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Sustained response to lenvatinib and pembrolizumab in two patients with KRAS -mutated endometrial mesonephric-like adenocarcinoma.
Gynecologic Oncology Reports 2021 August
•Endometrial mesonephric-like adenocarcinoma (MLA) is a rare and aggressive subtype of epithelial endometrial cancer.• KRAS mutations are characteristic in patients with endometrial MLA.•We report two cases of KRAS -mutated endometrial MLA with excellent and durable responses to lenvatinib and pembrolizumab.•Tumors with KRAS mutations may be particularly sensitive to lenvatinib, but this warrants further study.
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