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Journal of Microencapsulation

Annika Linke, Theresa Anzmann, Jochen Weiss, Reinhard Kohlus
Encapsulation is an established technique to protect sensitive materials from environmental stress. In order to understand the physical protection mechanism against oxidation, knowledge about the powder microstructure is required. Time domain-nuclear magnetic resonance (TD-NMR) has the potential to determine the surface oil (SO) and droplet size distribution by relaxation and restricted self-diffusion, respectively. The amount of SO, the retention and encapsulation efficiency are determined based on a lipid balance...
March 15, 2017: Journal of Microencapsulation
Taís Vanessa Gabbay Alves, Russany Silva da Costa, Bahar Aliakbarian, Alessandro Alberto Casazza, Patrizia Perego, José Otávio Carréra Silva Júnior, Roseane Maria Ribeiro Costa, Attilio Converti
The cocoa extract (Theobroma cacao L.) has a significant amount of polyphenols (TP) with potent antioxidant activity (AA). This study aims to optimise microencapsulation of the extract of cocoa waste using chitosan and maltodextrin. Microencapsulation tests were performed according to a Box-Behnken factorial design, and the results were evaluated by response surface methodology with temperature, maltodextrin concentration (MD) and extract flowrate (EF) as independent variables, and the fraction of encapsulated TP, TP encapsulation yield, AA, yield of drying and solubility index as responses...
March 13, 2017: Journal of Microencapsulation
Mehrdad Namdari, Babak Negahdari, Mostafa Cheraghi, Hammed T Aiyelabegan, Ali Eatmadi
Cardiac failure occurs when heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. The aim of this work is to detect highly expressed genes: follistatin-related protein 1 (FSTL1) in heart failure within 30 minutes, using gold nanoparticles. Gold nanoparticles were prepared by citrate reduction of HAuCl4 3H2O; probe sequence was designed based on the FSTL1 gene region. Preparation of gold nanoprobes (AuNPs) proceeded by treating all the containers with DEPC-treated water, followed by reduction and conjugation...
March 7, 2017: Journal of Microencapsulation
Pimporn Anantaworasakul, Siriporn Okonogi
Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improved by these micelles. Activity and toxicity of SGE loaded micelles were dependent on type and concentration of Pluronics. The micelles composed of 1:3 SGE to Pluronic F68 (SGE-PF68-13) showed small size (24...
February 5, 2017: Journal of Microencapsulation
Ke Wang, Qianjie Zhang, Yu-Lian Miao, Shao-Qiang Luo, Hong-Cai Wang, Wan-Ping Zhang
Three series of solid lipid are formulated in lipid nanoparticles carrier (NLC) system which encapsulated with sun filter to evaluate the effect on the physicochemical properties of the nanocarriers. Production is performed by ultrasonication-homogenization, analysis by particle size, Zeta Potential (ZP), Transmission Electron Microscope (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD). Moreover, the Encapsulation Efficiency (EE), Ultraviolet (UV) performance and in vitro release are also investigated...
February 3, 2017: Journal of Microencapsulation
Mohamed Mokhtar, Patrick M Gosselin, François Lacasse, Patrice Hildgen
Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs) was used to improve its oral bioavailability. In this work, we evaluated the potential impact of NPs prepared from a grafted copolymer of polylactic acid and PEG on P-gp function by studying in vitro permeability of Famotidine across Caco-2 cells. Copolymers of PEG grafted on polylactic acid a (PLA) backbone (PLA-g-PEG) were synthesized with 1 mol% and 5 mol% PEG vs...
February 2, 2017: Journal of Microencapsulation
Rita Cortesi, Giuseppe Valacchi, Ximena Maria Muresan, Markus Drechsler, Catia Contado, Elisabetta Esposito, Alessandro Grandini, Alessandra Guerrini, Giuseppe Forlani, Gianni Sacchetti
This study describes the preparation, characterisation and in vitro activity of nanostructured lipid carriers (NLCs) encapsulating natural molecules with antimicrobial activity, such as plumbagin, hydroquinon, eugenol, alpha-asarone and alpha-tocopherol. NLCs were prepared by melt and ultrasonication method, characterised by Cryo-TEM for morphology and SdFFF for dimensional distribution and active encapsulation yields. In vitro tests were conducted on bacteria, fungi and human cell cultures. In vitro tests demonstrated that plumbagin is strongly toxic towards F...
