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Journal of Microencapsulation

Menghua Xiong, Qian Lei, Xinyu You, Tiantao Gao, Xuejiao Song, Yong Xia, Tinghong Ye, Lidan Zhang, Ningyu Wang, Luoting Yu
Mannose receptor (MR) is a highly effective endocytic receptor. It is closely related to tumor immune escape and metastasis. We found that MR was highly expressed in some colon cancer cell lines such as CT26 and HCT116 cells. Therefore MR might be a potential target in colon cancer therapy. In this study, we aimed to develop mannosylated liposomes containing anticancer drug paclitaxel (PTX) and investigate the potential effects on targeted therapy for colon cancer. Mannosylated liposomes were prepared by film dispersion method...
July 14, 2017: Journal of Microencapsulation
Hamed Alizadeh Sardroud, Sorour Nemati, Ali Bardar Khoshfetrat, Mahbobeh Nabavinia, Younes Beygi Khosrowshahi
Influence of gelatin concentration and crosslinker ions of Ca(2+) and Ba(2+) was evaluated on characteristics of alginate hydrogels and proliferation behaviors of model adherent and suspandable stem cells of fibroblast and U937 embedded in alginate microcapsules. Increasing gelatin to 2.5% increased extent of swelling to 15% and 25% for barium and calcium-crosslinked hydrogels, respectively. Mechanical properties also decreased with increasing swelling of hydrogels. Both increasing gelatin concentration and using barium ion increased considerably the proliferation of encapsulated model stem cells...
July 12, 2017: Journal of Microencapsulation
Michael Przyklenk, Marina Vemmer, Miriam Hanitzsch, Anant Patel
This study reports the development of encapsulated and dried entomopathogenic fungus Metarhiuzm brunneum with reduced conidia content, increased conidiation, a high drying survival and enhanced shelf life. Dried beads prepared with the fillers corn starch, potato starch, carboxymethylcellulose or autoclaved baker's yeast, showed enhanced survival with increasing filler content. The maximum survival of 82% was found for beads with 20% corn starch at <0.1 water activity. While increasing starch content inhibits the conidiation, autoclaved baker´s yeast and a combination with starch enhanced the conidiation to 1...
July 12, 2017: Journal of Microencapsulation
Amira E El-Nahas, Ahmed N Allam, Amal H El-Kamel
Eudragit-loaded silymarin nanoparticles (SNPs) and their formulation into buccal mucoadhesive tablets were investigated to improve the low bioavailability of silymarin through buccal delivery. Characterisation of SNPs and silymarin buccal tablets (SBTs) containing the optimised NPs were performed. Ex vivo permeability of nominated SBTs were assessed using chicken pouch mucosa compared to SNPs and drug suspension followed by histopathological examination. Selected SNPs had a small size (<150 nm), encapsulation effciency (>77%) with drug release of about 90% after 6 h...
July 9, 2017: Journal of Microencapsulation
Murat Demirbilek, Nelisa Laçin Türkoglu, Selçuk Aktürk, Cem Akça
Vitamin D3 (VitD3) has several beneficial effects on many metabolic pathways such as immunity system, bone development. The aim of the study, encapsulation of VitD3 with solid lipids, determine encapsulation efficiency and biocompatibility of nanoparticles. Therefore, VitD3-loaded solid lipid nanoparticles (SLNPs) were developed by optimising ratios of VitD3, stearic acid, beeswax and sodium dodecyl sulphate (SDS). Thermal stability, degradation profile, crystallinity rate, encapsulation efficiency and release profile of SLNPs were determined...
July 4, 2017: Journal of Microencapsulation
Sudipta Chatterjee, Zaher M A Judeh
Fish oil microcapsules were successfully prepared from fish oil-in-water emulsions using chitosan as shell material and anionic surfactants sodium dodecyl sulphate (SDS), sodium dodecylbenzenesulfonate (SDBS), sodium cholate (cholate), and sodium deoxycholate (DOC) as emulsifiers. The type of emulsifier influenced the physicochemical characteristics of the prepared microcapsules to different extents. The microcapsules formed with DOC showed the least mean effective diameter (MED) of 500 nm. Emulsion formed with DOC exhibited the smallest MED of 100 nm...
June 28, 2017: Journal of Microencapsulation
Pavlina Holcapkova, Martina Hrabalikova, Petra Stoplova, Vladimir Sedlarik
This work is focused on preparation of novel porous type of core-shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent - nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy...
