Comtrifosides A and B, two new triterpenoid saponins from the leaves of Combretum trifoliatum .

The phytochemical composition of the Combretum trifoliatum leaves was studied for the first time. Two new triterpenoid saponins, named comtrifoside A ( 1 ) and comtrifoside B ( 2 ), together with two other saponins ( 3-4 ) were purified by variously chromatographic techniques. For the first time, compound 3 was informed from the Combretum genus, as well as all of the isolated compounds ( 1-4 ) were reported from C. trifoliatum . The chemical structures of them were clearly characterised using extensive UV-VIS, IR, HRMS-ESI, and NMR experimental data. The in vitro anti-inflammatory activities of 1 & 2 were examined against NO overproduction in LPS activation of RAW264.7.