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ESC Heart Failure

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https://www.readbyqxmd.com/read/30426729/patterns-of-dyspnoea-onset-in-patients-with-acute-heart-failure-clinical-and-prognostic-implications
#1
Justyna Maria Sokolska, Mateusz Sokolski, Robert Zymliński, Jan Biegus, Paweł Siwołowski, Sylwia Nawrocka-Millward, Ewa Anita Jankowska, John Todd, Waldemar Banasiak, Piotr Ponikowski
AIMS: Despite attempts to improve the management of patients with acute heart failure (HF), virtually all therapeutic agents investigated in large clinical trials failed to show any consistent reduction in mortality and morbidity. Complexity of the clinical syndrome of acute HF seems to be likely an underlying explanation. Traditionally, clinical trials studied mixed patient populations with acute HF, and only recently, better clinical characterization of patients has been proposed. Dyspnoea is the most common presenting symptom related to hospital admission for acute HF...
November 13, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30415506/prevalence-of-underlying-gastrointestinal-malignancies-in-iron-deficient-heart-failure
#2
Pieter Martens, Lennert Minten, Matthias Dupont, Wilfried Mullens
AIMS: Anaemia and iron deficiency (ferritin level < 100 or 100-300 μg/L with transferrin saturation < 20%) are prevalent in heart failure. Mechanistically, iron deficiency is linked to poor intestinal uptake, increased intestinal loss, and chronic inflammation. However, the prevalence of underlying gastrointestinal malignancies is not established in iron-deficient heart failure with or without anaemia. METHODS AND RESULTS: Patients followed up in a single-centre, heart failure database with baseline registration of haemoglobin and iron status were retrospectively evaluated...
November 10, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30378291/the-functional-consequences-of-sodium-channel-na-v-1-8-in-human-left-ventricular-hypertrophy
#3
Shakil Ahmad, Petros Tirilomis, Steffen Pabel, Nataliya Dybkova, Nico Hartmann, Cristina E Molina, Theodoros Tirilomis, Ingo Kutschka, Norbert Frey, Lars S Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla
AIMS: In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL ) is enhanced. We aimed to investigate the electrophysiological role of neuronal sodium channel NaV 1.8 in human hypertrophied myocardium. METHODS AND RESULTS: Myocardial tissue of 24 patients suffering from symptomatic severe aortic stenosis and concomitant significant afterload-induced hypertrophy with preserved ejection fraction was used and compared with 12 healthy controls...
October 30, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30378288/repetitive-levosimendan-infusions-for-patients-with-advanced-chronic-heart-failure-in-the-vulnerable-post-discharge-period
#4
Gerhard Pölzl, Shadab Allipour Birgani, Josep Comín-Colet, Juan F Delgado, Francesco Fedele, Martín Jesús García-Gonzáles, Finn Gustafsson, Josep Masip, Zoltán Papp, Stefan Störk, Hanno Ulmer, Bojan Vrtovec, Gerhard Wikström, Johann Altenberger
Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and with associated healthcare costs and an increased mortality risk. However, few if any major medical innovations have been witnessed in this area in recent times. Levosimendan is a first-in-class calcium sensitizer and potassium channel opener indicated for the management of acute HF. Experience in several clinical studies has indicated that administration of intravenous levosimendan in intermittent cycles may reduce hospitalization and mortality rates in patients with advanced HF; however, none of those trials were designed or powered to give conclusive insights into that possibility...
October 30, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30367561/cardiac-expression-of-neutrophil-gelatinase-associated-lipocalin-in-a-model-of-cancer-cachexia-induced-cardiomyopathy
#5
Vincenzo Musolino, Sandra Palus, Celine Latouche, Micaela Gliozzi, Francesca Bosco, Federica Scarano, Saverio Nucera, Cristina Carresi, Miriam Scicchitano, Stephan von Haehling, Frederic Jaisser, Gerd Hasenfuss, Stefan D Anker, Vincenzo Mollace, Jochen Springer
AIMS: Cachexia is a severe consequence of cancer. Although cancer-induced heart atrophy leads to cardiac dysfunction and heart failure (HF), biomarkers for their diagnosis have not been identified. Neutrophil gelatinase-associated lipocalin (NGAL) is an aldosterone-responsive gene increased in HF. We studied NGAL and its association with aldosterone levels in a model of cancer cachexia-induced cardiomyopathy. METHODS AND RESULTS: Rats were injected with Yoshida 108 AH-130 hepatoma cells to induce tumour...
