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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/30426062/pharmacokinetics-and-clinical-response-to-single-agent-rucaparib-in-a-dialysis-dependent-patient-with-brca-associated-breast-and-recurrent-ovarian-cancer
#1
Justin A Harold, Stephanie C Free, William H Bradley
A 56-year old woman with BRCA-associated breast cancer and recurrent ovarian cancer was treated with a poly (ADP-ribose) polymerase enzyme (PARP) inhibitor, rucaparib, in the setting of dialysis-dependence which required dose modification. Rucaparib trough levels were obtained before and after dialysis and a clinically significant disease response was appreciated.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30426061/brain-metastases-in-patients-with-low-grade-endometrial-carcinoma
#2
Paulina Cybulska, Marina Stasenko, Raanan Alter, Vicky Makker, Karen A Cadoo, Yukio Sonoda, Nadeem R Abu-Rustum, Jennifer J Mueller, Mario M Leitao
Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000-12/2016, who developed brain metastases. Electronic medical records were reviewed, data abstracted. Overall survival (OS) was determined from time of brain metastases to death or last follow-up. Appropriate statistical tests were used...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30417064/a-report-of-bell-s-palsy-triggered-by-leptomeningeal-metastases-from-recurrent-high-grade-serous-ovarian-cancer
#3
Khilen B Patel, Anna Gaidis, Angela Stephens, Thomas Z Thompson, Heather Williams, Bunja Rungruang
•CNS metastases involving leptomeninges (LM) are extremely rare in patients with ovarian cancer.•Prognosis for ovarian cancer patients with LM metastases is very poor and treatment is palliative in nature.•Chemotherapy is administered intrathecally via an Ommaya reservoir or intra-CSF via repeated lumbar punctures.•Early recognition of LM metastases can help maintain the patients' quality of life by minimizing neurological deficits.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30386812/liposarcoma-of-the-uterine-corpus-a-case-report-and-literature-review
#4
Kaori Kiuchi, Kiyoshi Hasegawa, Shoko Ochiai, Nobuaki Kosaka, Hajime Kuroda, Yasushi Kaji, Ichio Fukasawa
Liposarcoma of the uterine corpus is extremely rare. We performed a laparotomy on a 55-year-old woman with the complaints of abdominal distension and genital bleeding who was found to have a uterine tumor, 17 × 16 cm in diameter. The preoperative diagnosis was a lipoma or lipoleiomyoma of the uterine corpus. However, pathological examination revealed proliferation of mature adipocytes and lipoblast-like atypical cells with small, weakly pleomorphic nuclei and foamy or vacuolated cytoplasm present within a fibrous septum...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30364812/hysterectomy-at-the-time-of-risk-reducing-surgery-in-brca-carriers
#5
Navya Nair, Melissa Schwartz, Lisa Guzzardi, Nicki Durlester, Stephanie Pan, Jessica Overbey, Linus Chuang
In this study, women at risk for BRCA were surveyed to understand their choice of prophylactic surgery and associated risk of uterine cancers. The study was conducted as an anonymous online web-based survey that assessed personal and family histories and choice of prophylactic surgery. Respondents were targeted through social media groups that bring awareness to hereditary breast and ovarian cancer. The study cohort included an international group of 601 respondents. The majority were female (99.3%), in their 40s (34...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30364775/ultrasound-guided-transversus-abdominis-plane-tap-block-utilization-in-multimodal-pain-management-after-open-gynecologic-surgery
#6
Heidi Chang, B J Rimel, Andrew J Li, Ilana Cass, Beth Y Karlan, Christine Walsh
Transversus abdominis plane (TAP) block is a peripheral nerve block directed at the nerves in the anterior abdominal wall. We sought to determine whether TAP block reduces post-operative narcotic use or length of stay after open gynecologic surgery. Among 98 women who underwent an open hysterectomy between July 2016 - July 2017 by a gynecologic oncologist, 73 (74.5%) received a TAP block. The majority of patients who received a TAP block had a vertical incision (86.3%) while the majority of patients who did not receive TAP block had a transverse incision (64%)...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30364674/a-tailored-approach-to-building-specialized-surgical-oncology-capacity-early-experiences-and-outcomes-in-malawi
#7
REVIEW
