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Natural Product Research

Jia-Hao Liang, Xiao-Kui Huo, Zhong-Bin Cheng, Cheng-Peng Sun, Jian-Chao Zhao, Xiao-Hui Kang, Tian-Yuan Zhang, Zhong-Jian Chen, Tian-Mei Yang, Ying-Ying Wu, Xiao-Peng Deng, Yi-Xuan Zhang
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B...
September 17, 2018: Natural Product Research
Gurrala Alluraiah, Reddymasu Sreenivasulu, Choragudi Chandrasekhar, Rudraraju Ramesh Raju
The total synthesis of 16-membered C2 -Symmetric dilactone (-)-Pyrenophorol was accomplished starting from commercially available (S)-epoxide prepared by hydrolytic kinetic resolution of (±) - epoxide with key steps of Grignard reaction, Swern oxidation, Wittig reaction and cyclization was achieved by intermolecular Mitsunobu cyclization. The synthesis of (-)-Pyrenophorol accomplished from cheaply available starting material, easily work-up procedures and reduction of cost in industrial process were major advantages of this route...
September 17, 2018: Natural Product Research
Runguang Zhang, Xiaocheng Guo, Youlin Zhang, Chengrui Tian
Modified atmosphere storage can regulate the reactive oxygen metabolism of fruits and vegetables, reduce the accumulation of hazardous free radicals, and mitigate the peroxidation degree of fruit membrane lipids. In this study, different gas matching ratios were adopted for the modified atmosphere treatment of pomegranate fruits. Up to 120 d of storage, compared with the control treatment, the H2 O2 and malonaldehyde (MDA) contents in treatment 2 decreased by 8.88% and 18.28%, respectively, when the activities of superoxide dismutase (SOD), catalase (CAT) and ascorbic acid peroxidase (APX) in treatment 2 increased by 21...
September 3, 2018: Natural Product Research
Emilio Bottari, Maria Rosa Festa, Simone Mazzoni
The connection between chocolate and cocoa is studied. As cocoa is produced in different countries, samples coming from the same geographical region are analysed. The analyses focus on the characterisation of the considered samples for different aspects of quality and to individuate the original locations of production, also connecting this with the nutritional aspects. For this purpose, qualitative and quantitative traditional analysis and determination of fatty acid content are performed. The obtained experimental data show interesting correlations...
September 3, 2018: Natural Product Research
Katarzyna Szewczyk, Serhat Sezai Cicek, Christian Zidorn, Sebastian Granica
As a continuation of investigating Impatiens L. genus, eight flavonoids, eriodyctiol, eriodyctiol 7-O-β-ᴅ-glucoside, kaempferol 3-O-β-ᴅ-glucoside, kaempferol 3-O-β-ᴅ-galactoside, kaempferol 3-rhamnosyl-di-glucoside, kaempferol 3-O-β-ᴅ-rutinoside, quercetin 3-O-β-ᴅ-glucoside and quercetin 3-O-β-ᴅ-galactoside, two phenolic acids - p-hydroxybenzoic acid and protocatechuic acid, and 2-methoxynaphthalene-1,4-dione were isolated from the aerial parts of I. glandulifera collected in Poland. The structures of the compounds were established by analysis of their spectroscopic (1 H and 13 C NMR) and spectrometric (MS) data, as well as by comparison of these with those reported in the literature...
September 3, 2018: Natural Product Research
Akhtar Atiya, Barij Nayan Sinha, Uma Ranjan Lal
A new ether derivative of phenylpropanoid compound, γ-(γ'-isohydroxychavicol)-chavicol octanyl ether (K1) along with one known phenylpropanoid named allyl-pyrocatechol or hydroxychavicol (2) were isolated from Piper betle var. kali collected from Tumluk district, West Bengal India. We first report the presence of compound K1 in the genus Piper. Their structures were established on the basis of various spectroscopic analyses. Compounds K1 and 2 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 4...
