Changes in Metabolic Parameters in Patients with Diabetic Kidney Disease Depending on the Status of D3.

BACKGROUND: Type 2 diabetes is a metabolic disease characterized by hyperglycemia on the background of insulin resistance and decreased insulin secretion. A relatively large number of patients with this type of diabetes have abdominal obesity, which also affects insulin resistance development. Chronic hyperglycemia can lead to damage and dysfunction of various organs, and a striking example is diabetic nephropathy. Diabetic nephropathy is a specific kidney damage that occurs due to complications of diabetes and is accompanied by the formation of diffuse or nodular glomerulosclerosis, which can lead to terminal renal failure and requires the immediate substitution of renal therapy or renal transplantation. Diabetic nephropathy is diagnosed with albuminuria and a decrease in the rate of glomerular filtration.

METHODS: This review was based on a literature search for the most important evidence on the issue of considering vitamin D as a possible method of prevention of obesity, type 2 diabetes, and diabetic nephropathy. Collected published articles were summarized according to their overall themes.

RESULTS: In this review, we considered vitamin D as a possible method of treatment of type 2 diabetes, as well as its complications - diabetic nephropathy.

CONCLUSION: Studies show that vitamin D inhibits the renin-angiotensin-aldosterone system, resulting in improved renal function in diabetic nephropathy. Vitamin D also has the anti-inflammatory, antiproliferative, and anti-metastatic effect, which improves endothelial function.