We have located open access text paper links.
Spaceflight causes strain-dependent gene expression changes associated with lipid and extracellular matrix dysregulation in the mouse kidney in vivo.
bioRxiv 2024 March 15
UNLABELLED: To explore new worlds we must ensure humans can survive and thrive in the space environment. Incidence of kidney stones in astronauts is a major risk factor associated with long term missions, caused by increased blood calcium levels due to bone demineralisation triggered by microgravity and space radiation. Transcriptomic changes have been observed in other tissues during spaceflight, including the kidney. We analysed kidney transcriptome patterns in two different strains of mice flown on the International Space Station, C57BL/6J and BALB/c. Here we show a link between spaceflight and transcriptome patterns associated with dysregulation of lipid and extracellular matrix metabolism and altered transforming growth factor-beta signalling. A stronger response was seen in C57BL/6J mice than BALB/c. Genetic differences in hyaluronan metabolism between strains may confer protection against extracellular matrix remodelling through downregulation of epithelial-mesenchymal transition. We intend for our findings to contribute to development of new countermeasures against kidney disease in astronauts and people here on Earth.
HIGHLIGHTS: Spaceflight has a significant effect on gene expression in the kidney.Responses in the BALB/c indicate milder transcriptomic perturbations than C57BL/6J.Lipid metabolism was altered in both strains of mice.Extracellular matrix metabolism and TGF-β signalling up in BALB/c down in C57BL/6J.Reduced gene expression of hyaluronan synthesis pathway in BALB/c but not in C57BL/6J.
HIGHLIGHTS: Spaceflight has a significant effect on gene expression in the kidney.Responses in the BALB/c indicate milder transcriptomic perturbations than C57BL/6J.Lipid metabolism was altered in both strains of mice.Extracellular matrix metabolism and TGF-β signalling up in BALB/c down in C57BL/6J.Reduced gene expression of hyaluronan synthesis pathway in BALB/c but not in C57BL/6J.
Full text links
Related Resources
Trending Papers
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app