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Natural Product Research

Bing-Kun Ji, Xue-Mei Gao, Di Cui, Shan-Shan Wang, Wen-Zhong Huang, Yin-Ke Li, Shuang-Xi Mei, Zhi Yang, Gan-Peng Li, Meng-Yuan Jiang, Yong-Hui He, Zhi-Yong Jiang, Gang Du, Xiao-Xia Pan, Wen-Xing Liu, Qiu-Fen Hu
Two new biphenyls (1 and 2) and three known xanthones (3-5) were isolated from the ethanol extract of the stems of Garcinia tetralata. Structural elucidations of 1-2 were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic resonance spectroscopy techniques. Compounds 1-2 showed anti-rotavirus activities with SI above 10.
February 5, 2017: Natural Product Research
Noureddine Baaka, Wafa Haddar, Manel Ben Ticha, Maria Teresa Pessoa Amorim, Mohamed Farouk M'Henni
In this study, the ultrasound technique was investigated to dye wool fabrics with the natural extract obtained from grape pomace as a way of reducing time, temperature and environmental impact. Indeed, this natural material was very rich in total polyphenolic compounds and total flavonoids (which are, respectively, 310 (mg GAE/L) and 75 mg (CE/L)). Further, Fourier Transform Infrared Spectroscopy showed that the major chemical groups identified in the extracted dye and in the dyed wool fabrics are characteristics of phenolic compounds...
February 2, 2017: Natural Product Research
Ilias Marmouzi, Miloud El Karbane, Maha El Hamdani, Mourad Kharbach, Hanae Naceiri Mrabti, Rachid Alami, Souhail Dahraoui, Meryem El Jemli, Zhor Ouzzif, Yahia Cherrah, Soufiane Derraji, My El Abbes Faouzi
Scolymus hispanicus or the Golden Thistle, locally known as 'Guernina' or 'Taghediwt', is one of the most appreciated wild vegetables in Morocco. This study aims to characterise the functional chemical and pharmacological variability of Scolymus hispanicus parts (roots, stems, leaves and flowers). The chemical analysis revealed higher content of α-tocopherol in the flowers (2.79 ± 0.07 mg/100 g) and lead to the identification of 3 flavonoids and 13 phenolic acids, with high content of gallic acid in leaves (187...
February 2, 2017: Natural Product Research
Elasyed A Omer, Saber F Hendawy, Rasha F Ismail, Giacomo L Petretto, Jonathan P Rourke, Giorgio Pintore
Seeds of Tagetes lucida were imported to Egypt from Canada and propagated under greenhouse conditions in peat moss media. Soil was sandy in texture and the irrigation system was dripping irrigation. The growth parameters were determined at five successive plant ages, fresh and dry weights of herb were determined at three successive plant ages. The yield of aerial parts after 175 days, was about 7.5 Mg/ha. The essential oil (EO) was extracted by hydro-distillation for three hours with a yield of about 0.5% (w/v)...
February 2, 2017: Natural Product Research
Xiao Feng, Guozhu Su, Yunyun Ye, Ruifei Zhang, Xinyao Yang, Bingzhao Du, Bing Peng, Pengfei Tu, Xingyun Chai
Two new lignans, alashinols F and G (1 and 2), together with two known analogues (-)-secoisolariciresinol (3) and meso-secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute configurations were elucidated on the basis of experimental and calculated electronic circular dichroisms. The in vitro anti-inflammation and anti-hypoxia evaluations were also discussed...
February 2, 2017: Natural Product Research
Xinhua Ma, Jie Yang, Shihao Deng, Mi Huang, Sijian Zheng, Shicheng Xu, Jinyan Cai, Xinzhou Yang, Honglian Ai
To discover new bioactive compounds from nature plants, a primary screening of traditional Chinese medicines had been taken. The screening results showed that a EtOAc extract of Sedum sarmentosum displayed a certain degree of cytotoxic activity and bioassay-directed isolation of EtOAc extract gave two new megastigmanes, (6S,9R)-2-hydroxy-4-(2,6,6-trimethyl-4-oxo-cyclohex-2-enyl)-butyric acid (1) and (6S,9R)-2-hydroxy-4-(2,6,6-trimethyl-4-oxo-cyclohex-2-enyl)-butyric acid methyl ester (2) together with seven known flavonoids...
