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Reviews on Recent Clinical Trials

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https://www.readbyqxmd.com/read/29952264/trends-in-vena-cava-filter-placement-an-analysis-of-nationwide-inpatient-sample-database-over-an-11-year-period
#1
Dominika M Zotlowska, Guramrinder S Thind, Yashwant Agrawal, Jagadeesh K Kalavakunta, Soji Joseph, Sandeep Patri
Objectives There have been increasing concerns regarding inappropriate usage of vena caval filters. Our study was done to analyze the current trends in vena caval filter placement. Methods This study used the data from Nationwide Inpatient Sample database for the years 2002-2012 to identify patients with vena caval filter placement. Trends in both therapeutic and prophylactic vena caval filter use over the eleven year period were analyzed. Multiple simple logistic regression model was used to assess trends...
June 26, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29788896/association-between-delayed-graft-function-dgf-biomarkers-and-long-term-outcomes-after-living-donor-kidney-transplantation
#2
Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi
BACKGROUND AND OBJECTIVES: The Association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interlukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is any association between these postoperative biomarkers with important recipient outcomes beyond this time in live-donor transplants...
May 21, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29779486/risk-factors-for-prolonged-postoperative-ileus-in-adult-patients-undergoing-elective-colorectal-surgery-an-observational-cohort-study
#3
Andrea Pisani Ceretti, Nirvana Maroni, Marco Longhi, Marco Giovenzana, Roberto Santambrogio, Matteo Barabino, Carmelo Luigiano, Giovanni Radaelli, Enrico Opocher
Purpose Prolonged postoperative ileus (PPOI) after abdominal surgery may effect unfavourably the patient recovery. The aim of this study was to estimate the incidence of PPOI in patients elective for colorectal resection and investigate perioperative variables associated with PPOI. Methods A consecutive series of 428 patients undergoing colorectal resection (median age 72, range 24-92, years; men/women ratio 1.14) were analyzed. Data were extracted retrospectively throughout a five-year period from an electronic prospectively maintained database...
May 20, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29779485/tgn-1412-and-bia-2474-trials-with-tragic-end-lessons-learnt-to-make-clinical-trials-safer
#4
Rimple Jeet Kaur, Surjit Singh, Preeti Sidhu, Pramod Kumar Sharma
BACKGROUND: Globally, there have been tremendous efforts by regulatory authorities to make clinical trials safer by making stringent clinical trial regulations. Despite this, we witnessed several tragic events. TGN1412 and BIA 10-2474 phase I trials are infamous trails in which healthy volunteers either succumbed to severe adverse effects or faced irreversible impairments of the test drug. Such afflictions in clinical trials are not only turbulent to the image of pharmaceutical industry but it also conveys dispiriting message for clinical trial participants...
May 20, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29769008/biochemical-and-haematological-predictors-of-reduced-neutrophil-granulocyte-count-associated-with-intravenous-ceftriaxone-treatment
#5
Basant K Puri, Anne Derham, Jean A Monro
Background Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. Objective The first systematic study to determine whether six to 12 days' intravenous ceftriaxone treatment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. Method Baseline and follow-up haematological and biochemical blood indices were measured in 86 patients (mean age 39...
May 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29669504/atrial-fibrillation-in-autoimmune-rheumatic-diseases-from-the-pathogenesis-to-the-treatment
#6
Giuseppe Ciconte, Manuel Conti, Martina Evangelista, Carlo Pappone
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the general population and is associated with an increased number of adverse outcomes. The onset and maintenance of this arrhythmia requires a trigger event and the presence of a predisposing substrate. Atrial fibrosis, a major characteristic of AF-related structural remodeling, represents a process closely related to inflammation as demonstrated by emerging evidence. Aim of this article is to review the evidence linking AF to systemic autoimmune diseases...
April 17, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29658441/efficacy-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-in-the-treatment-of-apathy-in-patients-with-alzheimer-s-disease-study-protocol-for-a-randomized-trial
#7
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29651944/role-of-point-of-care-ultrasonography-for-management-of-sepsis-and-septic-shock
#8
Gentle Sunder Shrestha, Shrikanth Srinivasan
BACKGROUND: Sepsis and septic shock remain a major cause of morbidity and mortality globally. In recent years, outcome of patients with sepsis and septic shock has gradually improved, in part due to early recognition and timely appropriate management. Bedside physical examination can be of limited value to identify the source of infection and to decide appropriate management. Moreover, the clinical status of these patients can change rapidly, as a part of disease progression or in response to treatment or intervention...