October 26, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30353706/rapid-5-lb-weight-gain-is-not-associated-with-readmission-in-patients-with-heart-failure
#6
Jill Howie-Esquivel, Kathleen Dracup, Mary A Whooley, Charles McCulloch, Chengshi Jin, Debra K Moser, Robyn A Clark, Michele M Pelter, Martha Biddle, Linda G Park
AIMS: Heart failure (HF) patients are taught to identify a rapid 5 lb body-weight gain for early detection of cardiac decompensation. Few data support this common advice. The study aim was to determine whether a 5 lb weight gain in 1 week and signs and symptoms of HF increased risk for unplanned physician or emergency department (ED) visits or hospital admission in rural HF patients. METHODS AND RESULTS: This was a secondary analysis of a randomized trial. Patients tracked body weight and HF symptoms using diaries...
October 24, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30350926/changes-in-pulmonary-artery-pressure-before-and-after-left-ventricular-assist-device-implantation-in-patients-utilizing-remote-haemodynamic-monitoring
#7
Ahmet Kilic, Jason N Katz, Susan M Joseph, Meredith A Brisco-Bacik, Nir Uriel, Brian Lima, Rahul Agarwal, Rupinder Bharmi, David J Farrar, Sangjin Lee
AIMS: The time course of changes in pulmonary artery (PA) pressure due to left ventricular assist devices (LVADs) is not well understood. Here, we describe longitudinal haemodynamic trends during the peri-LVAD implantation period in patients previously implanted with a remote monitoring PA pressure sensor. METHODS AND RESULTS: We retrospectively studied PA pressure trends in patients implanted with CardioMEMS™ PA pressure sensor between October 2007 and March 2017 who subsequently had an LVAD procedure...
October 23, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30338668/self-reported-health-and-quality-of-life-outcomes-of-heart-failure-patients-in-the-aftermath-of-a-national-economic-crisis-a-cross-sectional-study
#8
Audur Ketilsdottir, Brynja Ingadottir, Tiny Jaarsma
AIMS: There are indications that economic crises can affect public health. The aim of this study was to describe characteristics, health status, and socio-economic status of outpatient heart failure (HF) patients several years after a national economic crisis and to assess whether socio-economic factors were associated with patient-reported outcome measures (PROMs). METHODS AND RESULTS: In this cross-sectional survey, PROMs were measured with seven validated instruments, as follows: self-care (the 12-item European Heart Failure Self-Care Behaviour scale), HF-related knowledge (Dutch Heart Failure Knowledge Scale), symptoms (Edmonton Symptom Assessment System), sense of security (Sense of Security in Care-'Patients' evaluation'), health status (EQ-5D visual analogue scale), health-related quality of life (HRQoL) (Kansas City Cardiomyopathy Questionnaire), and anxiety and depression (Hospital Anxiety and Depression Scale)...
October 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30334369/echocardiographic-predictors-of-worsening-renal-function-in-acute-heart-failure-observations-from-the-rashf-registry
#9
Mohammad Hossein Soltani, Mohsen Jamshir, Sepideh Taghavi, Reza Golpira, Mohsen Nasiri, Ahmad Amin, Nargeuss Abbaszade Marzbali, Nasim Naderi
AIMS: Echocardiography is known as the most useful diagnostic test in the assessment of patients with heart failure (HF), and the prognostic significance of echocardiographic findings in HF is well known. In this report, we aim to present the prognostic significance of a limited set of echocardiographic parameters obtained within 24 h of admission of patients enrolled in the Rajaie Acute Systolic Heart Failure registry. METHODS AND RESULTS: A total of 230 patients with the diagnosis of acute systolic HF (left ventricular ejection fraction ≤ 35%) were enrolled into the study...
