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Journal of Microencapsulation

Cristian Dima, Stefan Dima
Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-in-oil-in-water (W/O/W) double emulsions loaded with CA and its antioxidant capacity. For this purpose, CA-W/O/W double emulsions were prepared using Span 80 and lecithin as lipophilic emulsifiers, and Tween 20 as a hydrophilic emulsifier...
December 17, 2018: Journal of Microencapsulation
Jinan Li, Rui Guo, Hao Hu, Xuejiao Wu, Lianzhong Ai, Yan Wu
The present work formed lutein-enriched nanoemulsions stabilized by sodium caseinate (SC) using a high-pressure homogenization process, and the influence of environmental conditions on the physicochemical stability of the nanoemulsion were investigated. The results showed that the droplet diameter of the nanoemulsion was largely dependent on homogenization conditions. Optimum results were obtained for 1.0% (w/w) SC, 100 MPa pressure, and 7 homogenization cycles, which produced a nanoemulsion with a mean droplet diameter of 234...
December 17, 2018: Journal of Microencapsulation
Shahadali K, Anuj Garg, Wahajud Din
The aim of the present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Solid state properties (DSC, XRD) and morphology (AFM) of Ch-PC-SLNs were also studied...
December 17, 2018: Journal of Microencapsulation
Maryam Mohammadi, Reza Rezaei Mokarram, Hamed Hamishehkar
Nowadays, since the core-shell gold-magnetite nanoparticles include the saturation magnetization (iron oxide) and plasmon surface (gold shell) properties, they have been considered in biological and biomedicine research areas. In the present work, multifunctional glutathione decorated gold-coated iron oxide nanoparticles (GSH-AuMNPs) were successfully synthesized and fully characterized. From the absorption peak at 525, the formation of the core-shell GSH-AuMNPs was confirmed. Although the saturation magnetization value was slightly decreased during the formation process, they easily were recovered through magnetic decantation...
December 3, 2018: Journal of Microencapsulation
Gislaine Ferreira Nogueira, Luiz Gabriel Pereira Martin, Farayde Matta Fakhouri, Rafael Augustus de Oliveira
This research work aimed to obtain blackberry pulp powder by spray drying and, by an experimental design, evaluated the effect of inlet air temperature (100-150 °C) and blackberry pulp solids:arrowroot starch/gum arabic solids ratio of 1:0.5-1:2 on the physicochemical properties of the powders. Arrowroot starch and gum arabic present glass transition temperature (Tg) values above 100 °C; hence it was possible to employ them as carriers in blackberry pulp spray drying in order to increase Tg of the system...
November 30, 2018: Journal of Microencapsulation
Mu Wang, Cuina Wang, Fen Gao, Mingruo Guo
Lactobacillus acidophilus LA-5 has poor survivability in yoghurts. This study aims to microencapsulate L. acidophilus LA-5 using polymerised whey protein as wall material and evaluate its survivability and effects on physiochemical properties of yoghurts. The microencapsulation yield was 92.90% and average beads size was 744 μm. Microencapsulated L. acidophilus LA-5 showed higher survival at simulated gastrointestinal conditions. Microencapsulated L. acidophilus LA-5 had improved survivability (∼106 cfu/mL) than free cells (∼104 cfu/mL) after digesting by simulated intestinal juice (6 h) in yoghurts during 10-week storage...
November 30, 2018: Journal of Microencapsulation
Davina Perera, Michael Medini, Deepika Seethamraju, Ron Falkowski, Kristopher White, Ronke M Olabisi
Cell microencapsulation can be used in tissue engineering as a scaffold or physical barrier that provides immunoisolation for donor cells. When used as a barrier, microencapsulation shields donor cells from the host immune system when implanted for cell therapies. Maximizing therapeutic product delivery per volume of microencapsulated cells necessitates first optimising the viability of entrapped cells. Although cell microencapsulation within alginate is well described, best practices for cell microencapsulation within polyethylene glycol is still being elucidated...
