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European Thyroid Journal

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https://www.readbyqxmd.com/read/27843813/biochemical-hyperthyroidism-in-a-newborn-baby-caused-by-assay-interaction-from-biotin-intake
#1
Inge Bülow Pedersen, Peter Laurberg
We describe a case of biochemical neonatal thyrotoxicosis caused by biotin supplementation. Biotin may interact with thyroid function testing to imitate thyrotoxicosis with low thyroid-stimulating hormone and elevated triiodothyronine and thyroxine levels.
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843812/an-unusual-case-of-malignant-struma-ovarii-causing-thyrotoxicosis
#2
Elli Anagnostou, Antonios Polymeris, Georgios Morphopoulos, Alexios Travlos, Vassiliki Sarantopoulou, Irini Papaspyrou
BACKGROUND: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue, accounting for approximately 5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most SO cases are benign with only 5-10% being malignant, and malignant SO causing thyrotoxicosis is very uncommon. CASE: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years previously. The thyroid gland was palpable with a micronodular texture, and the patient was euthyroid under carbimazole...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843811/painful-radiation-thyroiditis-after-131-i-therapy-for-graves-hyperthyroidism-clinical-features-and-ultrasonographic-findings-in-five-cases
#3
Tetsuya Mizokami, Katsuhiko Hamada, Tetsushi Maruta, Kiichiro Higashi, Junichi Tajiri
BACKGROUND: Radiation thyroiditis caused by (131)I therapy for Graves' hyperthyroidism is asymptomatic in most patients and is rarely associated with pain or fever. Currently, there are few reports on the ultrasonographic findings of radiation thyroiditis after (131)I therapy for Graves' hyperthyroidism. CASE REPORT: We herein report 5 cases with painful radiation thyroiditis (including 2 febrile cases) after (131)I therapy for Graves' hyperthyroidism. The cases included 4 women, aged 49, 50, 76, and 81 years, and 1 man, aged 60 years...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843810/braf-v600e-mutation-has-it-a-role-in-cervical-lymph-node-metastasis-of-papillary-thyroid-cancer
#4
Neslihan Kurtulmus, Burak Ertas, Yesim Saglican, Hakan Kaya, Umit Ince, Mete Duren
BACKGROUND: The BRAF(V600E) mutation is common in papillary thyroid cancer (PTC). Lymph node metastasis (LNM) may be associated with poor prognosis. However, the LNM mechanism remains unclear. OBJECTIVES: Our aim was to evaluate the prevalence of the BRAF(V600E) mutation in primary tumors and accompanying LNM at the time of diagnosis. METHODS: This retrospective study included 51 PTC patients (40 women, 11 men; mean age 40.0 ± 16.5 years; range 6-81) who underwent total thyroidectomy accompanied by a lateral neck dissection due to preoperatively detected LNM...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843809/effect-of-an-outreach-programme-on-vandetanib-safety-in-medullary-thyroid-cancer
#5
Lars Bastholt, Michael C Kreissl, Dagmar Führer, Ana L Maia, Laura D Locati, Léa Maciel, Yi Wu, Kevin N Heller, Alan Webster, Rossella Elisei
OBJECTIVES: Effective management of adverse events (AEs) following vandetanib treatment is important to maximize clinical benefits. We examined whether more frequent contact with vandetanib-treated patients reduced AEs of CTCAE grade 2 or higher. STUDY DESIGN: In this open-label, multicentre, phase III study, patients with locally advanced or metastatic medullary thyroid cancer were randomized to a patient outreach programme (outreach) or a standard AE monitoring schedule (vandetanib control) for 52 weeks...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843808/therapeutic-strategies-and-clinical-outcome-in-papillary-thyroid-microcarcinoma-a-multicenter-observational-study
#6
F Cecoli, E M Ceresola, V Altrinetti, M Cabria, M Cappagli, A Montepagani, C M Cuttica, U Filippi, D Saverino, M Raffa, M Caputo, F Minuto, M Giusti, M Bagnasco
PURPOSE: Papillary thyroid microcarcinoma (MPTC) has an excellent prognosis. We aimed to evaluate the evolution of therapeutic strategies over time and the clinical outcome of MPTC. METHODS: In this retrospective multicenter observational study in a northwest Italian region, patients with intrathyroidal, unifocal tumor ≤1 cm in size, incidentally found at histology or preoperative cytology diagnosis, were included. Exclusion criteria were a previous head-and-neck irradiation and/or node metastases...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843807/relational-stability-of-thyroid-hormones-in-euthyroid-subjects-and-patients-with-autoimmune-thyroid-disease
