We have located links that may give you full text access.
The influence of biological DMARDs on aseptic arthroplasty loosening-a retrospective cohort study.
Rheumatology 2023 July 5
OBJECTIVE: To investigate whether biological DMARDs affect the risk of aseptic loosening after total hip/knee arthroplasty (THA/TKA) in patients with rheumatoid arthritis (RA).
METHODS: We retrospectively identified all patients suffering from RA who underwent THA/TKA at our academic center between 2002 and 2015 and linked them with an existing prospective observational RA database at our institution.The risk of aseptic loosening was estimated using radiological signs of component loosening (RCL). A time-dependent Cox regression analysis was used to compare the risk of implant loosening between patients treated with traditional DMARDS and biological DMARDs, or alternately both over time.
RESULTS: A total of 155 consecutive total joint arthroplasties (TJAs) (103 TKA vs. 52 THA) was retrospectively included in the study. Mean age at implantation was 59 ± 13 years. Mean follow-up time was 69 ± 43 months. Overall, 48 (31%) TJAs showed signs of RCL, with 28 (27.2%) RCLs occurring after TKA compared with 20 after THA (38.5%). A significant difference regarding the incidence of RCL between the traditional DMARDs-group (39 cases of RCL, 35%) and the biological DMARDs-group (9 cases of RCL, 21%) (p= 0.026) was observed using the Log Rank test. This was also true when using a time-dependent cox regression with therapy as well as arthroplasty location (hip vs. knee) as variables (p= 0.0447).
CONCLUSION: Biological DMARDs may reduce the incidence of aseptic loosening after TJA in patients with RA compared with traditional DMARDs. This effect seems to be more pronounced after TKA than THA.
METHODS: We retrospectively identified all patients suffering from RA who underwent THA/TKA at our academic center between 2002 and 2015 and linked them with an existing prospective observational RA database at our institution.The risk of aseptic loosening was estimated using radiological signs of component loosening (RCL). A time-dependent Cox regression analysis was used to compare the risk of implant loosening between patients treated with traditional DMARDS and biological DMARDs, or alternately both over time.
RESULTS: A total of 155 consecutive total joint arthroplasties (TJAs) (103 TKA vs. 52 THA) was retrospectively included in the study. Mean age at implantation was 59 ± 13 years. Mean follow-up time was 69 ± 43 months. Overall, 48 (31%) TJAs showed signs of RCL, with 28 (27.2%) RCLs occurring after TKA compared with 20 after THA (38.5%). A significant difference regarding the incidence of RCL between the traditional DMARDs-group (39 cases of RCL, 35%) and the biological DMARDs-group (9 cases of RCL, 21%) (p= 0.026) was observed using the Log Rank test. This was also true when using a time-dependent cox regression with therapy as well as arthroplasty location (hip vs. knee) as variables (p= 0.0447).
CONCLUSION: Biological DMARDs may reduce the incidence of aseptic loosening after TJA in patients with RA compared with traditional DMARDs. This effect seems to be more pronounced after TKA than THA.
Full text links
Related Resources
Trending Papers
Haemodynamic monitoring during noncardiac surgery: past, present, and future.Journal of Clinical Monitoring and Computing 2024 April 31
2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.Circulation 2024 May 9
Obesity pharmacotherapy in older adults: a narrative review of evidence.International Journal of Obesity 2024 May 7
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app