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Natural Product Research

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https://www.readbyqxmd.com/read/28100074/antioxidant-capacity-and-identification-of-the-constituents-of-ethyl-acetate-fraction-from-rhus-verniciflua-stokes-by-hplc-ms
#1
Hongxia Chen, Chengzhang Wang, Hao Zhou, Ran Tao, Jianzhong Ye, Wenjun Li
Ethyl acetate fraction (EAF) from Rhus verniciflua Stokes is an important source of bioactive compounds. The aim of this study was the tentative identification and quantification of phenolic compounds, comparison of the phenolic structure-antioxidant activity relationships. Twelve compounds of EAF belonging to polyphenol types were detected by high performance liquid chromatography and analysed on line with negative ion electrospray ionisation tandem mass spectrometry, which were ethoxy 3-hydroxy benzoic acid, gallic acid (GA), 3,4-dihydroxy amygdalic acid, gallic acid cetyl ester, protocatechuic acid (PA), fustin, ethyl gallate (EG), garbanzol, fisetin, sulfuretin, butin and 3,7-dihydroxyflavanone-4'-rhamnoside...
January 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28095708/locational-comparison-of-essential-oils-from-selected-conifers-of-himachal-pradesh
#2
Shruti Sharma, Vinod Bhatt, Neeraj Kumar, Bikram Singh, Upendra Sharma
Nine samples of essential oil from needles of three conifers of Pinacea family namely Abies pindrow, Picea smithiana and Cedrus deodara collected from three different locations of Himachal Pradesh (India) were evaluated using gas chromatography and gas chromatography-mass spectrometry. A total of 31, 17 and 13 compounds were identified from essential oil of A. pindrow, P. smithiana and C. deodara, respectively. Among the characterised components, monoterpenoid hydrocarbons were predominated. α-Pinene, β-pinene, β-merycene, limonene and camphene were characterised as major components...
January 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28092983/essential-oil-constituents-and-antimicrobial-activity-of-pycnocycla-bashagardiana-mozaff-from-iran
#3
Ardalan Alizadeh, Hamid Abdollahzadeh
Pycnocycla bashagardiana is a rare endemic and endangered species that has been used in folkloric medicine in Southern Iran. This study aimed to evaluate the essential oil constituents and antimicrobial activity of wild and cultivated p. bashagardiana. The aerial parts of wild and cultivated plants were collected from two provinces of Iran. The essential oil was isolated by hydrodistillation and analyzed by a combination of capillary GC and GC-MS. The main components in wild plants were myristicin (39.12%), (E)-β-ocimene (21...
January 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28092975/characterisation-of-the-antiproliferative-constituents-and-activity-of-ficus-exasperata-vahl-on-ovarian-cancer-cells-a-preliminary-investigation
#4
Enitome E Bafor, Jennifer McKenna, Edward G Rowan, RuAngelie Edrada-Ebel
Ovarian cancer is one of the most common gynaecological cancers today. This study therefore investigates the anticancer effects of Ficus exasperata extracts and fractions on ovarian cancer cells. The antiproliferative activity of the crude extracts (1 mg/mL) was assessed using the MTT assay on A2780 (ovarian cancer) cell line. Bio-activity guided fractionation was performed and preliminary identification was further achieved using high resolution mass spectrometry and nuclear magnetic resonance spectroscopy...
January 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28081652/a-new-dimeric-stilbene-from-the-lianas-of-gnetum-parvifolium
#5
Li-Wen Tian, Jun-Jiang Lv, Yao Liu, Lu-Yao Song, Lian-Bing Hou, Cheng Zhong, Yang Xie
A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2-8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.
January 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28076999/iridoids-and-anti-inflammatory-properties-of-n-butanol-extract-of-linaria-tingitana-boiss-reut
#6
Mourad Hanfer, Thamere Cheriet, Souad Ameddah, Ines Mancini, Ramdane Seghiri, Ahmed Menad, Samir Benayache, Fadila Benayache
The analysis of the n-butanol extract of Linaria tingitana (BELT) by HPLC-DAD-ESI/MS allowed the identification of four iridoids structurally confirmed by NMR and ESI-MS/MS extensive experiments data. The subjection of BELT to the anti-inflammatory activity showed that it exhibited a concentration dependent stabilisation of HRBC membrane, inhibition of protein denaturation and nitric oxide scavenging effect in the in vitro process. These results were confirmed in the in vivo experiments which showed that BELT was found to be most pronounced at 200 mg/kg after carrageenan injection which significantly reduced the swelling in both early and late phases of carrageenan-evoked oedema, as well as a significant reduce at the accumulation of infiltrating cells, inhibition of the myeloperoxidase activity and suppressed the lipid peroxidation...
