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Natural Product Research

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https://www.readbyqxmd.com/read/28820275/in-vitro-anti-acne-activity-of-phytoactives-from-the-stem-bark-of-artocarpus-hirsutus-lam-and-characterisation-of-pyranocycloartobiloxanthone-a-as-a-mixture-of-two-anomers
#1
Mahadeva Nayak, A Nagarajan, Muhammed Majeed, Kalyanam Nagabhushanam, Ambar K Choudhury
This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were determined by NMR and MS spectroscopic analysis. The present study is the first to report compound 1 as a mixture of two anomers (α and β), approximately 70:30 ratio. Both compounds 1 and 2 were isolated for the first time from this plant...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817985/rapid-characterisation-and-identification-of-compounds-in-saposhnikoviae-radix-by-high-performance-liquid-chromatography-coupled-with-electrospray-ionisation-quadrupole-time-of-flight-mass-spectrometry
#2
Luxiao Chen, Xiangyang Chen, Lei Su, Yanyan Jiang, Bin Liu
Saposhnikoviae Radix (SR), the dried root of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae), is commonly used as a traditional Chinese medicine. In this study, a rapid and accurate method was firstly, developed for the qualitative analysis of SR by high-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS/MS). A total of 45 compounds were identified or tentatively characterised, including 13 chromones, 28 coumarins and four others...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817984/study-on-optimizing-dyeing-of-cotton-using-date-pits-extract-as-a-combined-source-of-coloring-matter-and-bio-mordant
#3
Ahlem Guesmi, Naoufel Ben Hamadi
In this research, extraction of colouring matter from date pits powder was conferred by conventional and ultrasonic methods. Phenolic compounds present in the resulted extract were identified by HPLC analysis. Total phenolic, total flavonoid and total metallic contents were quantified; and the highest levels were obtained in case of ultrasonic extraction process at a frequency of 25 kHz. The different resultant extracts were diluted with distilled water and unified to a polyphenolic content of 48 mg per 100 mL...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817970/three-new-cassane-diterpenes-from-the-seeds-of-caesalpinia-minax-hance
#4
Qin Liu, Bai Bai, De-Po Yang, Shi-Yi Peng, Long-Ping Zhu, Mai-Hui Luo, Zhi-Min Zhao
Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation led to the isolation of three new cassane diterpenes, caesalmin X (1), caesalmin Y (2) and caesalmin Z (3), together with 19 known cassane diterpenoids (4-22). Their structures were mainly characterised on the basis of extensive spectroscopic analyses and comparison with reported data...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817968/destabilizing-the-interplay-between-mir-1275-and-igf2bps-by-tamarix-articulata-and-quercetin-in-hepatocellular-carcinoma
#5
Yasmin M Shaalan, H Handoussa, R A Youness, R A Assal, A H El-Khatib, M W Linscheid, H M El Tayebi, A I Abdelaziz
Insulin-like growth factor-2 binding proteins (IGF2BPs) are oncogenic RNA-binding proteins, highly up-regulated in HCC, and were recently validated as direct targets of the tumour suppressor miR-1275. It is worth noting that around 47% of FDA approved anticancer drugs are derived from plants. Modulation by miRNAs and their cellular signalling cascades could constitute new pathways by which these phytochemicals exert their effects. This study aimed to investigate the potential use of Tamarix articulata, quercetin and epigallocatechin gallate (EGCG) in HCC and how these phytochemicals could epigenetically modulate the IGF axis using their impact on miR-1275...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817965/trametes-versicolor-ethanol-extract-a-promising-candidate-for-health-promoting-food-supplement
#6
Ljiljana Janjušević, Boris Pejin, Sonja Kaišarević, Stanislava Gorjanović, Ferenc Pastor, Kristina Tešanović, Maja Karaman
This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O2(•-) and NO(•) (29.62 and 52.48 μg/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28814124/comparative-metabolic-profiling-of-costus-speciosus-leaves-and-rhizomes-using-nmr-gc-ms-and-uplc-esi-ms-ms
