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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/28616458/malignant-brenner-tumor-associated-with-a-germline-brca2-mutation
#1
Michael D Toboni, Haller J Smith, Sarah E Dilley, Lea Novak, Charles A Leath
•The first woman with a Malignant Brenner tumor and a BRCA2 mutation is described.•Not all women with epithelial ovarian cancers are referred for genetic counseling.•Women should be referred for genetics regardless of how rare the histology.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28616457/cervical-cancer-screening-at-a-tertiary-care-center-in-rwanda
#2
George Ruzigana, Lisa Bazzet-Matabele, Stephen Rulisa, Allison N Martin, Rahel G Ghebre
In limited resource settings such as Rwanda, visual inspection with acetic acid (VIA) is the primary model for cervical cancer screening. The objective of this study was to describe clinical characteristics and outcomes for women presenting for cervical cancer screening. A prospective, observational study was conducted between September 2015 and February 2016 at Kigali University Teaching Hospital (CHUK). Women referred to the VIA clinic were enrolled and completed a semi-structured questionnaire. During the six-month study period, 150 women were enrolled and evaluated with VIA followed by colposcopy directed biopsy for VIA positive...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28560298/successful-treatment-of-low-grade-endometrial-cancer-in-premenopausal-women-with-an-aromatase-inhibitor-after-failure-with-oral-or-intrauterine-progesterone
#3
Alli Straubhar, Andrew P Soisson, Mark Dodson, Elise Simons
INTRODUCTION: Young women with endometrial intraepithelial hyperplasia or low-grade endometrial carcinoma are potential candidates for conservative fertility sparing therapy utilizing progesterone rather than hysterectomy. High-dose progesterone treatment is associated with 55-80% initial response but high relapse rates. Using aromatase inhibitors in conjunction with high-dose progesterone has largely been unstudied. CASE DESCRIPTIONS: Three obese premenopausal women with endometrial cancer failed to respond to oral or intrauterine progesterone as first line therapy...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28560297/uterine-lipoleiomyosarcoma-complete-medullary-compression-as-presentation-of-a-solitary-metastasis
#4
Véronique Drapeau-Zgoralski, Josée Doyon, Marie-Josée Berthiaume, Sophie Mottard
•A rare case of lipoleiomyosarcoma.•Patient presented at our center with paraplegia caused by a solitary vertebral metastasis of a uterine cancer.•Lobectomy performed for a solitary lung metastasis.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28540361/efforts-towards-erasing-borders-in-gynecologic-cancer
#5
EDITORIAL
Linus T Chuang, Thomas C Randall, Beth Y Karlan
•Cervical cancer is the second most common cancer among women in LMIC.•Major efforts to improve research in gynecologic cancer in LMIC are needed.•GOR provides a platform featuring research and review of cancer care in LMIC.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28540360/epithelioid-angiosarcoma-arising-in-a-uterine-leiomyoma-with-associated-elevated-ca-125-a-case-report
#6
Sarah V Strickland, Mark R Kilgore, Elise J Simons, Mara H Rendi
We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithelioid cells forming anastomosing vascular channels. The neoplastic cells were diffusely positive for CD31 and FLI1, supporting the morphologic impression of epithelioid angiosarcoma. Few cases of epithelioid angiosarcoma arising within a leiomyoma have been described...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28508030/incidental-leiomyosarcoma-found-at-the-time-of-cesarean-hysterectomy-for-morbidly-adherent-placenta
#7
Lauren C Hand, Alexis C Gimovsky, Joanna S Y Chan, Norman G Rosenblum, Christine H Kim
BACKGROUND: Incidental leiomyosarcoma (LMS) is a rare diagnosis in pregnancy or in the puerperium. To our knowledge, this is the first case reported in the literature of incidental LMS after cesarean hysterectomy for morbidly adherent placenta. CASE: We present a case of a cesarean hysterectomy performed for a suspected morbidly adherent placenta in a patient with three prior cesarean deliveries, an anterior placenta previa and a fundal fibroid. Subsequent pathology identified a LMS on final specimen...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28491946/technique-of-icg-guided-targeted-compartmental-pelvic-lymphadenectomy-tcl-combined-with-pelvic-peritoneal-mesometrial-resection-pmmr-for-locoregional-control-of-endometrial-cancer-a-proposal
#8
Rainer Kimmig, Paul Buderath, Peter Rusch, Bahriye Aktas
•PMMR is a compartment based radical hysterectomy in endometrial cancer.•Pelvic PMMR may be combined with ICG guided Targeted Compartmental Lymphadenectomy (TCL).•Video of Pelvic PMMR and TCL technique may be basis for a prospective study.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28459098/endometrial-adenosarcoma-in-the-setting-of-a-germline-dicer1-mutation-a-case-report
#9
Mary M Mullen, Laura M Divine, Ian S Hagemann, Sheri Babb, Matthew A Powell
•DICER1 mutations play a significant role in gynecologic malignancy.•DICER1 may be involved in the sarcomagenesis of endometrial adenosarcoma.•The knowledge of a genetic mutation can help clarify a patient's medical history.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28443321/the-gynecologic-oncology-fellowship-interview-process-challenges-and-potential-areas-for-improvement
#10
Gregory M Gressel, Anne Van Arsdale, Shayan M Dioun, Gary L Goldberg, Nicole S Nevadunsky
The application and interview process for gynecologic oncology fellowship is highly competitive, time-consuming and expensive for applicants. We conducted a survey of successfully matched gynecologic oncology fellowship applicants to assess problems associated with the interview process and identify areas for improvement. All Society of Gynecologic Oncology (SGO) list-serve members who have participated in the match program for gynecologic oncology fellowship were asked to complete an online survey regarding the interview process...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28435850/paraneoplastic-myositis-secondary-to-poorly-differentiated-serous-carcinoma-of-ovarian-tubal-origin
