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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/28443321/the-gynecologic-oncology-fellowship-interview-process-challenges-and-potential-areas-for-improvement
#1
Gregory M Gressel, Anne Van Arsdale, Shayan M Dioun, Gary L Goldberg, Nicole S Nevadunsky
The application and interview process for gynecologic oncology fellowship is highly competitive, time-consuming and expensive for applicants. We conducted a survey of successfully matched gynecologic oncology fellowship applicants to assess problems associated with the interview process and identify areas for improvement. All Society of Gynecologic Oncology (SGO) list-serve members who have participated in the match program for gynecologic oncology fellowship were asked to complete an online survey regarding the interview process...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28435850/paraneoplastic-myositis-secondary-to-poorly-differentiated-serous-carcinoma-of-ovarian-tubal-origin
#2
Zachary Raizman, Boshra Hosseini, Sarah Kean, Alon D Altman
•Ovarian cancer can present as paraneoplastic myositis.•Presented with progressive weakness unresponsive to treatment with glucocorticoids•Imaging revealed bilateral ovarian masses, myositis resolved after surgery.•Ovarian cancer should be included on the differential diagnosis of a patient presenting with myositis.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28409179/vulva-cancer-in-ghana-review-of-a-hospital-based-data
#3
Mary Ann Dadzie, Charles A Aidoo, Verna Vanderpuye
•Seventy- 5% of vulvar cancer cases present with advance disease.•Definitive radiotherapy/chemoradiation is the main stay of treatment.•One third of patients default treatment.•Five year survival following radiotherapy was 36.7%.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393096/18f-fdg-positron-emission-tomography-findings-of-gliomatosis-peritonei-a-case-report-and-review-of-the-literature
#4
J-M Lavoie, F Lacroix-Poisson, L N Hoang, D C Wilson, M J Seckl, A V Tinker
•Gliomatosis peritonei (GP) is a rare benign complication of ovarian teratomas that does not impact overall survival.•GP exhibits high 18-F FDG uptake unlike other non-malignant forms of mature teratoma.•The specific characteristics of GP on functional imaging may be used to follow it with active surveillance in select cases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393095/profound-sensorineural-hearing-loss-after-one-cycle-of-intraperitoneal-cisplatin-in-treatment-of-advanced-ovarian-cancer
#5
Megan E McDonald, Jordan Mattson, Emily Hill
Few advances in the treatment of advanced epithelial ovarian cancer have improved patient overall survival. However, the incorporation of intraperitoneal administration of platinum based chemotherapy to standard treatment was one such advancement. It is understood that the intraperitoneal regimen is associated with increased toxicity when compared to intravenous administration alone; however, information regarding the specific risk of ototoxicity is lacking in the literature. We report a case of almost complete sensorineural hearing loss after one cycle of intraperitoneal cisplatin...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393094/laparoscopic-surgery-for-gynecologic-cancer-in-low-and-middle-income-countries-lmics-an-area-of-need
#6
Melissa Schwartz, Cherng-Jye Jeng, Linus T Chuang
Over 90% of people living in low- and middle-income countries (LMICs) do not have access to surgical care. In the absence of appropriate surgical care, there is high morbidity and mortality from surgically curable diseases, such as cervical cancer. Laparoscopic surgery for gynecologic cancer in LMICs is extremely limited. The benefits of laparoscopy over open surgery are even more pronounced in LMICs than in resource-rich countries. Barriers to implementation of laparoscopic surgery in LMICs should be identified and addressed in order to improve global cancer care and the lives of women worldwide...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393093/choriocarcinoma-with-brain-lung-and-vaginal-metastases-successfully-treated-without-brain-radiation-or-intrathecal-chemotherapy-a-case-report
#7
Anja S Frost, Jonathan H Sherman, Katayoon Rezaei, Alivia Aron, Micael Lopez-Acevedo
