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Gynecologic Oncology Reports

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https://www.readbyqxmd.com/read/27896308/small-cell-ovarian-carcinoma-long-term-survival-in-juvenile-case-with-poor-prognostic-features
#1
Lauren Stewart, Ruchi Garg, Rochelle Garcia, Elizabeth Swisher
BACKGROUND: Ovarian small cell carcinoma is a rare, aggressive neoplasm that occurs in young women and has a poor long-term prognosis. Treatment involves surgical resection and chemotherapy. The required radicality of surgery is uncertain, balancing cytoreduction with fertility preservation. Various chemotherapy regimens are utilized due to confusion regarding the neoplasm's lineage. Case We describe an adolescent with small cell carcinoma, hypercalcemic type, stage IA. Surgery included left salpingo-oopherectomy, left pelvic/paraaortic lymphadenectomy, omentectomy and peritoneal biopsies...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27872893/response-to-sunitinib-sutent-in-chemotherapy-refractory-clear-cell-ovarian-cancer
#2
C Alifrangis, A Thornton, C Fotopoulou, J Krell, H Gabra
•Case describes a response to sunitinib in clear cell ovarian cancer.•Discussion of unique molecular characteristics of clear cell ovarian cancers•Practical points regarding dosing and toxicity when using sunitinib discussed.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#3
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27844048/a-surgical-multi-layer-technique-for-pelvic-reconstruction-after-total-exenteration-using-a-combination-of-pedicled-omental-flap-human-acellular-dermal-matrix-and-autologous-adipose-derived-cells
#4
Anna Myriam Perrone, Alessandra Livi, Milena Fini, Elena Bondioli, Sergio Concetti, Alessio Giuseppe Morganti, Federico Contedini, Pierandrea De Iaco
•A multi-layer technique for reconstruction after pelvic exenteration is proposed.•Human acellular dermal matrix used in reconstruction after total pelvic exenteration.•A reconstructive technique based on human dermis, omental flap and fat is proposed.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27830172/an-unusual-case-of-basal-cell-carcinoma-of-the-vulva-with-lung-metastases
#5
G A Watson, D Kelly, L Prior, E Stanley, O MacEneaney, T Walsh, C M Kelly
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27822491/primary-gynecological-non-hodgkin-s-lymphoma-a-differential-diagnosis-of-a-pelvic-mass
#6
Shilpa Vijayakumar, Eli Serur, Bahar Bybordi, Nisha Lakhi
Primary Non-Hodgkin's lymphoma (NHL) can mimic gynecological malignancy, presenting as a pelvic mass in any organ of the female genital tract. Patients can present with elevated CA-125 and may lack the classical symptoms associated with lymphoma, such as fatigue, fever, night sweats and weight loss. We describe five patients that presented with primary NHL of the genital tract. Patients 1, 2, and 3 were not diagnosed pre-operatively, and underwent unnecessary cytoreductive surgery, while patients 4 and 5 were diagnosed by pre-operative biopsy...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27822490/primitive-neuroectodermal-tumor-of-the-uterus
#7
C R Elizalde, A Yagüe, J Fernandez, P Dieste, M J Puente, J Hernandez
•PNET of the uterus is rare and requires early diagnoses and treatment.•Molecular analysis is important to distinguish it from other tumors.•Different combinations of adjuvant chemotherapy have been report.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27819019/olaparib-treatment-for-brca-mutant-ovarian-cancer-with-leptomeningeal-disease
#8
Madeleine Bangham, Robert Goldstein, Henry Walton, Jonathan A Ledermann
•Leptomeningeal disease occurs more commonly in BRCA-mutated ovarian cancer.•A clinically significant dose of olaprib is able to penetrate the leptomeninges.•Leptomeningeal metastases in a BRCA-mutated ovarian cancer responded to olaparib.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27790636/papillary-squamous-cell-carcinoma-of-the-cervix-two-cases-and-a-review-of-the-literature
#9
Lauren B Turker, Gregory M Gressel, Maria Abadi, Marina Frimer
