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European Thyroid Journal

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https://www.readbyqxmd.com/read/29594062/liposarcoma-of-the-thyroid-a-case-report-with-a-review-of-the-literature
#1
Vittoria Guarda, Anja Pickhard, Melanie Boxberg, Katja Specht, Anna Maria Stefanie Buchberger
Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck. Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a cold nodule in the thyroid scan...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594061/effects-of-chronic-lymphocytic-thyroiditis-on-the-clinicopathological-features-of-papillary-thyroid-cancer
#2
Saleha Babli, Richard J Payne, Elliot Mitmaker, Juan Rivera
Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594060/prevalence-of-radiological-signs-of-dysthyroid-optic-neuropathy-in-magnetic-resonance-imaging-in-patients-with-active-moderate-to-severe-and-very-severe-graves-orbitopathy
#3
Beata Rutkowska-Hinc, Edyta Maj, Anna Jabłońska, Justyna Milczarek-Banach, Tomasz Bednarczuk, Piotr Miśkiewicz
Background: Differentiating between dysthyroid optic neuropathy (DON), which requires urgent therapy to prevent blindness, and moderate-to-severe Graves orbitopathy (GO) remains challenging. There is no pathognomonic feature of DON in either ophthalmological or radiological examinations. Objectives: Our aim was to investigate the prevalence of radiological signs of DON in magnetic resonance imaging (MRI) in patients with moderate-to-severe and very severe GO. Methods: Two researchers reassessed MRI scans of 23 consecutive patients (46 eyes) with active, moderate-to-severe GO and 14 patients (23 eyes) with very severe GO...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594059/severe-inflammatory-ophthalmopathy-in-a-euthyroid-patient-during-nivolumab-treatment
#4
Pauline Campredon, Philippe Imbert, Céline Mouly, Solange Grunenwald, Julien Mazières, Philippe Caron
Introduction: Nivolumab is a promising treatment in patients with advanced malignancies. Among immune-related adverse events, autoimmune thyroid disorders are frequently reported. Patient: A 61-year-old male patient had no history of familial or personal thyroid disease. In 2012, this patient, a heavy smoker, presented with non-small-cell lung cancer that was treated with radiotherapy and chemotherapy. In 2015, the cancer progressed with cervical compressive symptoms, and the patient was treated with nivolumab...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594058/trends-in-costs-of-thyroid-disease-treatment-in-denmark-during-1995-2015
#5
Line Tang Møllehave, Allan Linneberg, Tea Skaaby, Nils Knudsen, Lars Ehlers, Torben Jørgensen, Betina Heinsbæk Thuesen
Background: Iodine fortification (IF) may contribute to changes in costs of thyroid disease treatment through changes in disease patterns. From a health economic perspective, assessment of the development in costs of thyroid disease treatment in the population is pertinent. Objectives: To assess the trends in annual medicine and hospital costs of thyroid disease treatment during 1995-2015 in Denmark, i.e., before and after the introduction of mandatory IF in 2000...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594057/thyroid-cancer-induction-nitrates-as-independent-risk-factors-or-risk-modulators-after-radiation-exposure-with-a-focus-on-the-chernobyl-accident
#6
REVIEW
Valentina M Drozd, Igor Branovan, Nikolay Shiglik, Johannes Biko, Christoph Reiners
In recent decades, differentiated thyroid cancer (DTC) incidence has been increasing worldwide. The important contributions to this phenomenon of "overdiagnosis" driven by wider use of improved ultrasound systems are amply documented, notwithstanding the "real" carcinogenic effects of ionizing radiation, e.g., from the Chernobyl accident or health care interventions. Less well understood is the role of nitrates - as environmental pollutants, in diet, and in medication - in thyroid carcinogenesis...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594056/2018-european-thyroid-association-eta-guidelines-for-the-management-of-amiodarone-associated-thyroid-dysfunction
#7
Luigi Bartalena, Fausto Bogazzi, Luca Chiovato, Alicja Hubalewska-Dydejczyk, Thera P Links, Mark Vanderpump
Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH and AIT may develop in apparently normal thyroid glands or in the presence of underlying thyroid abnormalities. AIH does not require amiodarone withdrawal, and is treated with levothyroxine replacement if overt, whereas subclinical forms may be followed without treatment. Two main types of AIT are recognized: type 1 AIT (AIT 1), a form of iodine-induced hyperthyroidism occurring in nodular goitres or latent Graves disease, and type 2 AIT (AIT 2), resulting from destructive thyroiditis in a normal thyroid gland...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594055/occurrence-of-graves-orbitopathy-and-graves-hyperthyroidism-after-a-trauma-to-the-eye
#8
Elena Sabini, Ilaria Ionni, Roberto Rocchi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Background: Graves' orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes the appearance or deterioration of GO in patients with Graves' hyperthyroidism (GH), as it occurs following radioiodine treatment. In theory, a similar release of autoantigens may occur at the eye level, for example due to an orbital trauma or surgical manipulation. To our knowledge, this is the first report of a case of de novo appearance of GO and then GH after an eye trauma, possibly reflecting spreading of autoantigens and activation of the immune system against shared orbital and thyroid antigens...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594054/a-case-report-of-syndromic-multinodular-goitre-in-adolescence-exploring-the-phenotype-overlap-between-cowden-and-dicer1-syndromes
#9
Dorothée Bouron-Dal Soglio, Leanne de Kock, Richard Gauci, Nelly Sabbaghian, Elizabeth Thomas, Helen C Atkinson, Nicholas Pachter, Simon Ryan, John P Walsh, M Priyanthi Kumarasinghe, Karen Carpenter, Ayça Aydoğan, Colin J R Stewart, William D Foulkes, Catherine S Choong
Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome. Material and Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Fine needle cytology of the thyroid revealed a follicular neoplasm with features suggestive of follicular variant of papillary thyroid carcinoma and she underwent a hemithyroidectomy...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594053/indeterminate-thyroid-nodules-a-pragmatic-approach
#10
Aly Bernard Khalil, Roberto Dina, Karim Meeran, Ali M Bakir, Saf Naqvi, Alia Al Tikritti, Nader Lessan, Maha T Barakat
Background: Fine needle aspiration (FNA) cytology fails to provide a conclusive diagnosis in a subset of thyroid lesions labeled as "indeterminate" (Thy3). In this study, we aimed at ascertaining the prevalence of Thy3 thyroid nodules in a hitherto unreported ethnic group (residents of the United Arab Emirates). Methods: We retrospectively examined 688 FNA of the thyroid performed on 584 patients. Samples were reported using the Royal College of Physicians' (RCP) Thy classification...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594052/parathyroid-hormone-assays-following-total-thyroidectomy-is-there-a-predictive-value
#11
Camille Galy-Bernadoy, Benjamin Lallemant, Guillaume Chambon, Huy Trang Pham, Christophe Reynaud, Caroline Alovisetti, Quentin Bonduelle, Anne Marie Guedj, Serge Lumbroso, David-Paul De Brauwere
Objectives: Parathyroid hormone (PTH) is a risk marker for hypoparathyroidism (hypoPTH). This study aimed to determine the predictive values of early PTH assays carried out at the moment of skin closure (PTH SC), to establish a treatment algorithm, identifying two threshold values. We assessed the reproducibility of this approach with two different immunoassay kits (hypoPTH) after total thyroidectomy, but its practical application is not consensual. Study Design: We conducted a prospective descriptive study, including all patients who underwent a total thyroidectomy between March 2012 and November 2013...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594051/vitamin-d-in-graves-disease-levels-correlation-with-laboratory-and-clinical-parameters-and-genetics
#12
Tereza Planck, Bushra Shahida, Johan Malm, Jonas Manjer
Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase ( CYP27B1 ) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594050/ultrasound-measurements-of-thyroid-gland-volume-at-36-weeks-corrected-gestational-age-in-extremely-preterm-infants-born-before-28-weeks-gestation
#13
Sze May Ng, Mark A Turner, Shivaram Avula
