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Reviews on Recent Clinical Trials

A Rody, Liedtke Cornelia
BACKGROUND: Patients with triple negative breast cancer (TNBC) are characterized by an unfavorable prognosis particularly when not responding well to anthracycline-taxane chemotherapy. This is due to a more aggressive biology in some cases but most importantly to a lack of agents other than conventional chemotherapy. Hence, there is an urgent need to optimize therapy of patients with TNBC in order to improve prognosis. OBJECTIVE: The objective of this review is to present the current understanding of TNBC biology and give an insight of surrent theraoeutic concepts in the neoadjuvant treatment setting...
March 6, 2017: Reviews on Recent Clinical Trials
Da-Yong Lu, Rong-Xin Qu, Ting-Ren Lu, Hong-Ying Wu
Last two to three decades, this world witnesses a rapid progress of biomarkers and bioinformatics technology and medical applications. Cancer bioinformatics is one of such important omics branches for experimental/clinical studies and applications. Same as other biological techniques or systems, bioinformatics techniques are presently not omni-potent. Despite great popularity and improvements, cancer bioinformatics has its own limitations and shortcomings at this stage of technical advancements. This article will offer a panorama of bioinformatics in cancer researches and clinical therapeutic applications-possible advantages and limitations relating with cancer therapeutics...
February 9, 2017: Reviews on Recent Clinical Trials
Rachel Wuerstlein, Nadia Harbeck
In HER2-positive early breast cancer, neoadjuvant treatment with a combination of sequential chemotherapy and HER2-targeted therapy is currently the standard of care. This is followed by breast surgery, radiotherapy (if indicated), completion of 12 months of HER2-directed therapy, and -depending on the tumor biology - endocrine adjuvant therapy, and ultimately follow up. 10-year survival rates in the HER2-positive subgroup of breast cancer do reach now more than 75% with the introduction of first adjvuant and later neoadjuvant HER2-targeted therapies over the last 15 years...
February 2, 2017: Reviews on Recent Clinical Trials
M O Alshabanah, Mohamed Hegazy, Belal Moftah, Mohammad Shabanah
METHODS AND MATERIALS: Treatment plans were generated for 5 post mastectomy left sided breast cancer patients treated at king Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, comparing three-dimensional technique with the HT planning. The prescribed dose was 50 Gy in 25 fractions; the planning target volume (chest wall and nodal volumes) was contoured according to RTOG atlas and the heart, lungs, spinal cord and contralateral breast were contoured as Organs at Risks (OARs)...
February 1, 2017: Reviews on Recent Clinical Trials
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Max Bulsara, Jayant S Vaidya, Cornelia Liedtke
INTRODUCTION: Targeted intraoperative radiotherapy (TARGIT - IORT) as a tumour bed boost after breast conserving surgery is well established for women with early breast cancer. A previous study from our group shows a beneficial effect of TARGIT-IORT on overall survival (OS) but not disease-free survival (DFS) after neoadjuvant chemotherapy compared to an external boost suggesting a potential non-inferiority of TARGIT-IORT. In this study we present results regarding the high-risk subset of patients (i...
February 1, 2017: Reviews on Recent Clinical Trials
Hans-Christian Kolberg, Bahriye Aktas, Cornelia Liedtke
Primary endocrine therapy is an option in cases of hormone receptor positive and HER2 negative non-metastatic breast cancer. Aromatase inhibitors are considered therapy of choice in postmenopausal patients. In premenopausal patients aromatase inhibitors in combination with LHRH-analogues are regarded superior to tamoxifen. Three different settings have to be discriminated: • Patients too frail for surgery are candidates for primary endocrine therapy in order to control the disease. Treatment duration is determined by the course of the disease...
February 1, 2017: Reviews on Recent Clinical Trials
Somayeh Bakhtiari Harsini, Yadollaqh Abolfathi Momtaz, Ahmad Delbari, Robab Sahaf
BACKGROUND: Studies have shown that the quality of elderly care is substantially influenced by the attitudes of healthcare staff. The present study aimed to assess the attitude of rural community health workers towards elderly people. METHODS: A cross-sectional design was employed in this study, which conducted among all health workers of Harsin city (province of Kermanshah - Iran). The Kogan's Attitudes towards Older People Scale (KOPS) was used to measure data...