OBJECTIVE: Papillary squamous cell carcinoma of the cervix (PSCC) is a rare and distinct form of cervical carcinoma. Detecting stromal invasion on biopsy is difficult due to the papillary growth of the tumor. Here we present two cases that highlight the diagnostic and clinical challenges of PSCC. CASE 1: A 50-year-old woman found to have carcinoma on a routine pap-smear. The patient was diagnosed with PSCC on colposcopic biopsy and underwent a radical hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27790635/fertility-sparing-management-of-large-cell-neuroendocrine-tumour-of-cervix-a-case-report-review-of-literature
#10
S Rajkumar, R Iyer, G Culora, G Lane
Large cell neuroendocrine cervical carcinoma (LCNEC) is a rare and aggressive cancer that tends to spread and recur early despite intensive multimodal treatment. Conventional treatment strategies for early stage neuroendocrine tumour (NET) include radical hysterectomy followed by adjuvant chemotherapy. There are only 2 reported cases of fertility sparing treatment for NET. We report on the first case of successful conception and delivery at term following radical trachelectomy for early stage LCNEC.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27672677/left-paraaortic-inframesenteric-lymphadenectomy-preserving-the-superior-hypogastric-plexus-supported-by-indocyanine-green-icg-labeling-of-the-lymphatic-compartment-in-cervical-cancer
#11
Rainer Kimmig, Peter Rusch, Paul Buderath, Bahriye Aktas
Superior hypogastric plexus (SHG) contains mainly sympathetic and most probably also postganglionic parasympathetic fibers. Thus, surgical damage of SHG may cause autonomic pelvic organ dysfunction (Kraima et al., 2015). As already shown for rectal cancer, preservation of the autonomic nerves is facilitated by robotic surgery and may avoid sexual dysfunctions and voiding disorders (Kim et al., 2015). In this educational video, we demonstrate left lower paraaortic lymph node dissection preserving the SHG using ICG fluorescence to label the lymphatic compartment...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27672676/metastatic-papillary-serous-uterine-cancer-presenting-as-a-rash
#12
Eric S Chang, William D Baker, Charles N Landen
BACKGROUND: We report diagnosis and management of stage IV papillary serous uterine cancer with initial clinical presentation as a skin rash. CASE: A 62-year-old postmenopausal female developed an erythematous rash beginning on her right lower abdomen and progressively spreading to her left abdomen, vulva, and neck. After a trial of antibiotic treatment, biopsy of left neck and right thigh skin nodules revealed papillary serous carcinoma. Abdominopelvic tomography revealed endometrial thickening and a 5 cm left adnexal mass...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27660815/vesical-clear-cell-adenocarcinoma-arising-from-endometriosis-a-mullerian-tumor-indistinguishable-from-ovarian-clear-cell-adenocarcinoma
#13
Eirwen M Miller, Ying Sun, Ingride Richardson, Marina Frimer
Endometriosis is associated with increased rates of ovarian, particularly clear cell, adenocarcinomas. Malignant transformation of ovarian endometriosis is most common but rare cases have been reported in the bladder, abdominal wall, diaphragm, and rectum. We present the case of a 44-year-old female with vesical clear cell adenocarcinoma arising in a background of endometriosis in the absence of other pelvic endometriosis. The malignancy was diagnosed on transurethral resection of bladder tumor and managed with radical surgery...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27642626/fertility-sparing-surgery-for-the-management-of-young-women-with-embryonal-rhabdomyosarcoma-of-the-cervix-a-case-series
#14
Geneviève Bouchard-Fortier, Raymond H Kim, Lisa Allen, Abha Gupta, Taymaa May
OBJECTIVE: To report three cases of embryonal rhabdomyosarcoma (ERMS) of the cervix in young women successfully treated with fertility-sparing surgery and chemotherapy. METHODS: Between January 2014 and December 2015, three cases of ERMS of the cervix were confirmed in young women at a single tertiary cancer center. All cases were managed by a pediatric oncologist and a gynecologic oncologist with a combination of surgery and chemotherapy. Fertility-sparing surgeries (cervical conization or robotic-assisted radical trachelectomy) were offered to patients depending on the tumor size...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27617286/bevacizumab-induced-hypertension-in-gynecologic-cancer-does-it-resolve-after-completion-of-therapy