August 31, 2018: Natural Product Research
Yan-Qing Ye, Zu-Hong Ma, Qiao-Fen Yang, Yan-Qi Sun, Rui-Qi Zhang, Run-Fang Wu, Xin Ren, Li-Juan Mu, Zhi-Yong Jiang, Min Zhou
A new benzylated alkamide, N-(3,4-dimethoxybenzyl)-9Z-oleamide (1), along with two known ones (2 and 3) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan Province of China. Their structures were elucidated by extensive spectroscopic analyses and the new compound further confirmed by a one-step synthesis. All the isolated alkamides were evaluated for their cytotoxicity against five human cancer cell lines. However, no significant activities were detected at concentrations up to 40 μM...
August 20, 2018: Natural Product Research
Blessing O Umeokoli, Weaam Ebrahim, Mona El-Neketi, Werner E G Müller, Rainer Kalscheuer, Wenhan Lin, Zhen Liu, Peter Proksch
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains...
August 20, 2018: Natural Product Research
Tsvetelina Doncheva, Nadezhda Kostova, Violeta Valcheva, Radostina Toshkovska, Vassil Vutov, Stefan Philipov
New isoquinoline alkaloid hypepontine (1) together with a five known compounds, were identified in Hypecoum ponticum Velen, the partial synonym of Hypecoum procumbens L. The structure of the new substance was elucidated based on spectroscopic evidence. The tertiary and quaternary alkaloid mixtures as well as the isolated alkaloids were evaluated for their antibacterial and antifungal activity. The result revealed that the crude alkaloid mixture containing quaternary isoquinoline alkaloids showed potent antifungal and antibacterial activity...
August 17, 2018: Natural Product Research
Randa Abdou, Samah Shabana, Mostafa E Rateb
Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains...
August 9, 2018: Natural Product Research
Sunday O Okoh, Omobola O Okoh, Anthony I Okoh
Syzygium paniculatum Gaertn of the family Myrtaceae is a medicinal and aromatic plant. The hydrodistilled volatile oil (VO) from the aerial parts was characterised by GC-MS and Kovat's index, while the antioxidant property was investigated using spectrophotometric techniques. Antioxidant capacities of the aerial parts VOs range from 0.12 to 0.93 mg/mL in scavenging 2, 2-diphenyl-1-picrylhydrazyl radicals (DPPH• ). Overall, 75 and 67 compounds were identified from the summer and winter VOs, respectively...
August 9, 2018: Natural Product Research
Khaled M Meselhy, Manal M Shams, Noheir H Sherif, Sawsan M El-Sonbaty
The aim of the study is to evaluate common food by-products (Pomegranate peel, Rice bran, Rice straw & Mulberry bark) to screen out their medicinal importance such as cytotoxic & antioxidant activities. HPLC revealed that all tested samples were rich in phenolics. Tested samples exerted significant antioxidant activity with high potency to Pomegranate peel. All tested extracts were able to reduce cell viability of tested cell lines in a dose-response manner after treatment. In most cases, the IC50 values were under 30  μg/ml except IC50 of pomegranate peel against breast cell line (42...
August 6, 2018: Natural Product Research
Surendra Jatav, Nishant Pandey, Pratibha Dwivedi, Ranju Bansal, Vivek Ahluwalia, Vinod K Tiwari, Bhuwan B Mishra
Aegle marmelos is a plant species native to India. Commercially available food products such as jam, jelly, candy, squash etc. are prepared from ripe fruit pulp of A. marmelos. Ripe fruit processing accounts for 60% of whole fruit mass while 40% remains unutilized and generates waste (hard shell, pomace, fiber and seeds) on a massive scale which do not have high value applications. A new flavone 3,5,7-trihydroxy-2-(4'-hydroxy-3'-isopentyloxyphenyl-4H-chromen-4-one (5) in addition to the known compounds 1-4, has been isolated from seeds of A...