Lameck Chinula, Michael Hicks, Grace Chiudzu, Jennifer H Tang, Satish Gopal, Tamiwe Tomoka, James Kachingwe, Leeya Pinder, Maya Hicks, Vikrant Sahasrabuddhe, Groesbeck Parham
Objectives: Cervical cancer can often be cured by surgery alone, if diagnosed and treated early. However, of the cancer patients who live in the world's poorest countries less that 5% have access to safe, effective and timely cancer surgery. We designed a novel, competency-based curriculum to rapidly build surgical capacity for the treatment of cervical cancer. Here we report experiences and early outcomes of its implementation in Malawi. Methods: Curriculum implementation consisted of preoperative evaluation of patients and surgical video review, discussion of surgical instruments and suture material, deconstruction of the surgical procedure into critical subcomponents including trainees walking through the steps of the procedure with the master trainers, high-volume surgical repetition over a short time interval, intra-operative mentoring, post-operative case review, and mental narration...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30364622/serous-ovarian-carcinoma-in-patients-with-lynch-syndrome-caution-is-warranted
#8
Patrick R Benusiglio, Florence Coulet
No abstract text is available yet for this article.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30364558/renocolic-fistula-secondary-to-curative-intent-extended-field-radiotherapy-for-cervical-cancer
#9
Dhanalakshmi Thiyagarajan, Michael Hughes, Frank Tamarkin, Israel Zighelboim
•Renocolic fistula is a rare complication from extended field radiation.•Pathogenesis may involve colonic mucosal ischemia from radiation-induced colitis.•Conservative management with urethral stenting can result in complete resolution.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30302364/high-risk-gestational-choriocarcinoma-with-an-unusual-presentation-and-the-treatment-course-of-refractory-or-quiescent-minimally-invasive-disease
#10
Yutaka Nagai, Tomoko Nakamoto, Tadaharu Nakasone, Yusuke Taira, Yoichi Aoki
•A patient with high-risk choriocarcinoma who had refractory or quiescent/minimally invasive disease.•She was treated with seven lines of chemotherapy and salvage surgeries.•The patient had persistently low hCG levels without evidence of disease for 4 years.•Then radiological evidence of pulmonary metastasis was finally achieved, and the patient was salvaged by surgery.•It is crucial to identify the site of active disease to facilitate surgical resection and cure.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30302363/microsurgical-lymphaticovenular-anastomosis-for-refractory-chylous-ascites-following-para-aortic-lymph-nodes-dissection-in-a-patient-with-tubal-cancer
#11
Yoshihisa Arakaki, Yuko Shimoji, Shun Yamazaki, Yusuke Shimizu, Yoichi Aoki
•Postoperative chylous ascites is an important clinical issue in surgery for gynecological malignancy.•Our patient with refractory chylous ascites after surgery for tubal cancer.•She received great benefit from the microsurgical lymphaticovenular anastomosis.•The microsurgical lymphaticovenular anastomosis is the treatment of choice.•The entire procedure was performed under local anesthesia.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30294656/mullerian-carcinosarcoma-in-the-colon-of-a-patient-with-history-of-endometrial-carcinoma-a-case-report-and-insight-into-possible-pathogenesis
#12
Claire Anne Therese Hemedez, Michele Lomme, M Ruhul Quddus
•Mullerian carcinosarcoma can occur in extragenital sites.•Malignant transformation of endometriosis is common in the rectosigmoid area.•MLH1 hypermethylation has been implicated in endometriosis-associated carcinomas.•Adequate sampling is essential in determining the etiology of colonic tumors.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30255125/conservative-management-of-endometrial-hyperplasia-or-carcinoma-with-the-levonorgestrel-intrauterine-system-may-be-less-effective-in-morbidly-obese-patients
#13
Ashley Graul, Elise Wilson, Emily Ko, Ashley F Haggerty, Helen Reed, Nathanael Koelper, Sarah H Kim
•Endometrial hyperplasia/carcinoma regression rates with LNG-IUS were examined by BMI.•Morbidly obese patients with EH/EHA/EC are more likely to progress.•Despite addition of oral progesterone to LNG-IUS, morbid obesity increases the odds of progression.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30246138/dramatic-clinical-response-following-dabrafenib-and-trametinib-therapy-in-a-heavily-pretreated-low-grade-serous-ovarian-carcinoma-patient-with-a-braf-v600e-mutation
#14
