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Journal of Microencapsulation

Lijiang Chen, Jinfeng Zhang, Jinghong Rong, Yu Liu, Jinhua Zhao, Qingguo Cui, Xin Wang, Xiao Liang, Hao Pan, Hongsheng Liu
Rhein (RH) have many bioactivities, but the application was limited of its poor solubility. The present study aimed to establish an efficient method for the synthesis of rhein amide derivatives (RAD) to increase the solubility and anti-tumor activity. RAD exhibited stronger anti-tumor activity than RH in MTT assay. The solubility and oil/water partition coefficient results indicated that rhein-phenylalanine and rhein-isoleucine have better absorption effect, which was consolidated in pharmacokinetic study. Then, rhein-phenylalanine and rhein-isoleucine were prepared into nanocrystals via the precipitation-high pressure homogenization method...
April 23, 2018: Journal of Microencapsulation
Zhen Jiao, Xiudong Wang, Yuting Yin, Jingxin Xia, Yanan Mei
Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterized. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138nm and 249nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip...
April 19, 2018: Journal of Microencapsulation
Sonia Pandey, Vijayendra Swamy, Arti Gupta, Akshay Koli, Swagat Patel, Furqan Maulvi, Bhavin Vyas
Purpose To optimize the Eudragit/Surelease® coated pH-sensitive pellets for controlled and target drug delivery to the colon tissue and to avoid frequent high dosing and associated side effects which restrict its use in the colorectal-cancer therapy. Methods The pellets were prepared using extrusion-spheronization technique. Box-Behnken and 32 full factorial designs were applied to optimize the process parameters [extruder sieve size, spheronizer-speed and spheronizer-time] and the coating levels [%w/v of Eudragit S100/Eudragit-L100 and Surelease® ] respectively, to achieve the smooth optimized size pellets with sustained drug delivery without prior drug release in upper gastrointestinal tract (GIT)...
April 16, 2018: Journal of Microencapsulation
Alexandra Moschona, Maria Liakopoulou-Kyriakides
Grapes (Vitis vinifera) are produced in large amounts worldwide and mostly are used for winemaking. Their untreated wastes are rich in valuable secondary metabolites, such as phenolics. Thus, in this study, white and red wine wastes ("Malagouzia" and "Syrah" variety) were investigated for their added value phenolics, which were analyzed by HPLC-ESI/MS and subsequently encapsulated in several polymers. Extracts from all wastes gave high amounts of total phenolics (13±2.72-22±2.69 mg g-1 ) and possessed high antioxidant activity (67-97%)...
April 12, 2018: Journal of Microencapsulation
Jianfeng Hu, Xiaotong Zhang, Jinqing Qu
There is lack of understanding on controlling of mechanical properties of moisture-curing PU/MF microcapsules which limited its further application. PU/MF microcapsules containing a core of isophorone diisocyanate (IPDI) were prepared with different chain extenders, polyetheramine D400, H2 O, triethylenetetramine and Polyetheramine (PEA) D230 by following a two-step synthesis method in this study. Fourier transform infra-red (FTIR) spectroscopy, Malvern particle sizing, scanning electron microscopy (SEM), transmission electron microscopy (TEM)...
April 9, 2018: Journal of Microencapsulation
Guoqing Zhang, Fanyue Meng, Zhen Guo, Tao Guo, Hui Peng, Jian Xiao, Botao Liu, Vikaramjeet Singh, Shuangying Gui, Peter York, Wei Qian, Li Wu, Jiwen Zhang
γ-Cyclodextrin metal-organic frameworks (γ-CD-MOFs) are highly porous and bio-friendly novel materials formed by γ-CD as a organic ligand and potassium ion as a inorganic metal center. The aim of this study was to enhance the stability of vitamin A palmitate (VAP) using γ-CD-MOFs as the carrier. Herein, γ-CD-MOFs displayed VAP microencapsulating capacity of 9.77 ± 0.24% with molar ratio as nMOFs :nVAP = 3.2:1.0. It was important to find that the improved stability of VAP microencapsulated by γ-CD-MOFs without addition of any antioxidant(s) was better than that of the best available reference product in the market, with 1...
April 6, 2018: Journal of Microencapsulation
Lulu Wang, Yingying Ma, Yu Gu, Yangyang Liu, Juan Zhao, Beibei Yan, Yancai Wang
Freeze-drying is an effective way to improve long term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In the present study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nanosuspension and quercetin (QUE) nanosuspension was evaluated. D-α-tocopheryl polyethylene glycol succinate (TPGS) and folate modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) were selected as functional stabilizers formulated nanosuspension which were prepared by anti-solvent precipitation method...
