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Natural Product Research

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https://www.readbyqxmd.com/read/29451029/screening-of-ionic-liquids-for-extraction-of-flavonoids-from-heather
#1
Paulina Dróżdż, Krystyna Pyrzynska
Room temperature ionic liquids are novel solvents with the specific properties that makes them of interest for application for extraction for a wide range of compounds. In this work extraction efficiency of flavonoids from heather flowers using ionic liquids based on imidazolium cation were evaluated and compared with organic solvents. It was found that the anion of ionic liquid significantly influence the extraction yields. Flavonoid content as well as antioxidant activity based on radical scavenging on 1,1-diphenul-2-pirylhydrazyl radicals and cupric reducing antioxidant capacity increased in the order: [Bmim]PF 6 < [Bmim]BF 4 < [Bmim]Cl...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29451024/network-pharmacology-based-screening-of-the-active-ingredients-and-potential-targets-of-the-genus-of-pithecellobium-marthae-britton-killip-niezgoda-nevl-for-application-to-alzheimer-s-disease
#2
Han Zhang, Zhi-Yang Yan, Yu-Xi Wang, Ming Bai, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with synaptic dysfunction, pathological accumulation of β-amyloid (Aβ), and neuronal loss. Given the prevalence of AD and the lack of effective long-term therapies, there is a pressing need to discover viable leads that can be developed into clinically approved drugs with disease-modifying effects. The analysis of current reported literatures confirms the importance of the plants of Pithecellobium genus as candidate against AD...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29451019/antimicrobial-substances-from-the-rare-actinomycete-nonomuraea-rhodomycinica-nr4-asc07-t
#3
Khomsan Supong, Paranee Sripreechasak, Wongsakorn Phongsopitanun, Somboon Tanasupawat, Kannawat Danwisetkanjana, Nantiya Bunbamrung, Pattama Pittayakhajonwut
Nonomuraea rhodomycinica NR4-ASC07 T is a rare actinomycete isolated from soil in Sirindhorn peat swamp forest. The crude extract of its culture broth exhibited antimicrobial and anticancer against diverse human pathogens and cancer cells. The chemical investigation of the crude extract led to the isolation of two new metabolites named nonomuric acid (1) and 3-hydroxy deoxydaunorubicinol aglycone (2), along with two known bioactive compounds [ε-rhodomycinone (3) and 7-deoxy-13-dihydrocarminomycinone (4)]. Compounds 1 and 3 showed antimalarial activity with the half maximal inhibitory concentration (IC 50 ) of 8...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29451015/chemical-constituents-from-the-rhizomes-of-polygonatum-sibiricum-red-and-anti-inflammatory-activity-in-raw264-7-macrophage-cells
#4
Huan Zhao, Qiao-Lian Wang, Shu-Bing Hou, Guang Chen
Chemical investigation of the rhizomes of Polygonatum sibiricum Red. led to the identification of 27 constituents. Among them, a total of 16 compounds were obtained from Polygonatum for the first time, in which, 3 and 4 were also firstly isolated as natural products. Anti-inflammatory activity studies on 13 isolated compounds showed that β-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-α, IL-6 and IL-1β in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29451013/pradimicin-ird-from-amycolatopsis-sp-ird-009-and-its-antimicrobial-and-cytotoxic-activities
#5
Anelize Bauermeister, Felipe A Calil, Francisco das C L Pinto, Talita C T Medeiros, Larissa C Almeida, Leonardo J Silva, Itamar S de Melo, Tiago D Zucchi, Letícia V Costa-Lotufo, Luiz A B Moraes
A new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. The new compound was detected by a focused method of precursor ion (high-performance liquid chromatography coupled to tandem mass spectrometer) developed previously to identify unusual aminoglycosyl sugar moieties. The compound was isolated and its structure was, therefore, elucidated by high-resolution mass spectrometry, and 1D and 2D nuclear magnetic resonance experiments...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29451012/4-dehydroxyepisarcovagine-a-a-new-steroidal-alkaloid-from-sarcococca-pruniformis-lindl
#6
J-C Wu, S-J Huo, J Du
A new steroidal alkaloid, 4-dehydroxyepisarcovagine A (1), along with seven known alkaloids, sarcovagine D (2), sarcovagenine C (3), epoxysarcovagenine D (4), Pachysamine L (5), Pachysamine E (6), sarcovagine A (7) and sarcovagine B (8), was isolated from the roots and stems of Sarcococca pruniformis Lindl. The structure of compound 1 was elucidated by means of spectroscopic analysis.