#11
Zachary Raizman, Boshra Hosseini, Sarah Kean, Alon D Altman
•Ovarian cancer can present as paraneoplastic myositis.•Presented with progressive weakness unresponsive to treatment with glucocorticoids•Imaging revealed bilateral ovarian masses, myositis resolved after surgery.•Ovarian cancer should be included on the differential diagnosis of a patient presenting with myositis.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28409179/vulva-cancer-in-ghana-review-of-a-hospital-based-data
#12
Mary Ann Dadzie, Charles A Aidoo, Verna Vanderpuye
•Seventy- 5% of vulvar cancer cases present with advance disease.•Definitive radiotherapy/chemoradiation is the main stay of treatment.•One third of patients default treatment.•Five year survival following radiotherapy was 36.7%.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393096/18f-fdg-positron-emission-tomography-findings-of-gliomatosis-peritonei-a-case-report-and-review-of-the-literature
#13
J-M Lavoie, F Lacroix-Poisson, L N Hoang, D C Wilson, M J Seckl, A V Tinker
•Gliomatosis peritonei (GP) is a rare benign complication of ovarian teratomas that does not impact overall survival.•GP exhibits high 18-F FDG uptake unlike other non-malignant forms of mature teratoma.•The specific characteristics of GP on functional imaging may be used to follow it with active surveillance in select cases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393095/profound-sensorineural-hearing-loss-after-one-cycle-of-intraperitoneal-cisplatin-in-treatment-of-advanced-ovarian-cancer
#14
Megan E McDonald, Jordan Mattson, Emily Hill
Few advances in the treatment of advanced epithelial ovarian cancer have improved patient overall survival. However, the incorporation of intraperitoneal administration of platinum based chemotherapy to standard treatment was one such advancement. It is understood that the intraperitoneal regimen is associated with increased toxicity when compared to intravenous administration alone; however, information regarding the specific risk of ototoxicity is lacking in the literature. We report a case of almost complete sensorineural hearing loss after one cycle of intraperitoneal cisplatin...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393094/laparoscopic-surgery-for-gynecologic-cancer-in-low-and-middle-income-countries-lmics-an-area-of-need
#15
Melissa Schwartz, Cherng-Jye Jeng, Linus T Chuang
Over 90% of people living in low- and middle-income countries (LMICs) do not have access to surgical care. In the absence of appropriate surgical care, there is high morbidity and mortality from surgically curable diseases, such as cervical cancer. Laparoscopic surgery for gynecologic cancer in LMICs is extremely limited. The benefits of laparoscopy over open surgery are even more pronounced in LMICs than in resource-rich countries. Barriers to implementation of laparoscopic surgery in LMICs should be identified and addressed in order to improve global cancer care and the lives of women worldwide...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393093/choriocarcinoma-with-brain-lung-and-vaginal-metastases-successfully-treated-without-brain-radiation-or-intrathecal-chemotherapy-a-case-report
#16
Anja S Frost, Jonathan H Sherman, Katayoon Rezaei, Alivia Aron, Micael Lopez-Acevedo
•There is no consensus on optimal treatment for GTN and brain metastases.•Brain metastasis treated with craniotomy and intravenous, EMA-CO chemotherapy•Intravenous high-dose methotrexate may be adequate to treat brain metastases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393092/hormonal-based-treatment-of-ovarian-anaplastic-ependymoma-with-anastrozole
#17
Justin Wayne Gorski, Jolyn Sharpe Taylor, Jing Zhang, Jinsong Liu, Amir Anthony Jazaeri
OBJECTIVE: Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). CASE: A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28386581/paraneoplastic-cerebellar-degeneration-in-a-patient-with-a-primary-fallopian-tube-adenocarcinoma-a-case-report-and-brief-review
#18
Mario Campero, Alberto E Selman
We describe a 65-year-old woman with subacute cerebellar syndrome expressed as severe ataxia, and the presence of anti Purkinje cell antibodies (Anti-Yo). A small adnexal mass was only evident on PET CT with the pathological feature of fallopian tube adenocarcinoma. Anti-Yo antibodies have been strongly associated with paraneoplastic cerebellar degeneration, and nearly always associated to ovarian adenocarcinomas. Few cases have been reported in which this paraneoplastic syndrome has been related to fallopian tube adenocarcinoma...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28386580/surgical-management-of-a-retroperitoneal-pelvic-desmoid-tumour-involving-the-sacrifice-of-external-iliac-vein-and-internal-iliac-vessels
#19
E A Goulding, M Bunting, R Harle, P Blomfield
•Retroperitoneal pelvic desmoid tumours are rare with limited publications.•A rare case of a retroperitoneal pelvic desmoid tumour is discussed.•Excision was challenging requiring the sacrifice of some of the iliac vessels.•No other case reports document a surgical excision requiring this.•To date our patient suffers minimal morbidity and has had no recurrences.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28378010/epigenetic-therapy-for-the-treatment-of-epithelial-ovarian-cancer-a-clinical-review
#20
REVIEW
Haller J Smith, J Michael Straughn, Donald J Buchsbaum, Rebecca C Arend
Despite a good initial response to chemotherapy, the majority of patients with epithelial ovarian cancer will eventually recur and die of their disease. The introduction of targeted therapies to traditional chemotherapy regimens has done little to improve overall survival in women with ovarian cancer. It has become increasingly apparent that the cancer epigenome contributes significantly to the pathogenesis of ovarian cancer and may play an important role in cell proliferation, metastasis, chemoresistance, and immune tolerance...
May 2017: Gynecologic Oncology Reports
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