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Journal of Thrombosis and Haemostasis: JTH

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https://www.readbyqxmd.com/read/29325226/citrullinated-histone-h3-a-biomarker-of-neutrophil-extracellular-trap-formation-predicts-the-risk-of-venous-thromboembolism-in-cancer-patients
#1
Lisa-Marie Mauracher, Florian Posch, Kimberly Martinod, Ella Grilz, Thomas Däullary, Lena Hell, Christine Brostjan, Christoph Zielinski, Cihan Ay, Denisa D Wagner, Ingrid Pabinger, Johannes Thaler
BACKGROUND: Neutrophil extracellular traps (NETs) are decondensed chromatin fibers which might play a role in the prothrombotic state of cancer patients. OBJECTIVES: Here we investigated whether citrullinated histone H3 (H3Cit), a biomarker for NET formation, cell-free DNA (cfDNA), and nucleosomes predict venous thromboembolism (VTE) in cancer patients. PATIENTS/METHODS: Nine-hundred-forty-six patients with newly-diagnosed cancer or progression after remission were enrolled in this prospective observational cohort study...
January 11, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29322630/inter-laboratory-variability-for-the-measurement-of-direct-oral-anticoagulants-results-from-the-external-quality-assessment-scheme
#2
Armando Tripodi, Veena Chantarangkul, Cristina Legnani, Sophie Testa, Alberto Tosetto
BACKGROUND: Tests for direct oral anticoagulants (DOAC) are not widely available. The perception that they are difficult to be run and are subjected to large between-laboratory variation makes their implementation difficult. AIMS: We carried out proficiency-testing surveys for DOAC within the activity of the external quality-assessment scheme of the Italian Federation of Thrombosis Centers. DESIGN: Participants were provided with coded freeze-dried plasmas without or with graded concentrations of the three main DOAC and asked to measure PT, APTT, thrombin time and DOAC concentrations by dedicated tests...
January 10, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316235/antithrombin-concentrate-use-in-disseminated-intravascular-coagulation-of-sepsis-meta-analyses-revisited
#3
LETTER
Christian J Wiedermann
Recently, two meta-analyses examined the effect of antithrombin on mortality in patients with sepsis and disseminated intravascular coagulation (DIC) with diverging results. In the meta-analysis observing no significant survival effect of antithrombin, the results of a large trial were included under the assumption that all 2,314 participants of the trial had sepsis and DIC, which according to post hoc analyses is not the case. To the other meta-analysis reporting beneficial effect, the same trial contributed only those 229 patients that had confirmed sepsis-induced DIC...
January 9, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316193/thrombocytopenia-in-high-risk-patients-with-antiphospholipid-syndrome
#4
E Pontara, A Banzato, E Bison, M G Cattini, G Baroni, G Denas, A Calligaro, P Marson, T Tison, A Ruffatti, V Pengo
BACKGROUND: Thrombocytopenia is the most common non-criteria hematologic feature in patients with the antiphospholipid syndrome (APS). This condition is more common in catastrophic APS (CAPS). OBJECTIVES: To evaluate the prevalence of thrombocytopenia in a large series of high-risk patients with APS and to assess the behavior of platelet count during CAPS. METHODS/PATIENTS: This is a cross sectional study in which we analyzed the platelet count of a homogeneous group of high-risk APS patients (triple positive)...
January 8, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316171/optimal-patient-selection-for-anticoagulant-therapy-in-sepsis-an-evidence-based-proposal-from-japan
#5
LETTER
Yutaka Umemura, Kazuma Yamakawa
Selecting an appropriate target population is essential to maximize survival benefits of anticoagulant therapy against sepsis. Our meta-analysis of three populations with sepsis and nationwide observational study in Japan showed that anticoagulants improved mortality only in sepsis-induced disseminated intravascular coagulation (DIC) but not in non-DIC. This divergent effect was physiologically explained by host-protective immune responses of local thrombosis, which are mandatory in the early stage of sepsis...