#7
Ashish Kumar, Antim K Maurya, Gopi Chand, Vijai K Agnihotri
Costus speciosus had been used in oriental systems of medicines, to treat diverse ailments. The present study was focused on NMR, GC-MS and UPLC/ESI-MS/MS-based metabolic profiling of C. speciosus. This metabolic study resulted in the identification of 91 and quantification of 69 metabolites. Caffeic acid derivatives previously unreported in C. speciosus were also identified. High quantity of steroidal saponins namely methyl protogracillin (297.97 ± 0.07 mg/g dried wt.) and dioscin (158.72 ± 0.27 mg/g dried wt...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28814115/neuraminidase-inhibitory-activity-by-compounds-isolated-from-aerial-parts-of-rhinacanthus-nasutus
#8
Hee Jae Kwak, SeonJu Park, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Youngse Oh, Nguyen Xuan Nhiem, Seung Hyun Kim
Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of various diseases, such as cancer, fungal infections, herpes virus infections and several types of skin diseases in South-East Asian countries. In this study, eight compounds 1-8 were isolated from the aerial parts of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D and 2D NMR. The isolated compounds were evaluated for neuraminidase inhibitory activity. Several lignans, 2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol (5) and 8,8'-bisdihydrosiringenin glucoside (6), significantly inhibited neuraminidase activity, which was comparable to the positive controls, mangiferin and oseltamivir...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28814106/cameroonian-medicinal-plants-belonging-to-annonaceae-family-radical-scavenging-and-antifungal-activities
#9
Marguérite Kamdem Simo, Mireille Dongmo Nguepi, Modeste Lambert Sameza, Rufin Kouipou Toghueo, Fabrice Boyom Fekam, Guglielmina Froldi
The free-radical scavenging activity of ethanolic and methanolic extracts of leaves, stems and roots of Annona muricata, Monodora tenuifolia, Uvaria comperei, Uvaria muricata and Xylopia africana was evaluated using DPPH and ORAC assays. Further, phytochemical analysis, total phenolic and total flavonoid contents were also determined. Moreover, the antifungal activity of extracts was studied. The findings indicated that A. muricata and U. comperei extracts own antiradical activities and moderate antifungal properties...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28814101/antioxidative-sulphated-polygalactans-from-marine-macroalgae-as-angiotensin-i-converting-enzyme-inhibitors
#10
Fasina Makkar, Kajal Chakraborty
Antioxidant and antihypertensive potential of the sulphated polygalactans isolated from the marine macroalgae Kappaphycus alvarezii and Gracilaria opuntia were assessed by utilising different in vitro systems. The galactans isolated from K. alvarezii possessed significantly greater antioxidative properties as determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH IC90 0.97 mg/mL) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS(.+) IC90 0.72 mg/mL) scavenging activities than those isolated from G...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28812370/rauvolfianine-a-new-antimycobacterial-glyceroglycolipid-and-other-constituents-from-rauvolfia-caffra-sond-apocynaceae
#11
Robert Ebeh Messanga, Ngono Bikobo Dominique Serge, Auguste Abouem A Zintchem, Mbabi Nyemeck Ii Norbert, Moni Ndedi Esther Del Florence, Betote Diboué Patrick Hervé, Nyegue Maximilienne Ascension, Atchadé Alex De Théodore, Pegnyemb Dieudonné Emmanuel, Bochet Christian G, Ulrich Koert
The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most active (MIC = 7...
August 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28812369/two-new-cassane-diterpene-lactams-from-the-fruits-of-caesalpinia-mimosoides-lam
#12
Dewen Bi, Guanghui Xia, Yuanping Li, Xuesong Liang, Lanjun Zhang, Liqin Wang
Two new cassane ditepenoid lactams, caesmimotam A (1) and B (2), along with eight known compounds (3-10) were isolated from the fruits of Caesalpinia mimosoides Lam. Their structures were identified by 1D and 2D NMR spectral data. Compounds 1 and 2 were evaluated for their cytotoxicity on HL-60, SMMC-7721, A-549, MCF-7 and SW-480 human cancer cell lines, but they were inactive.