June 21, 2017: Journal of Microencapsulation
David Encinas-Basurto, Jaime Ibarra, Josué Juarez, María G Burboa, Silvia Barbosa, Pablo Taboada, Rosalba Troncoso-Rojas, Miguel A Valdez
The objective of this study is to establish the ability of entrap allyl isothiocyanate (AITC) into polymeric nanoparticles to extend its shelf life and enhance its antiproliferative properties. Natural compounds, such as AITC, have showed multi-targeting activity resulting in a wide-range spectrum of therapeutic properties in chronic and degenerative diseases, conversely with most current pharmaceutical drugs showing single targeting activity and often result in drug resistance after extended administration periods...
June 20, 2017: Journal of Microencapsulation
Fábio J Rodrigues, Michele H Omura, Marina F Cedran, Robert F H Dekker, Aneli M Barbosa-Dekker, Sandra Garcia
Linseed and okra mucilages, the fungal exopolysaccharide botryosphaeran, and commercial fructo-oligosaccharides (FOS) were used to microencapsulate Lactobacillus casei LC-01 and Lactobacillus casei BGP 93 in sodium alginate microspheres by the extrusion technique in calcium chloride. The addition of carbohydrate biopolymers from linseed, okra and the fungal exocellular (1→3)(1→6)-β-D-glucan, named botryosphaeran provided higher encapsulation efficiency (EE) (> 93% and > 86%) for L. casei LC 01 and L...
June 16, 2017: Journal of Microencapsulation
Jingyuan Xiong, Huile Gao
Tumor poses tremendous challenges to mankind. In various tumors, matrix metalloproteases (MMPs) are ubiquitously over expressed and participate throughout the process of tumor development. MMPs are commonly used as internal stimuli, and MMPs responsive nanomaterials are classified into three categories according to the drug delivery process: administration and distribution to tumor, intratumoral distribution and cell internalization, and specific drug release. Firstly, MMPs sensitive polyethylene glycol (PEG) de-shielding and activatable cell penetrating peptides were developed to improve the blood circulation time of drug delivery systems, thereby, enhancing tumor or stroma cells recognition and penetration...
June 15, 2017: Journal of Microencapsulation
Omer Salman Qureshi, Hyung-Seo Kim, Alam Zeb, Jin-Seok Choi, Hoo-Seong Kim, Jung-Eun Kwon, Myung-Sic Kim, Jong-Ho Kang, Chongsuk Ryou, Jeong-Sook Park, Jin-Ki Kim
The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) to improve the pharmacokinetic behaviour of docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid lipid and Tween-40/Span-40/Myrj S40 as a surfactants mixture. Spherical DTX-NPs below 100 nm were successfully prepared with a narrow particle size distribution, 96% of incorporation efficiency and 686 times increase in DTX solubility...
June 15, 2017: Journal of Microencapsulation
Abdulsalam M Kassem, Hany M Ibrahim, Ahmed M Samy
The objective of this study was to develop and optimise self-nanoemulsifying drug delivery system (SNEDDS) of atorvastatin calcium (ATC) for improving dissolution rate and eventually oral bioavailability. Ternary phase diagrams were constructed on basis of solubility and emulsification studies. The composition of ATC-SNEDDS was optimised using the Box-Behnken optimisation design. Optimised ATC-SNEDDS was characterised for various physicochemical properties. Pharmacokinetic, pharmacodynamic and histological findings were performed in rats...
May 23, 2017: Journal of Microencapsulation
Hitesh Dalvadi, Nikita Patel, Komal Parmar
The aim of present investigation is to improve dissolution rate of poor soluble drug Zotepine by a self-microemulsifying drug delivery system (SMEDDS). Ternary phase diagram with oil (Oleic acid), surfactant (Tween 80) and co-surfactant (PEG 400) at apex were used to identify the efficient self-microemulsifying region. Box-Behnken design was implemented to study the influence of independent variables. Principal Component Analysis was used for scrutinising critical variables. The liquid SMEDDS were characterised for macroscopic evaluation, % Transmission, emulsification time and in vitro drug release studies...