January 27, 2017: Reviews on Recent Clinical Trials
Wala Ben Kridis, Nabil Toumi, Hadil Chaari, Afef Khanfir, Kamel Ayedi, Hassib Kekes, Tahia Boudawara, Jamel Daoud, Mounir Frikha
BACKGROUND: The Ewing sarcoma (ES) represents 10 to 15% of malignant bone tumors and 40 to 45% of pediatric malignant bone tumors. The aim of this review is to clarify the therapeutic results and prognostic factors of this entity. METHODS: A systematic review of the literature was performed. Studies focused on the management of ES were considered for inclusion. RESULT: ES represents a model of multidisciplinary approach. The optimization of ES multimodality therapeutic strategies has resulted from the efforts of several national and international groups in Europe and North America and from cooperation between pediatric and medical oncologists...
January 19, 2017: Reviews on Recent Clinical Trials
Mehul Agrawal, Pramod Kumar Sharma, S P Dhaneria
BACKGROUND: Antimicrobial prophylaxis should be used in circumstances where efficacy has been demonstrated and benefits outweigh the risk. Each hospital must have an antibiotic policy that is implementable and fully adhered to. METHODS: A prospective observational study was conducted in 209 patients, admitted to swards of various surgical departments including surgery, obstetrics & gynaecology (O&G), otorhinolaryngology (ENT) and orthopaedics. Relevant antimicrobial use data of each patient was collected in a customized Case Record Form (CRF) from day one until patient was discharged...
September 26, 2016: Reviews on Recent Clinical Trials
Naser Aslanabadi, Sirous Vosooghi Moghadam, Babak Kazemi, Daniel Fadaei Fouladi, Golnaz Vaseghi, Azadeh Eshraghi, Mehran Mahmoodian, Sarvnaz Tutunchi
INTRODUCTION: There are no reliable non-invasive markers of restenosis after percutaneous coronary interventions (PCIs). The aim of our study was to measure changes incorrected QT interval (QTc), corrected QT dispersion (QTcd), corrected T wave peak to end interval (TPEc) and corrected TPE dispersion (TPEcd) after PCI and to determine whether restenosis subsequently affects these indices. METHODS: From 211 patients, who underwent successful PCI, 202 patients were referred for repeated coronary angiography in order to exclusion of coronary restenosis and included in this analysis...
September 16, 2016: Reviews on Recent Clinical Trials
Pingfu Fu, Afshin Dowlati, Nathan Pennell, Neelesh Sharma, Qizhi Yi, Balazs Halmos
PURPOSE: There has been a long-standing interest in the investigation of interactions in science. The objective of the study is to evaluate interaction between EGFR mutation and treatment from randomized, phase II study of chemotherapy versus chemotherapy plus erlotinib in patients with progressive NSCLC following clinical benefit from erlotinib. MATERIALS AND METHODS: Forty-six patients with advanced stage NSCLC and progression from erlotinib were randomized to receive chemotherapy (pemetrexed or docetaxel) or chemotherapy plus erlotinib between 2008 and 2012...
September 16, 2016: Reviews on Recent Clinical Trials
Martha Maria Fors, Carmen Elena Viada, Paloma de Las Mercedes Gonzalez
BACKGROUND: Recursive Partitioning Analysis (RPA) is a very flexible non parametric algorithm that allows to classify individuals according to certain criteria, particularly in clinical trials are used to predict response to treatment or classify individuals according prognostic factors. OBJECTIVE: In this paper with examine how often RPA is used in clinical trials and in meta-analysis. METHOD: We reviewed a group of abstracts records between 1990 until 2016 and extracted data regarding clinical trial phase, year of publication, kind of treatment, medical indication, main evaluated endpoints and class of RPA...
September 16, 2016: Reviews on Recent Clinical Trials
Christophe Toukam Tchakoute, Elaine Larson, Jianfang Liu, Bevin Cohen
BACKGROUND: HIV-infected patients may be at a greater risk of hospital-acquired infections (HAIs) but risks factors for HAIs have not been well described in this population. OBJECTIVE: The aim of this study was to examine the incidence, temporal trends and risk factors of HAIs among adult HIV positive patients. METHODS: This was a retrospective cohort study carried out in an academic health system in New York City which included four hospitals over a 9-year period from 2006 to 2014...