August 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28805461/a-new-caffeic-acid-tetramer-from-the-dracocephalum-moldavica-l
#13
Jun-Liang Zhang, Ren-Jie Yan, Ning Yu, Xue Zhang, Dai-Jie Chen, Tong Wu, Jian-Guo Xin
A new caffeic acid tetramer compound, named (+) methyl rabdosiin (4), together with seven known caffeic acid multimers (1-3, 5-8) and one caffeic acid monomer (9), were isolated from the aerial parts of Dracocephalum moldavica L. The structures of these compounds were assigned on the basis of 1D and 2D NMR spectroscopic and mass spectrometry analyses. The protective effects of compounds 2-4 against hydrogen peroxide (H2O2)-induced apoptosis were evaluated in primary cardiomyocytes of SD neonatal rats in vitro by the MTT method...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28805459/opuntia-ficus-indica-l-miller-as-a-source-of-bioactivity-compounds-for-health-and-nutrition
#14
M Aragona, E R Lauriano, S Pergolizzi, C Faggio
Plants with beneficial properties are known in traditional medicine. Nowadays, in spite of widespread availability of synthetic compounds, the search goes towards natural compounds to lower cost and few side effects. The increasing interest in preventive medicine encourages use of nutraceuticals, bioactive compounds of vegetable origin with important nutritional values. Among the medicinal plants, Opuntia ficus-indica (L.) Miller (Family Cactaceae, subfamily Opuntiodeae, Genus Opuntia, subgenus Platyopuntia, species Opuntia ficus-indica (L...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28805453/colletotrichine-a-a-new-sesquiterpenoid-from-colletotrichum-gloeosporioides-gt-7-a-fungal-endophyte-of-uncaria-rhynchophylla
#15
Xiao-Wei Chen, Zhong-Duo Yang, Jian-Hui Sun, Tong-Tong Song, Bao-Ying Zhu, Jun-Wen Zhao
One new compound, Colletotrichine A (1), was produced by the fungal Colletotrichum gloeosporioides GT-7. The structure was established by 1D and 2D NMR spectra. Monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitory activity of 1 was also evaluated. Compound 1 showed AChE-inhibiting activity with IC50 value of 28 μg/mL.
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28805446/epigallocatechin-gallate-as-an-anti-obesity-therapeutic-compound-an-in-silico-approach-for-structure-based-drug-designing
#16
Muhammad Shahid Javaid, Noreen Latief, Bushra Ijaz, Usman Ali Ashfaq
Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential. It was investigated that epigallocatechin gallate stopped the adipogenic differentiation of mice mesenchymal stem cells but its underlying mechanism is not well understood. Different proteins and transcription factors responsible for differentiation of adipocytes could be its targets. This study was designed to determine the potential target of epigallocatechin gallate in human...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28793804/a-new-rearranged-abietane-diterpene-from-clerodendrum-inerme-with-antioxidant-and-cytotoxic-activities
#17
Le Ba Vinh, Nguyen Thi Minh Nguyet, Seo Young Yang, Jang Hoon Kim, Le Thi Vien, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh, Inkyu Hwang, Young Ho Kim
Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated...
August 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28786310/new-asymmetrical-bispyrrolidinoindoline-diketopiperazines-from-the-marine-fungus-aspergillus-sp-dx4h
#18
Jinzhong Xu, Qian Hu, Wanjing Ding, Pinmei Wang, Yanan Di
Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their inhibitory activity against PC3 cell line had been tested.
August 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28783983/mechanisms-underlying-the-cytotoxic-effect-of-propolis-on-human-laryngeal-epidermoid-carcinoma-cells
#19
Yahima Frión-Herrera, Alexis Díaz-García, Jenny Ruiz-Fuentes, Hermis Rodríguez-Sánchez, José Maurício Sforcin
Propolis has been used as a traditional remedy for centuries because of its beneficial effects, including anticancer properties. The aim of this study was to compare the cytotoxic mechanism of Cuban red propolis (CP) and Brazilian green propolis (BP) on human laryngeal carcinoma (HEp-2) cells. Cell viability, leakage of lactate dehydrogenase, fluorescence staining, mitochondrial membrane potential (ΔΨm) and the expression of pro/anti-apoptotic genes were assessed. Cell viability and cytotoxic assays suggested a dose-dependent effect of CP and BP extracts with a possible association of intracellular reactive oxygen species production and decreased ΔΨm...
August 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28783981/isolation-and-validated-hptlc-analysis-of-four-cytotoxic-compounds-including-a-new-sesquiterpene-from-aerial-parts-of-plectranthus-cylindraceus
#20
Musarat Amina, Perwez Alam, Mohammad K Parvez, Nawal M Al-Musayeib, Samerah A Al-Hwaity, Nada S Al-Rashidi, Mohammed S Al-Dosari
We report isolation of a new sesquiterpene (compound 2: plectranol A) along with three known compounds (1: maaliol, 3: penduletin and 4: chrysosplenol D) from the aerial parts of Plectranthus cylindraceus Hoechst. Ex. Benth ethyl acetate extract (PCEAE). Their structures were established by UV, IR, NMR ((1)H & (13)C), HRESIMS and HSQC methods. The MTT cell proliferation assay of the compounds and the extract performed on human breast, skin and cervical cancer cell lines showed high toxicity, and their IC50 (μg/mL) values were determined...
August 8, 2017: Natural Product Research
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