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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/28795132/spontaneous-regression-of-gestational-trophoblastic-neoplasia
#1
Kaoru Niimi, Eiko Yamamoto, Kimihiro Nishino, Sawako Fujiwara, Kazuhiko Ino, Fumitaka Kikkawa
•We present two cases of postmolar gestational trophoblastic neoplasia (GTN).•Both cases presented with lung metastases after hydatidiform mole.•Both cases showed spontaneous regression without treatment.•The mechanism behind this phenomenon remains unclear.•Patients with postmolar GTN and declining hCG values may not need chemotherapy.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28795131/primary-pouch-of-douglas-malignancies-a-case-series-and-review-of-the-literature
#2
Ker Yi Wong, Ada Xinhui Ng, Timothy Yong Kuei Lim
•POD lesions are often diagnosed as ovarian or uterine in origin on imaging.•POD malignancies with concomitant endometriosis, appear to be of lower grade.•There is no consensus on the optimal treatment for rare primary POD neoplasms.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28795130/epithelioid-angiosarcoma-of-the-vulva-a-case-report
#3
S Yost, J Bradish, L Grossheim, A Hoekstra
•Vulvar angiosarcoma in a patient with pelvic radiation and chronic lymphedema•Epithelioid histologic staining positive for vimentin, ERG, CD31•Gross appearance of violaceous hyperpigmentation of the mons pubis.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28795129/placental-site-trophoblastic-tumor-with-sole-metastasis-to-breast-a-case-report
#4
Kimberly Nagamine, Sophia Iwasaki, David Shimizu, Pamela Tauchi-Nishi, Keith Terada
Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN). It most commonly occurs after a delivery but may arise after any type of pregnancy. PSTT arises after neoplastic transformation of intermediate trophoblastic cells. The most commonly reported symptoms are abnormal bleeding or amenorrhea. Due to the rarity of this disease, evidence on prognostic factors as well as optimal treatment is limited. While treatment for early-stage disease is usually limited to surgery, multimodal treatment with chemotherapy and surgery may be important for metastatic disease...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28761925/recurrent-atypical-polypoid-adenomyoma-and-pregnancy-a-new-conservative-approach-with-levonorgestrel-releasing-intrauterine-system
#5
Eugenio Solima, Valeria Liprandi, Gaia M Belloni, Michele Vignali, Mauro Busacca
•Levonorgestrel IUD was effective in treatment of recurrent APA.•No side effects were reported.•No impairments on a subsequent pregnancy were reported.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28761924/secondary-uterine-carcinosarcoma-after-concurrent-chemoradiotherapy-for-cervical-cancer-case-reports
#6
Akihiko Wakayama, Wataru Kudaka, Tadaharu Nakasone, Yusuke Taira, Yoichi Aoki
•Secondary uterine sarcomas occur in < 1% of patients treated with CCRT.•Secondary uterine sarcomas can occur > 5 years from CCRT.•The median survival period from the secondary tumor occurrence was only 4 months.•All our patients had heterologous carcinosarcoma of the uterine corpus.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28736741/elevated-tumor-mutational-burden-and-prolonged-clinical-response-to-anti-pd-l1-antibody-in-platinum-resistant-recurrent-ovarian-cancer
#7
Christopher B Morse, Julia A Elvin, Laurie M Gay, John B Liao
•We report an ovarian cancer patient with a prolonged response to immunotherapy.•Comprehensive genomic profiling may detect patients who benefit from immunotherapy.•Mutational burden thresholds for ovarian cancer may be lower than other cancers.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28725677/a-population-based-study-of-cervical-cytology-findings-and-human-papillomavirus-infection-in-a-suburban-area-of-thailand
#8
Natacha Phoolcharoen, Nuttavut Kantathavorn, Thaniya Sricharunrat, Siriporn Saeloo, Waraphorn Krongthong
Despite the high incidence of cervical cancer in Thailand, large population-based studies on cervical cytology and HPV prevalence and genotype distribution are rare. This study aimed to determine cervical cytology results and the prevalence and distribution of HPV among Thai females in Bangkhayaeng subdistrict, Pathumthani province, Thailand. Of 4681 female inhabitants, aged 20-70 years, 1523 women finally participated in the study. Cervical samples using liquid-based cytology were collected during February-August 2013 and analyzed for HPV genotype by the LINEAR ARRAY® HPV Genotyping Test (Roche, USA)...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28725676/challenges-to-cervical-cancer-treatment-in-bangladesh-the-development-of-a-women-s-cancer-ward-at-dhaka-medical-college-hospital
#9
REVIEW
N Haque, A F M K Uddin, B R Dey, F Islam, A Goodman
Cervical cancer is the second most common cause of female cancer mortality worldwide. Concurrent chemoradiotherapy represents the standard of care for patients with stages IB2 to IVa cervical cancer. Unfortunately radiation therapy capacity is severely limited to non-existent in many Low and Middle-Income Countries. One solution has been to use chemotherapy to reduce tumor size to allow for radical surgery or in the case of inoperable cancers, as a placeholder until radiation is available. In Bangladesh, there has been the progressive development of resources for the treatment of women with gynecologic cancers...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28706968/brca1-reversion-mutation-acquired-after-treatment-identified-by-liquid-biopsy
#10
Paul Mayor, Laurie M Gay, Shashikant Lele, Julia A Elvin
•Secondary, reversion mutations in BRCA genes can restore protein function.•Reversion mutations can underlie resistance to therapies such as PARP inhibitors.•Reversion mutations arise during the course of treatment.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28702501/patterns-of-cervical-cancer-care-in-argentina-applying-asco-recommendations-adjusted-by-local-resources
