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Journal of Microencapsulation

Yu Sun, Tian-Yi Shi, Ling-Yun Zhou, Yu-Yan Zhou, Bai-Wang Sun, Xiao-Ping Liu
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt(IV)-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG)...
October 13, 2017: Journal of Microencapsulation
Araceli Olivares, Paulina Silva, Claudia Altamirano
The target site of action of probiotics is the intestine. They must be surviving the stomach acidic condition before reaching the target site. Three probiotic bacteria were microencapsulated in sodium alginate beads using a sophisticated microencapsulation technology provided by BÜCHI B-390. This study reports the tolerance of the different microencapsulated Lactobacillus at low pH using simulated gastric juice, comparing it with the tolerance of free bacteria. The three microencapsulated strains displayed time-dependent acid sensitivity at pH values under 3...
October 6, 2017: Journal of Microencapsulation
Franklin Chimaobi Kenechukwu, Anthony Amaechi Attama, Emmanuel Chinedum Ibezim
OBJECTIVE: To develop and evaluate solidified-reverse-micellar-solution (SRMS)-based oromucosal nano lipid gels for improved localised delivery of miconazole nitrate (MN). METHODS: Phospholipon(®) 90G and Softisan(®) 154 (3:7) were used to prepare SRMS by fusion. Solid lipid nanoparticles (SLNs, 0.25-1.0% w/w MN) formulated with the SRMS by high shear homogenisation were employed to prepare mucoadhesive nano lipid gels. Physicochemical characterisation, drug release in simulated salivary fluid (SSF) (pH 6...
September 6, 2017: Journal of Microencapsulation
Quan Zhang, Chunfeng Ou, Shengying Ye, Xianliang Song, Shucan Luo
Melatonin-loaded liposomes (MLL) were successfully prepared using rapid expansion of supercritical solution technology. The effects of supercritical pressure on encapsulation efficiency and average particle size were then analyzed. Meanwhile, temperature, formation time and ethanol concentration in the products were studied and optimized based on the response surface methodology (RSM). An in vitro simulated digestion model was also established to evaluate the release performance of MLL. The results showed that 140 bar was the best pressure for maximizing the encapsulation efficiency value using RSM optimization, reaching up to 82...
September 4, 2017: Journal of Microencapsulation
Merari T Chevalier, Mónica C García, Daniela Gonzalez, Sandro M Gomes-Filho, Daniela S Bassères, Hernan Farina, Vera A Alvarez
Peptide active ingredients show great promise regarding the treatment of various health-endangering diseases. It is reported that L-lysine inhibits the proliferation of several tumour lines in vitro and in vivo. However, proteins and peptide drugs possess certain disadvantages such as in vivo instability and short biological half-life. On the grounds that drug delivery systems can overcome a wide spectrum of bioactive compounds issues, a biopolymeric blend-based microparticulated system capable of delivering ε-polylysine (PLL) was developed...
September 3, 2017: Journal of Microencapsulation
Nan Xia, Tian Liu, Qiang Wang, Qiang Xia, Xiaoli Bian
This study aimed at in vitro evaluation of α-lipoic acid-loaded lipid nanocapsules for topical delivery, which was prepared by hot high-pressure homogenisation. Stable particles could be formed and particle size was 148.54 ± 2.31 nm with polydispersity index below 0.15. Encapsulation efficiency and drug loading of α-lipoic acid were 95.23 ± 0.45% and 2.81 ± 0.37%. Antioxidant study showed α-lipoic acid could be protected by lipid nanocapsules without loss of antioxidant activity. Sustained release of α-lipoic acid from lipid nanocapsules was obtained and cumulative release was 62...
September 3, 2017: Journal of Microencapsulation
Adem Sahin, Digdem Yoyen-Ermis, Secil Caban-Toktas, Utku Horzum, Yesim Aktas, Patrick Couvreur, Gunes Esendagli, Yilmaz Capan
The blood-brain barrier is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determine the efficacy of the brain-targeted chitosan nanoparticles' uptake by the human blood-brain barrier cerebral microvessel endothelial cells (hCMECs) and to investigate the underlying mechanisms for enhanced cellular entry...
