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Journal Article
Review
Tissue-resident memory-like T cells in tumor immunity: Clinical implications.
Seminars in Immunology 2020 June
Tissue-resident memory (TRM ) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. TRM - like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. TRM cells have also been shown to mediate anti-tumor immunity in murine models. Biology of TRM cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of TRM T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.
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