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29448823/chemical-constituents-of-genista-numidica-spach-aerial-parts-and-their-antimicrobial-antioxidant-and-antityrosinase-activities
#7
Naima Boutaghane, Abdulmagid Alabdul Magid, Amin Abedini, Anaïs Cafolla, Hanène Djeghim, Sophie C Gangloff, Laurence Voutquenne-Nazabadioko, Zahia Kabouche
A previously undescribed triterpenoid saponin, 3-O-[α-l-rhamnopyranosyl-(1→2)-{β-d-glucopyranosyl-(1→6)-}β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl]-sophoradiol (1), in addition to twenty-nine known constituents (2-30) were isolated from the aerial parts of Genista numidica Spach. Structures elucidation was performed by comprehensive 1D- and 2D-NMR analyses and HRESIMS. The extracts, fractions and isolated compounds were evaluated for their antibacterial, antioxidant and tyrosinase inhibitory activities...
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29448811/production-of-a-new-mucilage-compound-in-lepidium-sativum-callus-by-optimizing-in-vitro-growth-conditions
#8
Pooran Golkar, Fatemeh Hadian, Mehrana Koohi Dehkordi
The mucilage in Lepidium sativum L. is considered a biologically active compound with diverse medicinal properties. Different explants (hypocotyls and leaf) were transferred to Murashige and Skoog (MS) medium supplemented with twelve different plant growth regulator combinations under two different incubations (light and dark). The best mucilage production from callus (36.76% g g -1 dry weight) was obtained in the MS medium supplemented with 1 mg L -1 of 2, 4-D and 2 mg L -1 of BAP under the light condition...
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29447479/two-new-lignans-from-horsfieldia-kingii
#9
Bo Liu, Shou-Zhen Du, Fang Kuang, Ying Liu, Xing-Jun Tian, Ye-Gao Chen, Rui Zhan
Two new dibenzylbutyrolactol lignans and three known dibenzylbutyrolactone lignans were isolated from the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation of these compounds against five human tumour lines showed no inhibitory effects.
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29447469/tricin-isolated-from-allium-atroviolaceum-potentiated-the-effect-of-docetaxel-on-pc3-cell-proliferation-role-of-mir-21
#10
Sorayya Ghasemi, Zahra Lorigooini, JokoPriyanto Wibowo, Hossein Amini-Khoei
For more effectiveness and overcoming the drug resistance Chemotherapy agents, the combination treatment is raised. Flavonoids with different anti-cancer effects are an appropriate choice as lead compounds. Over expressed MiR-21 in prostate cancer is associated with metastasis and drug resistance to chemotherapy with Docetaxel. In this study, the anticancer effect of 4', 5, 7-Trihydroxy-3', 5'-dimethoxyflavone (Tricin) was investigated with Docetaxel on PC3 cell line. Tricin was initially isolated from the Allium atroviolaceum by column chromatography and recrystallization method...
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29446995/secondary-metabolites-from-the-unique-bamboo-melocanna-baccifera
#11
Balaji Govindan, Anil John Johnson, Gayathri Viswanathan, Venkataraman Ramaswamy, Konnath Chacko Koshy, Sabulal Baby
Phytochemistry of fruits and leaves of the unique bamboo Melocanna baccifera resulted in the isolation of 27 secondary metabolites, including 4-Oxabicyclo[3.2.2]nona-1(7),5,8-triene and Verbacine. Biological activity studies of Verbacine revealed it as an inhibitor of acetylcholinesterase and as cytotoxic against C6 cancer cells.
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29446976/efficient-biosynthesis-analysis-solubility-and-anti-bacterial-activities-of-succinylglycosylated-naringenin
#12
S Zhang, D D Li, F Zeng, Z H Zhu, P Song, M Zhao, J A Duan
A novel water-soluble flavonoid with good anti-bacterial activities, naringenin-6″-succl-7-O-glucoside (7-SGN), was synthesised. It was biotransformed from naringenin by Bacillus amyloliquefaciens FJ18 in aqueous miscible organic media, and characterised by LC-MS and NMR analysis. The solubility of 7-SGN in water was approximately 102 times higher than that of naringenin. These results demonstrated that both the water solubility and the anti-bacterial activity of 7-SGN were significantly improved.
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29436858/kaurene-as-the-major-constituent-of-the-essential-oils-of-the-narcotic-plant-khat-catha-edulis-forsk
#13
Morteza Gholami, Sedigheh Esmaeilzadeh Bahabadi
Khat (Catha edulis Forsk) is a narcotic plant which contains significant amounts of amphetamines, like alkaloids. Herein, analysis of the essential oil composition showed that Khat has useful volatile chemicals in addition to its alkaloids. Results indicated that among 35 identified constituents including mono and sesquiterpenes, the diterpene kaurene, comprises the major part of the essential oil, around 50 percent of total. Kaurene is known as a potent biological agent for the treatment of cancer patients...
