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Journal of Microencapsulation

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https://www.readbyqxmd.com/read/29448884/ameliorating-the-in-vivo-antimalarial-efficacy-of-artemether-using-nanostructured-lipid-carriers
#1
Vanka Ravisankar, Gowthamarajan Kuppusamy, Praveen Kumar Simhadri, Uday Krishna Baruah, Veera Venkata Satyanarayana Reddy Karri, Vimal Pandey, Phanithi Prakash Babu
Cerebral malaria (CM) is a fatal neurological complication of Plasmodium falciparum infection that affects children (below five years old) in sub-Saharan Africa and adults in South-East Asia each year having the fatality rate of 10-25%. The survivors of CM also have high risk of long term neurological or cognitive deficits. The objective of the present investigation was to develop optimized nanostructured lipid carriers (NLCs) of artemether (ARM) for enhanced anti-malarial efficacy of ARM.NLCs of ARM were prepared by a combination of high speed homogenization (HSH) and probe sonication techniques...
February 16, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29448848/development-and-characterization-of-morin-hydrate-loaded-micellar-nanocarriers-for-the-effective-management-of-alzheimer-s-disease
#2
Manpreet Singh, Vandana Thakur, Rahul Deshmukh, Amit Sharma, M S Rathore, Ajay Kumar, Neeraj Mishra
The aim of this study was to prepare and characterize oral delivery of Morin hydrate loaded micellar nanocarriers using Pluronic P127 & Pluronic F123 for the effective management of Alzheimer's disease. After administration of formulation brain and blood drug concentration were found to be highest for optimized morin hydrate loaded micellar nanocarriers as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate loaded micellar nanocarriers as compared to disease control group...
February 16, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29376454/in-vivo-efficacy-and-evaluation-of-gel-cream-containing-dehydrated-betamethasone-dipropionate-nanocapsules
#3
Maiara Taís Bazana, Aline S Gonçalves, Paulo Guilherme R Schimites, Jader B Ruchel, João Felipe P Rezer, Daniela B Rosa Leal, Cristiane de B da Silva
This study aimed to develop gel-creams from the lyophilised product of betamethasone dipropionate-loaded lipid-core nanocapsule suspensions and evaluated its efficacy in a model of contact dermatitis. The gel-creams were prepared and characterized followed by a study of in vitro drug penetration/permeation and its in vivo efficacy. The suspensions and lyophilised products showed nanometric size; the betamethasone content was 0.25 ± 0.01 mg/mL and the encapsulation efficiency was approximately 100%. The nanocapsules and redispersed powders presented control of the drug release...
January 29, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29310481/nanostructured-lipid-carriers-for-intraocular-brimonidine-localization-development-in-vitro-and-in-vivo-evaluation
#4
Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal
Brimonidine ocular hypotensive effect can be enhanced by increasing residence time and corneal penetration. The current work aimed to formulate, evaluate and compare nanostructured lipid carriers (NLCs) to solid lipid nanoparticles (SLNs) and commercial eye drops for controlled brimonidine delivery. NLCs prepared by modified high shear homogenization were spherical with a mean size of 151.97 ±1.98 nm, negative zeta potential (ZP) of -44.2± 7.81 mV, % entrapment efficiency (EE) of 83.631 ±0.495% and low crystallinity index (CI) (17...
January 9, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29308688/novel-pogostone-analogous-xw-12-loading-nanoparticles-display-enhanced-systematic-activity-against-methicillin-resistant-staphylococcus-aureus
#5
Xiaoyun Wang, Fengbo Wu, Yuyu Chen, Feifei Qin, Jinku Bao, Guo Chen
Pogostone analogous XW-12 displays an inhibitory effect on Staphylococcus aureus. However, the insolubility of the compound has restricted its further applications. This work aims to improve the water-solubility of XW-12, we used previously synthesized pogostone derivatives XW-12, forming nanoparticles with PLGA-PEG by a single-emulsion solvent-evaporation technique. Characterizations of XW-12 nanoparticles were performed. The in vitro and vivo experiments confirmed its antimicrobial efficacy and toxicity. The results revealed that the XW-12 NPs had a particle size of approximately 200...
January 8, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29308686/self-double-emulsifying-drug-delivery-system-incorporated-in-natural-hydrogels-a-new-way-for-topical-application-of-vitamin-c
#6
Qiang Wang, Hong Zhang, Juan Huang, Nan Xia, Tong Li, Qiang Xia
This study aimed at the in vitro evaluation of topical hydrogels containing vitamin C-loaded self-double-emulsifying drug delivery system (SDEDDS). The liquid SDEDDS was converted into suitable unmodified xanthan gum hydrogels formulation and the prepared semi-solid hydrogels provided appropriate gel characteristics like pH, viscosity, spreadability, etc. The 5 week storage test displayed that the prepared hydrogels possessed good physicochemical stability. In addition, no significant cytotoxicity to L929 cells was observed for the vitamin C-loaded SDEDDS-based hydrogels, and the prepared hydrogels depicted a sustained drug release over a 8 h period...