#15
Bradley R Corr, Christopher Breed, Jeanelle Sheeder, Sarah Weisdack, Kian Behbakht
Hypertension (HTN) induced by bevacizumab is a side effect that is often thought to resolve after treatment. However, there are currently no reports on rates of resolution. We assess the incidence and timing of the resolution of bevacizumab induced HTN. We evaluated all patients treated with bevacizumab for gynecologic malignancies at a single institution from 2012 through 2014. HTN was retrospectively diagnosed and staged by CTCAE v4.0 criteria. Resolution of HTN was defined as ≥ 2 values return to baseline blood pressure and/or discontinuation/decrease of blood pressure medications...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27617285/pazopanib-mediated-long-term-disease-stabilization-after-resection-of-a-uterine-leiomyosarcoma-metastasis-to-the-brain-a-case-report
#16
Kayo Inoue, Hiroshi Tsubamoto, Yusuke Tomogane, Mariko Kamihigashi, Hiroaki Shibahara
A 48-year-old woman underwent a total abdominal hysterectomy after preoperative diagnosis of multiple uterine leiomyomas. The histopathological diagnosis was leiomyosarcoma (LMS). After 47 months, multiple lung metastases were detected and resected. The patient was also diagnosed with pelvic bone metastasis and received six cycles of adjuvant chemotherapy with gemcitabine plus docetaxel and local radiation therapy to control the pain. Seventy-seven months from the initial diagnosis, she had a headache and developed left hemiparesis and aphasia...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27556063/renal-transplantation-related-risk-factors-for-the-development-of-uterine-adenomatoid-tumors
#17
Teruyuki Mizutani, Osamu Yamamuro, Noriko Kato, Kazumasa Hayashi, Junya Chaya, Norihiko Goto, Toyonori Tsuzuki
•We analyzed the epidemiological factors for clinical manifestations of uterine adenomatoid tumors.•Renal transplantation with immunosuppression therapy is risk factor for the development of uterine adenomatoid tumors.•The length of time on dialysis is risk factor for the development of uterine adenomatoid tumors.
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27547810/primary-peritoneal-carcinoma-in-a-brca1-2-negative-palb2-positive-patient
#18
Ryan Kahn, Arlene Garcia-Soto, Rachel Silva-Smith, Andre Pinto, Sophia H L George
•First reported case of PPC after BSO in a BRCA1/2-negative, PALB2-positive patient•The PALB2 mutation and genetic counseling is discussed•Multi-gene panel testing can benefit prognostic factors and targeted therapy.
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27536721/treatment-of-early-stage-vaginal-cancer-with-ebrt-and-mri-based-intracavitary-brachytherapy-a-retrospective-case-review
#19
Shari Damast, Vinita Takiar, Shirley McCarthy, Susan A Higgins
This case series describes the use of pelvic radiotherapy (RT) and MRI-based intracavitary brachytherapy (ICBT) for patients with small volume, early-stage, primary vaginal cancer. A customized pelvic MRI protocol with a vaginal cylinder in place (MRVC) was used to measure disease extent and tumor thickness (defined as distance from lateral/apical margin of tumor to cylinder surface) at time of diagnosis. Non-bulky tumors with initial (pre-RT) thickness ≤ 2 cm from the cylinder surface received pelvic RT followed by ICBT...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27536720/obstetric-care-after-radical-abdominal-trachelectomy-in-a-patient-with-stage-ib1-cervical-cancer-a-case-report-and-a-review-of-medical-literature
#20
Yong Kuei Lim, Sze Min Lek, Seow Heong Yeo
•A case on obstetric care after radical trachelectomy in early cervical cancer•Fertility sparing surgery provides favorable oncological and obstetrical outcomes.•Multidisciplinary teams are essential in managing this patient population.
August 2016: Gynecologic Oncology Reports
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