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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/28070553/predicted-neoantigen-load-in-non-hypermutated-endometrial-cancers-correlation-with-outcome-and-tumor-specific-genomic-alterations
#1
Sachet A Shukla, Brooke E Howitt, Catherine J Wu, Panagiotis A Konstantinopoulos
Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have shown that the hypermutated MSI and POLE-mutated tumors harbor significantly higher predicted neoantigen load compared to the hypomutated CN-low/endometrioid and CN-high/serous-like tumors. Here, we report that predicted neoantigen load may be a prognostic factor in hypomutated endometrial cancers, both in CN-low/endometrioid and CN-high/serous-like tumors...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28070552/long-term-survival-after-anterior-pelvic-exenteration-and-total-vaginectomy-for-recurrent-endometrial-carcinoma-with-metastatic-inguinal-nodes-at-the-time-of-surgery
#2
Benjamin Margolis, Sun Woo Kim, Dennis S Chi
•Pelvic exenteration can be used in patients with multifocal recurrence.•Ability to achieve negative margins remains a necessity for pelvic exenteration.•Individualized treatments are essential for those with recurrent malignancy.
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28054022/low-grade-endometrial-stromal-sarcoma-with-extensive-sex-cord-differentiation-heterologous-elements-and-complex-atypical-hyperplasia-case-report-and-review-of-literature
#3
Abby M Richmond, Andrew J Rohrer, Susan A Davidson, Miriam D Post
•Endometrial stromal sarcoma (ESS) may have sex cord differentiation, usually focal.•Diagnosis of ESS is difficult when variant morphology predominates.•Prognosis differs between ESS and UTROSCT; therefore, distinction is critical.•Extensive tumor sampling is mandatory to identify neoplastic endometrial stroma.•Sex cord differentiation may be associated with endometrial hyperplasia.
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28050597/cardiophrenic-lymph-node-metastasis-in-low-grade-serous-ovarian-adenocarcinoma
#4
Tasha Serna-Gallegos, Nicolas Gallegos, Robert E Bristow
•Cardiophrenic lymph node metastasis in low-grade ovarian carcinoma is rare.•Two cases presented here identify clinical strategies needing further attention.•Low-grade disease is treated with surgery given high chemotherapeutic resistance.•Preoperative awareness of lymph node metastasis allows for optimal debulking.•Identifying radiologic evidence of distant metastasis improves patient outcomes.
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28050596/an-ovarian-mature-cystic-teratoma-evolving-in-squamous-cell-carcinoma-a-case-report-and-review-of-the-literature
#5
REVIEW
C Goudeli, A Varytimiadi, N Koufopoulos, J Syrios, E Terzakis
Mature cystic teratomas (MCT), also known as dermoid cysts, are the most common ovarian germ cell tumors and the most common ovarian neoplasms in patients younger than 20 years. Malignant transformation (MT) is a rare complication of MCTs which may occur in 1-2% of the cases. Squamous cell carcinoma (SCC) is the most frequent histology arising from MCTs and its appearance depends on diverse risk factors such as patient's age, the size of the tumor and levels of serum tumor markers. Diagnosis and treatment constitute a big challenge due to the rarity and the aggressive course of this entity...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28050595/cervical-cancer-prevention-training-in-south-east-asian-lmics
#6
Joseph Soon-Yau Ng, Ida Ismail-Pratt
The Association of Southeast Asian Nations (ASEAN) is a confederation of 10 sovereign states occupying approximately 1.7 million square miles of Southeast Asia with an estimated population of just under 630 million. Southeast Asia continues to have one of the world's highest rates of cervical cancer-related death. Organised training in cervical cancer screening is essential but lacking in low to middle income countries (LMICs). Systematic training of local doctors is an essential part of an effective screening program and an effective strategy to reduce cervical cancer-related mortality...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28018956/reproductive-counseling-contraception-and-unplanned-pregnancy-in-fertile-women-treated-by-gynecologic-oncologists
#7
Sarah M Crafton, Courtney D Lynch, David E Cohn, Eric L Eisenhauer
We sought to identify how gynecologic oncologists approach reproductive counseling for their fertile, reproductive age patients, and their experience with unplanned pregnancies. Members of the Society of Gynecologic Oncology (SGO) were surveyed electronically regarding consistency of counseling patterns of contraception and fertility concerns, most and least common contraceptive methods utilized, referral patterns, and incidence of unplanned pregnancy. Of the 1424 SGO members identified, 261 participated in the questionnaire, yielding a response rate of 18%...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28018955/wilms-tumor-of-the-ovary
#8
Vinita M Alexander, Jane Meisel, Shannon O'Brien, Namita Khanna
