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Journal of Thrombosis and Haemostasis: JTH

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https://www.readbyqxmd.com/read/27930855/diagnosis-and-management-of-ovarian-vein-thrombosis-in-a-healthy-individual-a-case-report-and-a-literature-review
#1
Namratha Kodali, Irina Veytsman, Sabrina Martyr, Kit Lu
Ovarian vein thrombosis (OVT) is a rare condition most often seen in the immediate post-partum period. We report a 40-year-old woman with no significant past medical or surgical history who presented to the emergency room for acute right lower quadrant pain of one day duration. A computed tomography (CT) scan showed a normal appendix but a new finding of right ovarian venous thrombosis. To date, only nine cases of idiopathic OVT have been reported. In this case report, we report a summary of these cases and review of literature regarding management of OVT...
December 8, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27930853/association-between-small-intestinal-bacterial-overgrowth-and-deep-vein-thrombosis-in-patients-with-spinal-cord-injuries
#2
Xuan Cheng, Lu Zhang, Nan-Chang Xie, Hong-Liang Xu, Ya-Jun Lian
BACKGROUND: Gastrointestinal dysfunction and vein thrombosis are well-known acute complications after spinal cord injuries (SCI). OBJECTIVE: The aim of this study was to determine the frequency and risk factors for deep vein thrombosis (DVT) and small intestinal bacterial overgrowth (SIBO) in patients with SCI. METHODS: A total of 377 consecutive eligible patients with SCI tested for SIBO using glucose hydrogen (H2)/methane(CH4) breath test from January 2011 to December 2015 and who also had venous ultrasound study for suspected DVT were evaluated within 3 months after admission...
December 8, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27930847/targeting-expression-to-megakaryocytes-and-platelets-by-lineage-specific-lentiviral-vectors
#3
Lisette Johana Latorre-Rey, Sabine Wintterle, Sebastian Dütting, Saskia Kohlscheen, Tobias Abel, Franziska Schenk, Susanne Wingert, Michael A Rieger, Bernhard Nieswandt, Niels Heinz, Ute Modlich
BACKGROUND: Lentiviral transduction and transplantation of hematopoietic stem cells (HSC) can be utilized to modify the phenotype of megakaryocytes and platelets. As the genetic modification in HSC is transmitted onto all hematopoietic progenies, transgene expression from the vector should be restricted to megakaryocytes to avoid un-physiologic effects by ectopic transgene expression. This can be achieved by lentiviral vectors that control expression by lineage-specific promoters. METHODS: in this study, we introduced promoters of megakaryocyte/platelet-specific genes, namely human glycoprotein 6 (hGP6) and hGP9, into third generation lentiviral vectors and analyzed their functionality in-vitro and in-vivo in bone marrow transplantation assays...
December 8, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27925685/in-vitro-characterization-of-synthoplate-%C3%A2-synthetic-platelet-technology-and-its-in-vivo-evaluation-in-severely-thrombocytopenic-mice
#4
Meenal Shukla, Ujjal D S Sekhon, Venkaiah Betapudi, Wei Li, DaShawn A Hickman, Christa L Pawlowski, Mitchell R Dyer, Matthew D Neal, Keith R McCrae, Anirban Sen Gupta
BACKGROUND: Platelet transfusion applications face severe challenges due to the limited availability and portability, high risk of contamination and short shelf-life of platelets. Therefore there is significant interest in synthetic platelet substitutes that can render hemostasis while avoiding these issues. Platelets promote hemostasis by injury site-selective adhesion and aggregation, and propagation of coagulation reactions on their membrane. Based on these mechanisms, we have developed a synthetic platelet technology (SynthoPlate(™) ) that integrates platelet-mimetic site-selective 'adhesion' and 'aggregation' functionalities via heteromultivalent surface-decoration of lipid vesicles with Von Willebrand Factor-binding, collagen-binding and active platelet integrin GPIIb-IIIa-binding peptides...