October 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30315634/incidence-and-impact-of-cardiorenal-anaemia-syndrome-on-all-cause-mortality-in-acute-heart-failure-patients-stratified-by-left-ventricular-ejection-fraction-in-the-middle-east
#10
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. METHODS AND RESULTS: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012...
October 12, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30311748/pulmonary-function-assessment-post-left-ventricular-assist-device-implantation
#11
Pavol Sajgalik, Chul-Ho Kim, John M Stulak, Sudhir S Kushwaha, Simon Maltais, David L Joyce, Lyle D Joyce, Bruce D Johnson, John A Schirger
AIM: The lungs-and particularly the alveolar-capillary membrane-may be sensitive to continuous flow (CF) and pulmonary pressure alterations in heart failure (HF). We aimed to investigate long-term effects of CF pumps on respiratory function. METHODS AND RESULTS: We conducted a retrospective study of patients with end-stage HF at our institution. We analysed pulmonary function tests [e.g. forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 )] and diffusing capacity of the lung for carbon monoxide (DLCO ) from before and after left ventricular assist device (LVAD) implantation and compared them with invasive haemodynamic studies...
October 12, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30311454/assessing-health-related-quality-of-life-in-heart-failure-patients-attending-an-outpatient-clinic-a-pragmatic-approach
#12
Angela M Gallagher, Rebecca Lucas, Martin R Cowie
AIMS: Improving quality of life (QoL) in heart failure patients is a key management objective. Validated health-related QoL (HR-QoL) measurement tools have been incorporated into clinical trials but not routinely into daily practice. The aims of this study were to investigate the acceptability and feasibility of implementing validated HR-QoL instruments into heart failure clinics and to examine the impact of patient characteristics on HR-QoL. METHODS AND RESULTS: One hundred and sixty-three patients attending heart failure clinics at a UK tertiary centre were invited to complete three HR-QoL assessments: the Minnesota Living with Heart Failure Questionnaire (MLHFQ); the EuroQoL 5D-3L (EQ-5D-3L); and the Kansas City Cardiomyopathy Questionnaire (KCCQ) in that order...
October 11, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30311437/impact-of-an-interatrial-shunt-device-on-survival-and-heart-failure-hospitalization-in-patients-with-preserved-ejection-fraction
#13
David M Kaye, Mark C Petrie, Scott McKenzie, Gerd Hasenfuβ, Filip Malek, Martijn Post, Robert N Doughty, Jean-Noël Trochu, Finn Gustafsson, Irene Lang, Adam Kolodziej, Ralf Westenfeld, Martin Penicka, Mark Rosenberg, Jörg Hausleiter, Philip Raake, Guillaume Jondeau, Martin W Bergmann, Tim Spelman, Huseyin Aytug, Piotr Ponikowski, Chris Hayward
AIMS: Impaired left ventricular diastolic function leading to elevated left atrial pressures, particularly during exertion, is a key driver of symptoms and outcomes in heart failure with preserved ejection fraction (HFpEF). Insertion of an interatrial shunt device (IASD) to reduce left atrial pressure in HFpEF has been shown to be associated with short-term haemodynamic and symptomatic benefit. We aimed to investigate the potential effects of IASD placement on HFpEF survival and heart failure hospitalization (HFH)...
October 11, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30299600/rationale-and-design-of-the-eu-cert-icd-prospective-study-comparative-effectiveness-of-prophylactic-icd-implantation
#14
Markus Zabel, Christian Sticherling, Rik Willems, Andrzej Lubinski, Axel Bauer, Leonard Bergau, Frieder Braunschweig, Josep Brugada, Sandro Brusich, David Conen, Iwona Cygankiewicz, Panagiota Flevari, Milos Taborsky, Jim Hansen, Gerd Hasenfuß, Robert Hatala, Heikki V Huikuri, Svetoslav Iovev, Stefan Kääb, Gabriela Kaliska, Jaroslaw D Kasprzak, Lars Lüthje, Marek Malik, Tomas Novotny, Nikola Pavlović, Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Simon Schlögl, Janko Szavits Nossan, Vassil Traykov, Anton E Tuinenburg, Vasil Velchev, Marc A Vos, Stefan N Willich, Tim Friede, Jesper Hastrup Svendsen, Béla Merkely
AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries...