Alberto A Mendivil, Paul K Tung, Randy Bohart, Karen Bechtol, Bram H Goldstein
Low grade serous ovarian cancer (LGSOC) is a slowly growing, relatively chemoresistant neoplasm that is associated with a more favorable prognosis, especially compared to the disease's high-grade serous counterpart. We recount a case involving a 47-year-old, heavily pretreated LGSOC patient who presented with an elevated CA-125 of 1047 U/mL during her recent course of pemetrexed therapy. Thereafter, she underwent molecular profiling, which revealed a BRAF V600E mutation; accordingly, the patient was administered dabrafenib and trametinib combination therapy, a regimen that resulted in a precipitous decline of her CA-125 to 35 U/mL following the 6th cycle...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30225334/sebaceous-carcinoma-arising-within-an-ovarian-mature-cystic-teratoma-a-case-report-with-discussion-of-clinical-management-and-genetic-evaluation
#15
Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J Li, Shivani Kandukuri
Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Here we present the case of a 67 year-old woman with a longstanding history of a small left ovarian cyst with sonographic features of an ovarian dermoid...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30225333/case-of-pulmonary-benign-metastasizing-leiomyoma-from-synchronous-uterine-leiomyoma-in-a-postmenopausal-woman
#16
H C Jo, J C Baek
Benign metastasizing leiomyoma (BML) is a rare tumor comprising histologically benign smooth muscle cells and exhibits the same histological findings as a uterine myoma although in an extra-uterine location. Most BMLs occur several years after surgery for uterine myoma in women of reproductive age. Here, we report a case of pulmonary BML in a 54-year-old postmenopausal woman with no previous history of myomectomy or hysterectomy. The patient presented with a rapid increase in abdominal girth over the past 3 months and a cough lasting for 2 months...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30211291/platinum-type-is-key-in-determining-degree-of-neuropathy
#17
Franco Muggia, David Kudlowitz
No abstract text is available yet for this article.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30211290/infectious-diseases-mimicking-ovarian-carcinomatosis
#18
Sara M Drayer, Jessica J Shank
Infectious diseases can present similar to ovarian cancer and occur concomitantly with ovarian pathology. With increased worldwide travel and migration of populations, infections endemic to developing countries can emerge in the United States. We present 2 cases of infectious diseases mimicking ovarian carcinomatosis. Two Filipino women presented with abdominal distension and had evaluations suggestive of advanced gynecologic malignancy. The first patient underwent surgery and was found to have peritoneal tuberculosis...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30186930/utilizing-v-y-fasciocutaneous-advancement-flaps-for-vulvar-reconstruction
#19
Lauren C Hand, Talia M Maas, Nadia Baka, Rebecca J Mercier, Patrick J Greaney, Norman G Rosenblum, Christine H Kim
Objectives: We aimed to analyze the outcomes of patients who underwent vulvectomy with subsequent V-Y fasciocutaneous flap reconstruction. Methods: All medical records of all patients who underwent vulvectomies with V-Y fasciocutaneous flap reconstruction from January 2007 to June 2016 were retrospectively reviewed. Patient clinical and surgical data, demographics, and outcomes were abstracted. Results: Of the 27 patients, 42 flaps were transferred...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30175211/recurrent-colon-perforation-after-discontinuation-of-bevacizumab-for-ovarian-cancer
#20
Michiko Nonaka, Seiya Sato, Daiken Osaku, Mayumi Sawada, Akiko Kudoh, Jun Chikumi, Shinya Sato, Tetsuro Oishi, Tasuku Harada
Bevacizumab (Bev) is an antiangiogenic drug used to treat various malignances, including ovarian cancer (OC). Bev is generally well-tolerated; however, it has a characteristic toxicity profile. In particular, gastrointestinal perforation (GIP) is a rare but serious side effect that can be lethal. A 55-year-old woman with recurrent OC had an episode of GIP during third-line chemotherapy comprising Bev and topotecan (TPT). Bev was discontinued while TPT was continued as monotherapy. Three months after discontinuation of Bev, the patient presented with left lower abdominal pain and was diagnosed with a second GIP...
November 2018: Gynecologic Oncology Reports
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