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Reviews on Recent Clinical Trials

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https://www.readbyqxmd.com/read/28403798/treating-older-hiv-1-infected-subjects-with-cobicistat-boosted-darunavir-in-a-48-week-phase-3-trial
#1
Kimberley Brown, Brooke Patterson-Browning, Chris Liu, Meera Patel, Lisa Stewart, Richard E Nettles
BACKGROUND: An aging HIV-1-infected population warrants examination of the acceptability of individual antiretroviral regimens. In a previous study of ritonavir-boosted darunavir (ARTEMIS), similar safety/efficacy profiles were observed in younger (≤45 years) and older (>45 years) HIV-1-infected subjects. OBJECTIVE: To evaluate safety and efficacy outcomes in HIV-1-infected younger versus older subjects treated with cobicistat-boosted darunavir. METHOD: In a 48-week, phase 3b, open-label trial, HIV-1-infected adults were administered darunavir 800 mg and cobicistat 150 mg once-daily with 2 nucleos(t)ide reverse transcriptase inhibitors (N[t]RTIs)...
April 7, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28393710/rolapitant-a-nk-1-receptor-antagonist-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting
#2
Bernardo Leon Rapaport
BACKGROUND: Nausea and vomiting are among the most feared side effects of chemotherapy and can prevent cancer patients from completing their treatment regimens. Rolapitant is a highly selective neurokinin-1 (NK-1) receptor antagonist with very good oral activity, central nervous system penetration and a long (180-hour) plasma half-life. Unlike other available NK-1 receptor antagonists, rolapitant does not inhibit or induce cytochrome P450 (CYP) 3A4. METHODS: Findings from recent phase II and III clinical trials of rolapitant in patients receiving highly or moderately emetogenic chemotherapy are reviewed and discussed...
April 6, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28356032/impact-of-percutaneous-closure-of-interatrial-shunts-on-migraine-attacks-single-operator-series-and-review-of-the-literature
#3
Antonis S Manolis
BACKGROUND: The association of migraine with intracardiac communications and a resultant improvement with their closure has been a matter of controversy. Mostly observational and retrospective studies indicate a significant improvement in migraine attacks in patients undergoing percutaneous closure procedures. However, there is a paucity of randomized trials on this topic and prospective data provide little evidence that the device closure approach has any significant effect on migrainous attacks...
March 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28356031/old-but-good-modified-release-prednisone-in-rheumatoid-arthritis
#4
Francesco Ursini, Saverio Naty, Caterina Bruno, Rosa Daniela Grembiale
Since more than 50 years glucocorticoids represent the milestone in the treatment of inflammatory diseases, including rheumatoid arthritis (RA). However, many patients with RA present a circadian rhythm in symptoms severity, with a significant worsening in the morning, that correlates with cyclic changes in circulating hormones and cytokines. Classical steroids therapy given in the morning fails to intercept this pathophysiological phenomenon. In the last years, a novel formulation of prednisone has been developed in order to better fit these variations, improve efficacy and minimize adverse events (chronotherapy)...
March 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28356030/comparison-of-the-effect-of-fish-oil-and-calcium-supplementation-on-treatment-of-primary-dysmenorrhea
#5
Maryam Mehrpooya, Azadeh Eshraghi, Soghra Rabiee, Amir Larki-Harchegani, Sara Ataei
BACKGROUND: Primary dysmenorrhea is common among young girls and childbearing women. Dysmenorrhea is a painful contraction of uterus which happens in the beginning of bleeding or before the menstrual cycle begins. Regarding to the mechanism of calcium in response to hormonal change and the role of fish oil on reducing prostaglandins, we compared the effectiveness of fish-oil and calcium supplementation in treating primarydysmenorrheal. METHODS: This randomized double-blinded clinical trial conducted on women aged 18 to 45 years with moderate to severe primary dysmenorrhea symptoms from January 2015 to March 2015...
March 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28325150/managing-expectations-in-the-transition-to-proof-of-concept-studies
#6
Thomas Kieber-Emmons, Issam Makhoul, Angela Pennisi, Eric R Siegel, Peter D Emanuel, Bejotaloh Monzavi-Karbassi, Zenon Steplewski, J Thaddeus Beck, Laura F Hutchins
BACKGROUND: As we are moving away from the traditional chemotherapy era to targeted therapy, the validity of old assessment paradigms associated with therapeutics are being raised in the context of immunotherapy. The old paradigm required elaborate assessment of toxicity with no expectation of efficacy in early phase trials. Safety data from Phase 1 and 2 studies with many immunotherapeutics show that they display limited toxicities and draw attention to the need to demonstrate efficacy in the early evaluation of new agents...
March 21, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28270088/neoadjuvant-therapy-for-patients-with-triple-negative-breast-cancer-tnbc
#7
Rody Adium, Cornelia Liedtke
BACKGROUND: Patients with triple negative breast cancer (TNBC) are characterized by an unfavorable prognosis particularly when not responding well to anthracycline-taxane chemotherapy. This is due to a more aggressive biology in some cases but most importantly to a lack of agents other than conventional chemotherapy. Hence, there is an urgent need to optimize therapy of patients with TNBC in order to improve prognosis. OBJECTIVE: The objective of this review is to present the current understanding of TNBC biology and give an insight of surrent theraoeutic concepts in the neoadjuvant treatment setting...
