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Natural Product Research

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https://www.readbyqxmd.com/read/28427277/biological-activity-and-lc-ms-ms-profiling-of-extracts-from-the-australian-medicinal-plant-acacia-ligulata-fabaceae
#1
Diana Jæger, Bradley S Simpson, Chi P Ndi, Anna K Jäger, Christoph Crocoll, Birger Lindberg Møller, Philip Weinstein, Susan J Semple
Acacia ligulata A.Cunn. ex Benth. (Fabaceae: Mimosoideae) is a native Australian plant used traditionally by Australian Aboriginal groups. This study was undertaken to investigate the bioactivity of A. ligulata extracts and to evaluate their chemical composition. Potential antibacterial, cytotoxic and enzyme inhibitory effects relevant to traditional medicinal and food uses of the species were examined and LC-MS/MS was performed to investigate the chemical composition. Antibacterial activity was observed for bark and leaf extracts with an MIC for the bark extract of 62...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28427276/stereoselective-total-synthesis-of-6s-2-r-cryptocaryalactone
#2
Feifei Huang, Xiaotong Li, Shuangjie Lin, Cheng Liang, Shuangping Huang, Xiaoji Wang
We described a novel stereoselective total synthesis of (-)-(6S,2'R)-cryptocaryalactone, a natural product containing syn/anti-6,8-diol/5,6-dihydro-2H-pyran-2-one unit. The approach, which characterised a highly diastereoselective chelation-controlled Mukaiyama aldol reaction of a benzyl-protected aldehyde and a Yamaguchi lactonisation of a δ-hydroxy-trans-α,β-unsaturated carboxylic acid, is an alternative synthetic strategy towards cryptocaryalactones.
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423933/phytochemical-composition-and-biological-activities-of-artemisia-quettensis-podlech-ethanolic-extract
#3
Zahra Bagheri Farahani, Amir Mirzaie, Fatemeh Ashrafi, Maryam Rahimpour Hesari, Ali Chitgar, Hassan Noorbazargan, Arian Rahimi
The present study aim to investigate the phytochemical composition, antibacterial, antioxidant and anticancer activities of the ethanolic extract from aerial parts of Artemisia quettensis Podlech. The aerial part of A. quettensis Podlech extract was used for Gas chromatography-mass spectrometry (GC-MS) analysis, antioxidant, antibacterial and anticancer activities. GC/MS analysis of extract from this plant showed 23 major components and the most dominant components were acetic acid, [4-(1-hydroxy-1-methylethyl) cyclohex-1-enyl] methyl ester (13...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423926/antibacterial-activity-of-a-triterpenoid-saponin-from-the-stems-of-caesalpinia-pulcherrima-linn
#4
Nidhi Asati, R N Yadava
A new compound 1 was isolated from the methanolic extract of the stems of the Caesalpinia pulcherrima Linn. along with a reported compound (2) 3-O-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester. The new compound 1 has m.p. 272-274°C, m.f. C46H74O17, [M](+) m/z 898. It was characterised as 3-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl hederagenin 28-O-β-D- xylopyranosyl ester by various colour reactions, chemical degradations and spectral analyses...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423925/antioxidant-and-alpha-glucosidase-inhibitory-activities-of-isoflavonoids-from-the-rhizomes-of-ficus-tikoua-bur
#5
Guangmiao Fu, Wenjuan Li, Xiangzhong Huang, Runzhi Zhang, Kai Tian, Shuqun Hou, Yukui Li
A new unique isoflavone derivatives with a cyclic-monoterpene-substituent, ficusin C (1), together with five known compounds (2-6), were isolated from the rhizomes of Ficus tikoua. Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analysis and comparison with literature data of related compounds. Antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay and α-glucosidase inhibitory experiment, respectively...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423923/a-new-wortmannine-derivative-from-a-tripterygium-wilfordii-endophytic-fungus-talaromyces-wortmannii-lgt-4
#6
Jing-Yun Sun, Zhong-Duo Yang, Guang-Chao Fu, Yong-Gang Wang, Hong-Yan Xue, Zong-Mei Shu
A new wortmannine derivative named wortmannine E (1) was isolated from Talaromyces wortmannii LGT-4, an endophytic fungus of Tripterygium wilfordii. Its structure was established by 1D and 2D NMR spectra.