Extrarenal Wilms' tumor of the ovary is a very rare tumor likely derived from embryonic mesonephros. We present the first reported case of a teratoid extrarenal Wilms' tumor of the ovary with a short review of the existing literature. In the case, a 26-year-old woman presented with back pain and was found to have a dermoid cyst; three years later, she presented again, now pregnant, with severe abdominal pain. She was diagnosed with an immature teratoma consisting of a Wilms' tumor (immature component) arising within a mature teratoma and treated exclusively with surgery and surveillance...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28018954/regression-of-metastatic-radiation-chemotherapy-resistant-uterine-serous-carcinoma-overexpressing-her2-neu-with-trastuzumab-emtansine-tdm-1
#9
Alessandro D Santin, Stefania Bellone, Natalia Buza, Peter E Schwartz
BACKGROUND: The management of uterine-serous-carcinoma (USC) no longer amenable to treatment with surgery, radiation and/or chemotherapy remains dismal. Alternative therapeutic options are desperately needed. CASE: We describe the case of a heavily pretreated 74-year-old patient with a recurrent USC overexpressing HER2/neu at 3 + level by IHC treated with the anti-HER2/neu antibody-drug-conjugate (ADC) trastuzumab-emtansine (TDM-1-Kadcyla-Genentech/Roche). She experienced a remarkable clinical response to TDM-1 with a complete resolution of a large metastatic, radiation/chemotherapy resistant tumor deposit in her abdominal wall muscle confirmed by multiple CAT scans and a prolonged systemic control of her disease...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28004030/clinical-trials-in-low-and-middle-income-countries-successes-and-challenges
#10
REVIEW
Surbhi Grover, Melody Xu, Anuja Jhingran, Umesh Mahantshetty, Linus Chuang, William Small, David Gaffney
Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27942575/in-vitro-maturation-and-cryopreservation-of-oocytes-retrieved-from-intra-operative-aspiration-during-second-enucleation-for-ovarian-tumor-a-case-report
#11
Hiromitsu Shirasawa, Yukiyo Kumazawa, Wataru Sato, Natsuki Ono, Yukihiro Terada
•We reported oocyte collection from an ovarian tumor with a single ovary.•Intra-operative retrieval of oocytes may be useful for preserving fertility.•We have done in vitro maturation for immature oocytes with ovarian enucleation.
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995177/response-to-comment-from-brasky-et-al
#12
F Verdoodt, S Friis, C Dehlendorff, V Albieri, S K Kjaer
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995176/epithelial-ovarian-cancer-inherent-resistance-may-the-pleiotropic-interaction-between-reduced-immunosurveillance-and-drug-resistant-cells-play-a-key-role
#13
Antonio Simone Laganà, Vincenza Sofo, Salvatore Giovanni Vitale, Onofrio Triolo
•Cancer cells may have inherent chemoresistance which allows an indefinite expansion.•Transformed ovarian epithelial cells may undergo an immunoediting process.•Immunoedited ovarian cancer drug-resistant cells escape first-line chemotherapy.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995175/response-to-the-letter-of-fagotti-et-al-regarding-the-manuscript-pattern-of-and-reason-for-postoperative-residual-disease-in-patients-with-advanced-ovarian-cancer-following-upfront-radical-debulking-surgery
#14
Florian Heitz, Philipp Harter, Beyhan Ataseven, Andreas du Bois
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995174/re-pattern-of-and-reason-for-postoperative-residual-disease-in-patients-with-advanced-ovarian-cancer-following-upfront-radical-debulking-surgery
#15
A Fagotti, G Vizzielli, M Petrillo, G Scambia
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995173/response-to-letter-to-the-editor-concerning-validation-of-iota-adnex-model
#16
Sebastian Szubert, Andrzej Wojtowicz, Patryk Zywica
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27995172/flawed-external-validation-study-of-the-adnex-model-to-diagnose-ovarian-cancer
#17
B Van Calster, E W Steyerberg, T Bourne, D Timmerman, G S Collins
No abstract text is available yet for this article.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27896308/small-cell-ovarian-carcinoma-long-term-survival-in-juvenile-case-with-poor-prognostic-features
#18
Lauren Stewart, Ruchi Garg, Rochelle Garcia, Elizabeth Swisher
BACKGROUND: Ovarian small cell carcinoma is a rare, aggressive neoplasm that occurs in young women and has a poor long-term prognosis. Treatment involves surgical resection and chemotherapy. The required radicality of surgery is uncertain, balancing cytoreduction with fertility preservation. Various chemotherapy regimens are utilized due to confusion regarding the neoplasm's lineage. Case We describe an adolescent with small cell carcinoma, hypercalcemic type, stage IA. Surgery included left salpingo-oopherectomy, left pelvic/paraaortic lymphadenectomy, omentectomy and peritoneal biopsies...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27872893/response-to-sunitinib-sutent-in-chemotherapy-refractory-clear-cell-ovarian-cancer
#19
C Alifrangis, A Thornton, C Fotopoulou, J Krell, H Gabra
•Case describes a response to sunitinib in clear cell ovarian cancer.•Discussion of unique molecular characteristics of clear cell ovarian cancers•Practical points regarding dosing and toxicity when using sunitinib discussed.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#20
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
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