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Journal of Microencapsulation

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https://www.readbyqxmd.com/read/28436713/modified-dextran-heparin-based-triggered-release-microspheres-for-cardiovascular-delivery-of-therapeutic-drugs-using-protamine-as-a-stimulus
#1
Hoai X Nguyen, Edgar A O'Rear
In this study, we describe the synthesis of an amine-modified acetalated dextran polymer, which is combined with heparin (HP) as the basis for a novel controlled release system. Dextran-amine (DEXAM) conjugates, synthesised using reductive amination, were incorporated into DEXAM/HP microspheres. HP binds to positively charged ammonium ions of the DEXAM conjugates, contributing to the structural integrity of the microspheres. Crystal violet (CV) was encapsulated inside DEXAM/HP microspheres as a model drug to test the system...
May 10, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28481663/development-and-optimization-of-atorvastatin-calcium-loaded-self-nanoemulsifying-drug-delivery-system-snedds-for-enhancing-oral-bioavailability-in-vitro-and-in-vivo-evaluation
#2
Abdulsalam M Kassem, Hany M Ibrahim, Ahmed M Samy
The objective of this study was to develop and optimize self-nanoemulsifying drug delivery system (SNEDDS) of atorvastatin calcium (ATC) for improving dissolution rate and eventually oral bioavailability. Ternary phase diagrams were constructed on basis of solubility and emulsification studies. The composition of ATC-SNEDDS was optimized using Box-Behnken optimization design. Optimized ATC-SNEDDS was characterized for various physicochemical properties. Pharmacokinetic, pharmacodynamic and histological finding were performed in rats...
May 8, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28425304/preparation-and-evaluation-of-1-deoxynojirimycin-sustained-release-pellets-vs-conventional-immediate-release-tablets
#3
Zhaoying Sun, Shujie Yuan, Huanan Zhao, Zhenyang Wang, Zhiming Liu
1-Deoxynojirimycin sustained-release pellets, which exhibit known release and absorption profiles, are used for the treatment of diabetes mellitus. In this study, a fluidised bed coater was employed to prepare new, drug-loaded pellets. In the dissolution test, it was found that 1-DNJ pellets exhibited a sustained release effect after being coated with hydroxypropyl methyl cellulose phthalate-55 S. For sustained-release pellets and immediate-release pellets, there was significant difference in the mean cumulative drug concentration profile in different media evaluation...
May 8, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28378606/efficacy-of-nano-and-microemulsion-based-topical-gels-in-delivery-of-ibuprofen-an-in-vivo-study
#4
Mosayeb Azizi, Fariba Esmaeili, Alireza Partoazar, Shahram Ejtemaei Mehr, Amir Amani
AIM: Nanoemulsion has shown many advantages in drug delivery systems. In this study, for the first time, analgesic and anti-inflammatory properties of a nanomelusion of almond oil with and without ibuprofen was compared with corresponding microemulsion and commercial topical gel of the drug using formalin and carrageenan tests, respectively. METHOD: Almond oil (oil phase) was mixed with Tween 80 and Span 80 (surfactants), and ethanol (co-surfactant) and them distilled water (aqueous phase) was then added to the mixture at once...
May 8, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28420311/exploring-the-effect-of-formulation-parameters-on-the-particle-size-of-carboxymethyl-chitosan-nanoparticles-prepared-via-reverse-micellar-crosslinking
#5
Zeinab Sadat Sheikholeslami, Hamed Salimi-Kenari, Mohammad Imani, Mohammad Atai, Azizollah Nodehi
Carboxymethyl chitosan (CMCh), as a non-toxic, biocompatible and biodegradable semi-synthetic biopolymer with mucoadhesive properties, is widely investigated for targeting drug or gene delivery applications. Here, fabrication of CMCh nanoparticles will be reported using a reverse (w/o) micellar system to provide particles with tuneable mean sizes. Reverse microemulsions were prepared by dispersing aqueous solution of CMCh in n-hexane using sodium-bis(ethylhexyl)-sulfosuccinate (AOT) and glutaraldehyde (GA) as an emulsifier and a crosslinking agent, respectively...
