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Journal of Microencapsulation

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https://www.readbyqxmd.com/read/29206479/microencapsulation-of-esterified-krill-oil-using-complex-coacervation
#1
Selim Kermasha, Sarya Aziz, Jagpreet Gill, Ronald Neufeld
The microencapsulation of the esterified krill oil (EKO), obtained from the transesterification of krill oil (KO) with 3,4-dihydroxyphenylacetic acid (DHPA), via complex coacervation, was investigated. The experimental findings showed that the DHPA and phenolic lipids (PLs) in the EKO affected the stability of the gelatin (GE)-EKO emulsion. To improve its stability, the effects of varying the pH of GE and the use of two emulsification devices, including the homogenizer and ultrasonic liquid processor were investigated, where the ultrasonic liquid processor was found to be a relatively more appropriate emulsification device...
December 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29198147/optimisation-of-%C3%AE-cyclodextrin-inclusion-complexes-with-natural-antimicrobial-agents-thymol-carvacrol-and-linalool
#2
Ghofran Al-Nasiri, Marlene J Cran, Andrew J Smallridge, Stephen W Bigger
Beta-cyclodextrin (β-CD) inclusion complexes with naturally derived antimicrobial (AM) agents: thymol, carvacrol, and linalool were prepared using a co-precipitation technique. Conditions including solvent composition, temperature, reaction time, and total solvent volume were investigated to optimise the inclusion efficiency (IE) and yield. Electrospray ionization mass spectrometry was used to confirm the formation of the thymol/β-CD complex and gas chromatography was used to quantify the amount AM agent that was encapsulated, absorbed onto the surface, or remaining in the filtered solvent...
December 4, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29195484/targeted-delivery-of-garcinia-glycosides-by-reconstituted-high-density-lipoprotein-nano-complexes
#3
Chang Liu, Zijun Zhou, Ye Chen, Ju Liu, Yang Wang, Hongsheng Liu
Scavenger receptor class B type 1 (SR-B1) is over-expressed in tumor cells where it mediates the uptake of drug payload of reconstituted high density lipoprotein (rHDL) via the process of reverse cholesterol transport. In this study, rHDL was prepared to determine its function as a drug delivery carrier for targeting hepatocellular carcinoma by incorporating the anti-tumor drug garcinia glycosides into rHDL to yield rHDL/GG nano-complexes. Structural analysis indicated that the rHDL/GG nano-complex was similar to HDL in size...
December 1, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29171778/effect-of-matrix-composition-sphere-size-and-hormone-concentration-on-diffusion-coefficient-of-insulin-for-controlled-gastrointestinal-delivery-for-diabetes-treatment
#4
Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz, Alvaro Luiz Mathias
Oral insulin administration is limited due to its degradation by proteases. The hormone was encapsulated in spheres made of either pure calcium alginate (ALG) or its association with whey protein isolate (WPI-ALG) in order to minimize loss in the stomach region while allowing liberation in the maximum absorption area, located in the intestine. Diffusion coefficients for both matrix compositions were determined in vitro for gastric pH (5.88 and 10.26 10(-12) m(2) s(-1)) and intestinal pH (21.11 and 79.29 10(-12) m(2) s(-1))...
November 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29168930/cyclodextrin-encapsulation-of-daidzein-and-genistein-by-grinding-implication-on-the-glycosaminoglycan-accumulation-in-mucopolysaccharidosys-type-ii-and-iii-fibroblasts
#5
Barbara Fumić, Jasna Jablan, Dominik Cinčić, Marijana Zovko Končić, Mario Jug
This work was aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidoes (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing, confirming the complexes formation with increased solubility with respect to starting compounds...
November 23, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29161939/oil-encapsulation-techniques-using-alginate-as-encapsulating-agent-applications-and-drawbacks
#6
Evandro Martins, Denis Poncelet, Ramila Cristiane Rodrigues, Denis Renard
Oils are used in agriculture, nutrition, food and cosmetics; however, these substances are oxidisable and may readily lose their properties. To reduce their degradation or to mask certain undesirable aspects, one strategy consists in encapsulating the oil in inert structures (capsules). The capsules are classified according to the morphology, the number of cores and size, can be produced by several techniques: jet-cutting, vibrating jet, spray-drying, dispersion and milli-microfluidic. Among the polymers used as a membrane in the capsules, alginates are used in oil encapsulation because of their high gelling capacity, biocompatibility and low toxicity...
November 21, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29141479/development-of-a-carboxymethyl-chitosan-functionalized-nanoemulsion-formulation-for-increasing-aqueous-solubility-stability-and-skin-permeability-of-astaxanthin-using-low-energy-method
#7
Liang Hong, Chuan-Li Zhou, Feng-Ping Chen, Dan Han, Chun-Yuan Wang, Jia-Xin Li, Zhe Chi, Chen-Guang Liu
In this research, firstly astaxanthin (ASX)-loaded nanoemulsions (NEs) were produced using a convenient low-energy emulsion phase inversion method. The optimised ASX-NEs were prepared in the presence of Cremophor(®) EL and Labrafil(®) M 1944 CS, with a surfactant-to-oil ratio of 4:6. The ASX-NE droplets were spherical with a mean droplet diameter below 100 nm and a small negative surface charge. The system was stable without alteration of mean droplet diameter for three months. Then, the ASX-NE was functionalised with carboxymethyl chitosan (CMCS) through direct CMCS (0...