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28076987/antioxidant-activity-and-cholinesterase-inhibition-studies-of-four-flavouring-herbs-from-alentejo
#7
Sílvia Arantes, Andreia Piçarra, Fátima Candeias, A Teresa Caldeira, M Rosário Martins
Essential oils (EOs) and aqueous extracts of aerial parts of four aromatic species, Calamintha nepeta, Foeniculum vulgare, Mentha spicata and Thymus mastichina, from southwest of Portugal were characterised chemically and analysed in order to evaluate their antioxidant potential and cholinesterase inhibitory activities. The main components of EOs were oxygenated monoterpenes, and aqueous extracts were rich in phenol and flavonoid compounds. EOs and aqueous extracts presented a high antioxidant potential, with ability to protect the lipid substrate, free radical scavenging and iron reducing power...
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28076985/two-new-diketopiperazines-from-the-tin-mine-tailings-derived-fungus-schizophyllum-commune-yim-dt-10058
#8
Wei-Xun Chunyu, Zhang-Gui Ding, Jiang-Yuan Zhao, Yong-Xia Wang, Xiu-Lin Han, Ming-Gang Li, Meng-Liang Wen
Two new diketopiperazines, named diphenylalazine C (1) and epicoccin U (2), together with six known compounds (3-8) were isolated from the EtOAc extract of the fermentation broth of the tin mine tailings-derived fungus Schizophyllum commune YIM DT 10058. Their structures were elucidated by detailed analysis of spectroscopic data and comparison with related known compounds. Compounds 1 and 2 exhibited weak antibacterial and cytotoxic activities.
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28074665/diterpenoid-alkaloids-from-the-root-of-aconitum-sinchiangense-w-t-wang-with-their-antitumor-and-antibacterial-activities
#9
Xiaoxia Liang, Lan Chen, Lei Song, Wenbo Fei, Min He, Changliang He, Zhongqiong Yin
A phytochemical study of the root barks of Aconitum sinchiangense W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C19-diterpenoid alkaloid, sinchiangensine A (1), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue 3 were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC50 comparable to cisplatin, and significant antibacterial activities against Staphylococcus aureus ATCC-25923 with MIC value of 0...
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28068859/isolation-and-characterisation-of-cytotoxic-compounds-from-euphorbia-clementei-boiss
#10
Abbes Benmerache, Abdulmagid Alabdul Magid, Amira Labed, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Jane Hubert, Hamid Morjani, Zahia Kabouche
A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses ((1)H and (13)C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC50 values ranging from 40 to 97 μM...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28068850/a-new-monoterpenoid-indole-alkaloid-from-ochrosia-elliptica
#11
A-Hong Chen, Qing-Long Liu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Ping Liu, Guang-Ying Chen, Yan-Hui Fu, Wei Xu
A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2-5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC50 values comparable to those of cisplatin...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28068844/hierarchical-cluster-analysis-and-chemical-characterisation-of-myrtus-communis-l-essential-oil-from-yemen-region-and-its-antimicrobial-antioxidant-and-anti-colorectal-adenocarcinoma-properties
#12
Sirajudheen Anwar, Rebecca A Crouch, Nasser A Awadh Ali, Mohamed A Al-Fatimi, William N Setzer, Ludger Wessjohann
The hydrodistilled essential oil obtained from the dried leaves of Myrtus communis, collected in Yemen, was analysed by GC-MS. Forty-one compounds were identified, representing 96.3% of the total oil. The major constituents of essential oil were oxygenated monoterpenoids (87.1%), linalool (29.1%), 1,8-cineole (18.4%), α-terpineol (10.8%), geraniol (7.3%) and linalyl acetate (7.4%). The essential oil was assessed for its antimicrobial activity using a disc diffusion assay and resulted in moderate to potent antibacterial and antifungal activities targeting mainly Bacillus subtilis, Staphylococcus aureus and Candida albicans...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28068839/antituberculosis-compounds-from-a-deep-sea-derived-fungus-aspergillus-sp-scsio-ind09f01
#13
Xiaowei Luo, Xuefeng Zhou, Xiuping Lin, Xiaochu Qin, Tianyu Zhang, Junfeng Wang, Zhengchao Tu, Bin Yang, Shengrong Liao, Yongqi Tian, Xiaoyan Pang, Kumaravel Kaliyaperumal, Jian Lin Li, Huaming Tao, Yonghong Liu
Eleven diketopiperazine and fumiquinazoline alkaloids (1-11) together with a tetracyclic triterpenoid helvolic acid (12) were obtained from the cultures of a deep-sea derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated. Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28067069/a-phytotoxic-bicyclic-lactone-and-other-compounds-from-endophyte-xylaria-curta
#14
Abdou Tchoukoua, Takuma Ota, Rima Akanuma, Yu-Ming Ju, Unang Supratman, Tetsuya Murayama, Takuya Koseki, Yoshihito Shiono
A new compound, (3aS,6aR)-4,5-dimethyl-3,3a,6,6a-tetrahydro-2H-cyclopenta [b]furan-2-one (2), along with two known metabolites, myrotheciumone A (1) and 4-oxo-4H-pyron-3-acetic acid (3) was isolated from the ethyl acetate extract of fermentation broth of Xylaria curta 92092022. The structures of these compounds were elucidated on the basis of spectroscopic methods (UV, IR, HRESITOFMS, 1D NMR, and 2D NMR). Compounds 1 and 2 showed moderate antibacterial and phytotoxic activities.