December 7, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27925683/inorganic-polyphosphate-a-key-modulator-of-inflammation
#5
REVIEW
Seyed Mahdi Hassanian, Amir Avan, Abdolreza Ardeshirylajimi
Inorganic polyphosphate (PolyP) is a molecule with prothrombotic and proinflammatory properties in blood. PolyP activates the NF-κB signaling pathway, increases the expression of cell surface adhesion molecules and disrupts the vascular barrier integrity of endothelial cells. PolyP-induced NF-κB activation and vascular hyperpermeability are regulated by the mTORC1 and mTORC2 pathways, respectively. Through interaction with RAGE and P2Y1 receptors, PolyP dramatically amplifies the proinflammatory responses of nuclear proteins...
December 7, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27896950/ppar%C3%AE-agonists-negatively-regulate-%C3%AE-iib%C3%AE-3-integrin-outside-in-signalling-and-platelet-function-through-upregulation-of-protein-kinase-a-activity
#6
A J Unsworth, N Kriek, A P Bye, K Naran, T Sage, G D Flora, J M Gibbins
BACKGROUND: Agonists for the peroxisome proliferator activated receptor PPARγ, have been shown to have inhibitory effects on platelet activity following stimulation by GPVI and GPCR agonists. OBJECTIVES: Profound effects on thrombus formation led us to suspect a role for PPARγ agonists in the regulation of integrin αIIbβ3 mediated signalling. Both GPVI and GPCR signalling pathways lead to αIIbβ3 activation, and signalling through αIIbβ3 plays a critical role in platelet function and normal haemostasis...
November 29, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27893182/inter-individual-variability-in-dabigatran-and-rivaroxaban-exposure-contribution-of-abcb1-genetic-polymorphisms-and-interaction-with-clarithromycin
#7
I Gouin-Thibault, X Delavenne, A Blanchard, V Siguret, J E Salem, C Narjoz, P Gaussem, P Beaune, C Funck-Brentano, M Azizi, P Mismetti, M A Loriot
BACKGROUND: The direct oral anticoagulants (DOACs) dabigatran and rivaroxaban are both substrates of the P-glycoprotein (P-gp) transporter, encoded by the ABCB1 gene. Rivaroxaban is metabolized by CYP3A4. Inter-individual variability in DOAC exposure and frequent P-gp associated drug-drug interactions have been described in patients. OBJECTIVE: To assess the influence of ABCB1 polymorphisms on the pharmacokinetics (PK) of dabigatran and rivaroxaban, associated or not with clarithromycin, a P-gp and CYP3A4 inhibitor...
November 28, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27893176/desmopressin-for-treatment-of-platelet-dysfunction-and-reversal-of-antiplatelet-agents-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#8
M J R Desborough, K A Oakland, G Landoni, M Crivellari, C Doree, L J Estcourt, S J Stanworth
BACKGROUND: Platelet dysfunction, including that caused by antiplatelet agents, increases the risk of perioperative bleeding. The optimal management of patients with platelet dysfunction undergoing surgery is unclear. OBJECTIVES: To assess whether desmopressin reduces perioperative allogeneic red cell transfusion and bleeding for patients with platelet dysfunction. PATIENTS/METHODS: We searched for randomised controlled trials in The Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, Embase, the Transfusion Evidence Library and ISI Web of Science to 7(th) July 2016...
November 28, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27888575/the-effect-of-fibrinogen-concentrate-on-perioperative-bleeding-in-transurethral-resection-of-the-prostate-a-double-blind-placebo-controlled-and-randomized-study
#9
Mohammad Soleimani, Navid Masoumi, Navid Nooraei, Alireza Lashay, Mohammad Reza Safarinejad
BACKGROUND: Hemorrhage during transurethral resection of the prostate (TUR-P) has always been a concern. Several studies have shown that pre-operative administration of fibrinogen concentrate has promising results in reducing hemorrhage in cardiac surgery. OBJECTIVES: This study investigated the hemostatic effect of fibrinogen concentrate administration on reducing the bleeding amount during TUR-P in patients with benign prostatic hyperplasia. METHODS: Sixty men with benign prostatic hyperplasia, who were chosen to undergo TUR-P, entered this prospective randomized double-blind placebo-controlled pilot study...
