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Natural Product Research

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https://www.readbyqxmd.com/read/29783892/applying-the-hydrodistillation-process-to-pentadiplandra-brazzeana-baill-root-a-chemical-assessment
#1
Maximilienne Ascension Nyegue, Sabine Montaut, Gina Rosalinda De Nicola, Patrick Rollin, Chantal Menut
A chemical study of the volatile components obtained by applying the hydrodistillation and reflux processes to Pentadiplandra brazzeana roots was performed by GC-FID and GC-MS. The hydrodistillation process showed a total yield of 0.97% with 0.11% of essential oil and 0.86% of volatile compounds from the aqueous reaction medium; in the reflux process, the volatile extract yield was 1.03%. Benzylic-type isothiocyanates were the major degradation products of glucosinolates in the essential oil (95.0%); the CH2 Cl2 extracts obtained from the aqueous solutions were characterised by alcohols and amines in both processes...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781313/anti-proliferative-diterpenes-from-dacrycarpus-imbricatus
#2
Nguyen Thanh Tam, Tran Duc Quan, Dang Viet Hau, Nguyen Thi Hoang Anh, Thi Thanh Thuy Tran, Nguyen Hoang Sa, Dao Duc Thien, Le Thi Hong Nhung, Dinh Thi Phong, Sabrina Adorisio, Domenico V Delfino, Trinh Thi Thuy
A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3-6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781312/diterpenoid-alkaloids-from-delphinium-naviculare-var-lasiocarpum-with-their-antifeedant-activity-on-spodoptera-exigua
#3
Lianhai Shan, Lin Chen, Feng Gao, Xianli Zhou
A new lycoctonine diterpenoid alkaloid navicularine, along with eighteen known diterpenoid alkaloids, were isolated from the whole plant of Delphinium naviculare var. lasiocarpum. Their structures were elucidated on the base of extensive spectroscopic analysis (HR-ESI-MS and NMR) and comparison with data reported in the literature. Most of alkaloids were tested for their antifeedant activity against larvae of Spodoptera exigua (Hübner). The compound shawurensine showed considerably potent antifeedant activity (EC50 = 0...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781307/anti-pseudomonas-aeruginosa-activity-of-hemlock-conium-maculatum-apiaceae-essential-oil
#4
Michela Di Napoli, Mario Varcamonti, Adriana Basile, Maurizio Bruno, Filippo Maggi, Anna Zanfardino
Conium maculatum is a nitrophilous weed belonging to the Apiaceae family and occurring in hedgerows, pastures, waste ground, along rivers and roadsides. Little is known on the chemistry and bioactivity of other secondary metabolites occurring in the plant. In the present work, we have analysed the chemical composition and antimicrobial activity of the essential oils hydrodistilled from leaves and inflorescenes of C. maculatum growing in Sicily, Italy. The composition of essential oils was achieved by gas chromatography-mass spectrometry (GC-MS) analysis, whereas the inhibitory effects on the growth of two Gram negative strains, namely Escherichia coli and Pseudomonas aeruginosa were assessed by two different analysis...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781304/a-phytochemical-study-of-the-cuphea-glutinosa-from-southern-brazil-na-k-atpase-activity-inhibition-and-antioxidant-properties
#5
Adriana M Zago, Fabiano B Carvalho, Jessié Martins Gutierres, Crystiani Bohnert, Marilda da Cruz Fernandes, Liziane M Morandini, Helena S Coelho, Aline O Fogaça, Cinthia M Andrade, Marco A Mostardeiro, Ionara I Dalcol, Ademir F Morel
