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Journal of Microencapsulation

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https://www.readbyqxmd.com/read/28097931/oil-encapsulation-in-core-shell-alginate-capsules-by-inverse-gelation-i-dripping-methodology
#1
Evandro Martins, Denis Renard, Zenia Adiwijaya, Emre Karaoglan, Denis Poncelet
The production of capsules by inverse gelation consists of adding dropwise oil containing calcium dispersion into an alginate bath. A dripping technique to produce capsules from O/W emulsions was proposed by Abang. However, little is known about the oil encapsulation using W/O emulsions. This work aims to develop a new method of W/O emulsions encapsulation by inverse gelation. The success of the W/O emulsion encapsulation is due to three factors: 1) use of an emulsion with moderate stability (50 min); 2) production of an emulsion with at least 90 g/L of CaCl2 and 3) addition of ethanol (20% v/v) into the alginate bath...
January 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28097930/encapsulation-of-sesbania-grandiflora-extract-in-polymeric-micelles-to-enhance-its-solubility-stability-and-antibacterial-activity
#2
Siriporn Okonogi, Pimporn Anantaworasakul
Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improved by these micelles. Activity and toxicity of SGE loaded micelles was depended on type and concentration of Pluronics. The micelles composed of 1:3 SGE to Pluronic F68 (SGE-PF68-13) showed small size (24...
January 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28097929/improved-survival-of-anchorage-dependent-cells-in-core-shell-hydrogel-microcapsules-via-co-encapsulation-with-cell-friendly-microspheres
#3
In-Yong Kim, Hyungsoo Choi, Kyekyoon Kevin Kim
In this study, we investigated the effect of intracapsular environment on the survival of anchorage-dependent cells (ADCs) encapsulated in alginate microcapsules with three different core structures, i.e., liquid, semi-liquid and microsphere-encapsulating semi-liquid core, using NIH 3T3 fibroblasts as an ADC model. For the latter, we fabricated poly (ε-caprolactone) microspheres and co-encapsulated them with the cells, to establish cell-substrate interactions in the capsule. The fibroblast cells co-encapsulated with the microspheres exhibited higher survival and growth than those without...
January 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28097914/nanostructured-lipid-carriers-nlc-for-the-delivery-of-natural-molecules-with-antimicrobial-activity-production-characterization-and-in-vitro-studies
#4
Rita Cortesi, Giuseppe Valacchi, Ximena M Muresan, Markus Drechsler, Catia Contado, Elisabetta Esposito, Alessandro Grandini, Alessandra Guerrini, Giuseppe Forlani, Gianni Sacchetti
This study describes the preparation, characterization and in vitro activity of nanostructured lipid carriers (NLC) encapsulating natural molecules with antimicrobial activity, such as plumbagin, hydroquinon, eugenol, alpha-asarone and alpha-tocopherol. NLC were prepared by melt and ultrasonication method, characterized by Cryo-TEM for morphology and SdFFF for dimensional distribution and active encapsulation yields. In vitro tests were conducted on bacteria, fungi and human cell cultures. In vitro tests demonstrated that plumbagin is strongly toxic towards F...
January 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28084135/calcium-gluconate-as-cross-linker-improves-survival-and-shelf-life-of-encapsulated-and-dried-metarhizium-brunneum-and-saccharomyces-cerevisiae-for-the-application-as-biological-control-agents
#5
Pascal Humbert, Michael Przyklenk, Marina Vemmer, Anant V Patel
Calcium chloride (CC) is the most common crosslinker for the encapsulation of biocontrol microorganisms in alginate beads. The aim of this study was to evaluate if calcium gluconate (CG) can replace CC as crosslinker and at the same time improve viability after drying and rehydration, hygroscopic properties, shelf life and nutrient supply. Hence, the biocontrol fungi Metarhizium brunneum and Saccharomyces cerevisiae were encapsulated in Ca-alginate beads supplemented with starch. Beads were dried and maximum survival was found in beads cross-linked with CG...
January 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28084127/vincristine-and-%C3%AE%C2%B5-viniferine-loaded-plga-b-peg-nanoparticles-pharmaceutical-characteristics-cellular-uptake-and-cytotoxicity
#6
Yüksel Öğünç, Müzeyyen Demirel, Arzu Yakar, Zerrin İncesu
The objective of this study was to prepare the ε-viniferine and vincristine loaded PLGA-b-PEG nanoparticle and to investigate advantages of these formulation on cytotoxicity of HepG2 cells. Prepared nanoparticle has shown a homogeneous distribution with 113±0.43 nm particle size and 0.323 ±0.01 polydispersity index. Zeta potential was determined as -35.03±1.0 mV. The drug loading percentages were 6.01 ± 0.23 and 2.01 ± 0.07 for ε-viniferine and vincristine, respectively.The cellular uptake efficiency of coumarin-6 loaded nanoparticles was increased upto 87...
