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Reviews on Recent Clinical Trials

O Korotkyi, A Vovk, O Blokhina, K Dvorshchenko, T Falalyeyeva, L Abenavoli, L Ostapchenko
Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes in the concentration of interleukins (ILs) -1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused by monoiodoacetate-induced osteoarthritis (OA) in experimental models on rats. We also investigated the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin sulfate to animals under experimental conditions...
November 2, 2018: Reviews on Recent Clinical Trials
Morteza Ghojazadeh, Sakineh Hajebrahimi, Fatemeh Pournaghi-Azar, Mohammad Mohseni, Naser Derakhshani, Saber Azami-Aghdash
BACKGROUND & AIMS: Evaluating the effect of Kangaroo Mother Care (KMC) on breastfeeding success shows conflicting results. Regarding the importance of breastfeeding and uncertainties about its effect, this study intended to conduct a systematic review and meta-analysis of randomised controlled trials on the effect of KMC on success of breastfeeding. METHODS: In this systematic review and meta-analysis study, required data were collected by searching the following key words: breastfeeding, Breast-Feeding, "skin-to-skin", "Kangaroo Mother Care", randomized clinical trial...
September 24, 2018: Reviews on Recent Clinical Trials
Aynaz Nourani, Haleh Ayatollahi, Masoud Solaymani Dodaran
BACKGROUND: Clinical data management system is a software supporting the data management process in clinical trials. In this system, the effective support of clinical data management dimensions leads to the increased accuracy of results and prevention of diversion in clinical trials. The objective of this review article is to investigate the dimensions of data management in clinical data management systems. METHODS: This study was conducted in 2017. The used databases included Web of Science, Scopus, Science Direct, ProQuest, Ovid Medline and PubMed...
September 24, 2018: Reviews on Recent Clinical Trials
Giovanni Clemente Actis, Rinaldo Pellicano, Davide Giuseppe Ribaldone
BACKGROUND: The need for immune suppressive strategies in the control of chronic inflammatory bowel diseases originated in the 1960s following the perception of a relative inefficacy of salazopyrin and its derivatives. In some 50 years upon an anecdotal claim, the indication for thiopurines in the management of inflammatory bowel diseases has come of age. OBJECTIVE: The aim of this minireview is to give an overview, after the historical premises, of the current use of thiopurines in the context of inflammatory bowel diseases...
September 10, 2018: Reviews on Recent Clinical Trials
Aven Sidhu, Rohan Kakkar, Osamah Alenezi
BACKGROUND: Human Immunodeficiency Virus (HIV) prevalence rates in refugee camps are inconclusive in current literature, with some studies highlighting the increased risk of transmission due to poor living conditions and lower levels of education. With the increasing number of refugees from HIV endemic countries, it is important to assess the programs established to support patients upon arrival. Refugees have been reported to have a lower health literacy and face disease-related stigmatization, which must be overcome for the lifelong treatment of HIV...
September 3, 2018: Reviews on Recent Clinical Trials
Nooraldaem Yousif, Mohammady Shahin, Thomas F Luscher, Slayman Obeid
BACKGROUND: Although not well established; gender may play a role in the incidence, clinical manifestations, and atherosclerotic burden of coronary artery anomalies (CAAS). Our aim is to investigate the impact of gender on coronary artery anomalies Methods: All coronary angiograms performed at the University Heart Center Zurich, Switzerland, between January 2000 and December 2016 were investigated. Those of anomalous origin, course and termination (fistula) were included in the analysis with the exclusion of coronary artery aneurysms and myocardial bridges...
August 19, 2018: Reviews on Recent Clinical Trials
Basant K Puri, Anne Derham, Jean A Monro
Background The use of indwelling central venous access devices (CVADs) is associated with the development of bloodstream infections. When CVADs are used to administer systemic antibiotics, particularly second- or higher-generation cephalosporins, there is a particular risk of developing Clostridium difficile infection. The overall bloodstream infection rate is estimated to be around 1.74 per 1000 central venous catheter (CVC)-days. Objective We hypothesised that daily oral administration of the anion-binding resin colestyramine (cholestyramine) would help prevent infections in those receiving intravenous antibiotic treatment via CVADs...
August 17, 2018: Reviews on Recent Clinical Trials
Mariadelina Simeoni, Ramona Nicotera, Elena Pelagi, Emanuela Libri, Nicolino Comi, Giorgio Fuiano
Introduction The early suspension of Altitude trial in recent years has induced most nephrologists and cardiologists to abandon Aliskiren use. Consequently, the potential usefulness of the direct renin inhibition in IgA glomerulonephritis remained an under-investigated therapeutic option. Case report We report the case of a 53 years old IgA GMN patient unresponsive to all conventional anti-angiotensin-2 agents, steroids and immunosuppressants, in which the administration of Aliskiren permitted to achieve and maintain a complete proteinuria remission in absence of any adverse event...
