Comparison of Isolated Sciatic Nerve and Sacral Nerve Root Endometriosis: A Review of the Literature.

OBJECTIVE: This review aimed to compare isolated sciatic and sacral nerve root endometriosis in terms of anatomical distribution, patients' symptoms and history, diagnostics, treatments, and outcomes.

DATA SOURCE: We searched PubMed, MEDLINE, Web of Science, and EMBASE from inception to October 2021 using a combination of keywords including "sciatic nerve endometriosis'', ''sacral nerve root endometriosis'' and associated Medical Subject Headings. Relevant publications and references were also checked for further articles.

METHODS OF STUDY SELECTION: Two independent researchers performed the study selection. We included all original research articles, case reports, case series in English that reported on the isolated sciatic nerve and sacral nerve root endometriosis.

TABULATION, INTEGRATION, AND RESULTS: The initial search identified 92 articles, and 40 articles, mostly case reports and case series, were included. The review included 362 patients: with 256 and 106 patients in the sacral and the sciatic groups, respectively. In both groups, the majority of the patients had right-sided endometriosis. In the sciatic group, most of the patients presented with foot drop, leg motor weakness, and sciatic dermatome hypoesthesia. The frequencies of all these symptoms were significantly higher in the sciatic group (all p<0,001). By contrast, in the sacral group, most of patients presented with pudendal neuralgia (p<0,001). Intraoperative, early, late, and 1-year postoperative complications did not differ significantly between the two groups.

CONCLUSION: This study indicated that isolated sciatic and sacral nerve root endometriosis were more common on the right side. Laparoscopic surgery was more commonly performed over traditional open or transgluteal surgery techniques. Sacral nerve root endometriosis is often accompanied by deep infiltrating endometriosis. MRI and myelography may be useful diagnostic tools in the preoperative workup. There was usually no significant improvement after surgery in cases of isolated sciatic nerve endometriosis presenting with foot drop.