April 12, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29629666/clinical-significance-of-anti-ribosomal-p-protein-antibodies-in-patients-with-lupus-nephritis
#9
Sabahat Sarfaraz, Sabiha Anis, Ejaz Ahmed, Rana Muzaffar
BACKGROUND: Systemic lupus erythematosus (SLE) is achronic inflammatory disorder affecting multiplesystems of the body. Clinical features show wide variations in patients with different ethnic background. Renal involvement is a predictor of poor prognosis. Immunological workup is an integral part of SLE diagnostic criteria. Anti-ribosomal P Protein (anti-P) antibodies are highly specific for SLE. They may be present inantinuclear antibodies (ANA) negative SLE patients. Their role in lupus nephritis (LN) is under debate, some researchers found them associated with poor prognosiswhereasothers found favorable effect of these antibodies on renal disease...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29629665/overall-and-multiphasic-findings-of-the-prostate-lung-colorectal-and-ovarian-plco-randomized-cancer-screening-trial
#10
Philip C Prorok, Patrick Wright, Thomas R Riley, Barnett S Kramer, Christine D Berg, John K Gohagan
BACKGROUND: Screening tests are typically evaluated for a single disease, but multiple tests for multiple diseases are performed in practice. The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial assessed testing for four cancers simultaneously and can be viewed as a multiphasic cancer intervention. This paper presents overall and multiphasic findings of this trial. METHODS: The PLCO trial was a randomized multi-center trial conducted at ten screening centers in the US...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29629664/impact-of-a-psycho-educational-team-in-early-breast-cancer-patients-coping-strategies-the-venere-project
#11
Federica Andreis, Fausto Meriggi, Claudio Codignola, Ilaria Frigoli, Tiziana Prochilo, Stefano Mutti, Alessandra Huscher, Michela Libertini, Brunella Di Biasi, Chiara Abeni, Chiara Ogliosi, Silvia Noventa, Luigina Rota, Chiara Pedrali, Alberto Zaniboni
AIMS AND BACKGROUND: The main purpose of our psycho-educational groups was to help women with breast cancer learn how to cope with the physical, emotional, and lifestyle changes associated with cancer as well as with medical treatments that can be painful and traumatic. With this study, we wanted to detect the effects that group action had on the women who participated in it. METHODS: We studied a total of 97 patients who participated in 13 psycho-education groups...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29623850/treatment-of-metastatic-castration-resistant-docetaxel-resistant-prostate-cancer-a-systematic-review-of-literature-with-a-network-meta-analysis-of-randomized-clinical-trials
#12
Davide Tassinari, Chiara Cherubini, Britt Roudnas, Emiliano Tamburini, Fabrizio Drudi, Emanuela Bianchi, Manuela Fantini, Francesco Montanari, Sergio Sartori
INTRODUCTION: To compare the efficacy of abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 in the treatment of castration-resistant, docetaxel-resistant metastatic prostate cancer. METHODS: An indirect comparison of overall survival (OS) and time to PSA progression among abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 was performed with a network meta-analysis. OS in the entire population of patients was the primary end point. OS in ECOG 0-1/2, BPI-SF≤4/>4, pretreated with 1 or 2 courses of chemotherapy, age≤65/>65 patients, patients with only bone metastases or bone and visceral metastases, and time to PSA progression were the secondary end points...
April 4, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29607786/association-between-hypothyroidism-and-takotsubo-cardiomyopathy-analysis-of-nationwide-inpatient-sample-database
#13
Dominika Zoltowska, Yashwant Agrawal, Sandeep Patri, Sourabh Aggarwal, Chandra S Reddy, Nishtha Sareen, Jagadeesh Kalavakunta, Vishal Gupta
BACKGROUND: Takotsubo cardiomyopathy (TC), also called transient left ventricular (LV) ballooning syndrome, satirizes myocardial infarction and is characterized by LV dysfunction in the absence of coronary artery disease. Hypothesis described for TC has been an intense social stressor, pheochromocytoma, thyrotoxicosis among others. We performed this study to analyze the association of hypothyroidism with TC. METHODS: We queried the Nationwide Inpatient Sample which represents 20% of all the United States hospital data for our study...
April 2, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542415/cardiovascular-disease-in-primary-sj%C3%A3-gren-s-syndrome
#14
Onorina Berardicurti, Piero Ruscitti, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Giuliana Guggino, Francesco Carubbi, Paola Di Benedetto, Giovanni Triolo, Roberto Giacomelli
BACKGROUND: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren's syndrome (pSS) experienced an increased risk of CVD. OBJECTIVE: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients...
