An Explicative Review on the Progress of Quinazoline Scaffold as Bioactive Agents in the Past Decade.

In the last decade, quinazoline was one of the most explored scaffolds by researchers around the globe in medicinal chemistry. Its unique structural features provide a wide range of substitutions on nitrogen and carbonyl groups. In the current situation of COVID-19, hydroxychloroquine an antimalarial drug of the quinoline category was used for the treatment of severe infections. Various substitution patterns, hybrids, and conjugates of quinazoline have been developed and studied for various pharmacological activities like anticancer, anti-inflammatory, antimalarial, antitubercular, etc. The scaffold can be considered as a potential molecule for various pharmacological activities especially as antimicrobial and antihypertensive. The current review aims to study, physicochemical properties, chemistry, and pharmacological profile of quinazoline.