March 6, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28190390/cancer-bioinformatics-for-update-anticancer-drug-developments-and-personalized-therapeutics
#8
Da-Yong Lu, Rong-Xin Qu, Ting-Ren Lu, Hong-Ying Wu
Last two to three decades, this world witnesses a rapid progress of biomarkers and bioinformatics technology and medical applications. Cancer bioinformatics is one of such important omics branches for experimental/clinical studies and applications. Same as other biological techniques or systems, bioinformatics techniques are presently not omni-potent. Despite great popularity and improvements, cancer bioinformatics has its own limitations and shortcomings at this stage of technical advancements. This article will offer a panorama of bioinformatics in cancer researches and clinical therapeutic applications-possible advantages and limitations relating with cancer therapeutics...
February 9, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28164759/neoadjuvant-therapy-for-her2-positive-breast-cancer
#9
Rachel Wuerstlein, Nadia Harbeck
In HER2-positive early breast cancer, neoadjuvant treatment with a combination of sequential chemotherapy and HER2-targeted therapy is currently the standard of care. This is followed by breast surgery, radiotherapy (if indicated), completion of 12 months of HER2-directed therapy, and -depending on the tumor biology - endocrine adjuvant therapy, and ultimately follow up. 10-year survival rates in the HER2-positive subgroup of breast cancer do reach now more than 75% with the introduction of first adjvuant and later neoadjuvant HER2-targeted therapies over the last 15 years...
February 2, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28155608/helical-tomotherapy-versus-conventional-technique-for-post-mastectomy-left-sided-breast-cancer-dosimetric-study
#10
M O Alshabanah, Mohamed Hegazy, Belal Moftah, Mohammad Shabanah
METHODS AND MATERIALS: Treatment plans were generated for 5 post mastectomy left sided breast cancer patients treated at king Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, comparing three-dimensional technique with the HT planning. The prescribed dose was 50 Gy in 25 fractions; the planning target volume (chest wall and nodal volumes) was contoured according to RTOG atlas and the heart, lungs, spinal cord and contralateral breast were contoured as Organs at Risks (OARs)...
February 1, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28155607/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy-in-her2-positive-and-triple-negative-breast-cancer
#11
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Max Bulsara, Jayant S Vaidya, Cornelia Liedtke
INTRODUCTION: Targeted intraoperative radiotherapy (TARGIT - IORT) as a tumour bed boost after breast conserving surgery is well established for women with early breast cancer. A previous study from our group shows a beneficial effect of TARGIT-IORT on overall survival (OS) but not disease-free survival (DFS) after neoadjuvant chemotherapy compared to an external boost suggesting a potential non-inferiority of TARGIT-IORT. In this study we present results regarding the high-risk subset of patients (i...
February 1, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28155606/clinical-utility-of-neoadjuvant-endocrine-therapy-for-hormone-receptor-positive-breast-cancer
#12
Hans-Christian Kolberg, Bahriye Aktas, Cornelia Liedtke
Primary endocrine therapy is an option in cases of hormone receptor positive and HER2 negative non-metastatic breast cancer. Aromatase inhibitors are considered therapy of choice in postmenopausal patients. In premenopausal patients aromatase inhibitors in combination with LHRH-analogues are regarded superior to tamoxifen. Three different settings have to be discriminated: • Patients too frail for surgery are candidates for primary endocrine therapy in order to control the disease. Treatment duration is determined by the course of the disease...
February 1, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28137211/the-attitudes-of-rural-community-health-workers-towards-older-adults-in-kermanshah-iran
#13
Somayeh Bakhtiari Harsini, Yadollaqh Abolfathi Momtaz, Ahmad Delbari, Robab Sahaf
BACKGROUND: Studies have shown that the quality of elderly care is substantially influenced by the attitudes of healthcare staff. The present study aimed to assess the attitude of rural community health workers towards elderly people. METHODS: A cross-sectional design was employed in this study, which conducted among all health workers of Harsin city (province of Kermanshah - Iran). The Kogan's Attitudes towards Older People Scale (KOPS) was used to measure data...
January 27, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28117008/a-review-of-ewing-sarcoma-treatment-is-it-still-a-subject-of-debate
#14
Wala Ben Kridis, Nabil Toumi, Hadil Chaari, Afef Khanfir, Kamel Ayedi, Hassib Kekes, Tahia Boudawara, Jamel Daoud, Mounir Frikha
BACKGROUND: The Ewing sarcoma (ES) represents 10 to 15% of malignant bone tumors and 40 to 45% of pediatric malignant bone tumors. The aim of this review is to clarify the therapeutic results and prognostic factors of this entity. METHODS: A systematic review of the literature was performed. Studies focused on the management of ES were considered for inclusion. RESULT: ES represents a model of multidisciplinary approach. The optimization of ES multimodality therapeutic strategies has resulted from the efforts of several national and international groups in Europe and North America and from cooperation between pediatric and medical oncologists...
