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The Impact of Recirculation on Extracorporeal Gas Exchange and Patient Oxygenation during Veno-Venous Extracorporeal Membrane Oxygenation-Results of an Observational Clinical Trial.
Journal of Clinical Medicine 2023 January 5
BACKGROUND: Recirculation during veno-venous extracorporeal membrane oxygenation reduces extracorporeal oxygen exchange and patient oxygenation. To minimize recirculation and maximize oxygen delivery (DO2 ) the interaction of cannulation, ECMO flow and cardiac output requires careful consideration. We investigated this interaction in an observational trial.
METHODS: In 19 patients with acute respiratory distress syndrome and ECMO, we measured recirculation with the ultrasound dilution technique and calculated extracorporeal oxygen transfer (VO2 ), extracorporeal oxygen delivery (DO2 ) and patient oxygenation. To assess the impact of cardiac output (CO), we included CO measurement through pulse contour analysis.
RESULTS: In all patients, there was a median recirculation rate of approximately 14-16%, with a maximum rate of 58%. Recirculation rates >35% occurred in 13-14% of all cases. In contrast to decreasing extracorporeal gas exchange with increasing ECMO flow and recirculation, patient oxygenation increased with greater ECMO flows. High CO diminished recirculation by between 5-20%.
CONCLUSIONS: Extracorporeal gas exchange masks the importance of DO2 and its effects on patients. We assume that increasing DO2 is more important than reduced VO2 . A negative correlation of recirculation to CO adds to the complexity of this phenomenon. Patient oxygenation may be optimized with the direct measurement of recirculation.
METHODS: In 19 patients with acute respiratory distress syndrome and ECMO, we measured recirculation with the ultrasound dilution technique and calculated extracorporeal oxygen transfer (VO2 ), extracorporeal oxygen delivery (DO2 ) and patient oxygenation. To assess the impact of cardiac output (CO), we included CO measurement through pulse contour analysis.
RESULTS: In all patients, there was a median recirculation rate of approximately 14-16%, with a maximum rate of 58%. Recirculation rates >35% occurred in 13-14% of all cases. In contrast to decreasing extracorporeal gas exchange with increasing ECMO flow and recirculation, patient oxygenation increased with greater ECMO flows. High CO diminished recirculation by between 5-20%.
CONCLUSIONS: Extracorporeal gas exchange masks the importance of DO2 and its effects on patients. We assume that increasing DO2 is more important than reduced VO2 . A negative correlation of recirculation to CO adds to the complexity of this phenomenon. Patient oxygenation may be optimized with the direct measurement of recirculation.
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