November 30, 2018: Journal of Microencapsulation
Luciana Erzinger Alves de Camargo, Daniel Brustolin Ludwig, Tania Toyomi Tominaga, Bruna Carletto, Giovani Marino Favero, Rubiana Mara Mainardes, Najeh Maissar Khalil
Curcumin is a natural compound presenting important antitumour activity. However, due to its low aqueous solubility, instability at physiological pH, and low oral bioavailability, its clinical use is limited. Bovine serum albumin (BSA) nanoparticles have been used as drug carriers to improve the drug properties. In this work, curcumin-loaded BSA nanoparticles were developed and the in vitro cytotoxicity over murine melanoma cells and the in vivo antitumour activity in a murine melanoma model were assessed. Nanoparticles presented 150 nm, polydispersity index of 0...
November 30, 2018: Journal of Microencapsulation
Eskandar Moghimipour, Mohsen Rezaei, Maryam Kouchak, Zahra Ramezani, Mohsen Amini, Kambiz Ahmadi Angali, Sadegh Saremy, Farid Abedin Dorkoosh, Somayeh Handali
This study was performed to prepare 5-fluorouracil (5FU) containing targeted liposomes for the safety and efficacy enhancement. Liposomes were prepared using thin layer method and transferrin (Tf) was employed as the targeting ligand. Morphology of 5FU-loaded liposomes was assessed by transmission electron microscopy (TEM). The in vitro cytotoxicity was investigated via MTT assay on HT-29, CT26 and fibroblast cells. Mitochondrial membrane and cell death evaluations were also investigated. Resulted showed that the encapsulation efficiency (EE%) and particle size of the liposomes were 40...
November 16, 2018: Journal of Microencapsulation
Ya Wang, Chaonan Li, Yuxiang Wang, Ying Zhang, Xiaogang Li
Controlled release system has been widely developed and utilised in agriculture to optimise efficacy and minimise environmental pollution. Here, the azoxystrobin and difenoconazole compound pesticide microsphere was constructed by the solvent evaporation method. Blending poly (butylene succinate) (PBS) and poly (lactic acid) (PLA) as shells, in order to increase its entrapment efficiency and match the goal of complex synergism. The resulting microsphere processes high entrapment efficiency with a mean diameter of 7...
November 5, 2018: Journal of Microencapsulation
Bably Khatun, Nibedita Banik, Anowar Hussain, Anand Ramteke, Tarun Maji
Here, we have reported the influence of MMT and genipin in releasing curcumin from the Genipin crosslinked Chitosan/MMT nanoparticles, prepared by ionic gelation method. The nanoparticles were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometry (XRD), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Zeta potential and average diameter of the nanoparticles were found in the range 32-47 mV and 430-560 nm. Swelling and release of curcumin from the nanoparticles increased with the decrease in pH of the medium, MMT and genipin content...
October 5, 2018: Journal of Microencapsulation
Jingjing Tang, Jiayin Bao, Xiangjun Shi, Xiaoxia Sheng, Weike Su
The research aimed to prepare febuxostat (FEB) solid dispersion via solvent evaporation. Optimized solid dispersion composed of FEB, Polyvinylpyrrolidone (PVP K30) and poloxamer at ratio of 1:3:3 was characterized. Powder X-ray diffraction(XRD) and Differential scanning calorimetry (DSC) indicated FEB was transformed from crystalline into amorphous state in solid dispersion and Scanning electron microscopy (SEM) revealed the morphology. Fourier transform infrared spectroscopy (FT-IR) suggested the interactions formed between FEB and polymers...
September 19, 2018: Journal of Microencapsulation
Gizem Rüya Topal, Burcu Devrim, Müjde Eryilmaz, Asuman Bozkir
In this study, ciprofloxacin hydrochloride (CIP)-loaded poly-ε-caprolactone (PCL) nanoparticles were prepared for pulmonary administration. CIP-loaded PCL nanoparticles were prepared by solid-in-oil-in-water (s/o/w) emulsion solvent evaporation method and the effects of various formulation parameters on the physicochemical properties of the nanoparticles were investigated. PCL nanoparticles showed spherical shapes with particle sizes around 143-489 nm. Encapsulation efficiency was found to be very low because of water-solubility properties of CIP...