This study investigated the antioxidant activity of Cuphea glutinosa (CG) and its effect on Na+ , K+ -ATPase from cardiac muscle. The ethanolic extract showed higher antioxidant capacity compared to aqueous and ethyl acetate fraction. Ethyl acetate fraction showed β-sitosterol-3-O-β-glucoside, kaempferol, quercetin, isoquercetin, gallic acid methyl ester, and gallic acid. The ethanolic extract also reduced the Na+ ,K+ -ATPase activity. CG presented a promising antioxidant activity and inhibitory effect on the Na+ , K+ -ATPase activity, supporting biochemical evidences the popular use of this plant in the treatment of heart failure...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781303/lavandula-x-intermedia-and-lavandula-angustifolia-essential-oils-phytochemical-composition-and-antimicrobial-activity-against-foodborne-pathogens
#6
Roberta Tardugno, Annalisa Serio, Federica Pellati, Serena D'Amato, Clemencia Chaves López, Maria Grazia Bellardi, Maura Di Vito, Vincenzo Savini, Antonello Paparella, Stefania Benvenuti
Four cultivars (cv) of Lavandula x intermedia ('Abrialis', 'Alba', 'Rinaldi Ceroni' (R.C.) and 'Sumiens') were cultivated in Italy and their essential oils (EOs) were distilled from Alfalfa Mosaic Virus-free plants. These EOs and one from L. angustifolia Miller were chemically characterised by GC-MS and GC-FID. Antimicrobial activity was evaluated against Listeria monocytogenes (24 strains) and Salmonella enterica (10 food strains). Minimal inhibitory concentrations (MIC) ≥ 10.0 μL/mL inhibited Salmonella (cv 'R...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781300/quaternary-ammonium-compounds-in-roots-and-leaves-of-capparis-spinosa-l-from-saudi-arabia-and-italy-investigation-by-hplc-ms-and-1-h-nmr
#7
Amal Al-Tamimi, Mohamad Khatib, Giuseppe Pieraccini, Nadia Mulinacci
Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in protecting against abiotic stress. Aim of this work was to determine QACs in root and leaves of caper from two proveniences. The presence of stachydrine, choline, glycine betaine and homo-stachydrine has been confirmed by high resolution MS, while 1 H NMR was applied to quantify the main QACs in the aqueous extracts...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781299/anticyanobacterial-phenolic-constituents-from-the-aerial-parts-of-eupatorium-fortunei-turcz
#8
Thanh Nga Pham, Huu Dien Pham, Dinh Kim Dang, Thi Thuy Duong, Thi Phuong Quynh Le, Quang Duong Nguyen, Dat Nguyen Tien
Four thymol derivatives and two phenolic compounds were isolated from the aerial parts of Eupatorium fortunei. The new structures were elucidated to be 7,8,9-trihydroxythymol (1), and 8,10-didehydro-7,9-dihydroxythymol (2) by means of MS and NMR analysis. The known compounds were identified as 8,9,10-trihydroxythymol (3), 10-acetoxy-8,9-dihydroxythymol (4), o-coumaric acid (5) and 4-(2-hydroxyethyl)benzaldehyde (6). Compound 3 showed strongest inhibitory effect on the growth of Microcystis aeruginosa in comparison with CuSO4 ...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781298/treatment-of-dental-biofilm-with-a-tincture-of-bauhinia-forficata-leaves-an-ex-vivo-study
#9
Julio Cesar C Ferreira-Filho, Andressa Temperini de Oliveira Marre, Juliana Soares de Sá Almeida, Leandro Araújo Lobo, Adriana Farah, Ana Maria Gondim Valença, Andréa Fonseca-Gonçalves
The inhibitory activity of a Bauhinia forficata tincture (TBF) was investigated against oral microorganism's strains and against a mature oral biofilm. The viability of planktonic cells was analyzed by Minimal Inhibitory and Microbicidal concentrations of TBF. Salivary samples from health volunteers were collected and mixed to form a saliva pool. An aliquot from this pool were seeded on membranes, which were incubated to form biofilm (48 h). The biofilm was treated according to the groups: G1-Chlorhexidine 0...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781297/degradation-kinetic-d-100-of-lycopene-during-the-thermal-treatment-of-concentrated-tomato-paste
