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Seminars in Immunology

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https://www.readbyqxmd.com/read/29066063/formation-of-the-protein-corona-the-interface-between-nanoparticles-and-the-immune-system
#1
REVIEW
Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G Bastús, Eudald Casals, Victor Puntes
The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles...
October 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29032891/modulating-the-immune-system-through-nanotechnology
#2
REVIEW
Tamara G Dacoba, Ana Olivera, Dolores Torres, José Crecente-Campo, María José Alonso
Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals...
October 9, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28988622/back-to-the-future-of-targeting-leukotriene-b4-mediated-inflammation
#3
EDITORIAL
Bodduluri Haribabu
No abstract text is available yet for this article.
October 4, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28985993/effects-of-engineered-nanoparticles-on-the-innate-immune-system
#4
REVIEW
Yuanchang Liu, Joseph Hardie, Xianzhi Zhang, Vincent M Rotello
Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine. When NPs enter the body, interactions with the immune system are unavoidable. The innate immune system, a non-specific first line of defense against potential threats to the host, immediately interacts with introduced NPs and generates complicated immune responses. Depending on their physicochemical properties, NPs can interact with cells and proteins to stimulate or suppress the innate immune response, and similarly activate or avoid the complement system...
October 3, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28947107/enhancing-cancer-immunotherapy-through-nanotechnology-mediated-tumor-infiltration-and-activation-of-immune-cells
#5
REVIEW
Haifa Shen, Tong Sun, Hanh H Hoang, Jana S Burchfield, Gillian F Hamilton, Elizabeth A Mittendorf, Mauro Ferrari
Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes - collectively referred to as transport barriers - including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers...
September 22, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28943093/natural-killer-cell-immunotherapies-against-cancer-checkpoint-inhibitors-and-more
#6
REVIEW
Laura Chiossone, Margaux Vienne, Yann M Kerdiles, Eric Vivier
After many years of research, recent advances have shed new light on the role of the immune system in advanced-stage cancer. Various types of immune cells may be useful for therapeutic purposes, along with chemical molecules and engineered monoclonal antibodies. The immune effectors suitable for manipulation for adoptive transfer or drug targeting in vivo include natural killer (NK) cells. These cells are of particular interest because they are tightly regulated by an array of inhibitory and activating receptors, enabling them to kill tumor cells while sparing normal cells...
September 22, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28941641/targeting-tumor-associated-macrophages-the-new-challenge-for-nanomedicine
#7
REVIEW
Fernando Torres Andón, Elisabeth Digifico, Akihiro Maeda, Marco Erreni, Alberto Mantovani, María José Alonso, Paola Allavena
The engineering of new nanomedicines with ability to target and kill or re-educate Tumor Associated Macrophages (TAMs) stands up as a promising strategy to induce the effective switching of the tumor-promoting immune suppressive microenvironment, characteristic of tumors rich in macrophages, to one that kills tumor cells, is anti-angiogenic and promotes adaptive immune responses. Alternatively, the loading of monocytes/macrophages in blood circulation with nanomedicines, may be used to profit from the high infiltration ability of myeloid cells and to allow the drug release in the bulk of the tumor...
September 20, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28941640/nanoparticle-impact-on-innate-immune-cell-pattern-recognition-receptors-and-inflammasomes-activation
#8
REVIEW
Ana Luísa Silva, Carina Peres, João Conniot, Ana I Matos, Liane Moura, Bárbara Carreira, Vanessa Sainz, Anna Scomparin, Ronit Satchi-Fainaro, Véronique Préat, Helena F Florindo
Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medicine, the clinical translation of those nanoparticulate systems has still been impaired by the limited understanding on their interaction with complex biological systems. As a result, unexpected effects due to unpredicted interactions at biomaterial and biological interfaces have been underlying the biosafety concerns raised by the use of nanomaterials...
