journal
MENU ▼
Read by QxMD icon Read
search

Journal of Microencapsulation

journal
https://www.readbyqxmd.com/read/30289012/genipin-crosslinked-curcumin-loaded-chitosan-montmorillonite-k-10-mmt-nanoparticles-for-controlled-drug-delivery-applications
#1
Bably Khatun, Nibedita Banik, Anowar Hussain, Anand Ramteke, Tarun Maji
Here, we have reported the influence of MMT and genipin in releasing curcumin from the Genipin crosslinked Chitosan/MMT nanoparticles, prepared by ionic gelation method. The nanoparticles were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometry (XRD), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Zeta potential and average diameter of the nanoparticles were found in the range 32-47 mV and 430-560 nm. Swelling and release of curcumin from the nanoparticles increased with the decrease in pH of the medium, MMT and genipin content...
October 5, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30280941/the-effect-of-polymer-molecular-weight-and-cell-seeding-density-on-viability-of-cells-entrapped-within-pegda-hydrogel-microspheres
#2
Davina Perera, Michael Medini, Deepika Seethamraju, Ron Falkowski, Kristopher White, Ronke Olabisi
Cell microencapsulation can be used in tissue engineering as a scaffold or physical barrier that provides immunoisolation for donor cells. When used as a barrier, microencapsulation shields donor cells from the host immune system when implanted for cell therapies. Maximizing therapeutic product delivery per volume of microencapsulated cells necessitates first optimizing the viability of entrapped cells. Although cell microencapsulation within alginate is well described, best practices for cell microencapsulation within polyethylene glycol is still being elucidated...
October 3, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30246573/bovine-serum-albumin-nanoparticles-improve-the-antitumor-activity-of-curcumin-in-a-murine-melanoma-model
#3
Luciana Erzinger Alves de Camargo, Daniel Brustolin Ludwig, Tania Toyomi Tominaga, Bruna Carletto, Giovani Marino Favero, Rubiana Mara Mainardes, Najeh Maissar Khalil
Curcumin is a natural compound presenting important antitumor activity. However, due to its low aqueous solubility, instability at physiological pH, and low oral bioavailability, its clinical use is limited. Bovine serum albumin (BSA) nanoparticles have been used as drug carriers to improve the drug properties. In this work, curcumin-loaded BSA nanoparticles were developed and the in vitro cytotoxicity over murine melanoma cells and the in vivo antitumor activity in a murine melanoma model were assessed. Nanoparticles presented 150 nm, polydispersity index of 0...
September 24, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30229692/preparation-optimization-and-in-vitro-in-vivo-evaluation-of-febuxostat-ternary-solid-dispersion
#4
Jingjing Tang, Jiayin Bao, Xiangjun Shi, Xiaoxia Sheng, Weike Su
The research aimed to prepare febuxostat (FEB) solid dispersion via solvent evaporation. Optimized solid dispersion composed of FEB, Polyvinylpyrrolidone (PVP K30) and poloxamer at ratio of 1:3:3 was characterized. Powder X-ray diffraction(XRD) and Differential scanning calorimetry (DSC) indicated FEB was transformed from crystalline into amorphous state in solid dispersion and Scanning electron microscopy (SEM) revealed the morphology. Fourier transform infrared spectroscopy (FT-IR) suggested the interactions formed between FEB and polymers...
September 19, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30213209/design-of-ciprofloxacin-loaded-nano-and-microcomposite-particles-for-dry-powder-inhaler-formulations-preparation-invitro-characterization-and-antimicrobial-efficacy
#5
Gizem Rüya Topal, Burcu Devrim, Müjde Eryilmaz, Asuman Bozkir
In this study, ciprofloxacin hydrochloride (CIP)-loaded poly-ε-caprolactone (PCL) nanoparticles were prepared for pulmonary administration. CIP-loaded PCL nanoparticles were prepared by solid-in-oil-in-water (s/o/w) emulsion solvent evaporation method and the effects of various formulation parameters on the physicochemical properties of the nanoparticles were investigated. PCL nanoparticles showed spherical shapes with particle sizes around 143-489 nm. Encapsulation efficiency was found to be very low because of water-solubility properties of CIP...
September 14, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30189763/preparation-and-characterisation-of-flame-retardant-encapsulated-with-functionalised-silica-based-shell
#6
Doan-Trang Hoang, Diane Schorr, Véronic Landry, Pierre Blanchet, Stéphanie Vanslambrouck, Christian Dagenais
Intumescent fire retardant (IFR) coatings are nowadays considered as the most effective flame retardant (FR) treatment. Nevertheless, the principal compound in an IFR system, ammonium polyphosphate (APP), is highly sensitive to moisture and IFR coating effectiveness decreases quickly. The main objective of this study is to encapsulate APP in a hybrid silica-based membrane by sol-gel process using alkoxysilane tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) precursor. The morphology and structure of APP and microencapsulated ammonium polyphosphate (MAPP) were assessed by scanning electron miscroscopy and Fourier transform infrared spectroscopy (FTIR)...