November 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29119840/preparation-of-soft-microcapsules-containing-multiple-core-materials-with-interfacial-dehydration-reaction-using-the-w-o-w-emulsion
#8
Yoshinari Taguchi, Takanori Suzuki, Natsukaze Saito, Hiroshi Yokoyama, Masato Tanaka
The soft microcapsules containing Eucalyptus oil, Ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the (W/O)/W emulsion. The diameters of the microcapsules and the content and the microencapsulation efficiency of the core materials were significantly affected by the revolution velocity (Nr1) to form the (W/O) emulsion and that (Nr2) to form the (W/O)/W emulsion and the lecithin concentration. The mean diameters of the inner water droplets and those of the microcapsules were proportional to Nr1(-1...
November 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29105520/preparation-and-characterization-of-textile-based-carrier-systems-for-anal-fissure-treatment
#9
A M Sarıışık, S Y Karavana, G C Türkoğlu, S Rençber, T Önder
Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement, encapsulation efficiency, drug loading and in vitro drug release. Mass yield was between 5.5 and 45.9%. The particle size was between 15.1 and 26.8 µm. Encapsulation efficiency were 96.142 ± 5...
November 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28985684/microencapsulation-of-probiotics-by-efficient-vibration-technology
#10
Araceli Olivares, Paulina Silva, Claudia Altamirano
The target site of action of probiotics is the intestine. They must be surviving the stomach acidic condition before reaching the target site. Three probiotic bacteria were microencapsulated in sodium alginate beads using a sophisticated microencapsulation technology provided by BÜCHI B-390. This study reports the tolerance of the different microencapsulated Lactobacillus at low pH using simulated gastric juice, comparing it with the tolerance of free bacteria. The three microencapsulated strains displayed time-dependent acid sensitivity at pH values under 3...
October 23, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29053065/investigation-of-the-role-of-alginate-containing-high-guluronic-acid-on-osteogenic-differentiation-capacity-of-human-umbilical-cord-wharton-s-jelly-mesenchymal-stem-cells
#11
Darioush Bijan Nejad, Saeed Azandeh, Rezvan Habibi, Vahid Bayati, Kambiz Ahmadi Angali
BACKGROUND AND AIM: Cell encapsulation using biodegradable material has promising results for tissue engineering. Since pressure is an effective factor on stem cell behavior and various concentrations of alginate create different pressures on the cells, therefore our goal was to evaluate the mechanical effect of 1/2% (w/v) and 1/8%(w/v) alginate containing high guluronic acid on viability and osteogenic capacity of HUCWJ cells. METHODS: Cell viability was evaluated by MTT assay after 1, 7 and 14 days...
October 20, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29027828/folate-decorated-and-nir-activated-nanoparticles-based-on-platinum-iv-prodrugs-for-targeted-therapy-of-ovarian-cancer
#12
Yu Sun, Tian-Yi Shi, Ling-Yun Zhou, Yu-Yan Zhou, Bai-Wang Sun, Xiao-Ping Liu
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt(IV)-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG)...
October 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28862072/intranasal-delivery-of-tapentadol-hydrochloride-loaded-chitosan-nanoparticles-formulation-characterisation-and-its-in-vivo-evaluation
#13
Ankit Javia, Hetal Thakkar
The aim of the present investigation was to formulate tapentadol hydrochloride-loaded chitosan nanoparticles (CS-NPs) for nose to brain delivery. Chitosan nanoparticles were prepared using ionotropic gelation technique. Optimisation of the formulation and process parameters was done using Box-Behnken Design. The entrapment efficiency, drug loading, Z-average size and zeta potential of the optimised batch were 63.49 ± 1.61%, 17.25 ± 1.38%w/w, 201.2 ± 1.5 nm and +49.3 mV, respectively. In-vitro release study showed 84...
September 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28866966/construction-of-nanoscale-liposomes-loaded-with-melatonin-via-supercritical-fluid-technology
#14
Quan Zhang, Chunfeng Ou, Shengying Ye, Xianliang Song, Shucan Luo
Melatonin-loaded liposomes (MLL) were successfully prepared using rapid expansion of supercritical solution technology. The effects of supercritical pressure on encapsulation efficiency (EE) and average particle size were then analysed. Meanwhile, temperature, formation time and ethanol concentration in the products were studied and optimised based on the response surface methodology (RSM). An in vitro simulated digestion model was also established to evaluate the release performance of MLL. The results showed that 140 bar was the best pressure for maximising the EE value using RSM optimisation, reaching up to 82...
