Denoising Multiphase Functional Cardiac CT Angiography Using Deep Learning and Synthetic Data.

"Just Accepted" papers have undergone full peer review and have been accepted for publication in Radiology: Artificial Intelligence . This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content. Coronary CT angiography (CTA) is increasingly used for cardiac diagnosis. Dose modulation techniques can reduce radiation dose, but resulting functional images are noisy and challenging for functional analysis. This retrospective study describes and evaluates a deep learning method for denoising functional cardiac imaging, taking advantage of multiphase information in a 3D convolutional neural network. Coronary CT angiograms ( n = 566) were used to derive synthetic data for training. Deep learning-based image denoising (DLID) was compared with unprocessed images and a standard noise reduction algorithm (BM3D). Noise and signal-to-noise ratio measurements, as well as expert evaluation of image quality were performed. To validate the use of the denoised images for cardiac quantification, threshold-based segmentation was performed, and results were compared with manual measurements on unprocessed images. Deep learning-based denoised images showed significantly improved noise compared with standard denoising-based images (SD of left ventricular blood pool, 20.3 ± 42.5 HU versus 33.4 ± 39.8 HU for DLID versus BM3D, P < .0001). Expert evaluations of image quality were significantly higher in deep learningbased denoised images compared with standard denoising. Semiautomatic left ventricular size measurements on deep learning-based denoised images showed excellent correlation with expert quantification on unprocessed images (intraclass correlation coefficient, 0.97). Deep learning-based denoising using a 3D approach resulted in excellent denoising performance and facilitated valid automatic processing of cardiac functional imaging. ©RSNA, 2024.