Background: Thyroid ultrasound is a non-invasive imaging tool and provides good evaluation of thyroid anatomy, location, vascularisation, and echogenicity. The aim of this study was to assess thyroid function and thyroid volume in extremely preterm infants born before 28 weeks' gestation evaluated at 36 weeks' corrected gestational age (CGA) compared to term infants' normative data in the literature. Design: In this largest prospective UK study of extremely premature infants born at less than 28 weeks' gestation, thyroid volume measurement was assessed at 36 weeks' CGA...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594049/positron-emission-tomography-pet-and-pet-ct-in-thyroid-cancer-a-systematic-review-and-meta-analysis
#14
Friederike Schütz, Christine Lautenschläger, Kerstin Lorenz, Johannes Haerting
Background: Positron emission tomography (PET) and PET/CT are functional imaging methods that are widely used in diagnostic procedures in oncology. Objectives: The objective of this study was to assess the patient-relevant benefit of PET or PET/CT in patients with thyroid cancer based on a literature review and meta-analysis. Methods: A systematic review including studies that had been published until December 2013 was performed. To be included, studies had to prospectively investigate patients with thyroid cancer in a clinical setting of staging, restaging, or diagnosing tumour recurrence...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594048/in-vivo-effects-of-repeated-thyronamine-administration-in-male-c57bl-6j-mice
#15
Lisbeth Harder, Nancy Schanze, Assel Sarsenbayeva, Franziska Kugel, Josef Köhrle, Lutz Schomburg, Jens Mittag, Carolin S Hoefig
Objectives: Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormones (THs). Of all possible thyronamine variants, only 3-iodothyronamine (3-T1 AM) and iodine-free thyronamine (T0 AM) have been detected in vivo. While intensive research has been done on the (patho-)physiological action of 3-T1 AM, the role of T0 AM has been studied less intensively. Study Design: We determined whether a single pharmacological dose (50 mg/kg, i.p.) or repeated administration (5 mg/kg/day, i...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594047/the-7th-year-of-uninterrupted-publication-of-the-european-thyroid-journal
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29234626/consumptive-hypothyroidism-case-report-of-hepatic-hemangioendotheliomas-successfully-treated-with-vincristine-and-systematic-review-of-the-syndrome
#17
Marina Weber Pasa, Rafael Selbach Scheffel, André Borsatto Zanella, Ana Luiza Maia, José Miguel Dora
Objectives: To provide a comprehensive description of consumptive hypothyroidism syndrome (CHS), a severe form of hypothyroidism that occurs due to the high expression levels of thyroid hormone inactivation enzyme type 3 deiodinase (D3) in tumors. Study Design: Case report and systematic review. Results: A 7-month-old girl with a diagnosis of massive hepatic hemangioendotheliomas was treated with high doses of thyroid hormones and tumor-directed chemotherapy with vincristine...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234625/insight-into-differentiated-thyroid-cancer-gross-pathological-specimen-shrinkage-and-its-influence-on-tnm-staging
#18
Alexis Lacout, Emmanuel Chamorey, Juliette Thariat, Mostafa El Hajjam, Carole Chevenet, Renaud Schiappa, Pierre Yves Marcy
Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements. Material and Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234624/thyroidectomy-improves-tracheal-anatomy-and-airflow-in-patients-with-nodular-goiter-a-prospective-cohort-study
#19
Jesper Roed Sorensen, Jeppe Faurholdt Lauridsen, Helle Døssing, Nina Nguyen, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
Objective: A large goiter may cause compression of the trachea. The aim of this study was to investigate the impact of thyroidectomy on tracheal anatomy and airflow and to correlate this with changes in health-related quality of life (HRQoL) in patients with benign nodular goiter. Methods: Magnetic resonance images of the neck and respiratory flow-volume curves, including both inspiration and expiration, were performed prior to and 6 months following surgery. HRQoL was measured by selected scales from the thyroid-specific patient-reported outcome (ThyPRO)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234623/are-perinatal-events-risk-factors-for-childhood-thyroid-autoimmunity
#20
Berglind Jonsdottir, Markus Lundgren, Sara Wallengren, Åke Lernmark, Ida Jönsson, Helena Elding Larsson
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse. Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study. Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes...
November 2017: European Thyroid Journal
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