July 25, 2018: Reviews on Recent Clinical Trials
Dominika M Zotlowska, Guramrinder S Thind, Yashwant Agrawal, Jagadeesh K Kalavakunta, Soji Joseph, Sandeep Patri
Objectives There have been increasing concerns regarding inappropriate usage of vena caval filters. Our study was done to analyze the current trends in vena caval filter placement. Methods This study used the data from Nationwide Inpatient Sample database for the years 2002-2012 to identify patients with vena caval filter placement. Trends in both therapeutic and prophylactic vena caval filter use over the eleven year period were analyzed. Multiple simple logistic regression model was used to assess trends...
June 26, 2018: Reviews on Recent Clinical Trials
Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi
BACKGROUND AND OBJECTIVES: The Association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interlukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is any association between these postoperative biomarkers with important recipient outcomes beyond this time in live-donor transplants...
May 21, 2018: Reviews on Recent Clinical Trials
Andrea Pisani Ceretti, Nirvana Maroni, Marco Longhi, Marco Giovenzana, Roberto Santambrogio, Matteo Barabino, Carmelo Luigiano, Giovanni Radaelli, Enrico Opocher
Purpose Prolonged postoperative ileus (PPOI) after abdominal surgery may effect unfavourably the patient recovery. The aim of this study was to estimate the incidence of PPOI in patients elective for colorectal resection and investigate perioperative variables associated with PPOI. Methods A consecutive series of 428 patients undergoing colorectal resection (median age 72, range 24-92, years; men/women ratio 1.14) were analyzed. Data were extracted retrospectively throughout a five-year period from an electronic prospectively maintained database...
May 20, 2018: Reviews on Recent Clinical Trials
Rimple Jeet Kaur, Surjit Singh, Preeti Sidhu, Pramod Kumar Sharma
BACKGROUND: Globally, there have been tremendous efforts by regulatory authorities to make clinical trials safer by making stringent clinical trial regulations. Despite this, we witnessed several tragic events. TGN1412 and BIA 10-2474 phase I trials are infamous trails in which healthy volunteers either succumbed to severe adverse effects or faced irreversible impairments of the test drug. Such afflictions in clinical trials are not only turbulent to the image of pharmaceutical industry but it also conveys dispiriting message for clinical trial participants...
May 20, 2018: Reviews on Recent Clinical Trials
Basant K Puri, Anne Derham, Jean A Monro
Background Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. Objective The first systematic study to determine whether six to 12 days' intravenous ceftriaxone treatment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. Method Baseline and follow-up haematological and biochemical blood indices were measured in 86 patients (mean age 39...
May 16, 2018: Reviews on Recent Clinical Trials
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
Gentle Sunder Shrestha, Shrikanth Srinivasan
BACKGROUND: Sepsis and septic shock remain a major cause of morbidity and mortality globally. In recent years, outcome of patients with sepsis and septic shock has gradually improved, in part due to early recognition and timely appropriate management. Bedside physical examination can be of limited value to identify the source of infection and to decide appropriate management. Moreover, the clinical status of these patients can change rapidly, as a part of disease progression or in response to treatment or intervention...
April 12, 2018: Reviews on Recent Clinical Trials
Sabahat Sarfaraz, Sabiha Anis, Ejaz Ahmed, Rana Muzaffar
BACKGROUND: Systemic lupus erythematosus (SLE) is achronic inflammatory disorder affecting multiplesystems of the body. Clinical features show wide variations in patients with different ethnic background. Renal involvement is a predictor of poor prognosis. Immunological workup is an integral part of SLE diagnostic criteria. Anti-ribosomal P Protein (anti-P) antibodies are highly specific for SLE. They may be present inantinuclear antibodies (ANA) negative SLE patients. Their role in lupus nephritis (LN) is under debate, some researchers found them associated with poor prognosiswhereasothers found favorable effect of these antibodies on renal disease...
April 9, 2018: Reviews on Recent Clinical Trials
Philip C Prorok, Patrick Wright, Thomas R Riley, Barnett S Kramer, Christine D Berg, John K Gohagan
BACKGROUND: Screening tests are typically evaluated for a single disease, but multiple tests for multiple diseases are performed in practice. The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial assessed testing for four cancers simultaneously and can be viewed as a multiphasic cancer intervention. This paper presents overall and multiphasic findings of this trial. METHODS: The PLCO trial was a randomized multi-center trial conducted at ten screening centers in the US...
April 9, 2018: Reviews on Recent Clinical Trials
Federica Andreis, Fausto Meriggi, Claudio Codignola, Ilaria Frigoli, Tiziana Prochilo, Stefano Mutti, Alessandra Huscher, Michela Libertini, Brunella Di Biasi, Chiara Abeni, Chiara Ogliosi, Silvia Noventa, Luigina Rota, Chiara Pedrali, Alberto Zaniboni
AIMS AND BACKGROUND: The main purpose of our psycho-educational groups was to help women with breast cancer learn how to cope with the physical, emotional, and lifestyle changes associated with cancer as well as with medical treatments that can be painful and traumatic. With this study, we wanted to detect the effects that group action had on the women who participated in it. METHODS: We studied a total of 97 patients who participated in 13 psycho-education groups...
April 9, 2018: Reviews on Recent Clinical Trials
Basant K Puri
No abstract text is available yet for this article.
January 31, 2018: Reviews on Recent Clinical Trials
Ludovico Abenavoli
No abstract text is available yet for this article.
January 31, 2018: Reviews on Recent Clinical Trials
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