January 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28067579/hot-melt-extrusion-microencapsulation-of-quercetin-for-taste-masking
#7
Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan, Yuancai Dong
Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking. In comparison with non-encapsulated quercetin, the microencapsulated powders exhibited significantly reduced dissolution in the simulated salivary pH 6.8 medium indicative of their potentially good taste-masking efficiency in the order of zein > carnauba wax > shellac...
January 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28067090/assessment-of-formulated-amodiaquine-microparticles-in-leishmania-donovani-infected-rats
#8
Henry Nettey, Grace Lovia Allotey-Babington, Isaac Somuah, N'guessan Benoit Banga, Barima Afrane, Seth Kwabena Amponsah, Henrietta Annor, Henry Darko, Kwame Hanson, Anoa Aidoo, Marisa Nyarkoa Broni, Clement Sasu, Alexander Nyarko
The aim of this study was to formulate, characterize and evaluate the activity of Amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency and in vitro release profile. The size range of the microparticles formulated was between 1.9 and 10 µm with an average zeta potential of -25.5 mV. Of the expected 20% drug loading, an average of 18...
January 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27903088/enhanced-thermal-properties-with-graphene-oxide-in-the-urea-formaldehyde-microcapsules-containing-paraffin-pcms
#9
Zhen Qiao, Jian Mao
In this study, compact urea-formaldehyde microcapsules containing paraffin (UFP) phase change materials (PCMs) were prepared via in situ polymerisation. The thermal conductivity of the PCMs was enhanced without influencing their enthalpy by adding graphene oxide (GO). Two modification methods were investigated: One in which GO is added to the inside of microcapsules, defined as "paraffin/GO@UF composite"; and another in which GO is coated onto the surface of shell, defined as "paraffin@UF/GO composite". The GO sheets were visible in scanning electron microscope (SEM) images of paraffin@UF/GO composite...
December 15, 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27901355/folic-acid-conjugated-and-ag-carrying-organoclay-nanoparticles-and-their-response-to-l929-fibroblast-and-dld-1-cancer-cells
#10
Zakir M O Rzayev, Sevda Khalilova, Kouroush Salimi
This work presents the synthesis and characterisation of intercalated nanocomposites (NCs) from dispersed water solution blends of octadecyl amine-montmorillonite (ODA-MMT) (NC-0), folic acid (FA) conjugated ODA-MMT (NC-1) and Ag-MMT clay as a stable silver carrying agent (NC-2). The composition, chemical/physical and morphology of NCs with in situ intercalating nanostructures were investigated. Effect of organoclay, FA and Ag-MMT on L929 fibroblast (control), human colon carcinoma (DLD-1) cell lines, and the cytotoxicity, apoptosis and necrosis degree were estimated via WST-1/hemocytometric, double staining (as a ribonuclease A enzyme based method) and fluorescence microscopy methods in a dose-dependent manner...
December 14, 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28093010/correction-to-factors-influencing-the-fabrication-of-albumin-bound-drug-nanoparticles-abdns-part-i-albumin-bound-betulinic-acid-nanoparticles-abbns
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27927052/microencapsulation-of-white-champaca-michelia-alba-d-c-extract-using-octenyl-succinic-anhydride-osa-starch-for-controlled-release-aroma
#12
Rajnibhas Samakradhamrongthai, Prodpran Thakeow, Phikunthong Kopermsub, Niramon Utama-Ang
The objective of the study was to optimise the encapsulation of Michelia alba D.C. (MAD) extract using octenyl succinic anhydride (OSA) starch. The MAD extract (5-10 g/100 g of dry starch) and the OSA starch (25-100 g/100 ml of water) was used in microcapsule preparation and analysed for the physicochemical and encapsulation properties. The optimised formula using the MAD extract and the OSA starch were 15.00 g/100 g of dry starch and 96.32 g/100 g water, which provided the highest in yield recovery (40...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27875065/evaluation-of-a-new-solid-non-aqueous-self-double-emulsifying-drug-delivery-system-for-topical-application-of-quercetin
#13
Qiang Wang, Caibiao Hu, Hong Zhang, Yali Zhang, Tian Liu, Airui Qian, Qiang Xia
This study aimed to the evaluation of a new solid non-aqueous self-double-emulsifying drug-delivery system (SDEDDS) for topical application of quercetin. The new formulation was prepared through two-step emulsification process and could spontaneously form oil-in-oil-in-water (O/O/W) double emulsions after dilution with aqueous medium, with inner oil phase mainly containing the drug. Solid state characterisation was performed by DSC and X-ray powder diffraction. Furthermore, the optimised QT-SDEDDS displayed sustained release profile and was found to be stable up to 30 days under 4 °C and 25 °C...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27866448/dehydration-of-co2-%C3%AE-cyclodextrin-complex-powder-by-desiccant-adsorption-method-and-its-release-properties