February 2, 2017: Journal of Microencapsulation
Yüksel Öğünç, Müzeyyen Demirel, Arzu Yakar, Zerrin İncesu
The objective of this study was to prepare the ɛ-viniferine and vincristine-loaded PLGA-b-PEG nanoparticle and to investigate advantages of these formulations on the cytotoxicity of HepG2 cells. Prepared nanoparticle has shown a homogeneous distribution with 113 ± 0.43 nm particle size and 0.323 ± 0.01 polydispersity index. Zeta potential was determined as -35.03 ± 1.0 mV. The drug-loading percentages were 6.01 ± 0.23 and 2.01 ± 0.07 for ɛ-viniferine and vincristine, respectively...
February 2, 2017: Journal of Microencapsulation
Evandro Martins, Denis Renard, Zenia Adiwijaya, Emre Karaoglan, Denis Poncelet
The production of capsules by inverse gelation consists of adding dropwise oil containing calcium dispersion into an alginate bath. A dripping technique to produce capsules from oil-in-water (O/W) emulsions was proposed by Abang. However, little is known about the oil encapsulation using water-in-oil (W/O) emulsions. This work aims to develop a new method of W/O emulsions encapsulation by inverse gelation. The success of the W/O emulsion encapsulation is due to three factors: 1) use of an emulsion with moderate stability (50 min); 2) production of an emulsion with at least 90 g/L of CaCl2 and 3) addition of ethanol (20% v/v) into the alginate bath...
January 31, 2017: Journal of Microencapsulation
Pascal Humbert, Michael Przyklenk, Marina Vemmer, Anant V Patel
Calcium chloride (CC) is the most common cross-linker for the encapsulation of biocontrol microorganisms in alginate beads. The aim of this study was to evaluate if calcium gluconate (CG) can replace CC as cross-linker and at the same time improve viability after drying and rehydration, hygroscopic properties, shelf life and nutrient supply. Hence, the biocontrol fungi Metarhizium brunneum and Saccharomyces cerevisiae were encapsulated in Ca-alginate beads supplemented with starch. Beads were dried and maximum survival was found in beads cross-linked with CG...
January 31, 2017: Journal of Microencapsulation
Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan, Yuancai Dong
Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking. In comparison with non-encapsulated quercetin, the microencapsulated powders exhibited significantly reduced dissolution in the simulated salivary pH 6.8 medium indicative of their potentially good taste-masking efficiency in the order of zein > carnauba wax > shellac...
January 23, 2017: Journal of Microencapsulation
Henry Nettey, Grace Lovia Allotey-Babington, Isaac Somuah, N'guessan Benoit Banga, Barima Afrane, Seth Kwabena Amponsah, Henrietta Annor, Henry Darko, Kwame Hanson, Anoa Aidoo, Marisa Nyarkoa Broni, Clement Sasu, Alexander Nyarko
The aim of this study was to formulate, characterise and evaluate the activity of amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency and in vitro release profile. The size range of the microparticles formulated was between 1.9 and 10 μm with an average zeta potential of -25.5 mV. Of the expected 20% drug loading, an average of 18...
January 23, 2017: Journal of Microencapsulation
In-Yong Kim, Hyungsoo Choi, Kyekyoon Kevin Kim
In this study, we investigated the effect of intracapsular environment on the survival of anchorage-dependent cells (ADCs) encapsulated in alginate microcapsules with three different core structures, i.e., liquid, semi-liquid and microsphere-encapsulating semi-liquid core, using NIH 3T3 fibroblasts as an ADC model. For the latter, we fabricated poly (ε-caprolactone) microspheres and co-encapsulated them with the cells, to establish cell-substrate interactions in the capsule. The fibroblast cells co-encapsulated with the microspheres exhibited higher survival and growth than those without...