January 8, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29307286/microemulsion-based-delivery-of-triamcinolone-acetonide-to-posterior-segment-of-eye-using-chitosan-and-butter-oil-as-permeation-enhancer-an-in-vitro-and-in-vivo-investigation
#7
Nidhi Raval, Dignesh Khunt, Manju Misra
The aim of the study was to formulate a microemulsion (ME) using chitosan (CH) and the Butter oil (BO) as a permeation enhancer for targeting drug to the posterior segment of the eye, via topical route. Triamcinolone acetonide (TA) was selected as the model drug since it undergoes extensive first-pass metabolism leading to poor oral bioavailability of 23%. For optimization of BO concentration, different ratios of TA:BO were prepared by simple physical mixing in the ratio of 1:9 to 9:1 and diffusion study was performed...
January 8, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29308689/iodinated-curcumin-bearing-dermal-cream-augmented-drug-delivery-antimicrobial-and-antioxidant-activities
#8
Gagandeep Manchanda, Rupinder Kaur Sodhi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
OBJECTIVES: Curcumin (Cur) exhibits weak microbicidal activity owing to high lipophilicity and low cell permeability. Therefore, in present investigation, Cur was iodinated using elemental iodine (I2) to synthesize Cur-I2 powder that later formulated as Cur-I2 dermal cream and characterized in vitro for antimicrobial and antioxidant activities. METHODS AND RESULTS: Electrophilic addition of I2 saturated the olefinic bonds of Cur, as confirmed by UV/Visible spectroscopy, FT-IR, 1H NMR and DSC techniques...
January 6, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29206479/microencapsulation-of-esterified-krill-oil-using-complex-coacervation
#9
Selim Kermasha, Sarya Aziz, Jagpreet Gill, Ronald Neufeld
The microencapsulation of the esterified krill oil (EKO), obtained from the transesterification of krill oil (KO) with 3,4-dihydroxyphenylacetic acid (DHPA), via complex coacervation, was investigated. The experimental findings showed that the DHPA and phenolic lipids (PLs) in the EKO affected the stability of the gelatin (GE)-EKO emulsion. To improve its stability, the effects of varying the pH of GE and the use of two emulsification devices, including the homogenizer and ultrasonic liquid processor were investigated, where the ultrasonic liquid processor was found to be a relatively more appropriate emulsification device...
December 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29198147/optimisation-of-%C3%AE-cyclodextrin-inclusion-complexes-with-natural-antimicrobial-agents-thymol-carvacrol-and-linalool
#10
Ghofran Al-Nasiri, Marlene J Cran, Andrew J Smallridge, Stephen W Bigger
Beta-cyclodextrin (β-CD) inclusion complexes with naturally derived antimicrobial (AM) agents: thymol, carvacrol, and linalool were prepared using a co-precipitation technique. Conditions including solvent composition, temperature, reaction time, and total solvent volume were investigated to optimise the inclusion efficiency (IE) and yield. Electrospray ionization mass spectrometry was used to confirm the formation of the thymol/β-CD complex and gas chromatography was used to quantify the amount AM agent that was encapsulated, absorbed onto the surface, or remaining in the filtered solvent...
December 4, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29195484/targeted-delivery-of-garcinia-glycosides-by-reconstituted-high-density-lipoprotein-nano-complexes
#11
Chang Liu, Zijun Zhou, Ye Chen, Ju Liu, Yang Wang, Hongsheng Liu
Scavenger receptor class B type 1 (SR-B1) is over-expressed in tumor cells where it mediates the uptake of drug payload of reconstituted high density lipoprotein (rHDL) via the process of reverse cholesterol transport. In this study, rHDL was prepared to determine its function as a drug delivery carrier for targeting hepatocellular carcinoma by incorporating the anti-tumor drug garcinia glycosides into rHDL to yield rHDL/GG nano-complexes. Structural analysis indicated that the rHDL/GG nano-complex was similar to HDL in size...
December 1, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29171778/effect-of-matrix-composition-sphere-size-and-hormone-concentration-on-diffusion-coefficient-of-insulin-for-controlled-gastrointestinal-delivery-for-diabetes-treatment
#12
Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz, Alvaro Luiz Mathias
Oral insulin administration is limited due to its degradation by proteases. The hormone was encapsulated in spheres made of either pure calcium alginate (ALG) or its association with whey protein isolate (WPI-ALG) in order to minimize loss in the stomach region while allowing liberation in the maximum absorption area, located in the intestine. Diffusion coefficients for both matrix compositions were determined in vitro for gastric pH (5.88 and 10.26 10(-12) m(2) s(-1)) and intestinal pH (21.11 and 79.29 10(-12) m(2) s(-1))...
November 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29168930/cyclodextrin-encapsulation-of-daidzein-and-genistein-by-grinding-implication-on-the-glycosaminoglycan-accumulation-in-mucopolysaccharidosys-type-ii-and-iii-fibroblasts
#13
Barbara Fumić, Jasna Jablan, Dominik Cinčić, Marijana Zovko Končić, Mario Jug
This work was aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidoes (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing, confirming the complexes formation with increased solubility with respect to starting compounds...