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423921/phytochemical-investigations-and-evaluation-of-antimutagenic-activity-of-the-alcoholic-extract-of-glycosmis-pentaphylla-and-tabernaemontana-coronaria-by-ames-test
#7
Ashish Kumar, Nilanjana Banerjee, Venugopal Singamaneni, Sudheer K Dokuparthi, Tulika Chakrabarti, Sibabrata Mukhopadhyay
Chemical investigation of root bark of Glycosmis pentaphylla and stem bark of Tabernaemontana coronaria led to the isolation of three carbazole alkaloids glycozoline, glycozolidine and methyl carbazole 3-carboxylate, two furoquinoline alkaloids skimmianine and dictamine, an acridone alkaloid arborinine, three monomeric indole alkaloids coronaridine, 10-methoxy coronaridine and tabernaemontanine, and two dimeric indole alkaloids voacamine and tabernaelegantine B. Their structures were established by detailed spectral analysis...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423915/isolation-of-flavonoids-from-apple-peel-using-novel-graphene-oxide-cotton-fiber
#8
Z Xu, R Peng, X Chen, R Ghosh, H P V Rupasinghe
A novel graphene oxide cotton fibre (GOF) was used to adsorb flavonoids from crude ethanol extracts derived from apple peels. Ultra-high pressure liquid chromatography-mass spectrometry was used to analyse polyphenol content, and the resulting data demonstrated that GOF-based flash chromatography can be used to efficiently separate polyphenols from sugars and can facilitate the removal of 95% of the sugar content. Flavonoids can be easily separated from phenolic acids. Chalcones and flavonols were eluted with 100% methanol and subsequently flavan-3-ols can be eluted with 0...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423912/antifungal-activity-of-cinnamic-acid-and-benzoic-acid-esters-against-candida-albicans-strains
#9
Tamires C Lima, Alana R Ferreira, Daniele F Silva, Edeltrudes O Lima, Damião P de Sousa
Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure-Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28421828/jasmonic-acid-changes-the-composition-of-essential-oil-isolated-from-narrow-leaved-lavender-propagated-in-in-vitro-cultures
#10
D Andrys, M Adaszyńska-Skwirzyńska, D Kulpa
The aim of the present study was to determine the effect of jasmonic acid added to the culture medium on composition of Lavandula angustifolia essential oils. The chemical composition was determined by gas chromatography coupled to mass detector (GC/MS). The experiment was conducted with the use of MS medium supplemented with increasing concentration of JA (0.2, 0.5, 1, 1.5 mg∙dm(-3)). It was found that the analysed essential oils varied in terms of chemical composition depending on the content of JA in the medium...
April 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28415854/new-phenolic-acids-from-salvia-yunnanensis-c-h-wright
#11
Yun Yu, Yin-Ru Wang, Zhen-Huan Dong, Wei Li, Shu-Ming Li, Xue-Feng Huang
Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl pro-lithospermate (2) were isolated from Salvia yunnanensis C.H.Wright, along with nineteen known compounds (3-21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14-16 were firstly isolated from S. yunnanensis C.H.Wright. Some of the isolated compounds were evaluated for their neuroprotection...
April 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28415850/a-new-iridoid-glycoside-from-the-fruits-of-vitex-rotundifolia
#12
Yuan-Yu Zhao, Lian Guo, Lan-Jie Cao, Jian Zhang, Zhi-Qi Yin
One new iridoid glycoside, 6',10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the first time from this plant. Their structures were elucidated by spectral analysis and by comparison with literature data. Furthermore, some of the isolated compounds were evaluated for their cytotoxicities against A549 and HepG-2 cell lines using MTT assay, and only compounds 9 and 10 exhibited potent cytotoxic activity with IC50 values of 13 ± 4 and 35 ± 10 μM against HepG-2 cell lines...
April 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28415847/synthesis-and-antitumour-activity-of-arctigenin-amino-acid-ester-derivatives-against-h22-hepatocellular-carcinoma
#13
Enbo Cai, Shijie Guo, Limin Yang, Mei Han, Jing Xia, Yan Zhao, Xiaorui Gao, Yu Wang
Arctigenin (ARG) is famous in its abundant pharmacological activity. However, many researches in it entered the bottleneck period because of its poor water solubility. The derivatives of ARG have been synthesised with five amino acids which have t-Butyloxy carbonyl (BOC) as a protective group. We examined the effects of removing BOC. The results showed that the amino acid derivatives without protective group have better water solubility and nitrite-clearing ability than ARG. Based on these results, ARG6' and ARG9' were selected at a dosage of 40 mg/kg to evaluate their antitumour activity...