April 6, 2018: Journal of Microencapsulation
Ankita Sharma, Navneet Kaur, Saurabh Sharma, Amit Sharma, M S Rathore, Kumar Ajay, Neeraj Mishra
The aim of the present study is to develop embelin loaded guar gum microparticles through emulsification technique. The in vitro release of the optimized formulation was found to be 88.5±3.8% in 24 hr, have exhibit remarkably sustain and delayed the release of embelin at a specific site. Embelin loaded microparticles showed average particle size of 12.9± 0.75 µm. The statistical analysis was carried out by one way anova followed by comparison test of Bonferroni. P values<0.05 were considered as significant...
March 15, 2018: Journal of Microencapsulation
Jitendrakumar Patel, Jitendra Amrutiya, Priyanka Bhatt, Ankit Javia, Mukul Jain, Ambikanandan Misra
Aim of this study was to develop anti EGFR antibody conjugated poly (lactide-co-glycolide) nanoparticles (NPs) to target epidermal growth factor receptor, highly expressed on non-small cell lung cancer cells to improve cytotoxicity and site specificity. Cetuximab was conjugated to Docetaxel loaded PLGA NPs by known EDC/NHS chemistry and characterized for size, zeta potential, conjugation efficiency and results were 128.4 ±3.6 nm, -31.0 ± 0.8 mV and 39.77 ± 3.4% respectively. In-vitro release study demonstrated sustained release of drug from NPs with 25% release at pH 5...
March 15, 2018: Journal of Microencapsulation
He Zhang, Jinglei Yang
Hollow glass bubbles (HGBs) with through-holes at micron level were fabricated by etching them using diluted 1% hydrofluoric acid (HF) solution in a specially designed reaction system. In this study, the function of each component in the system was carefully investigated and improved to realize the controllable etching process. Various parameters were investigated to explore the optimal etching condition. Highest gross yield of about 85% and effective yield of about 50% were obtained at the optimized etching condition...
March 14, 2018: Journal of Microencapsulation
Sandra Rojas-Moreno, Guillermo Osorio-Revilla, Tzayhrí Gallardo-Velázquez, Fernando Cárdenas-Bailón, Gabriela Meza-Márquez
Orange essential oil was microencapsulated by complex coacervation with whey protein isolate (WPI):carboxymethylcellulose (CMC), WPI:sodium alginate (SA) and WPI:chitosan (CH). Effect of pH, protein:polysaccharide ratio and solid concentration on coacervation efficiency were selected for the best coacervation conditions. Tannic acid, sodium tripolyphosphate, oxidized tannic acid and transglutaminase enzyme were used as cross-linking agents. Highest encapsulation efficiency (EE) for wet coacervated microcapsules ranged from 88-94%...
March 7, 2018: Journal of Microencapsulation
Zerrin Sezgin-Bayindir, Ayse Eser Elcin, Mahmut Parmaksiz, Yasar Murat Elcin, Nilufer Yuksel
Medication during pregnancy is often a necessity for women to treat their acute or chronic diseases. The goal of this study is to evaluate the potential of micelle-like nanoparticles (MNP) for providing safe drug usage in pregnancy and protect both fetus and mother from medication side effects. Clonazepam loaded MNP were prepared from copolymers (polystyrene-poly(acrylic acid) (PS-PAA), poly(ethylene glycol)-b-poly(lactic acid) (PEG-PLA) and distearyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol) (PEG-DSPE)) with varying monomer ratios and their drug loading efficiency, drug release ratio, particle size, surface charge and morphology were characterized...
March 1, 2018: Journal of Microencapsulation
Vanka Ravisankar, Gowthamarajan Kuppusamy, Praveen Kumar Simhadri, Uday Krishna Baruah, Veera Venkata Satyanarayana Reddy Karri, Vimal Pandey, Phanithi Prakash Babu
Cerebral malaria (CM) is a fatal neurological complication of Plasmodium falciparum infection that affects children (below five years old) in sub-Saharan Africa and adults in South-East Asia each year having the fatality rate of 10-25%. The survivors of CM also have high risk of long term neurological or cognitive deficits. The objective of the present investigation was to develop optimized nanostructured lipid carriers (NLCs) of artemether (ARM) for enhanced anti-malarial efficacy of ARM.NLCs of ARM were prepared by a combination of high speed homogenization (HSH) and probe sonication techniques...
