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Journal of Microencapsulation

Zhen Qiao, Jian Mao
In this study, compact urea-formaldehyde microcapsules containing paraffin (UFP) phase change materials (PCMs) were prepared via in situ polymerization. The thermal conductivity of the PCMs was enhanced without influencing their enthalpy by adding graphene oxide (GO). Two modification methods were investigated: One in which GO is added to the inside of microcapsules, defined as "paraffin/GO@UF composite"; and another in which GO is coated onto the surface of shell, defined as "paraffin@UF/GO composite". The GO sheets were visible in SEM images of paraffin@UF/GO composite...
December 1, 2016: Journal of Microencapsulation
Zakir M O Rzayev, Sevda Khalilova, Kouroush Salimi
This work presents the synthesis and characterization of intercalated nanocomposites (NCs) from dispersed water solution blends of octadecyl amine-montmorillonite (ODA-MMT) (NC-0), folic acid (FA) conjugated ODA-MMT (NC-1) and Ag-MMT clay as a stable silver carrying agent (NC-2). The composition, chemical/physical and morphology of NCs with in situ intercalating nanostructures were investigated. Effect of organoclay, FA and Ag-MMT on L929 fibroblast (control), human colon carcinoma (DLD-1) cell lines, and the cytotoxicity, apoptosis and necrosis degree were estimated via WST-1/hemocytometric, double staining (as a ribonuclease A enzyme based method) and fluorescence microscopy methods in dose-dependent manner...
November 30, 2016: Journal of Microencapsulation
Qiang Wang, Caibiao Hu, Hong Zhang, Yali Zhang, Tian Liu, Airui Qian, Qiang Xia
This study aimed at the evaluation of a new solid non-aqueous self-double-emulsifying drug delivery system (SDEDDS) for topical application of quercetin. The new formulation was prepared through two-step emulsification process and could spontaneously form oil-in-oil-in-water (O/O/W) double emulsions after dilution with aqueous medium, with inner oil phase mainly containing the drug. Solid state characterization was performed by DSC and X-ray powder diffraction. Furthermore, the optimized QT-SDEDDS displayed sustained release profile and was found to be stable up to 30 days under 4°C and 25°C...
November 22, 2016: Journal of Microencapsulation
Thao M Ho, Tony Howes, Bhesh R Bhandari
Stability and release properties of CO2-α-cyclodextrin complex powder prepared by solid encapsulation (water activity, aw ≈ 0.95) followed by moisture removal using silica gel and CaCl2 desiccants during post-dehydration were investigated. The results showed that CaCl2 reduced aw much faster than silica gel did under the same conditions. After approximately 60 h, aw of complex powders reduced using silica gel was almost constant at 0.247 (±0.012) while those treated with CaCl2, aw was 0.225 (±0.005) and had not yet reached their lowest value...
November 21, 2016: Journal of Microencapsulation
I Genta, C Colonna, B Conti, P Caliceti, S Salmaso, P Speziale, G Pietrocola, E Chiesa, T Modena, R Dorati
The aim of this work was the assessment of the "in vivo" immune response of a poly(lactide-co-glycolide) based nanoparticulate adjuvant for a sub-unit vaccine, namely a purified recombinant collagen binding bacterial adhesion fragment (CNA19), against S. aureus-mediated infections. "In vivo" immunogenicity studies were performed on mice: immunization protocols encompassed subcutaneous and intranasal administration of CNA19 formulated as nanoparticles (NPs) and furthermore CNA19 loaded NPs formulated in a set-up thermosetting chitosan-β-glycerolphosphate (chitosan-β-GP) solution for intranasal route in order to extend antigen exposure to nasal mucosa...
November 15, 2016: Journal of Microencapsulation
Kazunobu Kamiya, Noboru Suzuki
Some aluminum complexes are the excellent catalysts of cationic polymerization and are used for low-temperature and fast-curing adhesive, which is required for electronic parts. Microencapsulation is a suitable technique for getting high latency of the catalysts and long shelf life of the adhesives. For the higher latency in a cycloaliphatic epoxy compound, the microcapsule surface which retained small amount of aluminum complex was coated with epoxy polymer and the effect was examined. From the X-ray photoelectron spectroscopic results, the surface was recognized to be sufficiently coated and the differential scanning calorimetric analyses showed that the coating did not significantly affect the low-temperature and fast-curing properties of adhesive...