January 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27670801/clinical-practice-audit-of-perioperative-antimicrobial-prophylaxis-in-a-tertiary-care-hospital-do-routine-academic-activities-improve-adherence-to-practice-guidelines
#15
Mehul Agrawal, Pramod Kumar Sharma, S P Dhaneria
BACKGROUND: Antimicrobial prophylaxis should be used in circumstances where efficacy has been demonstrated and benefits outweigh the risk. Each hospital must have an antibiotic policy that is implementable and fully adhered to. METHODS: A prospective observational study was conducted in 209 patients, admitted to swards of various surgical departments including surgery, obstetrics & gynaecology (O&G), otorhinolaryngology (ENT) and orthopaedics. Relevant antimicrobial use data of each patient was collected in a customized Case Record Form (CRF) from day one until patient was discharged...
September 26, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27633966/qt-dispersion-and-age-independent-predictors-of-restenosis-after-percutaneous-coronary-intervention
#16
Naser Aslanabadi, Sirous Vosooghi Moghadam, Babak Kazemi, Daniel Fadaei Fouladi, Golnaz Vaseghi, Azadeh Eshraghi, Mehran Mahmoodian, Sarvnaz Tutunchi
INTRODUCTION: There are no reliable non-invasive markers of restenosis after percutaneous coronary interventions (PCIs). The aim of our study was to measure changes incorrected QT interval (QTc), corrected QT dispersion (QTcd), corrected T wave peak to end interval (TPEc) and corrected TPE dispersion (TPEcd) after PCI and to determine whether restenosis subsequently affects these indices. METHODS: From 211 patients, who underwent successful PCI, 202 patients were referred for repeated coronary angiography in order to exclusion of coronary restenosis and included in this analysis...
September 16, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27633965/interaction-of-treatment-and-biomarker-in-advanced-nsclc
#17
Pingfu Fu, Afshin Dowlati, Nathan Pennell, Neelesh Sharma, Qizhi Yi, Balazs Halmos
PURPOSE: There has been a long-standing interest in the investigation of interactions in science. The objective of the study is to evaluate interaction between EGFR mutation and treatment from randomized, phase II study of chemotherapy versus chemotherapy plus erlotinib in patients with progressive NSCLC following clinical benefit from erlotinib. MATERIALS AND METHODS: Forty-six patients with advanced stage NSCLC and progression from erlotinib were randomized to receive chemotherapy (pemetrexed or docetaxel) or chemotherapy plus erlotinib between 2008 and 2012...
September 16, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27633964/use-of-recursive-partitioning-analysis-in-clinical-trials-and-meta-analysis-of-randomized-clinical-trials-1990-2016
#18
Martha Maria Fors, Carmen Elena Viada, Paloma de Las Mercedes Gonzalez
BACKGROUND: Recursive Partitioning Analysis (RPA) is a very flexible non parametric algorithm that allows to classify individuals according to certain criteria, particularly in clinical trials are used to predict response to treatment or classify individuals according prognostic factors. OBJECTIVE: In this paper with examine how often RPA is used in clinical trials and in meta-analysis. METHOD: We reviewed a group of abstracts records between 1990 until 2016 and extracted data regarding clinical trial phase, year of publication, kind of treatment, medical indication, main evaluated endpoints and class of RPA...
September 16, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27600109/risk-factors-and-temporal-trends-of-hospital-acquired-infections-hais-among-hiv-positive-patients-in-urban-new-york-city-hospitals-2006-to-2014
#19
Christophe Toukam Tchakoute, Elaine Larson, Jianfang Liu, Bevin Cohen
BACKGROUND: HIV-infected patients may be at a greater risk of hospital-acquired infections (HAIs) but risks factors for HAIs have not been well described in this population. OBJECTIVE: The aim of this study was to examine the incidence, temporal trends and risk factors of HAIs among adult HIV positive patients. METHODS: This was a retrospective cohort study carried out in an academic health system in New York City which included four hospitals over a 9-year period from 2006 to 2014...
September 5, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27594437/evaluating-community-pharmacists-dyspepsia-knowledge-a-cross-sectional-study-in-tehran-iran
#20
Mohammad Abbasinazari, Jamshid Salamzadeh, Azadeh Eshraghi, Vahid Belbasi, Ashnagar Arezoo
Dyspepsia is one of the most frequent problems in the community. The public increasingly seeks out health advice from professionals such as community pharmacists due to a growing interest in understanding drugs and self-medication for common conditions such as dyspepsia. The purpose of our study was to assess dyspepsia-related knowledge of pharmacists in Iran.This study has been done among community pharmacists working in Tehran, Iran. This cross-sectional study was conducted as a survey questionnaire administered to 200 community pharmacists working in Tehran...
September 5, 2016: Reviews on Recent Clinical Trials
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