February 16, 2018: Journal of Microencapsulation
Manpreet Singh, Vandana Thakur, Rahul Deshmukh, Amit Sharma, M S Rathore, Ajay Kumar, Neeraj Mishra
The aim of this study was to prepare and characterize oral delivery of Morin hydrate loaded micellar nanocarriers using Pluronic P127 & Pluronic F123 for the effective management of Alzheimer's disease. After administration of formulation brain and blood drug concentration were found to be highest for optimized morin hydrate loaded micellar nanocarriers as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate loaded micellar nanocarriers as compared to disease control group...
February 16, 2018: Journal of Microencapsulation
Chang Liu, Zijun Zhou, Ye Chen, Ju Liu, Yang Wang, Hongsheng Liu
Scavenger receptor class B type 1 (SR-B1) is over-expressed in tumour cells where it mediates the uptake of drug payload of reconstituted high density lipoprotein (rHDL) via the process of reverse cholesterol transport. In this study, rHDL was prepared to determine its function as a drug delivery carrier for targeting hepatocellular carcinoma by incorporating the anti-tumour drug garcinia glycosides (GG) into rHDL to yield rHDL/GG nano-complexes. Structural analysis indicated that the rHDL/GG nano-complex was similar to HDL in size...
February 7, 2018: Journal of Microencapsulation
Maiara Taís Bazana, Aline S Gonçalves, Paulo Guilherme R Schimites, Jader B Ruchel, João Felipe P Rezer, Daniela B Rosa Leal, Cristiane de B da Silva
This study aimed to develop gel-creams from the lyophilised product of betamethasone dipropionate-loaded lipid-core nanocapsule suspensions and evaluated its efficacy in a model of contact dermatitis. The gel-creams were prepared and characterized followed by a study of in vitro drug penetration/permeation and its in vivo efficacy. The suspensions and lyophilised products showed nanometric size; the betamethasone content was 0.25 ± 0.01 mg/mL and the encapsulation efficiency was approximately 100%. The nanocapsules and redispersed powders presented control of the drug release...
January 29, 2018: Journal of Microencapsulation
Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal
Brimonidine ocular hypotensive effect can be enhanced by increasing residence time and corneal penetration. The current work aimed to formulate, evaluate and compare nanostructured lipid carriers (NLCs) to solid lipid nanoparticles (SLNs) and commercial eye drops for controlled brimonidine delivery. NLCs prepared by modified high shear homogenisation were spherical with a mean size of 151.97 ± 1.98 nm, negative zeta potential (ZP) of -44.2 ± 7.81 mV, % entrapment efficiency (EE) of 83.631 ± 0...
January 2018: Journal of Microencapsulation
Gagandeep Manchanda, Rupinder Kaur Sodhi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
OBJECTIVES: Curcumin (Cur) exhibits weak microbicidal activity owing to high lipophilicity and low cell permeability. Therefore, in the present investigation, Cur was iodinated using elemental iodine (I2 ) to synthesise Cur-I2 powder that was later formulated as Cur-I2 dermal cream and characterised in vitro for antimicrobial and antioxidant activities. METHODS AND RESULTS: Electrophilic addition of I2 saturated the olefinic bonds of Cur, as confirmed by UV/visible spectroscopy, FT-IR, 1 H NMR and DSC techniques...
January 2018: Journal of Microencapsulation
Xiaoyun Wang, Fengbo Wu, Yuyu Chen, Feifei Qin, Jinku Bao, Guo Chen
Pogostone analogous XW-12 displays an inhibitory effect on Staphylococcus aureus. However, the insolubility of the compound has restricted its further applications. This work aims to improve the water-solubility of XW-12, we used previously synthesised pogostone derivatives XW-12, forming nanoparticles with PLGA-PEG by a single-emulsion solvent-evaporation technique. Characterisations of XW-12 nanoparticles were performed. The in vitro and in vivo experiments confirmed its antimicrobial efficacy and toxicity...
January 2018: Journal of Microencapsulation
Qiang Wang, Hong Zhang, Juan Huang, Nan Xia, Tong Li, Qiang Xia
This study aimed at the in vitro evaluation of topical hydrogels containing vitamin C-loaded self-double-emulsifying drug delivery system (SDEDDS). The liquid SDEDDS was converted into suitable unmodified xanthan gum hydrogels formulation and the prepared semi-solid hydrogels provided appropriate gel characteristics like pH, viscosity, spreadability, etc. The 5-week storage test displayed that the prepared hydrogels possessed good physicochemical stability. In addition, no significant cytotoxicity to L929 cells was observed for the vitamin C-loaded SDEDDS-based hydrogels, and the prepared hydrogels depicted a sustained drug release over an 8-h period...
January 2018: Journal of Microencapsulation
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