September 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28862080/evaluation-of-brain-targeted-chitosan-nanoparticles-through-blood-brain-barrier-cerebral-microvessel-endothelial-cells
#15
Adem Sahin, Digdem Yoyen-Ermis, Secil Caban-Toktas, Utku Horzum, Yesim Aktas, Patrick Couvreur, Gunes Esendagli, Yilmaz Capan
The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determine the efficacy of the brain-targeted chitosan nanoparticles' uptake by the human BBB cerebral microvessel endothelial cells (hCMECs) and to investigate the underlying mechanisms for enhanced cellular entry...
September 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28862074/the-regulatory-effects-of-l-plantarum-peptidoglycan-microspheres-on-innate-and-humoral-immunity-in-mouse
#16
Xiuliang Li, Quan Sun, Yawei Wang, Dequan Han, Jiahui Fan, Jialing Zhang, Chunhai Yang, Xiaoxiong Ma, Qingshen Sun
OBJECTIVE: To study the effects of Lactobacillus Plantarum cell wall peptidoglycan (LPG) microspheres on mouse intestinal flora changes, peptidoglycan recognitions protein (PGRP) and cytokines expression levels. METHOD: Plate counting was used for enumeration of the intestinal flora. Real-time PCR was used for quantification PGRP in different tissues. Cytokines content were determined by ELISA kits. RESULT: The mouse administered orally with LPG microspheres showed significantly higher number of Lactobacillus and Bifidobacterium in caecum contents (p < 0...
September 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28847195/chitosan-microencapsulation-of-the-dispersed-phase-of-an-o-w-nanoemulsion-to-hydrochlorothiazide-delivery
#17
Cassiana Mendes, Aline Buttchevitz, Jéssica Henriques Kruger, Thiago Caon, Patricia Oliveira Benedet, Elenara Maria Teixeira Lemos-Senna, Marcos Antônio Segatto Silva
In view of biopharmaceutical limitations of hydrochlorothiazide (HCTZ), Trojan-type mucoadhesive systems were proposed, aiming to improve HCTZ pharmacological properties by modulating its release. Nanoemulsions were formed spontaneously by combining medium-chain triglycerides (Lipoid(®) S75 and Pluronic(®) F68) and high encapsulation efficiency was obtained. The mucoadhesive properties were provided by chitosan and microencapsulation of nanoemulsions in spray-dryer was successfully achieved by using Aerosil(®) as wall material...
September 10, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28877639/novel-solidified-reverse-micellar-solution-based-mucoadhesive-nano-lipid-gels-encapsulating-miconazole-nitrate-loaded-nanoparticles-for-improved-treatment-of-oropharyngeal-candidiasis
#18
Franklin Chimaobi Kenechukwu, Anthony Amaechi Attama, Emmanuel Chinedum Ibezim
OBJECTIVE: To develop and evaluate solidified-reverse-micellar-solution (SRMS)-based oromucosal nano lipid gels for improved localised delivery of miconazole nitrate (MN). METHODS: Phospholipon(®) 90G and Softisan(®) 154 (3:7) were used to prepare SRMS by fusion. Solid lipid nanoparticles (SLNs, 0.25-1.0% w/w MN) formulated with the SRMS by high shear homogenisation were employed to prepare mucoadhesive nano lipid gels. Physicochemical characterisation, drug release in simulated salivary fluid (SSF) (pH 6...
September 6, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28845737/biodistribution-study-of-99m-tc-gemcitabine-loaded-spherulites-in-sprague-dawley-rats-by-gamma-scintigraphy-to-investigate-its-lung-targeting-potential
#19
Rahul Dhande, Amit Tyagi, Rakesh Kumar Sharma, Hetal Thakkar
Gemcitabine hydrochloride (GCH) is drug of choice for treatment of non-small cell lung cancer. This project aims to formulate GCH-loaded spherulites for lung targeting using soyabean phosphatidylcholine, cholesterol (Chol) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]. Vesicles were characterised for size, entrapment efficiency, drug release and in vitro cytotoxicity. Radiolabelling of GCH was done using reduced technetium-99 m to study biodistribution in Sprague-Dawley rats...
September 6, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28868953/preparation-characterization-and-in-vitro-evaluation-of-%C3%AE%C2%B5-polylysine-loaded-polymer-blend-microparticles-for-potential-pancreatic-cancer-therapy
#20
Merari T Chevalier, Mónica C García, Daniela Gonzalez, Sandro M Gomes-Filho, Daniela S Bassères, Hernan Farina, Vera A Alvarez
Peptide active ingredients show great promise regarding the treatment of various health-endangering diseases. It is reported that L-lysine inhibits the proliferation of several tumour lines in vitro and in vivo. However, proteins and peptide drugs possess certain disadvantages such as in vivo instability and short biological half-life. On the grounds that drug delivery systems can overcome a wide spectrum of bioactive compounds issues, a biopolymeric blend-based microparticulated system capable of delivering ε-polylysine (PLL) was developed...
September 3, 2017: Journal of Microencapsulation
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