September 7, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30160590/formation-of-essential-oil-containing-microparticles-comprising-a-hydrogenated-vegetable-oil-matrix-and-characterisation-thereof
#7
Pia Gottschalk, Benjamin Brodesser, Denis Poncelet, Henry Jaeger, Harald Rennhofer, Stephen Cole
Microparticles with different essential oil concentrations 0, 75, 150, 225 and 300 gkg-1 , (g of essential oil per kg of microparticles), were produced by dispersing the essential oils within a hydrogenated vegetable fat matrix and forming spherical solid particles by spray-chilling. Size distribution, flowability, surface structure, essential oil recovery, melting properties and crystallinity of the microparticles were determined. With over 225 gkg-1 essential oil the microparticle surface became stickier, their flowability was reduced and the size distribution broadened...
August 30, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30146922/cell-encapsulation-potential-of-chitosan-alginate-electrostatic-complex-in-preventing-natural-killer-and-cd8-cell-mediated-cytotoxicity-an-in-vitro-experimental-study
#8
Vikas Chander, Ajay Kumar Singh, Gurudutta Gangenahalli
Natural killer and cytotoxic CD8+ T cells are involved in the rapid clearance of cells which express foreign antigens. Hence, these cells are crucial elements of the vertebrate immune system. However, these benefits turn problematic when they cause transplant rejection through their direct cytotoxic effects on donor organs/cells, which is attributed to the human leukocyte antigen disparity. To overcome these limitations, a strategy has been devised where in the above effects can be minimized by shielding the cells through encapsulation...
August 27, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30136606/novel-revaprazan-loaded-gelatin-microsphere-with-enhanced-drug-solubility-and-oral-bioavailability
#9
Jung Suk Kim, Jong Hyuck Park, Sung Chan Jeong, Dong Shik Kim, Abid Mehmood Yousaf, Fakhar Ud Din, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Sung Giu Jin, Han-Gon Choi
To develop a novel revaprazan-loaded gelatin microsphere with enhanced solubility and oral bioavailability, numerous gelatin microspheres were prepared using a spray-drying technique. The impact of gelatin amount on drug solubility in the gelatin microspheres was investigated. The physicochemical properties of the selected gelatin microsphere, such as shape, particle size and crystallinity, were evaluated. Moreover, its dissolution and pharmacokinetics in rats were assessed in comparison with revaprazan powder...
August 23, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30134755/chitosan-%C3%AE-glycerophosphate-based-microparticles-manufactured-by-laminar-jet-break-up-technology
#10
Wadiaa Benamer, Francesco Cellesi, Nicola Tirelli
This study is about the use of β-glycerophosphate (βGP) to modulate the production of chitosan microparticles through a technology of jet break-up. βGP has been described as capable of producing chitosan gels without additional complexing agents via a thermal transition (inverse gelation). A preliminary assessment on the effect of temperature on the viscosity and gelation of chitosan/βGP precursors demonstrated that the crosslinking process was too slow to afford microparticle production via jet break-up...