January 8, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316251/antithrombin-concentrate-use-in-sepsis-associated-disseminated-intravascular-coagulation-reevaluation-of-a-pendulum-effect-drug-using-a-nationwide-database
#6
LETTER
T Tagami
There are four systematic reviews and meta-analyses of trials of antithrombin use for sepsis or critically ill patients published to date with conflicting results. The two studies that showed positive results used data only from septic patients who were also diagnosed with disseminated intravascular coagulation (DIC), whereas the two studies showing negative results included data from all septic and/or critically ill patients in their analyses. We believe that the underlying diseases of the study population must be as homogeneous as possible when evaluating treatment efficacy for sepsis-associated DIC...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316215/oxidized-low-density-lipoprotein-in-inflammation-driven-thrombosis
#7
Georg Obermayer, Taras Afonyushkin, Christoph J Binder
Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke and pulmonary artery embolism. While platelet activation as well as activation of the plasmatic coagulation system are the hallmarks of thrombus formation, inflammatory processes and the cellular responses involved are increasingly recognized as critical modulators of thrombosis. In the context of many chronic inflammatory diseases that are associated with a high thrombotic risk, oxidized lipoproteins represent a prominent sterile trigger of inflammation...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29316202/anticoagulant-prophylaxis-and-therapy-in-children-current-challenges-and-emerging-issues
#8
Fiona Newall, Brian Branchford, Christoph Male
This review aims to describe the unique challenges of anticoagulant prophylaxis and treatment in children, and to highlight areas for research for improving clinical outcomes of children with thromboembolic disease. The evidence presented demonstrates the challenges of advancing the evidence-base informing optimal management of thromboembolic disease in children. Recent observational studies have identified risk factors of venous thromboembolism in children, but there are few interventional studies assessing the benefit-risk of using thromboprophylaxis in risk-stratified clinical subgroups...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29314712/incomplete-reversibility-of-platelet-inhibition-following-prolonged-exposure-to-ticagrelor-comment
#9
M Urooj Zafar, Juan Jose Badimon, Gines Escolar Gines
We read with interest the article by Gerrits et al on the incomplete reversibility of platelet inhibition following prolonged exposure to treatment with ticagrelor [1]. The results are intriguing and somewhat surprising, considering the reversible nature of the binding of ticagrelor with the platelet P2Y12 receptors. The study reported that prolonged exposure (24 hours) to ticagrelor decreased the reversibility of platelet function compared to short exposure (30 minutes) and the degree of this effect varied in the different testing methodologies used in the study...
January 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29314666/incomplete-reversibility-of-platelet-inhibition-following-prolonged-exposure-to-ticagrelor-reply-to-comment
#10
Anja J Gerrits, Joseph A Jakubowski, Alan D Michelson, Andrew L Frelinger
We thank Drs Zafar, Badimon, and Escolar for their comments on our recent publication on the reversibility of ticagrelor inhibition of platelets[1] and agree that the results are unexpected. We appreciate the opportunity to address the question of changes in platelet reactivity due to blood sample aging alone (as opposed to inhibitor-related changes) in samples tested after 30 min versus 24 hours in vitro incubation at 37°C. Platelet reactivity to 5 min stimulation with 5 μM ADP as measured by percentage platelet surface activated GPIIb-IIIa positive cells at 24 hours was 88% of that observed at 30 min...
January 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29314596/multiplate%C3%A2-evaluation-of-acetylsalicylic-acid-efficacy-in-carotid-surgery-routine-and-genetic-influencing-factors
#11
S Roullet, S Labrouche, C Carrie, H Auque, X Berard, G Freyburger
BACKGROUND: Acetylsalicylic acid (ASA) is recommended before, during and after carotid endarterectomy (CEA). Efficacy of ASA is influenced by numerous biological and genotypic factors. OBJECTIVES: To determine the biological efficacy of ASA by using the Multiplate® method and to explore the biological parameters and genomic factors influencing this efficacy. METHODS: This descriptive cross-sectional study included all patients scheduled for CEA between January 2012 and April 2013...