September 20, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28939389/recombinant-allergen-and-peptide-based-approaches-for-allergy-prevention-by-oral-tolerance
#9
REVIEW
Raffaela Campana, Huey-Jy Huang, Raphaela Freidl, Birgit Linhart, Susanne Vrtala, Thomas Wekerle, Alexander Karaulov, Rudolf Valenta
Several studies conducted in animal models for immunologically-mediated hypersensitivity diseases have shown that oral administration of antigens early in life can prevent the development of specific humoral and cellular immune responses and thus hypersensitivity reactions to the respective antigens. Such data were also obtained in models for Immunoglobulin E (IgE)-associated allergy, the most common hypersensitivity disease affecting more than 25% of the population. Based on data obtained in animal models for allergy several clinical intervention studies have been conducted in children to study if oral administration of materials containing allergens or allergen-derived peptides early in life can prevent the subsequent development of allergy...
September 20, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28890238/delivering-the-right-message-challenges-and-opportunities-in-lipid-nanoparticles-mediated-modified-mrna-therapeutics-an-innate-immune-system-standpoint
#10
REVIEW
Yasmin Granot, Dan Peer
mRNA molecules hold tremendous potential as a tool for gene therapy of a wide range of diseases. However, the main hurdle in implementation of mRNA for therapeutics, the systemic delivery of mRNA molecules to target cells, remains a challenge. A feasible solution for this challenge relies in the rapidly evolving field of nucleic acid-loaded nanocarriers and specifically in the established family of lipid-based nanoparticles (LNPs). Herein, we will discuss the main factors, which determine the fate of modified mRNA (mmRNA)-loaded LNPs in-vivo, and will focus on their interactions with the innate immune system as a main consideration in the design of lipid-based mmRNA delivery platforms...
September 7, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28888619/natural-killer-cell-mediated-immunosurveillance-of-human-cancer
#11
REVIEW
Karl-Johan Malmberg, Mattias Carlsten, Andreas Björklund, Ebba Sohlberg, Yenan T Bryceson, Hans-Gustaf Ljunggren
The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains debatable. Here, we discuss advances in several areas of human NK cell research, many of which support the ability of NK cells to prevent cancer development and avoid relapse following adoptive immunotherapy. We describe the molecular basis for NK cell recognition of human tumor cells and provide evidence for NK cell-mediated killing of human primary tumor cells ex vivo. Subsequently, we highlight studies demonstrating the ability of NK cells to migrate to, and reside in, the human tumor microenvironment where selection of tumor escape variants from NK cells can occur...
September 6, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28887001/major-findings-and-recent-advances-in-virus-like-particle-vlp-based-vaccines
#12
REVIEW
Mona O Mohsen, Lisha Zha, Gustavo Cabral-Miranda, Martin F Bachmann
Virus-like particles (VLPs) have made giant strides in the field of vaccinology over the last three decades. VLPs constitute versatile tools in vaccine development due to their favourable immunological characteristics such as their size, repetitive surface geometry, ability to induce both innate and adaptive immune responses as well as being safe templates with favourable economics. Several VLP-based vaccines are commercially available including vaccines against Human Papilloma Virus (HPV) such as Cervarix(®), Gardasil(®) & Gardasil9(®) and Hepatitis B Virus (HBV) including the 3rd generation Sci-B-Vac™...
September 5, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28863960/memory-responses-of-natural-killer-cells
#13
REVIEW
Clair D Geary, Joseph C Sun
Natural killer (NK) cells have traditionally been classified as a cellular component of the innate immune system, given their ability to rapidly produce effector cytokines and kill infected or transformed cells without prior exposure. More recently, NK cells have been shown to possess features of adaptive immunity such as clonal expansion, longevity, and robust recall responses. NK cell memory can be broadly divided into two categories: antigen-specific and antigen-independent. In the first case, exposure to certain viral or hapten stimuli endows NK cells with antigen-specific immunological memory, similar to T and B cells...