January 18, 2017: Journal of Microencapsulation
Zhen Qiao, Jian Mao
In this study, compact urea-formaldehyde microcapsules containing paraffin (UFP) phase change materials (PCMs) were prepared via in situ polymerisation. The thermal conductivity of the PCMs was enhanced without influencing their enthalpy by adding graphene oxide (GO). Two modification methods were investigated: One in which GO is added to the inside of microcapsules, defined as "paraffin/GO@UF composite"; and another in which GO is coated onto the surface of shell, defined as "paraffin@UF/GO composite". The GO sheets were visible in scanning electron microscope (SEM) images of paraffin@UF/GO composite...
December 15, 2016: Journal of Microencapsulation
Zakir M O Rzayev, Sevda Khalilova, Kouroush Salimi
This work presents the synthesis and characterisation of intercalated nanocomposites (NCs) from dispersed water solution blends of octadecyl amine-montmorillonite (ODA-MMT) (NC-0), folic acid (FA) conjugated ODA-MMT (NC-1) and Ag-MMT clay as a stable silver carrying agent (NC-2). The composition, chemical/physical and morphology of NCs with in situ intercalating nanostructures were investigated. Effect of organoclay, FA and Ag-MMT on L929 fibroblast (control), human colon carcinoma (DLD-1) cell lines, and the cytotoxicity, apoptosis and necrosis degree were estimated via WST-1/hemocytometric, double staining (as a ribonuclease A enzyme based method) and fluorescence microscopy methods in a dose-dependent manner...
December 14, 2016: Journal of Microencapsulation
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Microencapsulation
Rajnibhas Samakradhamrongthai, Prodpran Thakeow, Phikunthong Kopermsub, Niramon Utama-Ang
The objective of the study was to optimise the encapsulation of Michelia alba D.C. (MAD) extract using octenyl succinic anhydride (OSA) starch. The MAD extract (5-10 g/100 g of dry starch) and the OSA starch (25-100 g/100 ml of water) was used in microcapsule preparation and analysed for the physicochemical and encapsulation properties. The optimised formula using the MAD extract and the OSA starch were 15.00 g/100 g of dry starch and 96.32 g/100 g water, which provided the highest in yield recovery (40...
December 2016: Journal of Microencapsulation
Qiang Wang, Caibiao Hu, Hong Zhang, Yali Zhang, Tian Liu, Airui Qian, Qiang Xia
This study aimed to the evaluation of a new solid non-aqueous self-double-emulsifying drug-delivery system (SDEDDS) for topical application of quercetin. The new formulation was prepared through two-step emulsification process and could spontaneously form oil-in-oil-in-water (O/O/W) double emulsions after dilution with aqueous medium, with inner oil phase mainly containing the drug. Solid state characterisation was performed by DSC and X-ray powder diffraction. Furthermore, the optimised QT-SDEDDS displayed sustained release profile and was found to be stable up to 30 days under 4 °C and 25 °C...
December 2016: Journal of Microencapsulation
Thao M Ho, Tony Howes, Bhesh R Bhandari
Stability and release properties of CO2-α-cyclodextrin complex powder prepared by solid encapsulation (water activity, aw ≈ 0.95) followed by moisture removal using silica gel and CaCl2 desiccants during post-dehydration were investigated. The results showed that CaCl2 reduced aw much faster than silica gel did under the same conditions. After approximately 60 h, aw of complex powders reduced using silica gel was almost constant at 0.247 (±0.012), while those treated with CaCl2, aw was 0.225 (±0.005) and had not yet reached their lowest value...
December 2016: Journal of Microencapsulation
Ida Genta, Claudia Colonna, Bice Conti, Paolo Caliceti, Stefano Salmaso, Pietro Speziale, Giampiero Pietrocola, Enrica Chiesa, Tiziana Modena, Rossella Dorati
The aim of this work was the assessment of the "in vivo" immune response of a poly(lactide-co-glycolide)-based nanoparticulate adjuvant for a sub-unit vaccine, namely, a purified recombinant collagen-binding bacterial adhesion fragment (CNA19), against Staphylococcus aureus-mediated infections. "In vivo" immunogenicity studies were performed on mice: immunisation protocols encompassed subcutaneous and intranasal administration of CNA19 formulated as nanoparticles (NPs) and furthermore, CNA19-loaded NPs formulated in a set-up thermosetting chitosan-β-glycerolphosphate (chitosan-β-GP) solution for intranasal route in order to extend antigen exposure to nasal mucosa...
December 2016: Journal of Microencapsulation
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