February 2, 2017: Natural Product Research
Amandine Adrien, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, Nicolas Bridiau
The aim of this study was to evaluate the potential anticoagulant activity of sulphated polysaccharide-containing extracts of six french edible marine macroalgae. Aqueous extracts of brown (Himanthalia elongata, Laminaria digitata, Ascophyllum nodosum, Fucus vesiculosus), green (Ulva lactuca) and red (Chondrus crispus) macroalgae were prepared and their biochemical properties were determined, including major biomolecules, sulphate and ash contents. The anticoagulant activity of each extract was investigated using different scales from the specific antithrombin-dependent pathway (anti-Xa and anti-IIa) to the intrinsic and/or common (Activated Partial Thromboplastin Time, APTT), extrinsic (Prothrombin Time, PT) or common (Thrombin Time, TT) anticoagulant pathways, and compared with those of commercial anticoagulants, heparin and Lovenox®...
February 1, 2017: Natural Product Research
Huarong Huang, Ting Liu, Xiaoen Wu, Junxi Guo, Xiong Lan, Qin Zhu, Xi Zheng, Kun Zhang
One new chromone derivative, (2'S*)-2-(2'-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2...
February 1, 2017: Natural Product Research
Paula Karina S Uchoa, Antonia T A Pimenta, Raimundo Braz-Filho, Maria da Conceição F de Oliveira, Natália N Saraiva, Barbara S F Rodrigues, Ludwig H Pfenning, Lucas M Abreu, Diego V Wilke, Katharine G D Florêncio, Mary Anne S Lima
A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2...
January 30, 2017: Natural Product Research
Ke-Yun Yu, Wei Wu, Shang-Zhen Li, Li-Li Dou, Le-Le Liu, Ping Li, E-Hu Liu
A new compound, methylbergenin (1), was isolated from the whole plants of Ardisia japonica (Thunb.) Bl. (Myrsinaceae), along with eight known compounds: demethoxybergenin (2), bergenin (3), afzelin (4), quercitrin (5), bauerenol (6), bauerenone (7), α-spinasterol (8) and chondrillasterone (9). Compounds 1, 7 and 9 were isolated from A. japonica for the first time. The structure of compound 1 was determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The absolute configuration of 1 was assessed by single-crystal X-ray diffraction...
January 30, 2017: Natural Product Research
Ming-Bo Zhao, Si-Xiang Zhou, Qing-Ying Zhang, Wei-Feng Wei, Ming-Hui Li, Jian-Yong Xing, Yong Jiang, Peng-Fei Tu
Two new prenylated benzoic acid derivatives, leptoic acid A and (+)-S-anodendroic acid (1-2), along with one known compound, 2,2-dimethyl-2H-1-benzopyran-6-carboxylic acid (3) were isolated from the stem of Euodia lepta (spreng.) Merr. Their structures were elucidated on the basis of the chemical and spectroscopic evidence.
January 30, 2017: Natural Product Research
Urja Pandya, Ankit Doshi, Nirmal S Sahay
There are many household products like detergents, disinfectants, stain removers and cosmetics releasing chemicals that may be harmful to human health as well as cause hazardous effect on environment. Global world is now focusing on use of herbal products. They are eco-friendly and more suitable to household applications than chemicals. The present study focused on preparation of three plant-based formulations for household cleaning applications. Result showed antibacterial activity against most commonly available microbes viz...
January 30, 2017: Natural Product Research
Shuyan Li, Qinghu Wang, Baiyinmuqier Bao, Jingjing Han, Jiesi Wu
A new triterpenoid, namely 3β-hydroxy-13β,28-epoxyolean-11-enyl trans-caffeate (1), was isolated from the EtOAc extract from Ixeris chinensis Nakai. The structures of 1 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.
January 30, 2017: Natural Product Research
Tan Phat Nguyen, Cong Luan Tran, Chi Hung Vuong, Thi Hong Tuoi Do, Tien Dung Le, Dinh Tri Mai, Nhat Minh Phan
One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rhamnopyranoside (5), kaempferol 7-O-α-l-rhamnopyranoside (6), kaempferitrin (7) and kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (8) were isolated by various chromatography methods from the leaves of Cleome viscosa L. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR (1D & 2D) experiments...