August 30, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28869063/nanoparticles-and-innate-immunity-new-perspectives-on-host-defence
#14
REVIEW
Diana Boraschi, Paola Italiani, Roberto Palomba, Paolo Decuzzi, Albert Duschl, Bengt Fadeel, S Moein Moghimi
The innate immune system provides the first line of defence against foreign microbes and particulate materials. Engineered nanoparticles can interact with the immune system in many different ways. Nanoparticles may thus elicit inflammation with engagement of neutrophils, macrophages and other effector cells; however, it is important to distinguish between acute and chronic inflammation in order to identify the potential hazards of nanoparticles for human health. Nanoparticles may also interact with and become internalised by dendritic cells, key antigen-presenting cells of the immune system, where a better understanding of these processes could pave the way for improved vaccination strategies...
August 28, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28855088/drug-nanocarriers-to-treat-autoimmunity-and-chronic-inflammatory-diseases
#15
REVIEW
Davide Prosperi, Miriam Colombo, Ivan Zanoni, Francesca Granucci
Nanoparticles represent a new generation of drug delivery systems that can be engineered to harness optimal target selectivity for specific cells and tissues and high drug loading capacity, allowing for improved pharmacokinetics and enhanced bioavailability of therapeutics. The spontaneous propensity of both organic and colloidal nanoparticles to be captured by the cells of the reticuloendothelial system encouraged their utilization as passive targeting systems that can be preferentially directed to innate immune cells, such as macrophages, dendritic cells and neutrophils...
August 28, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29042030/recent-advances-in-clinical-development-of-leukotriene-b4-pathway-drugs
#16
REVIEW
L Bhatt, K Roinestad, T Van, E B Springman
The LTB4 pathway is an attractive target for therapeutic drug development. Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4. An initial wave of effort culminated in the 1990s. Over the past 15 years, a second wave of more selective drug candidates, including at least 5 BLT antagonists and 6 LTA4H inhibitors, have reached Phase 2 clinical trials. Despite the extensive efforts to discover and develop LTB4 pathway targeting drugs, only one has reached the market to date...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29042029/ltb4-and-blt1-in-inflammatory-arthritis
#17
REVIEW
Yoshishige Miyabe, Chie Miyabe, Andrew D Luster
Inflammatory arthritis, including rheumatoid arthritis (RA), is characterized by infiltration of inflammatory cells into the joints. Biological agents targeting TNF-α and IL-6 dramatically improve RA. However, some RA patients do not respond to current treatments and these broadly active upstream biological agents increase the risk of severe infection. Therefore, there remains a need for other effective and safe treatments for RA. Many studies have implicated that blockade of leukotriene B4 (LTB4) and its high affinity receptor BLT1 dramatically suppress arthritis in animal models...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29042028/importance-of-the-leukotriene-b4-blt1-and-ltb4-blt2-pathways-in-asthma
#18
REVIEW
Erwin W Gelfand
For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or experimental animals adds support to this notion. However, targeting of the leukotriene pathways has had, in general, limited success. The single exception in asthma therapy has been targeting of the cysteinyl leukotriene receptor 1, which clinically has proven effective but only in certain clinical situations...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29042027/too-much-of-a-good-thing-how-modulating-ltb4-actions-restore-host-defense-in-homeostasis-or-disease
#19
REVIEW
Stephanie L Brandt, C Henrique Serezani
The ability to regulate inflammatory pathways and host defense mechanisms is critical for maintaining homeostasis and responding to infections and tissue injury. While unbalanced inflammation is detrimental to the host; inadequate inflammation might not provide effective signals required to eliminate pathogens. On the other hand, aberrant inflammation could result in organ damage and impair host defense. The lipid mediator leukotriene B4 (LTB4) is a potent neutrophil chemoattractant and recently, its role as a dominant molecule that amplifies many arms of phagocyte antimicrobial effector function has been unveiled...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29042026/identification-signaling-and-functions-of-ltb4-receptors
#20
REVIEW
Kazuko Saeki, Takehiko Yokomizo
Leukotriene B4 (LTB4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2. BLT1 is expressed in various subsets of leukocytes, and analyses of BLT1-deficient mice revealed that the LTB4/BLT1 axis enhances leukocyte recruitment to infected sites, and is involved in the elimination of pathogens. Hyperactivation of the LTB4/BLT1 axis induces acute and chronic inflammation, resulting in various inflammatory diseases...
October 2017: Seminars in Immunology
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