November 12, 2016: Journal of Microencapsulation
Isabella Martignoni, Valentina Trotta, Wing-Hin Lee, Ching-Yee Loo, Michele Pozzoli, Paul M Young, Santo Scalia, Daniela Traini
This study focuses on development and in vitro characterization of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical characteristics of the SLMs loaded with resveratrol were evaluated in terms of morphology, size, thermal behaviour and moisture sorption. The SLMs appeared as aggregates larger than 20 µm. In vitro nasal deposition was evaluated using a USP specification Apparatus E 7-stage cascade impactor equipped with a standard or a modified nasal deposition apparatus...
November 12, 2016: Journal of Microencapsulation
Sanaul Mustafa, V Kusum Devi, Roopa S Pai
Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. KS is polycationic, a property responsible for KS poor oral absorption half-life (2.5 h) and rapid renal clearance, which results in serious nephrotoxicity/ototoxicity. The current study aimed to develop KS-loaded PLGA vitamin-E-TPGS microparticles (MPs) and nanoparticles (NPs) to reduce the dosing frequency and dose-related adverse effect. In vitro release was sustained up to 10 days for KS PLGA-TPGS MPs and 13 days for KS PLGA-TPGS NPs in phosphate-buffered saline (PBS) pH 7...
November 1, 2016: Journal of Microencapsulation
Abhishek Gupta, Wan Li Low, Iza Radecka, Stephen T Britland, Mohd Cairul Iqbal Mohd Amin, Claire Martin
Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S...
October 26, 2016: Journal of Microencapsulation
Xunan Zhang, Wei Zong, Ying Hu, Nan Luo, Wenlong Cheng, Xiaojun Han
In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
October 19, 2016: Journal of Microencapsulation
M Moreno-Sastre, M Pastor, A Esquisabel, E Sans, M Viñas, D Bachiller, J L Pedraz
In the last decades, the encapsulation of antibiotics into nanoparticulate carriers has gained increasing attention for the treatment of infectious diseases. Sodium colistimethate-loaded solid lipid nanoparticles (Colist-SLNs) and nanostructured lipid carriers (Colist-NLCs) were designed aiming to treat the pulmonary infection associated to cystic fibrosis patients. The nanoparticles were freeze-dried using trehalose as cryoprotectant. The stability of both nanoparticles was analysed over one year according to the International Conference of Harmonisation (ICH) guidelines by determining the minimum inhibitory concentration (MIC) against clinically isolated Pseudomonas aeruginosa strains and by studying their physico-chemical characteristics...
October 14, 2016: Journal of Microencapsulation
Mohammad Yusuf, Maria Khan, Riaz A Khan, Ibrahim Abdullah Maghrabi, Bahar Ahmed
Depression is a modern world epidemic. Its main causative factor is oxidative stress, as reported in study subjects. Natural products are yet to show significant therapeutic effects in comparison with synthetic drugs. Current study deals with the preparation of brain-targeted polysorbate-80-coated curcumin PLGA nanoparticles (PS-80-CUR-NP), and their characterisation via Spectral and optical methods. PS-80-CUR-NP were evaluated against the oxidative stress-mediated depressant (OSMD) activity via Force despair, Tail suspension tests and stress biomarker assay (SOD and catalase activity)...
October 14, 2016: Journal of Microencapsulation
Juntao Yin, Cuiyu Xiang, Guangxiu Lu
Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high pressure homogenization and characterized by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around...
October 13, 2016: Journal of Microencapsulation
Sedigheh Nadri, Hormoz Mahmoudvand, Ali Eatemadi
INTRODUCTION: In an effort of designing an alternative method for local nerve block, we demonstrated the possibility of inducing ankle block in the rat with intravenous (IV) injection of magnetic nanoparticles conjugated bupivacaine and application of a magnet at the ankle. METHODS: The anaesthetic effect of magnet-directed bupivacaine-associated MNPs (NIPAAM-MAA-bupivacaine) was tested in rat using paw withdrawal latencies from thermal stimuli on the hind paw. Thirteen (13) experimental animals were grouped into two; untreated left hind paw (control group) and test group with treated right hind paw...
