We have located links that may give you full text access.
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Maternal prolactin secretion is phasic during induced term and post-term labor.
OBJECTIVE: We hypothesized that regimens of labor induction do not alter the biphasic secretion of maternal prolactin (PRL) seen during spontaneous labor.
METHODS: Serial blood samples drawn from 12 women before, during, and after induced labor were assayed for PRL and hCG and compared with cervical dilatation and uterine contraction frequency (UCF). Induction methods were cervical ripening with dinoprostone gel (Prepidil) followed by oxytocin infusion (n = 1), amniotomy followed by oxytocin (n = 4), oxytocin followed by amniotomy (n = 3), amniotomy only (n = 2), and oxytocin only (n = 2).
RESULTS: Regardless of the induction method, PRL decreased with advancing cervical dilatation during the first stage of labor and reached a nadir at full dilatation. Prolactin levels then increased rapidly during the second stage, correlating significantly with the increase in UCF, and peaked at 1 hour postpartum before decreasing. Levels of hCG increased during labor and peaked just before or at delivery before rapidly decreasing.
CONCLUSIONS: The biphasic secretion of maternal PRL is a fundamental characteristic of active term labor and occurs regardless of the method used to induce labor.
METHODS: Serial blood samples drawn from 12 women before, during, and after induced labor were assayed for PRL and hCG and compared with cervical dilatation and uterine contraction frequency (UCF). Induction methods were cervical ripening with dinoprostone gel (Prepidil) followed by oxytocin infusion (n = 1), amniotomy followed by oxytocin (n = 4), oxytocin followed by amniotomy (n = 3), amniotomy only (n = 2), and oxytocin only (n = 2).
RESULTS: Regardless of the induction method, PRL decreased with advancing cervical dilatation during the first stage of labor and reached a nadir at full dilatation. Prolactin levels then increased rapidly during the second stage, correlating significantly with the increase in UCF, and peaked at 1 hour postpartum before decreasing. Levels of hCG increased during labor and peaked just before or at delivery before rapidly decreasing.
CONCLUSIONS: The biphasic secretion of maternal PRL is a fundamental characteristic of active term labor and occurs regardless of the method used to induce labor.
Full text links
Related Resources
Trending Papers
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app