January 30, 2017: Natural Product Research
Ben-Qin Tang, Shu-Sheng Huang, Ye-Er Liang, Jian-Bo Sun, Yan Ma, Bao Zeng, Simon Ming-Yuen Lee, Jian-Lin Lu
Two new flavans, named (2S)-2',4'-dihydroxy-7-methoxy-8-methylflavan (1) and (2S)-2'-hydroxy-4',7-dimethoxy-8-methylflavan (2) were isolated from the roots of Dianella ensifolia. Their structures were elucidated by extensive spectroscopic measurements and comparison with data reported in literatures. Compounds 1 and 2 displayed cytotoxic effects against cancer cell lines MDA-MB-231, B16-F10, HCT116 and A549.
January 30, 2017: Natural Product Research
Pier Giorgio Peiretti, Giorgia Meineri, Francesco Gai, Erica Longato, Ryszard Amarowicz
Phenolic compounds were extracted from pumpkin (Cucurbita pepo) seed and amaranth (Amaranthus caudatus) grain into 80% (v/v) methanol. The extracts obtained were characterised by the contents of total phenolic compounds (TPC), trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP) and antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH(·)) radical. The content of individual phenolic compounds was determined by HPLC-DAD method. Pumpkin seeds showed the higher content of TPC than that from amaranth...
January 23, 2017: Natural Product Research
Ahmed Shah Syed, Je-Seung Jeon, Chul Young Kim
Phytochemical investigation of a methanolic extract of aerial parts Actinidia polygama Miq. led to the isolation of one new diacetylated flavonol triglycoside, kaempferol 3-O-[α-L-rhamnopyranosyl(1→3)-(4-O-acetyl)-O-α-L-rhamnopyranosyl(1→6)-(2-Oacetyl)-O-β-D-galactopyranoside] (1) along with 12 known compounds (2-13). The chemical structures were determined using their spectroscopic data including 1D and 2D NMR. To the best of our knowledge, this is the first time that compounds 2, 4, 6, 7, 8, 9, 12 and 13 are isolated from this plant...
January 23, 2017: Natural Product Research
M G Donadu, D Usai, V Mazzarello, P Molicotti, S Cannas, M G Bellardi, S Zanetti
Lavender is an aromatic evergreen shrub diffused in the Mediterranean basin appreciated since antiquity. The genus Lavandula is part of Lamiaceae family and includes more than 20 species, among which true lavender (L. vera D.C. or L. angustifolia Miller.) and spike lavender (L. latifolia Medikus); there are also numerous hybrids known as lavandins (L. hybrida Rev.). L. vera, spike lavender and several hybrids are the most intensely used breeding species for the production of essential oils. Lavender and lavandin essential oils have been applied in food, pharmaceutical and other agro industries as biological products...
January 23, 2017: Natural Product Research
Shou-Ji Zhu, Shi-Chao Xu, Zhen-Dong Zhao
A novel aziridine compound N-acetyl-1,2-azacyclo-p-menthane d was synthesised using turpentine as raw material and characterised by FT-IR, (1)H NMR, (13)C NMR, ESI(+)-MS and HRMS. The pre-emergence herbicidal activities of d and its synthetic intermediates cis- and trans-N,N'-diacetyl-p-menthane-1,8-diamine (b2 and b1) were determined. The result showed that d exhibited much higher herbicidal activities against annual ryegrass, Digitaria sanguinalis and Ixeris denticulate than b2 and b1. The IC50 of d against the root and shoot growth of these three plants were lower than 1 mmol L(-1)...
January 23, 2017: Natural Product Research
He Yan, Li Rong Han, Xing Zhang, Jun Tao Feng
Two new chalconoid analogues, emblirol A (1) and B (2), along with three known ones (3-5), were isolated from the root of the Phyllanthus emblica L. Their structures were elucidated on the basis of spectral data. Compound 1 and 2 showed moderate anti-TMV activity with inhibition rates 79.6 and 62.1% at a concentration of 1 mg/mL, respectively.
January 23, 2017: Natural Product Research
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