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Journal of Microencapsulation

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October 17, 2016: Journal of Microencapsulation
M Moreno-Sastre, M Pastor, A Esquisabel, E Sans, M Viñas, D Bachiller, J L Pedraz
In the last decades, the encapsulation of antibiotics into nanoparticulate carriers has gained increasing attention for the treatment of infectious diseases. Sodium colistimethate-loaded solid lipid nanoparticles (Colist-SLNs) and nanostructured lipid carriers (Colist-NLCs) were designed aiming to treat the pulmonary infection associated to cystic fibrosis patients. The nanoparticles were freeze-dried using trehalose as cryoprotectant. The stability of both nanoparticles was analysed over one year according to the International Conference of Harmonisation (ICH) guidelines by determining the minimum inhibitory concentration (MIC) against clinically isolated Pseudomonas aeruginosa strains and by studying their physico-chemical characteristics...
October 14, 2016: Journal of Microencapsulation
Mohammad Yusuf, Maria Khan, Riaz A Khan, Ibrahim Abdullah Maghrabi, Bahar Ahmed
Depression is a modern world epidemic. Its main causative factor is oxidative stress, as reported in study subjects. Natural products are yet to show significant therapeutic effects in comparison with synthetic drugs. Current study deals with the preparation of brain-targeted polysorbate-80-coated curcumin PLGA nanoparticles (PS-80-CUR-NP), and their characterisation via Spectral and optical methods. PS-80-CUR-NP were evaluated against the oxidative stress-mediated depressant (OSMD) activity via Force despair, Tail suspension tests and stress biomarker assay (SOD and catalase activity)...
October 14, 2016: Journal of Microencapsulation
Sanaul Mustafa, V Kusum Devi, Roopa S Pai
Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. KS is polycationic, a property responsible for KS poor oral absorption half-life (2.5 h), and rapid renal clearance, which results in serious nephrotoxicity/ototoxicity. The current study aimed to develop KS-loaded PLGA-Vitamin-E-TPGS microparticles (MPs) and nanoparticles (NPs) to reduce the dosing frequency and dose related adverse effect. In vitro release was sustained up to 10 days for KS PLGA-TPGS MPs and 13 days for KS PLGA-TPGS NPs in PBS pH 7...
October 13, 2016: Journal of Microencapsulation
Juntao Yin, Cuiyu Xiang, Guangxiu Lu
Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high pressure homogenization and characterized by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around...
October 13, 2016: Journal of Microencapsulation
Sedigheh Nadri, Hormoz Mahmoudvand, Ali Eatemadi
INTRODUCTION: In an effort of designing an alternative method for local nerve block, we demonstrated the possibility of inducing ankle block in the rat with intravenous (IV) injection of magnetic nanoparticles conjugated bupivacaine and application of a magnet at the ankle. METHODS: The anaesthetic effect of magnet-directed bupivacaine-associated MNPs (NIPAAM-MAA-bupivacaine) was tested in rat using paw withdrawal latencies from thermal stimuli on the hind paw. Thirteen (13) experimental animals were grouped into two; untreated left hind paw (control group) and test group with treated right hind paw...
October 13, 2016: Journal of Microencapsulation
Yochana Srivari, Parnali Chatterjee
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water soluble drug betulinic acid (BA) to improve its aqueous solubility. Monomeric albumin-bound BA (ABBns) nanoparticles can be fabricated in the range of 10-20 nm. BA self-assembled with HSA at 0.1: 1 to 2: 1 molar ratio within 0.5 h in phosphate buffer pH 7.4 and 8.4. Approximately, 85%-90% BA could be loaded onto HSA in the presence of Tween 20 (T20) and sodium cholate (NaC)...