January 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29297977/the-association-between-idiopathic-thrombocytopenic-purpura-and-cardiovascular-disease-a-retrospective-cohort-study
#12
Joht Singh Chandan, Tom Thomas, Sophie Lee, Tom Marshall, Brian Willis, Krishnarajah Nirantharakumar
BACKGROUND: Idiopathic Thrombocytopenic Purpura (ITP) is classically characterized by a transient or persistent decrease of platelet count. Mortality is higher in the ITP population than the general population, with a possible association to increased cardiovascular disease (CVD). OBJECTIVES: The objective was to assess the strength of the association between ITP and CVD, with a secondary aim to assess the impact of splenectomy on CVD. METHODS: A population-based retrospective, open cohort study using clinical codes was performed using data from 6,591 patients with ITP and 24,275 randomly matched controls (up to 1:4 ratio matched by age, sex, body mass index and smoking status)...
January 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29288565/high-and-long-term-von-willebrand-factor-expression-after-sleeping-beauty-transposon-mediated-gene-therapy-in-a-mouse-model-of-severe-von-willebrand-disease
#13
Irina Portier, Karen Vanhoorelbeke, Sebastien Verhenne, Inge Pareyn, Nele Vandeputte, Hans Deckmyn, Daniel S Goldenberg, Himanshu B Samal, Manvendra Singh, Zoltán Ivics, Zsuzsanna Izsvák, Simon F De Meyer
BACKGROUND: Type 3 von Willebrand disease (VWD) is characterized by complete absence of von Willebrand factor (VWF). Current therapy is limited to treatment with exogenous VWF/FVIII products, which only provide a short-term solution. Gene therapy offers the potential for a long-term treatment for VWD. OBJECTIVES: To develop an integrative Sleeping Beauty (SB) transposon-mediated VWF gene transfer approach in a preclinical mouse model of severe VWD. METHODS: We established a robust platform for sustained transgene murine (m)VWF expression in the liver of Vwf-/- mice by combining a liver-specific promoter with a sandwich transposon design and the SB100X transposase via hydrodynamic gene delivery...
December 29, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29285876/metabolomic-analysis-of-92-pulmonary-embolism-patients-from-a-nested-case-control-study-identifies-metabolites-associated-with-adverse-clinical-outcomes
#14
O A Zeleznik, E M Poole, S Lindstrom, P Kraft, A Van Hylckama Vlieg, J A Lasky-Su, L B Harrington, K Hagan, J Kim, B A Parry, N Giordano, C Kabrhel
BACKGROUND: Patients with acute pulmonary embolism (PE) exhibit wide variation in clinical presentation and outcomes. Our understanding of the pathophysiologic mechanisms differentiating low-risk and high-risk PE is limited, so current risk-stratification efforts often fail to predict clinical deterioration and are insufficient to guide management. OBJECTIVES: To improve our understanding of the physiology differentiating low-risk from high-risk PE, we conducted the first-ever high-throughput metabolomics analysis (843 named metabolites) comparing PE patients across risk strata within a nested case-control study...
December 29, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29285874/early-cellular-interactions-and-immune-transcriptome-profiles-in-human-factor-viii-exposed-hemophilia-a-mice
#15
J D Lai, D Cartier, R B Hartholt, L L Swystun, A S van Velzen, J M M den Haan, C Hough, J Voorberg, D Lillicrap
BACKGROUND: Developing factor VIII (FVIII) inhibitory antibodies is the most serious complication in hemophilia A treatment, representing a significant health and economic burden. A better understanding of the early events in an immune response leading to this outcome may provide insight into inhibitor development. OBJECTIVE: To identify early mediators of FVIII immunity and to detail immune expression profiles in the spleen and liver. METHODS: C57Bl/6 F8 E16 knockout mice were infused with 5-20 μg (2000-8000 IU/kg) of recombinant FVIII...
December 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29285859/determinants-of-impaired-renal-and-vascular-function-are-associated-with-higher-levels-of-procoagulant-factors-in-the-general-population
#16
Ilona A Dekkers, Renée de Mutsert, Aiko P J de Vries, Frits R Rosendaal, Suzanne C Cannegieter, J Wouter Jukema, S le Cessie, Ton J Rabelink, Hildo J Lamb, Willem M Lijfering
BACKGROUND: Impaired renal and vascular function have been associated with venous thrombosis, but the mechanism is unclear. OBJECTIVES: We investigated whether estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (UACR), and pulse wave velocity (PWV) are associated with a procoagulant state. METHODS: In this cross-sectional analysis of the NEO Study, eGFR, UACR, fibrinogen, and coagulation factors (F)VIII, FIX, and FXI were determined in all participants (n=6536), and PWV was assessed in a random subset (n=2433)...
