, Jitendra Amrutiya, Priyanka Bhatt, Ankit Javia, Mukul Jain, Ambikanandan Misra
The aim of this study was to develop anti-EGFR antibody conjugated poly(lactide-co-glycolide) nanoparticles (NPs) to target epidermal growth factor receptor, highly expressed on non-small cell lung cancer cells to improve cytotoxicity and site specificity. Cetuximab was conjugated to docetaxel (DTX) loaded PLGA NPs by known EDC/NHS chemistry and characterised for size, zeta potential, conjugation efficiency and the results were 128.4 ± 3.6 nm, -31.0 ± 0.8 mV, and 39.77 ± 3.4%, respectively...
March 2018: Journal of Microencapsulation
He Zhang, Jinglei Yang
Hollow glass bubbles (HGBs) with through-holes at micron level were fabricated by etching them using diluted 1% hydrofluoric acid (HF) solution in a specially designed reaction system. In this study, the function of each component in the system was carefully investigated and improved to realise the controllable etching process. Various parameters were investigated to explore the optimal etching condition. Highest gross yield of about 85% and effective yield of about 50% were obtained at the optimised etching condition...
March 2018: Journal of Microencapsulation
Sandra Rojas-Moreno, Guillermo Osorio-Revilla, Tzayhrí Gallardo-Velázquez, Fernando Cárdenas-Bailón, Gabriela Meza-Márquez
Orange essential oil was microencapsulated by complex coacervation with whey protein isolate (WPI): carboxymethylcellulose (CMC), WPI:sodium alginate (SA) and WPI:chitosan (CH). Effect of pH, protein:polysaccharide ratio and solid concentration on coacervation efficiency were selected for the best coacervation conditions. Tannic acid (TA), sodium tripolyphosphate, oxidised tannic acid and transglutaminase enzyme (TG) were used as cross-linking agents. Highest encapsulation efficiency (EE) for wet coacervated microcapsules ranged from 88% to 94%...
March 2018: Journal of Microencapsulation
Zerrin Sezgin-Bayindir, Ayse Eser Elcin, Mahmut Parmaksiz, Yasar Murat Elcin, Nilufer Yuksel
Medication during pregnancy is often a necessity for women to treat their acute or chronic diseases. The goal of this study is to evaluate the potential of micelle-like nanoparticles (MNP) for providing safe drug usage in pregnancy and protect both foetus and mother from medication side effects. Clonazepam-loaded MNP were prepared from copolymers [polystyrene-poly(acrylic acid) (PS-PAA), poly(ethylene glycol)-b-poly(lactic acid) (PEG-PLA) and distearyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol) (PEG-DSPE)] with varying monomer ratios and their drug-loading efficiency, drug release ratio, particle size, surface charge and morphology were characterised...
March 2018: Journal of Microencapsulation
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