October 6, 2016: Journal of Microencapsulation
Anita Chudecka-Głaz, Joanna Szczeblińska, Aneta Cymbaluk-Płoska, Joachim Kohn, Miroslawa El Fray
New poly(ester-amide) copolymers modified with polyethers were developed for carboplatin encapsulation. These new copolymers contain hydrophobic blocks made of tyrosine derivative and dimer fatty acid, and poly(ethylene glycol) (PEG) as hydrophilic blocks. Short term hydrolytic degradation revealed high water absorption, slight increase of pH of simulated body fluid and change of sample shape, which indicated the erosive mechanism of polymers degradation. Poly(ester-amide)-PEG copolymers were used for microspheres preparation and carboplatin encapsulation...
October 5, 2016: Journal of Microencapsulation
Jagruti Desai, Hetal Thakkar
The present investigation aimed to study the effect of particle size of solid lipid nanoparticles (SLNs) on oral bioavailability of Darunavir. High pressure homogenization technique was used to prepare SLNs. Three different sized SLNs loaded with Darunavir were developed with mean particle sizes of around 100 nm, 200 nm and 500 nm respectively. The in-vivo pharmacokinetics in rats showed a significant increase in oral bioavailability of Darunavir from all the three formulations in comparison to plain drug suspension and reference tablet...
October 5, 2016: Journal of Microencapsulation
Zahra Mahdizadeh Barzoki, Zahra Emam-Djomeh, Elaheh Mortazavian, Ali Akbar Moosavi-Movahedi, M Rafiee Tehrani
The present study was performed to optimise the formulation of a muco-adhesive buccal patch for insulin nanoparticles (NPs) delivery. Insulin NPs were synthesised by an ionic gelation technique using N-di methyl ethyl chitosan cysteine (DMEC-Cys) as permeation enhancer biopolymer, tripolyphosphate (TPP) and insulin. Buccal patches were developed by solvent-casting technique using chitosan and gelatine as muco-adhesive polymers. Optimised patches were embedded with 3 mg of insulin-loaded NPs with a homogeneous distribution of NPs in the muco-adhesive matrix, which displayed adequate physico-mechanical properties...
October 5, 2016: Journal of Microencapsulation
Soraya Ghayempour, Majid Montazer
Herbal products have been widely used due to good antimicrobial, fragrance and medical properties. Essential oils and fragrances can be applied on the textile substrates as micro/nanocapsules to prolong lifetime by controlling the release rate. The present review tries to give a general overview on the application of micro/nanoencapsulated essential oils on the textile substrates to achieve aromatherapy textiles. These are divided into four diverse categories as the following: antimicrobial, perfumed, mosquito-repellent and medical textiles...
October 4, 2016: Journal of Microencapsulation
Xunan Zhang, Wei Zong, Ying Hu, Nan Luo, Wenlong Cheng, Xiaojun Han
In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains Trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterized by fluoresence microscopic images and fourier transform infrared spectrum. In vitro cytotoxicity of the vesicles carrying 5-Fluorouacil (5-FU) has also been studied.
September 28, 2016: Journal of Microencapsulation
Hui Li, Jinyong Zhang, Nannan Zhang, Joe Kershaw, Lei Wang
It is important to fabricate biocompatible and chemical resistant microstructures that can be powered and controlled without a tether in fluid environment for applications when contamination must be avoided, like cell manipulation, and applications where connecting the power source to the actuator would be cumbersome, like targeted delivery of chemicals. In this work, a novel fabrication method was described to encapsulate magnetic composite into pure SU-8 structures, enabling the truly microscale ferromagnetic microrobots biocompatible and chemical resistant...
September 15, 2016: Journal of Microencapsulation
Gülsel Yurtdaş Kırımlıoğlu, Yusuf Menceloğlu, Kevser Erol, Yasemin Yazan
Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, nontoxic and biocompatible polymeric nanoparticles, and investigating their effectiveness in epilepsy. For this purpose, GABA conjugated N,N-dimethylacrylamide based pegylated nanoparticles were designed and characterized for particle size, zeta potential, pH, morphology, DSC, XRD, FTIR, GABA quantification and in vitro release. Formulations showed smaller particle size, cationic zeta potential characteristic, possible GABA polymeric matrix interaction and prolonged release pattern...