•There is no consensus on optimal treatment for GTN and brain metastases.•Brain metastasis treated with craniotomy and intravenous, EMA-CO chemotherapy•Intravenous high-dose methotrexate may be adequate to treat brain metastases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28393092/hormonal-based-treatment-of-ovarian-anaplastic-ependymoma-with-anastrozole
#8
Justin Wayne Gorski, Jolyn Sharpe Taylor, Jing Zhang, Jinsong Liu, Amir Anthony Jazaeri
OBJECTIVE: Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). CASE: A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28386581/paraneoplastic-cerebellar-degeneration-in-a-patient-with-a-primary-fallopian-tube-adenocarcinoma-a-case-report-and-brief-review
#9
Mario Campero, Alberto E Selman
We describe a 65-year-old woman with subacute cerebellar syndrome expressed as severe ataxia, and the presence of anti Purkinje cell antibodies (Anti-Yo). A small adnexal mass was only evident on PET CT with the pathological feature of fallopian tube adenocarcinoma. Anti-Yo antibodies have been strongly associated with paraneoplastic cerebellar degeneration, and nearly always associated to ovarian adenocarcinomas. Few cases have been reported in which this paraneoplastic syndrome has been related to fallopian tube adenocarcinoma...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28386580/surgical-management-of-a-retroperitoneal-pelvic-desmoid-tumour-involving-the-sacrifice-of-external-iliac-vein-and-internal-iliac-vessels
#10
E A Goulding, M Bunting, R Harle, P Blomfield
•Retroperitoneal pelvic desmoid tumours are rare with limited publications.•A rare case of a retroperitoneal pelvic desmoid tumour is discussed.•Excision was challenging requiring the sacrifice of some of the iliac vessels.•No other case reports document a surgical excision requiring this.•To date our patient suffers minimal morbidity and has had no recurrences.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28378010/epigenetic-therapy-for-the-treatment-of-epithelial-ovarian-cancer-a-clinical-review
#11
REVIEW
Haller J Smith, J Michael Straughn, Donald J Buchsbaum, Rebecca C Arend
Despite a good initial response to chemotherapy, the majority of patients with epithelial ovarian cancer will eventually recur and die of their disease. The introduction of targeted therapies to traditional chemotherapy regimens has done little to improve overall survival in women with ovarian cancer. It has become increasingly apparent that the cancer epigenome contributes significantly to the pathogenesis of ovarian cancer and may play an important role in cell proliferation, metastasis, chemoresistance, and immune tolerance...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28367489/clear-cell-carcinoma-arising-from-abdominal-wall-endometriosis-brief-report-and-review-of-the-literature
#12
Cecília Marques, Teresa S Silva, Margarida F Dias
•Endometriosis-associated abdominal wall cancer is a rare entity with poor prognosis.•Personal history of C-section is extremely relevant.•The treatment consists in a wide local excision with adjuvant chemotherapy.•Proper treatment of abdominal endometriosis could prevent these situations.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28349118/vulvar-condylomatosis-after-sex-reassignment-surgery-in-a-male-to-female-transsexual-complete-response-to-imiquimod-cream
#13
Trinidad Labanca, Ivan Mañero
BACKGROUND: The number of patients seeking sex reassignment surgery is increasing. Approximately 1:30,000 adult males and 1: 100,000 adult females seek this procedure. Neovaginal-related disorders after sex reassignment surgery are increasingly more common. Vulvar condylomatosis is the clinical manifestation of HPV 6- and 11 infection in biological women. The same HPV-subtypes are associated with anogenital warts and penile intraepithelial neoplasia in biological men. We aim to present a case of vulvar condylomatosis after sex reassignment surgery in a male-to-female transsexual and its complete response to 5% imiquimod cream...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28349117/anogenital-lichen-sclerosus-change-of-tissue-position-as-pathogenetic-factor
#14
Benjamin Wolf, Lars-Christian Horn, Michael Höckel