September 1, 2017: Journal of Microencapsulation
Xiuliang Li, Quan Sun, Yawei Wang, Dequan Han, Jiahui Fan, Jialing Zhang, Chunhai Yang, Xiaoxiong Ma, Qingshen Sun
OBJECTIVE: To study the effects of Lactobacillus Plantarum cell wall peptidoglycan (LPG) microspheres on mouse intestinal flora changes, peptidoglycan recognitions protein (PGRP) and cytokines expression levels. METHOD: Plate counting was used for enumeration of the intestinal flora. Real-time PCR was used for quantification PGRP in different tissues. Cytokines content were determined by ELISA kits. RESULT: The mouse administered orally with LPG microspheres showed significantly higher number of Lactobacillus and Bifidobacterium in cecum contents (P < 0...
September 1, 2017: Journal of Microencapsulation
Ankit Javia, Hetal Thakkar
The aim of the present investigation was to formulate Tapentadol Hydrochloride loaded chitosan nanoparticles (CS-NPs) for nose to brain delivery. Chitosan nanoparticles were prepared using ionotropic gelation technique. Optimization of the formulation and process parameters was done using Box-Behnken Design. The entrapment efficiency, drug loading, Z-average size and zeta potential of the optimized batch were 63.49±1.61%, 17.25±1.38%w/w, 201.2±1.5 nm and +49.3 mV respectively. In-vitro release study showed 84...
September 1, 2017: Journal of Microencapsulation
Cassiana Mendes, Aline Buttchevitz, Jéssica Henriques Kruger, Thiago Caon, Patricia Oliveira Benedet, Elenara Maria Teixeira Lemos-Senna, Marcos Antônio Segatto Silva
In view of biopharmaceutical limitations of hydrochlorothiazide (HCTZ), Trojan-type mucoadhesive systems were proposed, aiming improve HCTZ pharmacological properties by modulating its release. Nanoemulsions were formed spontaneously by combining medium chain triglycerides (Lipoid® S75 and Pluronic(®) F68) and high encapsulation efficiency was obtained. The mucoadhesive properties were provided by chitosan and microencapsulation of nanoemulsions in spray-dryer was successfully achieved by using Aerosil(®) as wall material...
August 29, 2017: Journal of Microencapsulation
T P F Cabral, N C Bellini, K R Assis, C C C Teixeira, A D Lanchote, H Cabral, L A P Freitas
The aim of this work was to obtain microencapsulated stable Aspergillus niger peptidases by post fermentation spray drying. The enzymatic extract was evaluated before and after spray drying microencapsulation to verify the effects of five different process parameters on the extract enzymatic activity, i.e. air flow, extract feed rate, drying temperature, homogenising time and weight ratio of extract to encapsulation material. The optimal conditions were determined by desirability functions and experimentally confirmed...
August 29, 2017: Journal of Microencapsulation
Rahul Dhande, Amit Tyagi, Rakesh Kumar Sharma, Hetal Thakkar
Gemcitabine Hydrochloride (GCH) is drug of choice for treatment of Non-Small Cell Lung Cancer. This project aims to formulate GCH loaded Spherulites for lung targeting using Soyabean Phosphatidylcholine, Cholesterol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]. Vesicles were characterized for size, entrapment efficiency, drug release and in vitro cytotoxicity. Radiolabeling of GCH was done using reduced technetium-99m to study biodistribution in Sprague Dawley rats...
August 28, 2017: Journal of Microencapsulation
Ki Hyun Kim, Tuan-Ho Le, Hee Kyung Oh, Bora Heo, Jeonghyun Moon, Sangmun Shin, Seong Hoon Jeong
Even though β-lapachone is a novel drug with pharmacological activity, it has limitations including instability under light conditions. The main purpose of the study was to enhance the stability of β-lapachone using the microencapsulation method. The Shirasu porous glass membrane was used to achieve uniform-sized microcapsules. The prepared microcapsules were evaluated to investigate how process parameters affect the encapsulation efficiency, photostability and particle size distribution. The experimental design was conducted to obtain optimal formulations...