August 23, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30112917/spray-dried-fucoidan-microparticles-for-pulmonary-delivery-of-antitubercular-drugs
#11
Ludmylla Cunha, Ana M Rosa da Costa, João P Lourenço, Francesca Buttini, Ana Grenha
Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity. This work aimed at using fucoidan as matrix of inhalable microparticles that associate two first-line antitubercular drugs, for an application in pulmonary tuberculosis therapy. Fucoidan is composed of fucose and sulphated sugar residues, moieties described as being recognised by surface receptors of alveolar macrophages, which host mycobacteria...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30086674/formation-of-organosilica-nanoparticles-with-dual-functional-groups-and-simultaneous-payload-entrapment
#12
Ya-Ling Su, Chien-Yu Lin, Shih-Jiuan Chiu, Teh-Min Hu
A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20-80%, R6G exhibited near 100% efficiency...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/30010458/colon-targeted-curcumin-microspheres-laden-with-ascorbic-acid-for-bioavailability-enhancement
#13
Preeti G Karade, Namdeo R Jadhav
An objective of the present study was to prepare colon-specific microspheres of curcumin (CUR) containing ascorbic acid (AA) for improved oral bioavailability. 32 factorial design was used to optimise chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimised CSMS were coated with Eudragit S-100, for delivery to colon. In vitro drug release, in vivo pharmacokinetics, and organ distribution studies were performed in Albino Wistar rats. Stabilisation of CUR in alkaline pH was successfully guarded by AA to the extent 98...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29889613/a-comparative-study-of-stabilising-effect-and-antioxidant-activity-of-different-antioxidants-on-levodopa-loaded-liposomes
#14
Elena García Esteban, María José Cózar-Bernal, Antonio M Rabasco Álvarez, María Luisa González-Rodríguez
The aim of this study was to evaluate the stability of levodopa liposomes co-loaded with three different antioxidants (curcumin, ascorbic acid, and superoxide dismutase (SOD)). For this purpose, multilamellar liposomes were prepared. Curcumin was added into the lipid bilayer while ascorbic acid and SOD were placed into the aqueous phase. The influence of preparation technique and surface charge were also investigated. Vesicles were characterised and free radical scavenging potential was determined. From stability study, ascorbic acid showed better stabilising effect...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29889598/design-of-minocycline-containing-starch-nanocapsules-for-topical-delivery
#15
J M Marto, L F Gouveia, L M D Gonçalves, H M Ribeiro, A J Almeida
Pharmaceutical research has been focussed on developing improved delivery systems while exploring new ways of using approved excipients. The present work investigated the potential of starch nanocapsules (StNC) as a topical delivery platform for hydrophilic antimicrobial drugs using minocycline hydrochloride (MH) as a model drug. Thus, a quality by design approach was used to assess the role of different factors that affect the main pharmaceutical properties of StNC prepared using an emulsification-solvent evaporation method...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29873288/improvement-of-oral-efficacy-of-irinotecan-through-biodegradable-polymeric-nanoparticles-through-in-vitro-and-in-vivo-investigations
#16
Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Sadiq Umar, Farhan Jalees Ahmad
BACKGROUND: Irinotecan (IRN) (CPT-11) is a camptothecin derivative with low oral bioavailability due to active efflux by intestinal P-glycoprotein (p-gp) receptors. Hence, no oral formulation is marketed for IRN till date and its oral ingestion continues to remain a challenge. AIM OF STUDY: The study aims to develop a nanoformulation i.e. Chitosan (CS)-coated-IRN-loaded-poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) (CS-IRN-PLGA-NPs)in order to enhance oral bioavailability of IRN...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29683357/synthesis-screening-and-nanocrystals-preparation-of-rhein-amide-derivatives
#17
Lijiang Chen, Jinfeng Zhang, Jinghong Rong, Yu Liu, Jinghua Zhao, Qingguo Cui, Xin Wang, Xiao Liang, Hao Pan, Hongsheng Liu
Rhein (RH) has many bioactivities, but the application was limited of its poor solubility. The present study aimed to establish an efficient method for the synthesis of rhein amide derivatives (RAD) to increase the solubility and anti-tumour activity. RAD exhibited stronger anti-tumour activity than RH in MTT assay. The solubility and oil/water partition coefficient results indicated that rhein-phenylalanine and rhein-isoleucine have better absorption effect, which was consolidated in pharmacokinetic study...
June 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29790801/development-and-characterisation-of-polymeric-microparticle-of-poly-d-l-lactic-acid-loaded-with-holmium-acetylacetonate
#18
Mariangela de Burgos M de Azevedo, Vitor H S de Melo, Carlos Roberto J Soares, Douglas M Miyamoto, Ricardo A Katayama, Peterson L Squair, Caio H N Barros, Ljubica Tasic
Biodegradable polymers containing radioactive isotopes such as Holmium 166 (166 Ho) have potential applications as beta particle emitters in tumour tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Poly(d,l-lactic acid), PDLLA, was used to encapsulate holmium acetylacetonate (HoAcAc) using an emulsion solvent extraction/evaporation technique...
May 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29781344/design-and-development-of-vitamin-c-encapsulated-proliposome-with-improved-in-vitro-and-ex-vivo-antioxidant-efficacy
#19
Elahehnaz Parhizkar, Marzieh Rashedinia, Maryam Karimi, Shohreh Alipour
Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert® software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. This formulation released about 90% vitamin C within 2 h and showed higher (1...
May 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29771175/tamoxifen-citrate-loaded-chitosan-gellan-nanocapsules-for-breast-cancer-therapy-development-characterisation-and-in-vitro-cell-viability-study
#20
Pankaj Kumar Kathle, Nivedita Gautam, Karthikeyan Kesavan
The objective of this study was to evaluate the potential of chitosan-gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by Fourier-transform infra-red (FT-IR), differential scanning colorimetric (DSC), and X-ray diffraction (XRD) to investigate any interaction between drug and excipients. Physicochemical parameters, in vitro drug release and release kinetic were studied...
May 2018: Journal of Microencapsulation
journal
journal
28931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"