•Lichen sclerosus in females primarily involves the hairless anogenital skin.•Skin tissue outside this area is constitutionally not at risk for lichen sclerosus.•Transplantation into the vulvar field may turn skin susceptible to lichen sclerosus.•Tissue inherent positional information might affect lichen sclerosus susceptibility.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28349116/poorly-differentiated-high-grade-urothelial-carcinoma-presenting-as-paget-s-disease-of-the-vulva-with-no-overt-urinary-tract-neoplasm-detected
#15
Radha R Padhy, Niloo Nasseri-Nik, Fouad Abbas
OBJECTIVE: There are few reported cases of secondary (non-cutaneous) vulvar Paget's disease related to urothelial carcinoma (UC), with only 7 of them presenting initially with Paget's disease and up to a 13-year lapse from detecting a urinary tract neoplasm after the onset of symptoms. This is a case of Paget's disease of urothelial origin with no urinary tract neoplasm detected on initial presentation. METHODS: This is a 59-year-old African-American female who presented with worsening eczematous lesions for two years...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28349115/posterior-reversible-encephalopathy-syndrome-pres-associated-with-ovarian-cancer-and-voltage-gated-potassium-channel-antibodies-a-case-report
#16
Laura K Hadad, Caroline C Billingsley
•We report a case of PRES in conjunction with high grade serous ovarian carcinoma•There is a documented association between chemotherapy agents and PRES•Paraneoplastic panel was positive for voltage-gated potassium channel antibodies•Paraneoplastic workup may be justified in cases with high suspicion of PRES.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28349114/comprehensive-genomic-profiling-cgp-of-ovarian-clear-cell-carcinomas-occc-identifies-clinically-relevant-genomic-alterations-crga-and-targeted-therapy-options
#17
Julia A Elvin, Justin Chura, Laurie M Gay, Maurie Markman
•MTOR pathway genes are often mutated in ovarian clear cell carcinomas (OCCC).•11.2% of OCCC have targetable alterations only in the mTOR pathway.•MTOR pathway mutations in OCCC can underlie robust, lasting responses to everolimus.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28337474/cervical-cancer-prevention-in-el-salvador-cape-an-hpv-testing-based-demonstration-project-changing-the-secondary-prevention-paradigm-in-a-lower-middle-income-country
#18
Mauricio Maza, Karla Alfaro, Jillian Garai, Mario Morales Velado, Julia C Gage, Philip E Castle, Juan Felix, Silvana Luciani, Nicole Campos, Jane Kim, Rachel Masch, Miriam Cremer
•CareHPV tests were used to compare screen-and-treat and colposcopy management.•Screen-and-treat strategy with HPV testing was found to be very cost-effective.•CAPE has screened > 25,000 women in the Paracentral region.•Over 70% of screen-positive women received recommended treatment within six months.•CAPE is an example of public-private partnership resulting in paradigm change.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28331901/isolated-port-site-recurrence-of-node-negative-clinical-stage-ib1-cervical-adenocarcinoma
#19
Uma Deshmukh, Molly McAdow, Jonathan Black, Pei Hui, Masoud Azodi
INTRODUCTION: Port site metastasis after laparoscopic surgery for cervical cancer is a rare phenomenon. METHODS: We present a case report of isolated port site recurrence 4 years following laparoscopic surgery in a patient with node-negative, clinical stage IB1 cervical adenocarcinoma. RESULTS: A 44 year-old woman presented with a necrotic cervical lesion. A biopsy of the mass revealed invasive endocervical adenocarcinoma. She underwent a robotic-assisted radical hysterectomy, bilateral salpingectomy, and pelvic lymph node dissection with bilateral oophoropexy...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28331900/a-recurrent-endometrial-stromal-sarcoma-harbors-the-novel-fusion-jazf1-bcorl1
#20
Allison J Allen, Siraj M Ali, Kyle Gowen, Julia A Elvin, Tanja Pejovic
•Genomic alterations may improve diagnostic certainty and subsequent treatment of endometrial stromal sarcoma.•Novel JAZF1-BCORL1 mutation was identified.•Targeted therapeutics to down-stream targets may improve survival benefit in these patients.
May 2017: Gynecologic Oncology Reports
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