#10
Nadia Manzo, Antonello Santini, Fabiana Pizzolongo, Alessandra Aiello, Raffaele Romano
Heat treatments can cause degradation in tomatoes of lycopene which has important antioxidant effects. No information about decimal reduction time (D100 ) of lycopene is available. D-value is the time required at a given temperature to reduce 90% of the molecule. This study for the first time determine the kinetic of lycopene thermal degradation. The content was measured at regular intervals of pasteurization using canned tomato paste to determinate D value. Microbiological analysis was carried out to verify product stability after packaging...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29781296/variation-in-essential-oil-composition-of-teucrium-hircanicum-l-from-iran-a-rich-source-of-e-%C3%AE-bergamotene
#11
Mohammad Ali Rahimi, Vahideh Nazeri, Seyed Ali Andi, Fatemeh Sefidkon
In present work, the chemical composition of the essential oils obtained from dried flowering aerial parts of Teucrium hircanicum L. (Labiatae) originated from ten wild populations in Iran was analyzed by a GC-FID and GC/MS system. The oil yields varied from 0.04% to 0.1%. A total of thirty-two compounds representing 67.6-97.7% of the oil were identified. The essential oil was found to be rich in sesquiterpene hydrocarpons (E)-α-bergamotene (17.5-86.9%) and (E)-β-farnesene (0.5-21.4%). Of the total identified compounds, sesquiterpene hydrocarpons (36...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29772948/a-new-isoflavane-4-ol-derivative-from-melilotus-officinalis-l-pall
#12
Mert Ilhan, Zulfiqar Ali, Ikhlas A Khan, Esra Küpeli Akkol
A new isoflavane derivative, melilofficinaside together with seven other metabolites including coumarin, uridine, methyl-α-d-fructofuranoside, and flavonoid glucosides were isolated from the aerial parts of Melilotus officinalis (L.) Pall.
May 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29772944/hilic-ms-ms-determination-of-amino-acids-in-herbs-of-fumaria-schleicheri-l-ocimum-basilicum-l-and-leaves-of-corylus-avellana-l
#13
Yuliya Prokopenko, Valdas Jakštas, Vaidotas Žvikas, Victoriya Georgiyants, Liudas Ivanauskas
The aim of research was to study the content of amino acids using in extracts of Fumaria schleicheri L., Ocimum basilicum L., and Corylus avellana L. by HILIC MS/MS method. Separation of amino acids in the samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with SeQuant ZIC-Hilic collumn (2.1 × 150 mm, 3.5 μm) (Merck Millipore, Darmstadt, Germany). The MS/MS fragment ion chromatograms of the test solutions established the presence of 19 amino acids. The obtained results have shown that O...
May 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29772929/new-cembrane-type-diterpenoids-from-bornean-soft-coral-nephthea-sp-with-antifungal-activity-against-lagenidium-thermophilum
#14
Kazuki Tani, Takashi Kamada, Chin-Soon Phan, Charles Santhanaraju Vairappan
Three new cembrane diterpenes, nephthecrassocolides A-B (1-2) and 6-acetoxy nephthenol acetate (3) along with three known compounds, 6-acetoxy-7,8-epoxy nephthenol acetate (4), epoxy nephthenol acetate (5) and nephthenol (6) were isolated from one population of Nephthea sp. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1-6 were evaluated.