September 14, 2018: Journal of Microencapsulation
Doan-Trang Hoang, Diane Schorr, Véronic Landry, Pierre Blanchet, Stéphanie Vanslambrouck, Christian Dagenais
Intumescent fire retardant (IFR) coatings are nowadays considered as the most effective flame retardant (FR) treatment. Nevertheless, the principal compound in an IFR system, ammonium polyphosphate (APP), is highly sensitive to moisture and IFR coating effectiveness decreases quickly. The main objective of this study is to encapsulate APP in a hybrid silica-based membrane by sol-gel process using alkoxysilane tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) precursor. The morphology and structure of APP and microencapsulated ammonium polyphosphate (MAPP) were assessed by scanning electron miscroscopy and Fourier transform infrared spectroscopy (FTIR)...
September 7, 2018: Journal of Microencapsulation
Pia Gottschalk, Benjamin Brodesser, Denis Poncelet, Henry Jaeger, Harald Rennhofer, Stephen Cole
Microparticles with different essential oil concentrations 0, 75, 150, 225 and 300 gkg-1 , (g of essential oil per kg of microparticles), were produced by dispersing the essential oils within a hydrogenated vegetable fat matrix and forming spherical solid particles by spray-chilling. Size distribution, flowability, surface structure, essential oil recovery, melting properties and crystallinity of the microparticles were determined. With over 225 gkg-1 essential oil the microparticle surface became stickier, their flowability was reduced and the size distribution broadened...
August 30, 2018: Journal of Microencapsulation
Vikas Chander, Ajay Kumar Singh, Gurudutta Gangenahalli
Natural killer and cytotoxic CD8+ T cells are involved in the rapid clearance of cells which express foreign antigens. Hence, these cells are crucial elements of the vertebrate immune system. However, these benefits turn problematic when they cause transplant rejection through their direct cytotoxic effects on donor organs/cells, which is attributed to the human leukocyte antigen disparity. To overcome these limitations, a strategy has been devised where in the above effects can be minimized by shielding the cells through encapsulation...
August 27, 2018: Journal of Microencapsulation
Jung Suk Kim, Jong Hyuck Park, Sung Chan Jeong, Dong Shik Kim, Abid Mehmood Yousaf, Fakhar Ud Din, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Sung Giu Jin, Han-Gon Choi
To develop a novel revaprazan-loaded gelatin microsphere with enhanced solubility and oral bioavailability, numerous gelatin microspheres were prepared using a spray-drying technique. The impact of gelatin amount on drug solubility in the gelatin microspheres was investigated. The physicochemical properties of the selected gelatin microsphere, such as shape, particle size and crystallinity, were evaluated. Moreover, its dissolution and pharmacokinetics in rats were assessed in comparison with revaprazan powder...
August 23, 2018: Journal of Microencapsulation
Wadiaa Benamer, Francesco Cellesi, Nicola Tirelli
This study is about the use of β-glycerophosphate (βGP) to modulate the production of chitosan microparticles through a technology of jet break-up. βGP has been described as capable of producing chitosan gels without additional complexing agents via a thermal transition (inverse gelation). A preliminary assessment on the effect of temperature on the viscosity and gelation of chitosan/βGP precursors demonstrated that the crosslinking process was too slow to afford microparticle production via jet break-up...
August 23, 2018: Journal of Microencapsulation
Ludmylla Cunha, Ana M Rosa da Costa, João P Lourenço, Francesca Buttini, Ana Grenha
Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity. This work aimed at using fucoidan as matrix of inhalable microparticles that associate two first-line antitubercular drugs, for an application in pulmonary tuberculosis therapy. Fucoidan is composed of fucose and sulphated sugar residues, moieties described as being recognised by surface receptors of alveolar macrophages, which host mycobacteria...
June 2018: Journal of Microencapsulation
Ya-Ling Su, Chien-Yu Lin, Shih-Jiuan Chiu, Teh-Min Hu
A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20-80%, R6G exhibited near 100% efficiency...
June 2018: Journal of Microencapsulation
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