April 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412869/a-novel-salvialactomine-from-the-callus-culture-of-salvia-santolinifolia-boiss
#14
Tour Jan, Raiha Qadri, Beena Naqvi, Achyut Adhikari, Said Nadeem, Akhtar Muhammad
A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D-NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412859/determination-and-quantification-of-carotenoids-in-sea-sponges-raspaciona-aculeata-and-dictyonella-marsilii-present-in-the-ganzirri-lake-messina-italy
#15
Andrea Salvo, Daniele Giuffrida, Archimede Rotondo, Paolo De Pasquale, Giovanna Loredana La Torre, Giacomo Dugo
Considering the crucial role of carotenoids exploitable both as nutraceuticals and also as dyes in food industry, there are many efforts in seeking for new sources of these pigments, especially in the marine world. In this study, for the first time, we extracted carotenoids from sea sponges Raspaciona aculeata and Dictyonella marsilii taken from Ganzirri Lake Messina (Italy). The determination and quantification of carotenoids was made by UPLC-PDA-MS. Remarkable results concern renieratene content in R. aculeate found to be over 2570 ppm...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412858/profile-of-lipophilic-antioxidants-in-the-by-products-recovered-from-six-cultivars-of-sour-cherry-prunus-cerasus-l
#16
Vitalijs Radenkovs, Daina Feldmane
The content of tocochromanols and carotenoids in kernels recovered from fruit pits of six sour cherry (Prunus cerasus L.) cultivars was studied. The highest concentration was noted for γ-T (23.50-52.76 mg/100 g dry weight basis (dw)). Considerably, lower amounts compared to γ-T were detected for α-T, δ-T and α-T3 (5.74-13.33, 2.74-4.54 and 0.30-1.16 mg/100 g dw, respectively). The β-T and γ-T3 were quantified only in minor levels. The total amount of tocochromanols was in the range 41.69-63.48 mg/100 g dw...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412844/compounds-with-inhibitory-activity-on-peristalsis-from-the-seeds-of-holarrhena-antidysenterica
#17
Hai-Hua Xie, Jian Su, Xiao-Lei Ge, Ting-Ting Dong, Xin Li, Hui-Min Wen, Bo-Hang Sun
Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1) was identified as a new compound, compounds 2-3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds 4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412842/four-new-sesquiterpenoids-from-sphaeranthus-indicus
#18
Lakshma Reddy Emani, Suryachandra Rao Ravada, Machi Raju Garaga, Bharani Meka, Trimurtulu Golakoti
Isolation and characterisation of two new eudesmanolides, 5α-hydroperoxy-7α-hydroxy-isosphaerantholide (1) and (11α,13-dihydro-7α-hydroxyfrullanolide-13-yl)-adenine (2) from the flower heads of Sphaeranthus indicus are described. In addition, 5α-hydroxy-isosphaerantholide (3) and 11α,13-dihydro-eudesman-3,5,7-triene-6α-12-olide (4) are reported first time as a metabolite of S. indicus and as a natural product, respectively. The structures of these compounds were established from rigorous analysis of their high-resolution mass, IR, UV, (1)H NMR, (13)C NMR and 2D NMR spectral data...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412841/a-new-pyranoxanthone-from-garcinia-nervosa
#19
Ka Woong Wong, Gwendoline Cheng Lian Ee, Intan Safinar Ismail, Thiruventhan Karunakaran, Vivien Yi Mian Jong
Phytochemical studies on the stem bark of Garcinia nervosa has resulted in the discovery of one new pyranoxanthone derivative, garner xanthone (1) and five other compounds, 1,5-dihydroxyxanthone (2), 6-deoxyisojacareubin (3), 12b-hydroxy-des-D-garcigerrin A (4) stigmasterol (5), and β-sitosterol (6). The structures of these compounds were elucidated with the aid of spectroscopic techniques, such as NMR and MS. The crude extracts of the plant were assessed for their antimicrobial activity.
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412840/anti-proliferative-and-pro-apoptotic-effects-of-cinobufagin-on-human-breast-cancer-mcf-7-cells-and-its-molecular-mechanism
#20
Ling Zhu, Yuxin Chen, Cheng Wei, Xi Yang, Jing Cheng, Zhimin Yang, Chuanrong Chen, Zhaoning Ji
Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited obvious cytotoxicity on MCF-7 cells in a dose- and time-dependent manner, as indicated by CCK-8 assays. Also, Hoechst 33258 staining and flow cytometry assays showed that CBF strongly induced MCF-7 cell apoptosis and G1 phase arrest...
April 17, 2017: Natural Product Research
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