November 26, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27873439/stand-alone-d-dimer-testing-to-rule-out-acute-pulmonary-embolism
#10
Nick van Es, Tom van der Hulle, Harry Büller, Frederikus A Klok, Menno V Huisman, Javier Galipienzo, Marcello Di Nisio
BACKGROUND: Recently, stand-alone D-dimer testing at a positivity threshold of 750 μg/L has been proposed as a safe and efficient approach to rule out acute pulmonary embolism (PE), without additional imaging, but this approach needs validation. OBJECTIVES: To evaluate stand-alone D-dimer testing at a positivity threshold of 750 μg/L to rule out PE. METHODS: Individual data from 7,268 patients with suspected PE previously enrolled in 6 prospective management studies were used...
November 22, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27868337/enhanced-uptake-of-blood-coagulation-factor-viii-containing-immune-complexes-by-antigen-presenting-cells
#11
R B Hartholt, A Wroblewska, E Herczenik, I Peyron, A Ten Brinke, T Rispens, M A Nolte, E Slot, J W Claassens, F Nimmerjahn, J S Verbeek, J Voorberg
BACKGROUND: A major complication in the treatment of hemophilia A is the development of inhibitory antibodies targeting coagulation factor VIII (FVIII). Eradication of these inhibitors can be established by immune tolerance induction (ITI) which consists of daily administration of high dosages of FVIII. FVIII immune complexes (FVIII-IC) could be formed following FVIII infusion in patients with pre-existing anti-FVIII antibodies. OBJECTIVES: Here we studied endocytosis of FVIII-IC by bone marrow derived dendritic cells (BMDCs)...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27868334/consensus-on-the-standardization-of-terminology-in-thrombotic-thrombocytopenic-purpura-and-related-thrombotic-microangiopathies
#12
M Scully, S Cataland, P Coppo, J de la Rubia, K D Friedman, J Kremer Hovinga, B Lämmle, M Matsumoto, K Pavenski, E Sadler, R Sarode, H Wu
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are two important acute conditions to diagnose. Thrombotic Microangiopathy is a broad pathophysiological process that leads to microangiopathic hemolytic anemia, thrombocytopenia and involves capillary and small vessel platelet aggregates. The most common cause being disseminated intravascular coagulation (DIC), which may be differentiated by abnormal coagulation. Clinically, a number of conditions present with microangiopathic hemolytic anemia and thrombocytopenia (MAHAT), including cancer, infection, transplantation, drugs, autoimmune disease and pre-eclampsia and HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome in pregnancy...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27868333/to-measure-or-not-to-measure-direct-oral-anticoagulants-before-surgery-or-invasive-procedures-comment
#13
R Selby, Z Shah, L Black, J Ongteco, S Kulkarni, D Piraino
With interest, we read a recent publication by Armando Tripodi, aimed at discussing whether direct oral anticoagulants (DOACs) should be measured prior to surgical or invasive procedures [1]. Although specific assays for the assessment of anticoagulant activity of the direct oral anticoagulants (dabigatran and the oral factor Xa inhibitors) have been developed and are easy to perform on automated coagulation analyzers [1-3], they are currently not available in the majority of Ontario laboratories. Since the APTT is readily available at most of our laboratories, we studied the effect of different dabigatran concentrations on the APTT, using six different APTT reagents and performed on three coagulation analyzer platforms...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27868324/to-measure-or-not-to-measure-direct-oral-anticoagulants-before-surgery-or-invasive-procedures-reply
#14
Armando Tripodi
I read with interest the Letter by Selby et al [1] on sensitivity of commonly used APTT reagents in Ontario Canada to increasing dabigatran concentrations published recently in the Journal. The Letter is dealing with the Forum on the need to measure direct oral anticoagulants (DOAC) before surgery or invasive procedures and subsequent correspondence recently published by the Journal [2-4]. I wish to make the following comments. Selby et al [1] investigated six APTT reagents on three common coagulometers by testing in vitro spiked (fixed concentrations of dabigatran) plasmas and found that the prolongation of the APTT was related to the dabigatran concentration, although with some between-reagent variability...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27860129/the-postthrombotic-syndrome-current-evidence-and-future-challenges
#15
REVIEW
A Rabinovich, S R Kahn
Post thrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT), which develops in 20%-50 % of patients. PTS manifests as a spectrum of symptoms and signs of chronic venous insufficiency that can impose significant morbidity and have a negative impact on quality of life. Chronic venous hypertension caused by a combination of residual venous obstruction and valvular reflux is believed to play a major role in the pathophysiology of PTS. The Villalta scale is the most widely applied clinical scale used to diagnose and define PTS...
