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ESC Heart Failure

Werner Mohl, Ernest Spitzer, Robert M Mader, Vilas Wagh, Filomain Nguemo, Dejan Milasinovic, Alem Jusić, Cesar Khazen, Edit Szodorai, Beatrice Birkenberg, Gert Lubec, Juergen Hescheler, Patrick W Serruys
AIMS: Cardiac repair has steered clinical attention and remains an unmet need, because available regenerative therapies lack robust mechanistic evidence. Pressure-controlled intermittent coronary sinus occlusion (PICSO), known to induce angiogenetic and vasoactive molecules as well as to reduce regional ischemia, may activate endogenous regenerative processes in failing myocardium. We aimed to investigate the effects of PICSO in patients with advanced heart failure undergoing cardiac resynchronization therapy...
September 19, 2018: ESC Heart Failure
Saif Altaie, Wissam Khalife
AIMS: Mid-range ejection fraction is a new entity of heart failure (HF) with undetermined prognosis till now. In our systematic review and meta-analysis, we assess the mortality and hospitalization rates in mid-range ejection fraction HF (HFmrEF) and compare them with those of reduced ejection fraction heart failure (HFrEF) and preserved ejection fraction HF (HFpEF). METHODS AND RESULTS: We conducted our search in March 2018 in the following databases for relevant articles: PubMed, CENTRAL, Google Scholar, Web of Science, Scopus, NYAM, SIEGLE, GHL, VHL, and POPLINE...
September 13, 2018: ESC Heart Failure
Cristina Giannini, Fabrizio D'ascenzo, Francesca Fiorelli, Paolo Spontoni, Martin J Swaans, Eric J Velazquez, Patrizio Armeni, Marianna Adamo, Marco De Carlo, Anna Sonia Petronio
AIMS: Survival benefit of percutaneous mitral valve repair with the MitraClip over conservative treatment of functional mitral regurgitation (MR) remains unclear. The purpose of this meta-analysis is to compare survival outcomes of MitraClip with those of medical therapy in patients with functional MR. METHODS AND RESULTS: A comprehensive literature search of PubMed, MEDLINE, and Google Scholar was conducted including studies evaluating MitraClip vs. medical therapy with multivariate adjustment and with >80% of patients with functional MR...
September 6, 2018: ESC Heart Failure
Mahmoud Hassanein, Magdy Abdelhamid, Bassem Ibrahim, Mohamed Sobhy, Gamela Nasr, Mohamed Wafaie Aboleineen, Ashraf Reda, Nabil Farag, Ahmed Elshazly, Tarek Khairy Abdeldayem, Fatma Elmesseiry, Hesham Boshra, Hesham Sobhy, Atef Elbahry, Amr Youssef, Medhat Ashmawy, Ahmed Abdelmoneim, Ayman Saleh, Yahya Elrakshy, Hamdy Ebeid
AIMS: This analysis evaluates gender differences in the Egyptian cohort of patients hospitalized for acute heart failure (AHF) in the European Society of Cardiology Heart Failure Long-Term Registry. METHODS AND RESULTS: From April 2011 to September 2014, 1634 patients hospitalized with AHF were enrolled by 20 hospitals all over Egypt. Of these patients, 1112 (68%) patients were male and 522 (32%) were female. Women presented with a higher admission systolic blood pressure and resting heart rate...
September 3, 2018: ESC Heart Failure
Marcello Chinali, Giorgia Grutter
No abstract text is available yet for this article.
September 3, 2018: ESC Heart Failure
Karin A L Mueller, Johannes Patzelt, Manuela Sauter, Philipp Maier, Sarah Gekeler, Karin Klingel, Reinhard Kandolf, Peter Seizer, Meinrad Gawaz, Tobias Geisler, Harald F Langer
AIM: The aim of this study is to analyse the prognostic value of complement anaphylatoxin receptors in patients with non-ischaemic cardiomyopathy undergoing endomyocardial biopsy. METHODS AND RESULTS: In 102 patients (72.5% male patients, median age 54 years) with non-ischaemic cardiomyopathy, myocardial expression of C3aR was assessed among other parameters. The primary study endpoint was a composite of death, heart transplantation, heart failure-related re-hospitalization, and deterioration of left ventricular ejection fraction within a mean follow-up of 11...
August 31, 2018: ESC Heart Failure
Thor Ueland, Lars Gullestad, Lei Kou, Pål Aukrust, Inderjit S Anand, Marianne Nordlund Broughton, John J McMurray, Dirk J van Veldhuisen, David J Warren, Nils Bolstad
AIMS: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin-releasing peptide (GRP), derived from the precursor proGRP1-125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction. METHODS AND RESULTS: The association between plasma proGRP (time-resolved immunofluorometric assay) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anaemia, enrolled in the Reduction of Events by Darbepoetin alfa in Heart Failure (RED-HF) trial...