November 23, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29161939/oil-encapsulation-techniques-using-alginate-as-encapsulating-agent-applications-and-drawbacks
#14
Evandro Martins, Denis Poncelet, Ramila Cristiane Rodrigues, Denis Renard
Oils are used in agriculture, nutrition, food and cosmetics; however, these substances are oxidisable and may readily lose their properties. To reduce their degradation or to mask certain undesirable aspects, one strategy consists in encapsulating the oil in inert structures (capsules). The capsules are classified according to the morphology, the number of cores and size, can be produced by several techniques: jet-cutting, vibrating jet, spray-drying, dispersion and milli-microfluidic. Among the polymers used as a membrane in the capsules, alginates are used in oil encapsulation because of their high gelling capacity, biocompatibility and low toxicity...
November 21, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29141479/development-of-a-carboxymethyl-chitosan-functionalized-nanoemulsion-formulation-for-increasing-aqueous-solubility-stability-and-skin-permeability-of-astaxanthin-using-low-energy-method
#15
Liang Hong, Chuan-Li Zhou, Feng-Ping Chen, Dan Han, Chun-Yuan Wang, Jia-Xin Li, Zhe Chi, Chen-Guang Liu
In this research, firstly astaxanthin (ASX)-loaded nanoemulsions (NEs) were produced using a convenient low-energy emulsion phase inversion method. The optimised ASX-NEs were prepared in the presence of Cremophor(®) EL and Labrafil(®) M 1944 CS, with a surfactant-to-oil ratio of 4:6. The ASX-NE droplets were spherical with a mean droplet diameter below 100 nm and a small negative surface charge. The system was stable without alteration of mean droplet diameter for three months. Then, the ASX-NE was functionalised with carboxymethyl chitosan (CMCS) through direct CMCS (0...
November 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29119840/preparation-of-soft-microcapsules-containing-multiple-core-materials-with-interfacial-dehydration-reaction-using-the-w-o-w-emulsion
#16
Yoshinari Taguchi, Takanori Suzuki, Natsukaze Saito, Hiroshi Yokoyama, Masato Tanaka
The soft microcapsules containing Eucalyptus oil, Ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the (W/O)/W emulsion. The diameters of the microcapsules and the content and the microencapsulation efficiency of the core materials were significantly affected by the revolution velocity (Nr1) to form the (W/O) emulsion and that (Nr2) to form the (W/O)/W emulsion and the lecithin concentration. The mean diameters of the inner water droplets and those of the microcapsules were proportional to Nr1(-1...
November 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29105520/preparation-and-characterization-of-textile-based-carrier-systems-for-anal-fissure-treatment
#17
A M Sarıışık, S Y Karavana, G C Türkoğlu, S Rençber, T Önder
Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement, encapsulation efficiency, drug loading and in vitro drug release. Mass yield was between 5.5 and 45.9%. The particle size was between 15.1 and 26.8 µm. Encapsulation efficiency were 96.142 ± 5...
November 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28985684/microencapsulation-of-probiotics-by-efficient-vibration-technology
#18
Araceli Olivares, Paulina Silva, Claudia Altamirano
The target site of action of probiotics is the intestine. They must be surviving the stomach acidic condition before reaching the target site. Three probiotic bacteria were microencapsulated in sodium alginate beads using a sophisticated microencapsulation technology provided by BÜCHI B-390. This study reports the tolerance of the different microencapsulated Lactobacillus at low pH using simulated gastric juice, comparing it with the tolerance of free bacteria. The three microencapsulated strains displayed time-dependent acid sensitivity at pH values under 3...
October 23, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29053065/investigation-of-the-role-of-alginate-containing-high-guluronic-acid-on-osteogenic-differentiation-capacity-of-human-umbilical-cord-wharton-s-jelly-mesenchymal-stem-cells
#19
Darioush Bijan Nejad, Saeed Azandeh, Rezvan Habibi, Vahid Bayati, Kambiz Ahmadi Angali
BACKGROUND AND AIM: Cell encapsulation using biodegradable material has promising results for tissue engineering. Since pressure is an effective factor on stem cell behavior and various concentrations of alginate create different pressures on the cells, therefore our goal was to evaluate the mechanical effect of 1/2% (w/v) and 1/8%(w/v) alginate containing high guluronic acid on viability and osteogenic capacity of HUCWJ cells. METHODS: Cell viability was evaluated by MTT assay after 1, 7 and 14 days...
October 20, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29027828/folate-decorated-and-nir-activated-nanoparticles-based-on-platinum-iv-prodrugs-for-targeted-therapy-of-ovarian-cancer
#20
Yu Sun, Tian-Yi Shi, Ling-Yun Zhou, Yu-Yan Zhou, Bai-Wang Sun, Xiao-Ping Liu
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt(IV)-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG)...
October 13, 2017: Journal of Microencapsulation
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