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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.
Stem Cell Research 2018 March
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers. Many hot-spot mutations of TP53 confer novel functions not found in wild-type p53 and contribute to tumor development and progression. We report on the generation of a H1 human embryonic stem cell line carrying a homozygous TP53 R282W mutation using TALEN-mediated genome editing. The generated cell line demonstrates normal karyotype, maintains a pluripotent state, and is capable of generating a teratoma in vivo containing tissues from all three germ layers.
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