May 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28420308/nanodispersion-loaded-mucoadhesive-polymeric-inserts-for-prolonged-treatment-of-post-operative-ocular-inflammation
#6
Nadia Morsi, Dalia Ghorab, Hanan Refai, Hoda Teba
Mucoadhesive polymeric films incorporated with ketorolac tromethamine-loaded nanodispersion aiming the sustained delivery of the drug to the cornea have been developed and characterised for the treatment of post-operative ocular inflammation. Nanodispersions were prepared by ionic gelation method with various concentrations of chitosan and sodium tripolyphosphate. The developed nanodispersions were analysed for morphology, particle size, dispersion homogeneity, zeta potential, entrapment efficiency and drug release...
May 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28452252/systematic-development-of-doe-optimized-self-microemulsifying-drug-delivery-system-of-zotepine
#7
Hitesh Dalvadi, Nikita Patel, Komal Parmar
The aim of present investigation is to improve Dissolution rate of poor soluble drug Zotepine by a Self- micro emulsifying drug delivery system (SMEDDS). Ternary phase diagram with oil (Oleic acid), surfactant (Tween 80) and co-surfactant (PEG 400) at apex were used to identify the efficient self-microemulsifying region. Box-Behnken design (BBD) was implemented to study the influence of independent variables. Principal Component Analysis was used for scrutinizing critical variables. The liquid SMEDDS were characterized for macroscopic evaluation, % Transmission, emulsification time and in vitro drug release studies...
April 28, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28449614/poly-lactic-co-glycolic-acid-nanoparticles-for-sustained-release-of-allyl-isothiocyanate-characterization-in-vitro-release-and-biological-activity
#8
David Encinas-Basurto, Jaime Ibarra, Josué Juarez, María G Burboa, Silvia Barbosa, Pablo Taboada, R Troncoso-Rojas, Miguel A Valdez
The objective of this study is to establish the ability of entrap allyl isothiocyanate (AITC) into polymeric nanoparticles to extend its shelf life and enhance its antiproliferative properties. Natural compounds, such as AITC, have showed multi-targeting activity resulting in a wide-range spectrum of therapeutic properties in chronic and degenerative diseases, conversely with most current pharmaceutical drugs showing single targeting activity and often result in drug resistance after extended administration periods...
April 28, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28385044/eucalyptus-oil-loaded-microcapsules-grafted-to-cotton-fabrics-for-acaricidal-effect-against-dermatophagoides-farinae
#9
Joo Ran Kim
The purpose of this study was to develop acaricidal cotton fabrics grafted with eucalyptus oil-loaded microcapsules (EOMCs) produced from green resources. EOMCs showed a broad size distribution between 0.5 and 6.5 μm, and had the average diameter 1.8 μm. EOMCs exhibited nonporous spherical shapes and individually remained on cotton fibres. Through AATCC mortality tests against house dust mites (HDMs) (Dermatophagoides farinae), the treated cotton fabric containing EOMCs resulted in 98.7% mortality. Acaricidal efficiency was due to the large amount of oxygenated monoterpene, 1,8-eucalyptol (75...
April 26, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28393603/improving-functional-properties-of-pea-protein-isolate-for-microencapsulation-of-flaxseed-oil
#10
Poonam R Bajaj, Kanishka Bhunia, Leslie Kleiner, Helen S Joyner Melito, Denise Smith, Girish Ganjyal, Shyam S Sablani
Unhydrolysed pea protein (UN) forms very viscous emulsions when used at higher concentrations. To overcome this, UN was hydrolysed using enzymes alcalase, flavourzyme, neutrase, alcalase-flavourzyme, and neutrase-flavourzyme at 50 °C for 0 min, 30 min, 60 min, and 120 min to form hydrolysed proteins A, F, N, AF, and NF, respectively. All hydrolysed proteins had lower apparent viscosity and higher solubility than UN. Foaming capacity of A was the highest, followed by NF, N, and AF. Hydrolysed proteins N60, A60, NF60, and AF60 were prepared by hydrolysing UN for 60 min and used further for microencapsulation...