May 17, 2017: Journal of Microencapsulation
Hoai X Nguyen, Edgar A O'Rear
In this study, we describe the synthesis of an amine-modified acetalated dextran polymer, which is combined with heparin (HP) as the basis for a novel controlled release system. Dextran-amine (DEXAM) conjugates, synthesised using reductive amination, were incorporated into DEXAM/HP microspheres. HP binds to positively charged ammonium ions of the DEXAM conjugates, contributing to the structural integrity of the microspheres. Crystal violet (CV) was encapsulated inside DEXAM/HP microspheres as a model drug to test the system...
May 10, 2017: Journal of Microencapsulation
Zhaoying Sun, Shujie Yuan, Huanan Zhao, Zhenyang Wang, Zhiming Liu
1-Deoxynojirimycin sustained-release pellets, which exhibit known release and absorption profiles, are used for the treatment of diabetes mellitus. In this study, a fluidised bed coater was employed to prepare new, drug-loaded pellets. In the dissolution test, it was found that 1-DNJ pellets exhibited a sustained release effect after being coated with hydroxypropyl methyl cellulose phthalate-55 S. For sustained-release pellets and immediate-release pellets, there was significant difference in the mean cumulative drug concentration profile in different media evaluation...
May 8, 2017: Journal of Microencapsulation
Zeinab Sadat Sheikholeslami, Hamed Salimi-Kenari, Mohammad Imani, Mohammad Atai, Azizollah Nodehi
Carboxymethyl chitosan (CMCh), as a non-toxic, biocompatible and biodegradable semi-synthetic biopolymer with mucoadhesive properties, is widely investigated for targeting drug or gene delivery applications. Here, fabrication of CMCh nanoparticles will be reported using a reverse (w/o) micellar system to provide particles with tuneable mean sizes. Reverse microemulsions were prepared by dispersing aqueous solution of CMCh in n-hexane using sodium-bis(ethylhexyl)-sulfosuccinate (AOT) and glutaraldehyde (GA) as an emulsifier and a crosslinking agent, respectively...
May 5, 2017: Journal of Microencapsulation
Nadia Morsi, Dalia Ghorab, Hanan Refai, Hoda Teba
Mucoadhesive polymeric films incorporated with ketorolac tromethamine-loaded nanodispersion aiming the sustained delivery of the drug to the cornea have been developed and characterised for the treatment of post-operative ocular inflammation. Nanodispersions were prepared by ionic gelation method with various concentrations of chitosan and sodium tripolyphosphate. The developed nanodispersions were analysed for morphology, particle size, dispersion homogeneity, zeta potential, entrapment efficiency and drug release...
May 5, 2017: Journal of Microencapsulation
Joo Ran Kim
The purpose of this study was to develop acaricidal cotton fabrics grafted with eucalyptus oil-loaded microcapsules (EOMCs) produced from green resources. EOMCs showed a broad size distribution between 0.5 and 6.5 μm, and had the average diameter 1.8 μm. EOMCs exhibited nonporous spherical shapes and individually remained on cotton fibres. Through AATCC mortality tests against house dust mites (HDMs) (Dermatophagoides farinae), the treated cotton fabric containing EOMCs resulted in 98.7% mortality. Acaricidal efficiency was due to the large amount of oxygenated monoterpene, 1,8-eucalyptol (75...
April 26, 2017: Journal of Microencapsulation
Yijun Chen, James G Boyd, Mohammad Naraghi
A novel sequential processing approach to fabricate versatile fibres containing encapsulated materials is presented. It is based on developing highly porous fibres, to be filled with functional materials and coated with protective layers. Applicability of the approach to develop porous poly(methyl methacrylate) (PMMA) fibres with encapsulated antibacterial salts within a coating is demonstrated. The salt was introduced to the fibre via a sacrificial solvent. Desired solvent properties to ensure successful filling was discussed...
June 2017: Journal of Microencapsulation
Archu Singh, Yub Raj Neupane, Bibhu Prasad Panda, Kanchan Kohli
This study aims at developing an optimised nanostructured lipid carrier (NLC) of lycopene for efficient absorption following oral administration. The optimised formulation showed an average particle size of 121.9 ± 3.66 nm, polydispersity index (PDI) 0.370 ± 0.97 and zeta potential -29.0 ± 0.83 mV. Encapsulation Efficiency (% EE) and drug loading (% DL) was found to be 84.50% ± 4.38 and 9.54% ± 2.65, respectively. In vitro release studies demonstrated the burst release within 4-9 h followed by sustained release over 48 h...
June 2017: Journal of Microencapsulation
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