October 13, 2016: Journal of Microencapsulation
Yochana Srivari, Parnali Chatterjee
Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water soluble drug betulinic acid (BA) to improve its aqueous solubility. Monomeric albumin-bound BA (ABBns) nanoparticles can be fabricated in the range of 10-20 nm. BA self-assembled with HSA at 0.1: 1 to 2: 1 molar ratio within 0.5 h in phosphate buffer pH 7.4 and 8.4. Approximately, 85%-90% BA could be loaded onto HSA in the presence of Tween 20 (T20) and sodium cholate (NaC)...
October 6, 2016: Journal of Microencapsulation
Anita Chudecka-Głaz, Joanna Szczeblińska, Aneta Cymbaluk-Płoska, Joachim Kohn, Miroslawa El Fray
New poly(ester-amide) copolymers modified with polyethers were developed for carboplatin encapsulation. These new copolymers contain hydrophobic blocks made of tyrosine derivative and dimer fatty acid, and poly(ethylene glycol) (PEG) as hydrophilic blocks. Short term hydrolytic degradation revealed high water absorption, slight increase of pH of simulated body fluid and change of sample shape, which indicated the erosive mechanism of polymers degradation. Poly(ester-amide)-PEG copolymers were used for microspheres preparation and carboplatin encapsulation...
October 5, 2016: Journal of Microencapsulation
Jagruti Desai, Hetal Thakkar
The present investigation aimed to study the effect of particle size of solid lipid nanoparticles (SLNs) on oral bioavailability of Darunavir. High pressure homogenization technique was used to prepare SLNs. Three different sized SLNs loaded with Darunavir were developed with mean particle sizes of around 100 nm, 200 nm and 500 nm respectively. The in-vivo pharmacokinetics in rats showed a significant increase in oral bioavailability of Darunavir from all the three formulations in comparison to plain drug suspension and reference tablet...
October 5, 2016: Journal of Microencapsulation
Zahra Mahdizadeh Barzoki, Zahra Emam-Djomeh, Elaheh Mortazavian, Ali Akbar Moosavi-Movahedi, M Rafiee Tehrani
The present study was performed to optimise the formulation of a muco-adhesive buccal patch for insulin nanoparticles (NPs) delivery. Insulin NPs were synthesised by an ionic gelation technique using N-di methyl ethyl chitosan cysteine (DMEC-Cys) as permeation enhancer biopolymer, tripolyphosphate (TPP) and insulin. Buccal patches were developed by solvent-casting technique using chitosan and gelatine as muco-adhesive polymers. Optimised patches were embedded with 3 mg of insulin-loaded NPs with a homogeneous distribution of NPs in the muco-adhesive matrix, which displayed adequate physico-mechanical properties...
October 5, 2016: Journal of Microencapsulation
Gülsel Yurtdaş Kırımlıoğlu, Yusuf Menceloğlu, Kevser Erol, Yasemin Yazan
Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, non-toxic and biocompatible polymeric nanoparticles, and investigating their effectiveness in epilepsy. For this purpose, GABA conjugated N,N-dimethylacrylamide-based pegylated nanoparticles were designed and characterised for particle size, zeta potential, pH, morphology, DSC, XRD, FTIR, GABA quantification and in vitro release. Formulations showed smaller particle size, cationic zeta potential characteristic, possible GABA polymeric matrix interaction and prolonged release pattern...
September 22, 2016: Journal of Microencapsulation
Hui Li, Jinyong Zhang, Nannan Zhang, Joe Kershaw, Lei Wang
It is important to fabricate biocompatible and chemical resistant microstructures that can be powered and controlled without a tether in fluid environment for applications when contamination must be avoided, like cell manipulation, and applications where connecting the power source to the actuator would be cumbersome, like targeted delivery of chemicals. In this work, a novel fabrication method was described to encapsulate magnetic composite into pure SU-8 structures, enabling the truly microscale ferromagnetic microrobots biocompatible and chemical resistant...
September 15, 2016: Journal of Microencapsulation
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