August 1, 2018: Natural Product Research
Z M Babar, Wan Mohd Azizi, Solachuddin Ja Ichwan, Qamar Uddin Ahmed, Abul Kalam Azad, Imranul Mawa
The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1 kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72 hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4 °C, NSO and WSE were obtained at the same instant. Solubility tests of 24 solvents and 11 thin layer chromatographic analyses while 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay of NSO (73.66) , WSE (33.32) and NSO + WSE (78...
July 24, 2018: Natural Product Research
Jun Yin, Hye Shin Ahn, Seong Yi Ha, In Hyeok Hwang, Kee Dong Yoon, Young Won Chin, Min Won Lee
Carpinus tschonoskii (CT) is distributed through in southern regions of South Korea. Six known compounds, including three ellagitannins, one gallotannin, and two flavonoids were isolated from CT. In conclusion, the tannins, especially ellagitannins, and CT extract showed potent anti-oxidative, anti-inflammatory and anti-skin ageing activities.
July 23, 2018: Natural Product Research
Cai-Ping Yao, Zhen-Xing Zou, Yan Zhang, Jing Li, Fei Cheng, Ping-Sheng Xu, Gan Zhou, Xiao-Min Li, Kang-Ping Xu, Gui-Shan Tan
Phytochemical study on the n-BuOH extract of Selaginella delicatula lead to the isolation, characterization and structure elucidation of two new adenine analogues, delicatulines A (1) and B (2), one new pyrrole alkaloid (4), and five known compounds (3, 5-8). These new substances all contain an aliphatic chain in their parent nucleus, which were unusual to find in plants. In the present study, they were identified from Selaginellaceae for the first time. The structures and absolute configurations of these new compounds were determined by a combination of NMR and CD spectroscopic analyses...
July 4, 2018: Natural Product Research
Yingjie Sun, Hongmin Zhang, Ming Cheng, Shijie Cao, Miao Qiao, Boli Zhang, Liqin Ding, Feng Qiu
Two new isoflavone glucosides, 3'-methoxyneopuerarin A (1) and 3'-methoxyneopuerarin B (2), together with nine known isoflavones including puerarin (3), neopuerarin A (4), neopuerarin B (5), daidzin (6), daidzein (7), 3'-methoxypuerarin (PG-3) (8), puerarin xyloside (9), mirificin (10), 3'-hydroxypuerarin (11) were isolated from the water extraction of the dried roots of Pueraria lobata (Willd.) Ohwi. Their structures were elucidated by the means of spectroscopic and chromatographic analysis methods. All compounds were evaluated for their hepatoprotective activity on HepG2 cells...
July 3, 2018: Natural Product Research
Ghislain Fotso W, Jean Na-Iya, Armelle Mbaveng T, Patrick Ango Yves, Ibrahim Demirtas, Victor Kuete, Yeboah Samuel, Bathelemy Ngameni, Thomas Efferth, Bonaventure Ngadjui T
The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes...
June 25, 2018: Natural Product Research
Shuai Liu, Jiahui Zhang, Yingtong Di, Jinyan Dong, Xiaojiang Hao
A new Daphniphyllum alkaloid, daphnezomine W (1), together with four known ones, were isolated from the stems of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 1 was a new daphnezomine L-type alkaloid and exhibited moderate cytotoxic activity against Hela cell line with IC50 of 16.0 μg/mL. A plausible biosynthetic pathway of 1 was also proposed.
September 2018: Natural Product Research
Qingwen Hu, Ying-Ying Chen, Qi-Yang Jiao, Afsar Khan, Jimiao Shan, Gui-Dong Cao, Feng Li, Chao Zhang, Hong-Xiang Lou
One new 4-chromanone glycoside, 5-O-β-d-glucopyranoside-4-chromanone (1), together with 21 known polyphenols, was isolated from the leaves of Malus hupehensis. Their structures were elucidated on the basis of extensive spectroscopic methods including NMR (1D and 2D), mass (ESIMS and HRESIMS), IR, and by comparison with the data reported in the literature. Some of the isolated compounds were screened for antioxidant activity. Compounds 18 and 14 exhibited significant antioxidant activities with SC50 values 2...
September 2018: Natural Product Research
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