February 13, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29431466/daphne-striata-tratt-and-d-mezereum-l-a-study-of-anti-proliferative-activity-towards-human-cancer-cells-and-antioxidant-properties
#14
Rosa Tundis, Monica R Loizzo, Marco Bonesi, Lorenzo Peruzzi, Thomas Efferth
In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430966/major-terpenoids-from-telekia-speciosa-flowers-and-their-cytotoxic-activity-in-vitro
#15
Anna Stojakowska, Agnieszka Galanty, Janusz Malarz, Marta Michalik
In addition to known constituents of Telekia speciosa, an acetone extract from ray florets of the plant yielded: 5,5'-dibutoxy-2,2'-bifuran (1), 5,5'-diisobutoxy-2,2'-bifuran (2), α-tocopherol (3), β-tocopherol (4), loliolide palmitate (5), a mixture of calenduladiol esters - 16β-hydroxylupeol-3-O-palmitate (7) and 16β-hydroxylupeol-3-O-myristate (8), 1-epiinuviscolide (12), inuviscolide (13), 3-epiisotelekin (16), 4α-hydroxy-9β,10β-epoxy-1β(H)-11(13)-guaien-8α,12-olide (17), 4α-hydroxy-1β(H)-9(10),11(13)-guaiadien-8α,12-olide (18), loliolide (19) and 4β,10β-dihydroxy-1α(H),5α(H)-11(13)-guaien-8α,12-olide (20)...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430965/extraction-optimization-total-phenolic-flavonoid-contents-hplc-dad-analysis-and-diverse-pharmacological-evaluations-of-dysphania-ambrosioides-l-mosyakin-clemants
#16
Tanzeel Zohra, Muhammad Ovais, Ali Talha Khalil, Muhammad Qasim, Muhammad Ayaz, Zabta Khan Shinwari
The present study aims to evaluate phytochemical and pharmacological potentials of Dysphania ambrosioides (L.) Mosyakin & Clemants previously known as Chenopodium ambrosioides L. Extraction was carried out using 14 solvents with wide range of polarity to find out the best solvent system for each bioactivity. Total phenolic and flavonoids contents were measured colorimetrically and polyphenolics were quantified via HPLC-DAD analysis. The samples were screened for inhibitory potentials against free radicals, leishmania, cancer cell lines, protein kinase, α-Amylase enzymes and microbial strains...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430949/heliotropium-bacciferum-forssk-boraginaceae-extracts-chemical-constituents-antioxidant-activity-and-cytotoxic-effect-in-human-cancer-cell-lines
#17
Hanane Aïssaoui, Teresa Mencherini, Tiziana Esposito, Nunziatina De Tommasi, Patrizia Gazzerro, Samir Benayache, Fadila Benayache, Ratiba Mekkiou
Heliotropium bacciferum (Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it is traditionally used for skin diseases and tonsillitis. Herein, we report the isolation and characterization of sixteen secondary metabolites from the aerial part extracts. They include a sterol (1), megastigman type nor-isoprenoids (2, 3, 4, 6, 8, 10), C-11 terpene lactones (5 and 9), and a monoterpene (7) from the chloroform extract (HB-C); monoterpene glucoside (14), and phenolic compounds (11-13, 15, 16) from the methanol one (HB-M)...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430945/diterpenoid-alkaloids-from-aconitum-brevicalcaratum-as-autophagy-inducers
#18
Haiyue Jiang, Shuai Huang, Feng Gao, Yongqi Zhen, Chunying Li, Xianli Zhou
A new C 19 diterpenoid alkaloid, brevicanine (1) and six known ones (2-7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures were elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity of those compounds was investigated against HCT116 human cancer cell line, which showed none of them possessing considerable anti-proliferative activities. To evaluate the autophagy effect of compounds 1-7, Western blot was used to detect the expression of autophagic marker by stimulating human cancer HCT116 cells...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430943/two-new-compounds-from-the-fruit-of-ailanthus-altissima
#19
Jian-Cheng Ni, Jian-Ting Shi, Qing-Wei Tan, Qi-Jian Chen
A new phenolic derivative, 4-hydroxyphenol-1-O-[6-O-(E)-feruloyl-β-d-glucopyranosyl]-(1→6)-β-d-glucopyranoside (1), and a new terpenylated coumarin, named altissimacoumarin H (2) were identified from the fruit of Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with ten known compounds (3-12), including two coumarins and eight phenylpropanoids. Their structures were determined on the basis of chemical method and spectroscopic data. Antiviral effect against Tobacco mosaic virus (TMV) of all the compounds obtained were evaluated using leaf-disc method...
February 12, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29430942/quorum-sensing-inhibitors-from-marine-bacteria-oceanobacillus-sp-xc22919
#20
Xiaochun Chen, Jianwei Chen, Yinchun Yan, Su Chen, Xuewei Xu, Huawei Zhang, Hong Wang
In this study, three active compounds isolated from Oceanobacillus sp. XC22919 were identified as 2-methyl-N-(2'-phenylethyl) butyramide (1), 3-methyl-N-(2'-phenylethyl)-butyramide (2) and benzyl benzoate (3), and were first reported to exhibit the apparent quorum sensing inhibitory activities against C. violaceum 026 and P. aeruginosa. Compounds 1-3 inhibited violacein production of C. violaceum 026 by 10.5-55.7, 11.2-55.7, and 27.2%-95.7%, respectively, and inhibited pyocyanin production of P. aeruginosa by 1...
February 12, 2018: Natural Product Research
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