August 25, 2018: ESC Heart Failure
Paulo Bettencourt, João Ferreira-Coimbra, Pedro Rodrigues, Pedo Marques, Helena Moreira, Maria João Pinto, João Tiago Guimarães, Patrícia Lourenço
AIMS: Growth differentiation factor (GDF)-15 mirrors inflammation and oxidative stress in cardiovascular diseases. Brain natriuretic peptide (BNP) is associated with cardiomyocyte stretch in heart failure (HF). The objective of this study was to evaluate the prognostic impact of plasma GDF-15 and BNP in acute HF. METHODS AND RESULTS: We studied a subgroup of patients prospectively recruited in an acute HF registry (follow-up: 2 years; endpoint: all-cause mortality)...
August 24, 2018: ESC Heart Failure
Abhinav Sharma, Andrew P Ambrosy, Adam D DeVore, Kenneth B Margulies, Steven E McNulty, Robert J Mentz, Adrian F Hernandez, Gary Michael Felker, Lauren B Cooper, Anuradha Lala, Justin Vader, John D Groake, Barry A Borlaug, Eric J Velazquez
AIMS: Obesity is present in up to 45% of patients with heart failure (HF). Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor antagonist, facilitates weight loss in obese patients. The efficacy of liraglutide as a weight loss agent among patients with HF and reduced ejection fraction (HFrEF) and a recent acute HF hospitalization remains unknown. METHODS AND RESULTS: The Functional Impact of GLP-1 for Heart Failure Treatment study randomized 300 patients with HFrEF (ejection fraction ≤ 40%), both with and without diabetes and a recent HF hospitalization to liraglutide or placebo...
August 17, 2018: ESC Heart Failure
Claudia Stöllberger, Birke Schneider, Josef Finsterer
No abstract text is available yet for this article.
August 14, 2018: ESC Heart Failure
Sophie Van Linthout, Ahmed Elsanhoury, Oliver Klein, Marzena Sosnowski, Kapka Miteva, Dirk Lassner, Mohamed Abou-El-Enein, Burkert Pieske, Uwe Kühl, Carsten Tschöpe
AIMS: Myocarditis is often associated with parvovirus B19 (B19V) persistence, which can induce vascular damage. Based on the antiviral and anti-inflammatory properties of telbivudine, we aimed to evaluate its efficacy to protect B19V-infected endothelial cells in vitro and to treat chronic lymphocytic myocarditis patients with B19V transcriptional activity. METHODS AND RESULTS: We evaluated the endothelial-protective potential of telbivudine in human microvascular endothelial cells-1, which were infected with B19V...
August 11, 2018: ESC Heart Failure
Michael Kleiner Shochat, Marat Fudim, Avraham Shotan, David S Blondheim, Mark Kazatsker, Iris Dahan, Aya Asif, Yoseph Rozenman, Ilia Kleiner, Jean Marc Weinstein, Gurusher Panjrath, Paul A Sobotka, Simcha R Meisel
AIMS: Readmissions for heart failure (HF) are a major burden. We aimed to assess whether the extent of improvement in pulmonary fluid content (ΔPC) during HF hospitalization evaluated by lung impedance (LI), or indirectly by other clinical and laboratory parameters, predicts readmissions. METHODS AND RESULTS: The present study is based on pre-defined secondary analysis of the IMPEDANCE-HF extended trial comprising 266 HF patients at New York Heart Association Class II-IV and left ventricular ejection fraction ≤ 35% randomized to LI-guided or conventional therapy during long-term follow-up...
August 10, 2018: ESC Heart Failure
Cristiane C K Mayerhofer, Ayodeji O Awoyemi, Samuel D Moscavitch, Knut Tore Lappegård, Johannes R Hov, Pål Aukrust, Anders Hovland, Andrea Lorenzo, Sigrun Halvorsen, Ingebjørg Seljeflot, Lars Gullestad, Marius Trøseid, Kaspar Broch
AIMS: Heart failure (HF) is a multifactorial disease. Current treatments target only a fraction of the putative pathophysiological pathways. In patients with HF, reduced cardiac output and congestion cause increased gut wall permeability. It has been suggested that leakage of microbial products is detrimental to the heart, at least partly through activation of systemic inflammatory pathways, which again could promote gut leakage. Whether manipulating the gut microbiota can improve cardiac function in patients with HF remains unknown...