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28067067/chemical-composition-antimicrobial-antioxidant-and-anthocyanin-activities-of-mosses-cinclidotus-fontinaloides-hedw-p-beauv-and-palustriella-commutata-hedw-ochyra-gathered-from-turkey
#15
Ozlem Tonguc Yayintas, Duygu Alpaslan, Yonca Karagul Yuceer, Selehattin Yilmaz, Nurettin Sahiner
Cinclidotus fontinaloides (Hedw.) P. Beauv. and Palustriella commutata (Hedw.) Ochyra were used in this study. The chemical composition of mosses in the ethanol and water extract was determined using GC-MS and FT-IR. Antioxidant activities of moss extracts were tested by total phenol and ABTS methods. Trolox equivalent value (TEAC) of mosses was calculated as 26 ± 0.32 and 10 ± 0.22 mg/g. The amounts of the flavonoid compounds were calculated as mg gallic acid. Gallic acid equivalent value of mosses was calculated as 587 ± 0...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28067066/a-new-indole-alkaloid-with-anti-inflammatory-activity-from-nauclea-officinalis
#16
Qing-Long Liu, A-Hong Chen, Jin-Ying Tang, Yan-Lei Ma, Zhi-Hua Jiang, Yan-Ping Liu, Guang-Ying Chen, Yan-Hui Fu, Wei Xu
A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28067055/chemical-composition-and-antioxidant-activity-of-essential-oil-from-leaves-and-rhizomes-of-curcuma-angustifolia-roxb
#17
Sudipta Jena, Asit Ray, Anwesha Banerjee, Ambika Sahoo, Noohi Nasim, Suprava Sahoo, Basudeba Kar, Jeetendranath Patnaik, Pratap Chandra Panda, Sanghamitra Nayak
The essential oil extracted from rhizome and leaf of Curcuma angustifolia Roxb. (Zingiberaceae) was characterised by gas chromatography-mass spectrometry (GC-MS). The GC-MS analysis revealed the presence of 32 and 35 identified constituents, comprising 92.6% and 92% of total leaf and rhizome oil, respectively. Curzerenone (33.2%), 14-hydroxy-δ-cadinene (18.6%) and γ-eudesmol acetate (7.3%) were the main components in leaf oil. In rhizome oil, curzerenone (72.6%), camphor (3.3%) and germacrone (3.3%) were found to be the major constituents...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28064519/three-new-antitumor-annonaceous-acetogenins-from-the-seeds-of-annona-squamosa
#18
Chengyao Ma, Qiwen Wang, Yeye Shi, Yue Li, Xunan Wang, Xiang Li, Yong Chen, Jianwei Chen
Two new annonaceous acetogenins squamocin P (2) and annosquatin III (3) and one new ACG precursor dieporeticenin B (1) along with five known precursors (4-8) were isolated from the seeds of Annona squamosa. Their structures were ascertained by chemical methods and various spectral evidences. These compounds showed inhibitory effects against three multidrug-resistant (MDR) cancer cell lines. Compound 2 and 3 displayed selective cytotoxicity against SMMC 7721/T (IC50 0.435 and 1.79 μM) and MCF-7/ADR (IC50 values 3...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28064512/the-roman-thermal-complex-from-curinga-calabria-italy
#19
Caterina Gattuso, Philomène Gattuso, Valentina Caramazza, Chiara Gallo, Valentina Roviello, Luigi Campanella
Since ancient times, the Calabrian territories were affected continuously and in different dominations: first Magna Greece civilisation and after the Roman domination. The latter influenced strongly some areas of the Calabrian territory, where we witnessed a gradual replacement of small farmer properties with plants of the first Roman villas. An example of Roman thermal plant was in the city of Curinga (CZ), where in 1966 were found the remains of a thermal building dating to late-Roman period, probably a part of a much more complex structure identifiable as a large Roman villa...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28056544/a-new-pyridine-alkaloid-from-zingiberis-rhizoma
#20
Feng Shao, Ding-Qing Wang, Wei Xiong, Pu-Zhao Zhang, Guang-Qiang Ma, Rong-Hua Liu, Xue-Lian Yao
A new alkaloid, named 2-methoxy-4-(2-(2-pyridine)-ethyl) phenol (1), together with two known compounds, was isolated from Zingiberis rhizoma. Their structures were elucidated on the basis of 1D and 2D NMR spectra and MS spectra. Compound 1 exhibited substantial bioactivity against Canidia albicans ATCC 10231 with a minimum inhibitory concentration of 1.0 mg/mL.
January 6, 2017: Natural Product Research
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