April 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28378596/bcg-loaded-chitosan-microparticles-interaction-with-macrophages-and-preliminary-in-vivo-studies
#11
Liliana Aranha Caetano, Lara Figueiredo, António J Almeida, L M D Gonçalves
The aim of this study was to develop a novel BCG-loaded chitosan vaccine with high association efficiency which can afford efficient interaction with APC and elicit local and Th1-type-specific immune response after intranasal administration. Chitosan-suspended BCG and BCG-loaded chitosan-alginate microparticles were prepared by ionotropic gelation. Interaction with APC was evaluated by fluorescence microscopy using rBCG-GFP. Specific immune responses were evaluated following intranasal immunisation of mice...
April 19, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28350268/molecular-and-biopharmaceutical-investigation-of-alginate-inulin-synbiotic-coencapsulation-of-probiotic-to-target-the-colon
#12
Abdelbasset Atia, Ahmed I Gomma, Ismail Fliss, Eric Beyssac, Ghislain Garrait, Muriel Subirade
Colon targeting, as a site-specific delivery for oral formulation, remains a major challenge, especially for sensitive bioactive components such as therapeutic forms of phages, live attenuated virus and prebiotics-probiotics association. Synbiotics could be used to protect encapsulated probiotics during the gastrointestinal tract and control their release in the colon. To achieve these goals, effective prebiotics, such as inulin, could be combined with alginate - the most exploited polymer used for probiotic encapsulation - in the form of beads...
April 19, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28406043/cardioprotective-effect-of-magnetic-hydrogel-nanocomposite-loaded-n-%C3%AE-l-rhamnopyranosyl-vincosamide-isolated-from-moringa-oleifera-leaves-against-doxorubicin-induced-cardiac-toxicity-in-rats-in-vitro-and-in-vivo-studies
#13
Mostafa Cheraghi, Mehrdad Namdari, Hadis Daraee, Babak Negahdari, Hammed T Aiyelabegan
Cardioprotective effect of N, α-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into 3 groups; 2 rats received distilled water in the control group, 5 rats in group I received varying concentration of VR treatment, and group II containing 5 rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks...
April 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28378597/preparation-of-intravenous-injection-nanoformulation-of-cholesterylated-gemcitabine-by-co-assemble-with-cholesterylated-mpeg
#14
Yanyun Xu, Xin Zhong, Xiongwen Zhang, Wei Lu, Jiahui Yu, Jin Huang
The objective of this study was to prepare the CHS-mPEG/CHS-dFdC nanoformulation could be administrated through intravenous injection in nude mice. Particularly, CHS-mPEG was selected to co-assemble with CHS-dFdC to improve the prodrug concentration and enhance the stability of nanoformulation. The nanoformulation could be prepared by codissolution-coprecipitation. All of the nanoformulations kept stable in PBS at 4°C or simulative human plasma at 37°C. As molar ratios of CHS-mPEG1900/CHS-dFdC increased from 0...
April 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28345377/green-microparticles-based-on-a-chitosan-lactobionic-acid-linoleic-acid-association-characterization-and-evaluation-as-a-new-carrier-system-for-cosmetics
#15
C Chaouat, S Balayssac, M Malet-Martino, F Belaubre, E Questel, A M Schmitt, S Poigny, S Franceschi, E Perez
The association chitosan/linoleic acid/lactobionic acid in aqueous solution spontaneously led to the formation of stable microparticles with a liquid hydrophobic core consisting of linoleic acid surrounded by a shell of chitosan/lactobionic acid. The originality of the microparticles arises from the fact that they are formed by the association of three ingredients of cosmetic interest, including a skin penetration enhancer (linoleic acid). DLS measurements showed microparticles with a mean diameter of 1 to 2 µm...
