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Protease activated receptor-1 impedes prostate and intestinal tumor progression in mice: comment.
Journal of Thrombosis and Haemostasis : JTH 2018 November 10
Protease activated receptor 1 (PAR-1), originally identified as the thrombin receptor on platelets and vascular endothelial cells, is expressed on numerous cells throughout the body. Tumor cells, and cells in the tumor microenvironment like cancer-associated fibroblasts, macrophages, T cells and endothelial cells, are no exception and PAR-1 expression is abundant in a variety of cancer tissues [1,2]. The potential relevance of PAR-1 expression for tumor growth is underscored by observations that PAR-1 expression levels correlate with cancer progression and overall survival [1,2]. This article is protected by copyright. All rights reserved.
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