#14
Thao M Ho, Tony Howes, Bhesh R Bhandari
Stability and release properties of CO2-α-cyclodextrin complex powder prepared by solid encapsulation (water activity, aw ≈ 0.95) followed by moisture removal using silica gel and CaCl2 desiccants during post-dehydration were investigated. The results showed that CaCl2 reduced aw much faster than silica gel did under the same conditions. After approximately 60 h, aw of complex powders reduced using silica gel was almost constant at 0.247 (±0.012), while those treated with CaCl2, aw was 0.225 (±0.005) and had not yet reached their lowest value...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27845595/cna-loaded-plga-nanoparticles-improve-humoral-response-againsts-aureus-mediated-infections-in-a-mouse-model-subcutaneous-vs-nasal-administration-strategy
#15
Ida Genta, Claudia Colonna, Bice Conti, Paolo Caliceti, Stefano Salmaso, Pietro Speziale, Giampiero Pietrocola, Enrica Chiesa, Tiziana Modena, Rossella Dorati
The aim of this work was the assessment of the "in vivo" immune response of a poly(lactide-co-glycolide)-based nanoparticulate adjuvant for a sub-unit vaccine, namely, a purified recombinant collagen-binding bacterial adhesion fragment (CNA19), against Staphylococcus aureus-mediated infections. "In vivo" immunogenicity studies were performed on mice: immunisation protocols encompassed subcutaneous and intranasal administration of CNA19 formulated as nanoparticles (NPs) and furthermore, CNA19-loaded NPs formulated in a set-up thermosetting chitosan-β-glycerolphosphate (chitosan-β-GP) solution for intranasal route in order to extend antigen exposure to nasal mucosa...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27841073/treatment-of-high-latency-microcapsules-containing-an-aluminium-complex-with-an-epoxy-functionalised-trialkoxysilane
#16
Kazunobu Kamiya, Noboru Suzuki
Some aluminium complexes are excellent catalysts of cationic polymerisation and are used for low-temperature and fast-curing adhesive, used in electronic part mounting. Microencapsulation is a suitable technique for getting high latency of the catalysts and long shelf life of the adhesives. For the higher latency in a cycloaliphatic epoxy compound, the microcapsule surface which retained small amount of aluminium complex was coated with epoxy polymer and the effect was examined. From the X-ray photoelectron spectroscopic results, the surface was recognised to be sufficiently coated and the differential scanning calorimetric analyses showed that the coating did not significantly affect the low-temperature and fast-curing properties of adhesive...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27841060/resveratrol-solid-lipid-microparticles-as-dry-powder-formulation-for-nasal-delivery-characterization-and-in-vitro-deposition-study
#17
Isabella Martignoni, Valentina Trotta, Wing-Hin Lee, Ching-Yee Loo, Michele Pozzoli, Paul M Young, Santo Scalia, Daniela Traini
This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical characteristics of the SLMs loaded with resveratrol were evaluated in terms of morphology, size, thermal behaviour and moisture sorption. The SLMs appeared as aggregates larger than 20 μm. In vitro nasal deposition was evaluated using a USP specification Apparatus E 7-stage cascade impactor equipped with a standard or a modified nasal deposition apparatus...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27781557/characterisation-and-in-vitro-antimicrobial-activity-of-biosynthetic-silver-loaded-bacterial-cellulose-hydrogels
#18
Abhishek Gupta, Wan Li Low, Iza Radecka, Stephen T Britland, Mohd Cairul Iqbal Mohd Amin, Claire Martin
Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27733080/cationic-lipid-emulsions-as-potential-bioadhesive-carriers-for-ophthalmic-delivery-of-palmatine
#19
Juntao Yin, Cuiyu Xiang, Guangxiu Lu
Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high-pressure homogenisation and characterised by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27707051/factors-influencing-the-fabrication-of-albumin-bound-drug-nanoparticles-abdns-part-i-albumin-bound-betulinic-acid-nanoparticles-abbns
#20
Yochana Srivari, Parnali Chatterjee
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water-soluble drug betulinic acid (BA) to improve its aqueous solubility. Monomeric albumin-bound BA (ABBns) nanoparticles can be fabricated in the range of 10-20 nm. BA self-assembled with HSA at 0.1:1 to 2:1 molar ratio within 0.5 h in phosphate buffer pH 7.4 and 8.4. Approximately, 85-90% BA could be loaded onto HSA in the presence of Tween 20 (T20) and sodium cholate (NaC)...
December 2016: Journal of Microencapsulation
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