August 28, 2017: Journal of Microencapsulation
Pedro Henrique Campelo, Jayne de Abreu Figueiredo, Rosana Zacarias Domingues, Regiane Victória de Barros Fernandes, Diego Alvarenga Botrel, Soraia Vilela Borges
The aim of this work was to study the use of different prebiotic biopolymers in lime essential oil microencapsulation. Whey protein isolate, inulin and oligofructose biopolymers were used. The addition of prebiotic biopolymers reduced emulsion viscosity, although it produced larger droplet sizes (0.31-0.32 µm). Moisture values (2.94-3.13 g/100 g dry solids) and water activity (0.152-0.185) were satisfactory, being within the appropriate range for powdered food quality. Total oil content, limonene retention values and antioxidant activity of the microparticles containing essential oil decreased in the presence of the carbohydrates...
August 24, 2017: Journal of Microencapsulation
Evandro Martins, Denis Poncelet, Ramila Cristiane Rodrigues, Denis Renard
In the first part of this article, it was described an innovative method of oil encapsulation from dripping-inverse gelation using water-in-oil (W/O) emulsions. It was noticed that the method of oil encapsulation was quite different depending on the emulsion type (W/O or oil-in-water (O/W)) used and that the emulsion structure (W/O or O/W) had a high impact on the dripping technique and the capsules characteristics. The objective of this article was to elucidate the differences between the dripping techniques using both emulsions and compare the capsule properties (mechanical resistance and release of actives)...
August 23, 2017: Journal of Microencapsulation
Farshad Zarei, Babak Negahdari
Plastic and reconstructive surgery is a distinct specialty, which entails craniofacial and hand surgery; trauma, oncologic and congenital reconstruction; burn care, and aesthetic surgery. However, advances in nanotechnology have significantly affected wound management, skin care, implant and prosthetic design, tissue engineering, and drug delivery systems. Presently, plastic surgeons are applying the efficacy of stem cells (ADSCs), biomaterials and growth factors in different facets of plastic surgery. In this review, we will elucidate the applications of stem cells, biomaterials and growth factors in plastic surgeries...
August 21, 2017: Journal of Microencapsulation
Ana Kalušević, Steva Lević, Bojan Čalija, Milena Pantić, Miona Belović, Vladimir Pavlović, Branko Bugarski, Jela Milić, Slađana Žilić, Viktor Nedović
Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-0.33), good powders characteristics, high solubility (80...
August 2, 2017: Journal of Microencapsulation
Menghua Xiong, Qian Lei, Xinyu You, Tiantao Gao, Xuejiao Song, Yong Xia, Tinghong Ye, Lidan Zhang, Ningyu Wang, Luoting Yu
Mannose receptor (MR) is a highly effective endocytic receptor. It is closely related to tumour immune escape and metastasis. We found that MR was highly expressed in some colon cancer cell lines such as CT26 and HCT116 cells. Therefore, MR might be a potential target in colon cancer therapy. In this study, we aimed to develop mannosylated liposomes containing anticancer drug paclitaxel and investigate the potential effects on targeted therapy for colon cancer. Mannosylated liposomes were prepared by film dispersion method...
July 26, 2017: Journal of Microencapsulation
Hamed Alizadeh Sardroud, Sorour Nemati, Ali Baradar Khoshfetrat, Mahbobeh Nabavinia, Younes Beygi Khosrowshahi
Influence of gelatine concentration and cross-linker ions of Ca(2+) and Ba(2+) was evaluated on characteristics of alginate hydrogels and proliferation behaviours of model adherent and suspendable stem cells of fibroblast and U937 embedded in alginate microcapsules. Increasing gelatine concentration to 2.5% increased extent of swelling to 15% and 25% for barium- and calcium-cross-linked hydrogels, respectively. Mechanical properties also decreased with increasing swelling of hydrogels. Both by increasing gelatine concentration and using barium ions increased considerably the proliferation of encapsulated model stem cells...
July 26, 2017: Journal of Microencapsulation
Michael Przyklenk, Marina Vemmer, Miriam Hanitzsch, Anant Patel
This study reports the development of encapsulated and dried entomopathogenic fungus Metarhiuzm brunneum with reduced conidia content, increased conidiation, a high drying survival and enhanced shelf life. Dried beads prepared with the fillers corn starch, potato starch, carboxymethylcellulose or autoclaved baker's yeast, showed enhanced survival with increasing filler content. The maximum survival of 82% was found for beads with 20% corn starch at <0.1 water activity. While increasing starch content inhibits the conidiation, autoclaved baker's yeast and a combination with starch enhanced the conidiation to 1...
July 24, 2017: Journal of Microencapsulation
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