#11
REVIEW
Agustín Apás Pérez De Nucci, Lucas Minig, Myriam Perrotta
There are significant differences in cervical cancer incidence and mortality between low-middle and high-income countries. The American Society of Clinical Oncology (ASCO) resource-stratified clinical practice guideline was designed to provide an appropriate cervical cancer treatment based on the best available evidence in scenarios with different diagnostic and therapeutic resources. Argentina, a Latin American high middle income country, shows however, that cervical cancer rates are similar to those of low-income countries...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28702500/surgical-management-of-a-large-neurilemmoma-like-leiomyoma-of-the-uterine-cervix-mimicking-a-retroperitoneal-tumor
#12
David A Morales F, Oscar Suescún, Laura Martínez, Isabel Dulcey
•A large cervical neurilemmoma-like leiomyoma can simulate a retroperitoneal tumor.•They are extremely rare tumors that require adequate bleeding control.•Comprehensive anatomo-pathological study should be done to rule out malignancy.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28702499/metastasis-of-cervical-cancer-to-breast-a-case-report-and-review-of-literature
#13
Ankit Mangla, Nikki Agarwal, Farid Saei Hamedani, Jiaxiang Liu, Shweta Gupta, Michael R Mullane
Metastasis to the breast from an extra-mammary malignancy has been documented in literature, however cervical cancer metastasis to the breast is very rare. Thirty-eight cases of metastatic deposit to the breast from cervical cancer have been reported in literature. Though most patients present with a breast lump, it is very difficult to clinically distinguish a primary breast malignancy from a metastatic deposit. Histopathology of the tissue, aided with immune-histochemical staining pattern provides a definitive diagnosis...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28664182/abdominal-radical-trachelectomy-for-vaginal-cancer-a-case-report
#14
Mari Matsuoka, Rumiko Yamamoto, Natsuki Tsuji, Koichi Terakawa, Tadayoshi Nagano
•Vaginal cancer is most common in elderly woman and very rare in young woman.•Stage I vaginal cancer is treated with surgery and radiotherapy.•Vaginal cancer in a young patient was treated by intra-arterial chemotherapy followed by abdominal radical trachelectomy.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28664181/apparent-ectopic-pregnancy-with-unexpected-finding-of-a-germ-cell-tumor-a-case-report
#15
Calen Kucera, Callie Cox-Bauer, Caela Miller
•Ovarian germ cell tumors can produce hCG and be confused with ectopic pregnancy.•Ovarian germ cell tumors can present with subacute pelvic pain.•Ectopic pregnancy should be the primary differential diagnosis due to its acuity.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28664180/metastatic-hepatoid-carcinoma-of-ovarian-origin-a-case-report-from-northern-pakistan
#16
Humera Mahmood, Hadia Fatima, Mohammad Faheem
•Hepatoid carcinoma of the ovary is rapidly progressing rare epithelial ovarian tumor.•The term 'hepatoid' refers to the morphological resemblance with hepatocellular carcinoma.•Final diagnosis is made via positive staining for alpha fetoprotein along with immunohistochemistry•Combination chemotherapy can be considered superior over the targeted agents while treating this tumor.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28664179/the-tell-tale-heart-a-case-of-recurrent-vulvar-carcinoma-with-cardiac-metastasis-and-review-of-literature
#17
Syed Imran Mustafa Jafri, Naveed Ali, Salman Farhat, Faizan Malik, Mark Shahin
A 50-year-old female was diagnosed with vulvar cancer treated with left partial vulvectomy and bilateral lymphadenectomy. Ten months after her surgery, she presented with increased labial swelling, pain and discharge. Biopsy confirmed recurrence of squamous cell vulvar carcinoma. Incidentally, on restaging radiographic scans, she was found to have a large right ventricular mass which, after surgical debulking, was shown to be a squamous cell cancer of vulvar origin. She was commenced on chemotherapy with carboplatin and paclitaxel along with concurrent radiation therapy...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28653032/paraneoplastic-antigens-as-biomarkers-for-early-diagnosis-of-ovarian-cancer
#18
REVIEW
Madhumita Chatterjee, Laura C Hurley, Michael A Tainsky
Paraneoplastic syndromes are a group of rare disorders that can be triggered by an abnormal immune response to proteins from tumors of the lung, ovary, lymphatics, or breast. Paraneoplastic clinical syndromes affect < 1% of patients with cancer; however, the frequency of subclinical levels of paraneoplastic autoantibodies in asymptomatic patients with cancer is unknown. Numerous studies have reported that ovarian cancer patients show signs of paraneoplastic neurological syndromes (PNSs) before or after their cancers are diagnosed...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28653031/the-hook-effect-causing-a-negative-pregnancy-test-in-a-patient-with-an-advanced-molar-pregnancy
#19
Abigail D Winder, Adria Suarez Mora, Emily Berry, John R Lurain
•At high hCG levels in molar pregnancies, a "hook effect" can cause an artificially negative value.•Delay in diagnosis of a molar pregnancy due to the "hook effect" can lead to severe complications.•Suspicion of a molar pregnancy should be communicated so a diluted sample is used to quantify hCG.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28649595/unusual-indolent-behavior-of-leiomyosarcoma-of-the-vagina-is-observation-a-viable-option
#20
Ayatallah M Khafagy, Lauren S Prescott, Anais Malpica, Shannon N Westin
•Primary leiomyosarcoma of the vagina is a rare disease.•We identified a case of unanticipated indolent behavior of vaginal leiomyosarcoma.•Observation or hormonal therapy may be viable option for select patients.
August 2017: Gynecologic Oncology Reports
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