September 5, 2016: Reviews on Recent Clinical Trials
Mohammad Abbasinazari, Jamshid Salamzadeh, Azadeh Eshraghi, Vahid Belbasi, Ashnagar Arezoo
Dyspepsia is one of the most frequent problems in the community. The public increasingly seeks out health advice from professionals such as community pharmacists due to a growing interest in understanding drugs and self-medication for common conditions such as dyspepsia. The purpose of our study was to assess dyspepsia-related knowledge of pharmacists in Iran.This study has been done among community pharmacists working in Tehran, Iran. This cross-sectional study was conducted as a survey questionnaire administered to 200 community pharmacists working in Tehran...
September 5, 2016: Reviews on Recent Clinical Trials
Suliang Chen, Xinli Lu, Ze Cui, Hongru Zhao
INTRODUCTION: With the scale-up of antiretroviral drugs, coupling with high-risk behaviors, the spread of HIV-1 resistant strains has increased the difficulty of Hebei`s HIV prevention and control. MATERIALS AND METHODS: Plasma samples were collected from HIV/AIDS patients undergoing antiviral treatment in eleven prefectures in Hebei using stratified sampling. HIV-1 drug resistance test was performed using in-house assay. RESULTS: A total of 536 pol gene sequences, with subtype B(68...
September 2, 2016: Reviews on Recent Clinical Trials
Juan Rosas-Guzmán, Juan Rosas-Saucedo, Alma R J Romero-García
Type 2 Diabetes Mellitus (T2DM) is a chronic illness with high prevalence in Mexico, Latin-America, and the world and is associated to high morbidity, disability, and mortality rate, especially in developing countries. T2DM physiopathology is very complex; insulin resistance in the muscle, liver, and adipose tissue, a reduction in the production of incretins (mainly GLP-1) in the intestine, increased glucagon synthesis, an insufficient response of insulin generation, and increased glucose reabsorption in the kidney lead all together to an hyperglycemic state, which has been closely associated with the development of micro and macrovascular complications...
August 29, 2016: Reviews on Recent Clinical Trials
Dongsheng Jiang, Weihong Kong, Joanna J Jiang
BACKGROUND: Physicians encounter various symptom-based complaints each day. While physicians strive to support patients with chronic illnesses, evidence indicates that patients who are actively involved in their health care have better health outcomes and sometimes lower costs. AIM: This article is to analyze how patient engagement is described when complex interventions such as Tai Chi were delivered in randomized controlled clinical trials (RCTs). It reviews the dynamic patient-physician relationship in chronic illness management and to illustrate the patient engagement process, using Tai Chi as an example intervention...
August 15, 2016: Reviews on Recent Clinical Trials
Alessandro Federico, Vittorio Maria Ormando, Marcello Dallio, Ludovico Abenavoli, Mario Masarone, Marcello Persico, Carmela Loguercio
Alcoholic and virus C hepatitis currently represent the main causes of chronic liver disease worldwide. Every year many people die and are subjected to complex hospitalization and medical assistance due to these pathologies. Alcoholic liver disease and hepatitis C virus chronic infection are often present in the same patient. These two pathologies sinergically act in determining the onset and progression of liver damage that, from the chronic hepatitis staging, may rapidly progress to fibrosis, cirrhosis and hepatocellular carcinoma...
July 23, 2016: Reviews on Recent Clinical Trials
Neda Eslami, Azadeh Eshraghi, Golnaz Vaseghi, Mona Mehdizadeh, Moein Masjedi, Maryam Mehrpooya
OBJECTIVES: To identify the knowledge and attitudes of community pharmacists towards upper respiratory infections. SETTING: The pharmacists, who participated in an annual clinical pharmacy congress in Tehran, were enrolled in this study. INTERVENTION: We conducted a cross-sectional descriptive study to assess the knowledge and attitudes of 72 community pharmacists towards upper respiratory infections (URI) using a questionnaire. MAIN OUTCOME MEASURES: We investigated the knowledge and attitudes of pharmacists towards rational antibiotics use in URI in Iran...
2016: Reviews on Recent Clinical Trials
Ludovico Abenavoli
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2016: Reviews on Recent Clinical Trials
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