March 27, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28338368/alginate-and-whey-protein-based-multilayered-particles-production-characterization-and-resistance-to-ph-ionic-strength-and-artificial-gastric-intestinal-fluid
#16
Gislaine Ferreira Nogueira, Ana Silvia Prata, Carlos Raimundo Ferreira Grosso
Multiple layers of whey protein and sodium alginate were assembled onto gelled alginate microparticles using electrostatic interaction. An experimental design was employed to evaluate the effect of the concentration of both hydrocolloids on the amount of protein that was adsorbed. In the first layer, a higher protein adsorption 32.5% w/w was obtained at pH 3.75. In the multilayered particle, the protein adsorbed reached 64.9% w/w. An analysis of protein solubilization verified that 22% w/w was solubilized at an acidic pH (pH 2...
March 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28298154/advanced-characterisation-of-encapsulated-lipid-powders-regarding-microstructure-by-time-domain-nuclear-magnetic-resonance
#17
Annika Linke, Theresa Anzmann, Jochen Weiss, Reinhard Kohlus
Encapsulation is an established technique to protect sensitive materials from environmental stress. In order to understand the physical protection mechanism against oxidation, knowledge about the powder microstructure is required. Time domain-nuclear magnetic resonance (TD-NMR) has the potential to determine the surface oil (SO) and droplet size distribution by relaxation and restricted self-diffusion, respectively. The amount of SO, the retention and encapsulation efficiency are determined based on a lipid balance...
March 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28288552/microencapsulation-of-theobroma-cacao-l-waste-extract-optimization-using-response-surface-methodology
#18
Taís Vanessa Gabbay Alves, Russany Silva da Costa, Bahar Aliakbarian, Alessandro Alberto Casazza, Patrizia Perego, José Otávio Carréra Silva Júnior, Roseane Maria Ribeiro Costa, Attilio Converti
The cocoa extract (Theobroma cacao L.) has a significant amount of polyphenols (TP) with potent antioxidant activity (AA). This study aims to optimise microencapsulation of the extract of cocoa waste using chitosan and maltodextrin. Microencapsulation tests were performed according to a Box-Behnken factorial design, and the results were evaluated by response surface methodology with temperature, maltodextrin concentration (MD) and extract flowrate (EF) as independent variables, and the fraction of encapsulated TP, TP encapsulation yield, AA, yield of drying and solubility index as responses...
March 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28264603/cardiac-failure-detection-in-30%C3%A2-minutes-new-approach-based-on-gold-nanoparticles
#19
Mehrdad Namdari, Babak Negahdari, Mostafa Cheraghi, Hammed T Aiyelabegan, Ali Eatmadi
Cardiac failure occurs when heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. The aim of this work is to detect highly expressed genes: follistatin-related protein 1 (FSTL1) in heart failure within 30 minutes, using gold nanoparticles. Gold nanoparticles were prepared by citrate reduction of HAuCl4 3H2O; probe sequence was designed based on the FSTL1 gene region. Preparation of gold nanoprobes (AuNPs) proceeded by treating all the containers with DEPC-treated water, followed by reduction and conjugation...
March 7, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28097930/encapsulation-of-sesbania-grandiflora-extract-in-polymeric-micelles-to-enhance-its-solubility-stability-and-antibacterial-activity
#20
Pimporn Anantaworasakul, Siriporn Okonogi
Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improved by these micelles. Activity and toxicity of SGE loaded micelles were dependent on type and concentration of Pluronics. The micelles composed of 1:3 SGE to Pluronic F68 (SGE-PF68-13) showed small size (24...
February 5, 2017: Journal of Microencapsulation
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