December 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29285851/von-willebrand-factor-propeptide-to-antigen-ratio-identifies-platelet-activation-and-reduced-vwf-survival-phenotype-in-mice
#17
Paula M Jacobi, Sachiko Kanaji, David Jakab, Ashley L Gehrand, Jill M Johnsen, Sandra L Haberichter
BACKGROUND: Reduced plasma survival of VWF is characteristic of patients with type 1C VWD. These subjects can be identified by an increased steady-state ratio of plasma VWFpp to VWF:Ag. A similar phenotype occurs in mice with the Mvwf1 allele. OBJECTIVES: To 1) determine if VWFpp/VWF:Ag ratio can be used to identify a "type 1C" phenotype in mice, 2) determine the most reliable method for murine blood sampling, and 3) identify the source of VWF released during problematic blood collection...
December 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29274254/french-lyophilized-plasma-versus-fresh-frozen-plasma%C3%A2-for-the-initial-management-of-trauma-induced-coagulopathy-a-randomized-open-label-trial
#18
Delphine Garrigue, Anne Godier, Alexandre Glacet, Julien Labreuche, Eric Kipnis, Camille Paris, Alain Duhamel, Eric Resch, Anne Bauters, François Machuron, Pascale Renom, Patrick Goldstein, Benoit Tavernier, Anne Sailliol, Sophie Susen
BACKGROUND: Guidelines recommend to begin haemostatic resuscitation immediately in trauma patients. We aimed to investigate if French Lyophilised Plasma (FLyP) was more effective than Fresh Frozen Plasma (FFP) for the initial management of the trauma-induced-coagulopathy. METHODS: In an open-label, phase 3, randomized trial (NCT02750150), we enrolled adult trauma patients requiring an emergency pack of 4 plasma units within 6 hours of injury. We randomly assigned patients to receive 4-FLyP units or 4-FFP units...
December 23, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29274198/dabigatran-versus-vitamin-k-antagonist-an-observational-across-cohort-comparison-in-acute-coronary-syndrome-patients-with-atrial-fibrillation
#19
Mélanie Gaubert, Noémie Resseguier, Marc Laine, Laurent Bonello, Laurence Camoin-Jau, Franck Paganelli
BACKGROUND: Dual antithrombotic therapy comprising a vitamin K antagonist (VKA) plus clopidogrel reduces the incidence of major bleeding compared with triple therapy (VKA+clopidogrel+aspirin) in acute coronary syndrome (ACS) patients with atrial fibrillation (AF), with a similar thrombotic risk. The oral thrombin inhibitor dabigatran (150 mg twice a day) showed superiority over VKA in non-valvular AF, but data supporting its use in AF patients presenting with ACS are limited. OBJECTIVE: We sought to evaluate the efficacy of dabigatran versus VKA in the management of AF patients undergoing percutaneous coronary intervention for an ACS...
December 23, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29274196/musculoskeletal-ultrasound-for-intra-articular-bleed-detection-a-highly-sensitive-imaging-modality-compared-to-conventional-magnetic-resonance-imaging
#20
S Nguyen, X Lu, Y Ma, J Du, E Y Chang, A von Drygalski
BACKGROUND: There is increasing demand for musculoskeletal ultrasound (MSKUS) to detect hemophilic joint bleeding, but there is uncertainty regarding blood detection concentration thresholds or if magnetic resonance imaging (MRI) is more accurate. AIMS: Compare the sensitivity of blood detection by MSKUS and MRI. METHODS: Increasing blood concentrations in plasma were imaged with MSKUS and MRI 1-2 hours, 3-4 days and 7 days after blood withdrawal in vitro, and after injection into cadaveric pig joints...
December 23, 2017: Journal of Thrombosis and Haemostasis: JTH
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