September 8, 2016: Journal of Microencapsulation
G Poorani, Spandana Uppuluri, Kiran Babu Uppuluri
CONTEXT: Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. SNEDDS were extensively practiced for systemic delivery of poorly aqueous soluble drugs to achieve maximum bioavailability. OBJECTIVE: The present study was focussed on the formulation, optimisation and evaluation of LSP SNEDDS using castor oil, for enhancement of drug absorption and bioavailability. MATERIALS AND METHODS: Pseudo-ternary phase diagram was plotted to identify the range of SNEDDS components...
September 6, 2016: Journal of Microencapsulation
G Güney Eskiler, G Cecener, G Dikmen, I Kani, U Egeli, B Tunca
Manganese(Mn)-based complexes have been drawing attention due to the fact that they are more effective than other metal complexes. However, the use of Mn(II)-based complexes in medicine remains limited because of certain side effects. The aim of this study was to investigate the cytotoxic and apoptotic effects of a novel Mn(II) complex [Mn2(µ-((C6H5)2CHCOO)2(bipy)4](bipy)2(ClO4) and Mn(II) complex loaded solid lipid nanoparticles (SLNs) on MCF-7 and HUVEC control cells. The average diameter of Mn(II) complex was about 1120±2...
August 30, 2016: Journal of Microencapsulation
Armin Mooranian, Rebecca Negrulj, Hani Al-Salami
OBJECTIVE: In a recent study, we developed a new microencapsulating method for β-cell microencapsulation, but cell viability declined rapidly, post microencapsulation, due to potential polymer-polyelectrolyte chelation and non-porous microcapsules' membranes resulting in cell apoptosis. Thus, this study tested the effects of incorporating cationic polyamine at 1% w/v, on microcapsule strength and cell viability, in the absence or presence of an anionic tertiary bile acid (ATBA) with potential cell-protective effects...
August 30, 2016: Journal of Microencapsulation
Srikanth Bandi, Krishna Sanka, Vasudha Bakshi
CONTEXT: The oral delivery of risperidone encounters a number of problems, such as pH dependent solubility and low bioavailability, due to its lipophilicity and aqueous insolubility. OBJECTIVE: To improve the solubility, dissolution and intestinal permeation thereby bioavailability of risperidone through a novel self-nanoemulsifying powder (SNEP) formulations. MATERIALS AND METHODS: Oleic acid, Tween(®) 20, PEG 600 and Aerosil(®) 200 were chosen as oil, surfactant, co-surfactant and carrier, respectively from solubility and emulsification studies...
August 28, 2016: Journal of Microencapsulation
Alireza Mehregan Nikoo, Rassoul Kadkhodaee, Behrouz Ghorani, Hussam Razzaq, Nick Tucker
Electrospraying nano and micro-particle fabrication is a one-step, non-invasive process, which has application in encapsulating of thermosensitive functional, bioactive materials and cells, and making microhydrogels. This study investigates the effect of various electrospraying process parameters on the characteristics of calcium alginate microhydrogel particles. The alginate solution concentration, CaCl2 coagulation bath concentration, voltage, nozzle diameter, distance between nozzle and collecting bath (D), Alginate delivery pressure (∼H) were examined...
August 25, 2016: Journal of Microencapsulation
Katharina J Geh, Madlen Hubert, Gerhard Winter
Gelatin nanoparticles (GNPs) are biodegradable and biocompatible drug delivery systems with excellent clinical performances. A two-step desolvation is commonly used for their preparation, although this methodology has several shortcomings: lack of reproducibility, small scales and low yields. A straightforward and more consistent GNP preparation approach is presented with focus on the development of a one-step desolvation with the use of a commercially available gelatin type. Controlled stirring conditions and ultrafiltration are used to achieve large-scale production of nanoparticles of up to 2...
August 24, 2016: Journal of Microencapsulation
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