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29772923/carbazole-alkaloids-from-clausena-emarginata-with-their-potential-antiproliferative-activities
#15
Yan-Hui Fu, Yan-Lei Ma, Gui Yan, Qing Wen, Shi Hu, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Ping Liu
A phytochemical investigation on the stems and leaves of Clausena emarginata led to the isolation of a previously undescribed carbazole alkaloid, clausemargine A (1), together with 11 known analogues (2-12). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-12) were isolated from C. emarginata for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29770716/new-pyrazinoquinazoline-alkaloids-isolated-from-a-culture-of-stenotrophomonas-maltophilia-qb-77
#16
Sheng-Yan Qian, Cai-Ling Yang, Afsar Khan, Rong-Xiang Chen, Ming-Song Wu, Li Tuo, Qian Wang, Jian-Guo Liu, Gui-Guang Cheng
Two new pyrazinoquinazoline alkaloids, epi-fiscalin D (1) and epi-fiscalin E (2), as well as three known analogues, norquinadoline A (3), quinadoline A (4), and fiscalin C (5), were isolated from ethyl acetate extract of the fermentation broth of Stentrophomonas maltophilia QB-77. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis including UV, HRESIMS, and 1D and 2D NMR experiments. All the isolated compounds were tested for their in vitro cytotoxicity against five human cancer cell lines (SMMC-7721, MCF-7, HL-60, SW480, and A-549) and antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus...
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29770713/component-composition-of-the-extracts-and-essential-oils-from-the-alhagi-canescens-growing-in-uzbekistan-and-their-antimicrobial-activity
#17
Sabir Nishanbaev, Khayrulla Bobakulov, Bakhodir Okhundedaev, Sobirdjan Sasmakov, Elvira Yusupova, Shakhnoz Azimova, Nasrulla Abdullaev
The volatile compounds of hexane, benzene extracts and essential oils (EOs) isolated by steam- and hydrodistillation methods from aerial part of Alhagi canescens were studied by GC-MS analysis. Seventeen components were found in the hexane and benzene extracts, among them palmitic acid (25.2 and 22.1%), neophytadiene (7.3 and 22.3%), cis-chrysanthenyl acetate (11.0% in benzene), cis-geranyl acetate (7.8% in benzene) were major components. The first time fifty-six volatile compounds were identified in the EOs and camphor (5...
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29770711/two-new-aromadendrane-sesquiterpenes-from-verticillium-psalliotae
#18
A Qiu, Li-Zhi Dang, Pei-Ji Zhao, Ke-Qin Zhang, Guo-Hong Li
The chemical constituents of the fungus Verticillium psalliotae were studied. Two new aromadendrane sesquiterpenes inonotin M (1) and inonotin N (2) were isolated from the EtOAc extract of the fungal culture broth. The structures of compounds were elucidated mainly by HRESIMS experiments, and 1D, 2D-NMR spectroscopy analysis.
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29770710/convergent-synthesis-of-carpatamide-a-cytotoxic-arylamine-derivative-from-marine-derived-streptomyces-sp
#19
Rohani Prasad Burman, Shantanu Gupta, Jyoti Bhatti, Krishan Verma, Devendra Rajak, Manjinder Singh Gill
First total synthesis of carpatamide-A 7a, cytotoxic arylamine derivative isolated from marine derived Streptomyces sp., was achieved in twelve steps with overall yield of 24% with seven longest linear steps. In the penultimate step, dienoic acid 13 and an amino-phenylpropionic acid methyl ester core 21 were coupled to synthesize methylated derivativative of carpatamide-A 22 followed by demethylation of the intermediate with BBr3 to accomplish carpatamide-A 7a. Both precursors 13 and 21 were synthesized from readily available starting materials i...
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29768037/naturally-occurring-furofuran-lignans-structural-diversity-and-biological-activities
#20
Wen-Hui Xu, Ping Zhao, Meng Wang, Qian Liang
Furofuran lignans containing the 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane skeleton, represent one of the major subclasses of the lignan family of natural products. Furofuran lignans feature a wide variety of structures due to different substituents at aryl groups and diverse configurations at furofuran ring. Moreover, they exhibit a wide range of significant biological activities, including antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. This review summarizes source, phytochemistry, and biological activities of 137 natural furofuran lignans isolated from 53 species in 41 genera of 27 plant families for the last 20 years, which provides a comprehensive information for further research of these furofuran lignans as potential pharmaceutical agents...
May 16, 2018: Natural Product Research
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