March 15, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542422/the-emerging-role-of-il-1-inhibition-in-patients-affected-by-rheumatoid-arthritis-and-diabetes
#15
Piero Ruscitti, Paola Cipriani, Vasiliky Liakouli, Francesco Carubbi, Onorina Berardicurti, Paola Di Benedetto, Francesco Ciccia, Giuliana Guggino, Saverio Alvaro, Giovanni Triolo, Roberto Giacomelli
BACKGROUND: Although in the past, prevention of the joint destruction and disability were strongly emphasised in rheumatoid arthritis (RA), at present, a growing body of evidence is focused at identifying the best management of associated comorbidities, such as type 2 diabetes (T2D). Recently, the hypothesis that blocking pro-inflammatory activity may be helpful in the treatment of some comorbidities has been proposed in RA patients. OBJECTIVE: We reviewed the role of IL-1β during RA and T2D, the efficacy of IL-1 blocking agents in controlling both diseases and, possible, decreasing the concomitant enhanced atherosclerotic process...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542421/serum-complement-c3-and-type-2-diabetes-in-rheumatoid-arthritis-a-case-control-study
#16
Francesco Ursini, Salvatore D'Angelo, Emilio Russo, Giorgio Ammerata, Ludovico Abenavoli, Daniele Mauro, Caterina Bruno, Saverio Naty, Rosa Daniela Grembiale, Ignazio Olivieri, Giovambattista De Sarro
BACKGROUND: Recent evidence demonstrated a potential role of complement C3 as a candidate biomarker of cardiometabolic risk in the general population. OBJECTIVE: Aim of the present study was to investigate the correlation between complement C3 levels and comorbid type 2 diabetes (T2DM) in rheumatoid arthritis (RA) patients. METHODS: For the present study, 40 consecutive diabetic RA patients (RA/T2DM+ group) and 80 consecutive RA patients without diabetes (RA/T2DM- group) were recruited...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542420/insulin-sensiting-effects-of-tumor-necrosis-factor-alpha-inhibitors-in-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#17
Christian Leporini, Emilio Russo, Salvatore D'Angelo, Franco Arturi, Giovanni Tripepi, Rosario Peluso, Rosa Daniela Grembiale, Ignazio Olivieri, Giovambattista De Sarro, Francesco Ursini
BACKGROUND: Rheumatoid arthritis (RA) has been associated with insulin resistance (IR), a well-established pathophysiological feature of type 2 diabetes (T2DM). Inconsistent literature evidence suggests that IR could be ameliorated by biological medications targeting TNFα. OBJECTIVE: Aim of this systematic review was to evaluate the effect of TNFα inhibitors (TNFi) on IR in RA patients. METHODS: We performed a systematic review in order to identify the available data on the effect of anti-TNFα medications on IR in RA patients...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542419/endothelial-dysfunction-in-systemic-lupus-erythematosus-pathogenesis-assessment-and-therapeutic-opportunities
#18
Alessandra Nerviani, Daniele Mauro
Systemic lupus erythematosus (SLE) is characterised by increased mortality secondary to cardiovascular diseases (CVD). Despite being common in SLE, traditional cardiovascular risk factors cannot entirely justify such increase in CVD-associated mortality. The endothelium is a key regulator of the vascular homeostasis; lupus-associated persistent systemic inflammation may impair endothelium functionality, thus initiating a cascade of events that, in concert with traditional CVD-risk factors, leads to atherosclerosis development and progression...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542417/cardiovascular-risk-markers-and-major-adverse-cardiovascular-events-in-psoriatic-arthritis-patients
#19
Rosario Peluso, Francesco Caso, Marco Tasso, Pasquale Ambrosino, Matteo Nicola, Dario Di Minno, Roberta Lupoli, Livio Criscuolo, Paolo Caso, Francesco Ursini, Antonio Del Puente, Raffaele Scarpa, Luisa Costa
BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis and leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and serologic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriatic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29542416/bariatric-surgery-and-rheumatic-diseases-a-literature-review
#20
Gaetano Gallo, Giuseppe Candilio, Emilia De Luca, Angelo Iannicelli, Guido Sciaudone, Gianluca Pellino, Rosario Sacco, Francesco Selvaggi, Giuseppe Sammarco
BACKGROUND: Obesity is a disabilitating growing condition and represent a challenge for every surgeon. It is associated with the activation of the inflammatory pathway and this may have a negative impact on the natural history of some rheumatic diseases. Bariatric surgery, reducing obesity, could bring to a minor activation of the well-known inflammatory pathway with improvement of these diseases. The aim of this review is to investigate the role of weight loss, achieved through bariatric surgery, in rheumatic diseases...
March 13, 2018: Reviews on Recent Clinical Trials
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