We have located links that may give you full text access.
HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia.
Genetics Research 2024
MATERIALS AND METHODS: This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology.
RESULTS: Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1 ∗ 04:02:01 ( p =0.001, OR = 1.05) and HLA-DRB3 ∗ 02:01:01 ( p =0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A ∗ 24:02:01 0.01 ( p =0.01, OR = 0.38), HLA-DQA1 ∗ 05:05:01 ( p =0.01, OR = 0.56), HLA-DQB1 ∗ 03:02:01 ( p =0.03, OR = 0.40), and HLA-DRB4 ∗ 01:03:01 ( p =0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men.
CONCLUSIONS: Our data are the first to indicate that in Romanian patients with CLL, the HLA-A ∗ 24:02:01 and HLA-DQA1 ∗ 05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1 ∗ 04:02:01 and HLA-DRB3 ∗ 02:01:01alleles are positively associated with CLL.
RESULTS: Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1 ∗ 04:02:01 ( p =0.001, OR = 1.05) and HLA-DRB3 ∗ 02:01:01 ( p =0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A ∗ 24:02:01 0.01 ( p =0.01, OR = 0.38), HLA-DQA1 ∗ 05:05:01 ( p =0.01, OR = 0.56), HLA-DQB1 ∗ 03:02:01 ( p =0.03, OR = 0.40), and HLA-DRB4 ∗ 01:03:01 ( p =0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men.
CONCLUSIONS: Our data are the first to indicate that in Romanian patients with CLL, the HLA-A ∗ 24:02:01 and HLA-DQA1 ∗ 05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1 ∗ 04:02:01 and HLA-DRB3 ∗ 02:01:01alleles are positively associated with CLL.
Full text links
Related Resources
Trending Papers
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.Endocrine Reviews 2024 April 28
The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.Circulation 2024 April 26
Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials.European Journal of Medical Research 2024 April 19
Interstitial Lung Disease: A Review.JAMA 2024 April 23
Management of Diverticulitis: A Review.JAMA Surgery 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app