August 7, 2018: ESC Heart Failure
Philippe Timmermans, Filip Rega, Jan Bogaert, Marie-Christine Herregods
Neuroendocrine tumours are a rare malignancy, which can be complicated by a carcinoid syndrome and, in more rare cases, also valve destruction. The correct timing for surgical repair remains unknown. We report the first-in-men exercise cardiac magnetic resonance imaging with pulmonary artery catheter measurements in order to better understand the haemodynamic impact of isolated tricuspid valve insufficiency in a low symptomatic patient. Not pressure but volume overload is the key factor in the development of symptoms, as long as the right ventricular function is intact...
August 6, 2018: ESC Heart Failure
Jörg Eiringhaus, Okka W Hamer, David Hollemann, Christoph Brochhausen, Dirk Vollmann, Lars S Maier, Samuel Sossalla
Here we discuss a case of arrhythmia-induced cardiomyopathy (AIC) with consecutive severe multiple organ failure. In relation to this imposing case, we discuss the significance of this potentially underestimated cause of newly occurred left-ventricular systolic dysfunction and concomitant arrhythmia. We further delineate the diagnostic algorithm and differential diagnoses of AIC.
August 6, 2018: ESC Heart Failure
Carolyn S P Lam, Wolfram Doehner, Josep Comin-Colet
In patients with chronic heart failure, iron deficiency, even in the absence of anaemia, can aggravate the underlying disease and have a negative impact on clinical outcomes and quality of life. The 2016 European Society of Cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure recognize iron deficiency as a co-morbidity in chronic heart failure and recommend iron status screening in all newly diagnosed patients with chronic heart failure. Furthermore, the guidelines specifically recommend considerations of intravenous iron therapy, ferric carboxymaltose, for the treatment of iron deficiency...
August 2, 2018: ESC Heart Failure
Nicolas A Geis, Sven T Pleger, Raffi Bekeredjian, Emmanuel Chorianopoulos, Michael M Kreusser, Lutz Frankenstein, Arjang Ruhparwar, Hugo A Katus, Philip W J Raake
AIMS: Functional mitral regurgitation is complicating end-stage heart failure and potential heart transplantation by increasing pulmonary artery pressures. The aim of the present study was to investigate feasibility and haemodynamic effects of percutaneous mitral valve edge-to-edge repair using the MitraClip™ device in patients with end-stage heart failure awaiting heart transplantation. METHODS AND RESULTS: In this retrospective study, we identified nine patients suffering from end-stage heart failure listed for heart transplantation in whom moderate-severe or severe functional mitral regurgitation was recognized and treated with percutaneous mitral valve edge-to-edge repair...
July 30, 2018: ESC Heart Failure
Nirav Patel, Jason A Gluck, Joseph Radojevic, Craig I Coleman, William L Baker
AIMS: Heart failure (HF) and diabetes mellitus (DM) often coexist and have bidirectional association. Advanced HF is associated with worsened glycaemic control. This meta-analysis investigated the effects of left ventricular assist device (LVAD) implantation on markers of DM control. METHODS AND RESULTS: We performed a systematic search of MEDLINE and Cochrane through October 2017 to identify studies evaluating advanced HF patients who had received an LVAD and reported markers of glycaemic control...
July 27, 2018: ESC Heart Failure
Vojtech Melenovsky, Milos Kubanek, Petr Kacer
Protein-losing enteropathy (PLE) due to leakage of lymph into the gut sometimes occurs in young patients after Fontan palliation but is very rarely reported with other aetiologies of chronic heart failure (HF). PLE leads to severe hypoalbuminemia and immunodeficiency and is associated with poor prognosis. The mechanisms and the predispositions to PLE are poorly understood. Here, we report an adult patient with advanced HF due to non-ischaemic non-dilated hypocontractile cardiomyopathy who developed severe PLE, probably owing to increased ventricular stiffness and constraint by atypically placed epicardial electrode encircling both ventricles...
July 27, 2018: ESC Heart Failure
Alwin Zweerink, Wouter M van Everdingen, Robin Nijveldt, Odette A E Salden, Mathias Meine, Alexander H Maass, Kevin Vernooy, Frederik J de Lange, Marc A Vos, Pierre Croisille, Patrick Clarysse, Bastiaan Geelhoed, Michiel Rienstra, Isabelle C van Gelder, Albert C van Rossum, Maarten J Cramer, Cornelis P Allaart
AIMS: Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response. METHODS AND RESULTS: Twenty-seven patients were prospectively enrolled and underwent CMR and echocardiographic examination before CRT implantation...
July 26, 2018: ESC Heart Failure
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