November 18, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27862941/a-century-of-heparin-past-present-and-future
#16
H Coenraad Hemker
It is not unlikely that more lives have been saved by heparin than by penicillin. However, where the discovery of penicillin was, rightfully, hailed as a major breakthrough right from the very beginning, heparin materialized slowly from murky tissue preps about a century ago and never reached the star status of the antibiotics. This is in line with the humble position of thrombosis among the mechanisms of disease. More people die from it than from any other pathogenic condition, yet it remains largely "nobody's disease and everybody's complication" (to cite A...
November 9, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27813343/a-multicenter-study-to-assess-the-reproducibility-of-antiphospholipid-antibody-results-produced-by-an-automated-system
#17
K M Devreese, A Poncet, E Lindhoff-Last, J Musial, P de Moerloose, P Fontana
BACKGROUND: Inter-assay variability is a well-known problem in antiphospholipid antibody testing, due to the lack of standardization. Inter-lab reproducibility for a same assay is similarly important. OBJECTIVES: Testing repeatability and reproducibility of HemosIL(®) AcuStar for anticardiolipin (aCL) and aβ2GPI IgG and IgM. PATIENTS/METHODS: In this observational study, out of 420 samples from the thrombophilia centers of Ghent and Geneva, 100 samples were randomly selected and successively analyzed in three centers: Ghent (C1, in duplicate for repeatability evaluation), Geneva (C2) and Frankfurt (C3)...
November 4, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27813324/coagulation-factor-xi-vaccination-an-alternative-strategy-to-prevent-thrombosis
#18
Conghao Zhong, Li Zhang, Lei Chen, Li Deng, Rongxiu Li
BACKGROUND: Coagulation Factor XI (FXI) serves as a signal amplifier in the intrinsic coagulation pathway. Blockade of FXI by monoclonal antibodies or small molecule inhibitors inhibits thrombosis without causing severe bleeding, which is an inherent risk of currently available antithrombotic agents. OBJECTIVES: In this study, we designed an FXI vaccine and assessed its efficacy in inhibiting FXI activity and preventing thrombosis. METHODS: An FXI antigen was generated by fusing the catalytic domain of human FXI to the carboxyl terminus of the transmembrane domain of diphtheria toxin...
November 4, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27813265/association-of-stroke-risk-biomarkers-with-stroke-symptoms-the-reasons-for-geographic-and-racial-differences-in-stroke-cohort
#19
K K Landry, K S Alexander, N A Zakai, S E Judd, D O Kleindorfer, V J Howard, G Howard, M Cushman
BACKGROUND: History of stroke symptoms in the absence of prior diagnosed stroke or transient ischemic attack (TIA) is associated with future stroke risk, as are biomarkers of inflammation, cardiac function and hemostasis. OBJECTIVE: To better elucidate pathobiology of stroke symptoms, we studied associations of these biomarkers with history of stroke symptoms. METHODS: The REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort enrolled 30,239 black and white Americans age 45 and older in 2003-7...
November 4, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27801970/the-c-terminus-of-tissue-factor-pathway-inhibitor-%C3%AE-inhibits-factor-v-activation-by-protecting-the-arg-1545-cleavage-site
#20
P van Doorn, J Rosing, S J Wielders, T M Hackeng, E Castoldi
: Essentials The C-terminus of tissue factor pathway inhibitor (TFPIα) binds to the B-domain of factor V (FV). The functional consequences of this interaction were investigated in plasma and model systems. The TFPIα C-terminus inhibited thrombin generation in plasma, but not in the presence of FVa. The TFPIα C-terminus inhibited FV activation by preventing cleavage at Arg(1545) . SUMMARY: Background Factor V (FV) is a carrier and a cofactor of the anticoagulant protein tissue factor pathway inhibitor-α (TFPIα), whose basic C-terminus binds to an acidic region in the B-domain of FV...
November 1, 2016: Journal of Thrombosis and Haemostasis: JTH
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