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30299591/effectiveness-and-safety-of-rivaroxaban-vs-warfarin-in-patients-with-non-valvular-atrial-fibrillation-and-heart-failure
#15
Brandon K Martinez, Thomas J Bunz, Daniel Eriksson, Anna-Katharina Meinecke, Nitesh A Sood, Craig I Coleman
AIMS: Heart failure (HF) is a common co-morbidity in non-valvular atrial fibrillation (NVAF) patients and a potent risk factor for stroke, bleeding, and a decreased time-in-therapeutic range with warfarin. We assessed the real-world effectiveness and safety of rivaroxaban and warfarin in NVAF patients with co-morbid HF. METHODS AND RESULTS: Using US Truven MarketScan Commercial and Medicare supplemental database claims data from 11/2011 to 12/2016, we identified oral anticoagulant (OAC)-naïve NVAF patients with HF (International Classification of Diseases, 10th Revision codes of I50 or I09...
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30299590/short-term-and-long-term-incidence-of-stroke-in-takotsubo-syndrome
#16
LETTER
Ibrahim El-Battrawy, Thorsten Gietzen, Uzair Ansari, Michael Behnes, Siegfried Lang, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin
No abstract text is available yet for this article.
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30298997/reply-sacubitril-valsartan-for-chagas-heart-disease-heart-failure
#17
LETTER
Edimar Alcides Bocchi, Salvador Rassi, Guilherme Veiga Guimarães
No abstract text is available yet for this article.
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30298996/post-hoc-analyses-of-shift-and-paradigm-hf-highlight-the-importance-of-chronic-chagas-cardiomyopathy-comment-on-safety-profile-and-efficacy-of-ivabradine-in-heart-failure-due-to-chagas-heart-disease-a-post-hoc-analysis-of-the-shift-trial-by-bocchi-et-al
#18
LETTER
Felix J A Ramires, Felipe Martinez, Efraín A Gómez, Caroline Demacq, Claudio R Gimpelewicz, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, Milton Packer, John J V McMurray
No abstract text is available yet for this article.
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30295437/early-urine-electrolyte-patterns-in-patients-with-acute-heart-failure
#19
Sean P Collins, Cathy A Jenkins, Adrienne Baughman, Karen F Miller, Alan B Storrow, Jin H Han, Nancy J Brown, Dandan Liu, James M Luther, Candace D McNaughton, Wesley H Self, Dungeng Peng, Jeffrey M Testani, JoAnn Lindenfeld
AIMS: We conducted a prospective study of emergency department (ED) patients with acute heart failure (AHF) to determine if worsening HF (WHF) could be predicted based on urinary electrolytes during the first 1-2 h of ED care. Loop diuretics are standard therapy for AHF patients. A subset of patients hospitalized for AHF will develop a blunted natriuretic response to loop diuretics, termed diuretic resistance, which often leads to WHF. Early detection of diuretic resistance could facilitate escalation of therapy and prevention of WHF...
October 8, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30295431/intrarenal-venous-flow-in-cardiorenal-syndrome-a-shining-light-into-the-darkness
#20
Rafael de la Espriella-Juan, Eduardo Núñez, Gema Miñana, Juan Sanchis, Antoni Bayés-Genís, Jessika González, Javier Chorro, Julio Núñez
The aim of this case report is to assess the potential role of intrarenal Doppler ultrasonography as a non-invasive method to evaluate intrarenal venous flow (IRVF) in acute heart failure (AHF) and concomitant renal dysfunction. We report a case of an 81-year-old woman with valvular heart disease (previous mitral valve replacement) that presented with acutely decompensated heart failure and concomitant worsening renal function (WRF). In addition to complete physical examination, laboratory analysis, and echocardiography, IRVF was assessed at baseline and 48 h after the administration of diuretic treatment...
October 8, 2018: ESC Heart Failure
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