#7
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
BACKGROUND/AIM: Operating far from its equilibrium resting point, the thyroid gland requires stimulation via feedback-controlled pituitary thyrotropin (TSH) secretion to maintain adequate hormone supply. We explored and defined variations in the expression of control mechanisms and physiological responses across the euthyroid reference range. METHODS: We analyzed the relational equilibria between thyroid parameters defining thyroid production and thyroid conversion in a group of 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#8
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843805/impaired-repressor-function-in-sumoylation-defective-thyroid-hormone-receptor-isoforms
#9
Joachim M Weitzel
BACKGROUND: Many nuclear receptors are modified by posttranslational modifications. OBJECTIVES: The transcriptional activity of thyroid hormone receptors (TRs) is modified by the influence of its ligand (thyroid hormones T3 and T4), but is also affected by posttranslational modifications. This study focuses on the SUMOylation of TR isoforms and the consequences on transcriptional activity and promoter occupancy. METHODS: SUMOylation of TR wild-type as well as isoform-specific point mutations have been studied in vitro...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843804/selenium-in-the-treatment-of-thyroid-diseases-an-element-in-search-of-the-relevant-indications
#10
EDITORIAL
Laszlo Hegedüs, Steen J Bonnema, Kristian H Winther
No abstract text is available yet for this article.
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493890/iodide-transport-defect-and-breast-milk-iodine
#11
Tetsuya Mizokami, Shuji Fukata, Akira Hishinuma, Takahiko Kogai, Katsuhiko Hamada, Tetsushi Maruta, Kiichiro Higashi, Junichi Tajiri
BACKGROUND: Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS) gene mutations. In the lactating mammary gland, iodide is concentrated by NIS, and iodine for thyroid hormone synthesis is thereby supplied to the infant in the breast milk. CASE DESCRIPTION: A 34-year-old Japanese woman was diagnosed with ITD caused by a homozygous NIS gene mutation T354P. She had begun treatment of primary hypothyroidism with levothyroxine at the age of 5...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493889/plasma-levels-of-free-thyroxine-and-risk-of-major-bleeding-in-bariatric-surgery
#12
Laura P B Elbers, Hjalmar A Boon, Maaike I Moes, Bregje van Zaane, Dees P M Brandjes, Eric Fliers, Harry R Büller, Suzanne Cannegieter, Victor E A Gerdes
BACKGROUND: In a recent study of patients using vitamin K antagonists, those with low free thyroxin (FT4) levels within the normal range had a 3- to 5-fold increased risk of major bleeding. We tested the hypothesis that low levels of preoperative FT4 within the reference range are associated with an increased risk of major bleeding during and after bariatric surgery. METHODS: The charts of 2,872 consecutive patients undergoing bariatric surgery were retrospectively screened for bleeding episodes...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493888/recreational-physical-activity-and-differentiated-thyroid-cancer-risk-a-pooled-analysis-of-two-case-control-studies
#13
Constance Xhaard, Juan J Lence-Anta, Yan Ren, Françoise Borson-Chazot, Geneviève Sassolas, Claire Schvartz, Marc Colonna, Brigitte Lacour, Arlette Danzon, Michel Velten, Enora Clero, Stéphane Maillard, Emilie Marrer, Laurent Bailly, Eugènia Mariné Barjoan, Martin Schlumberger, Jacques Orgiazzi, Elisabeth Adjadj, Celia M Pereda, Silvia Turcios, Milagros Velasco, Mae Chappe, Idalmis Infante, Marlene Bustillo, Anabel García, Sirced Salazar, Regla Rodriguez, Mohamed Amine Benadjaoud, Rosa M Ortiz, Carole Rubino, Florent de Vathaire
PURPOSE: Physical activity has been hypothesized to influence cancer occurrence through several mechanisms. To date, its relation with thyroid cancer risk has been examined in relatively few studies. We pooled 2 case-control studies conducted in Cuba and Eastern France to assess the relationship between self-reported practice of recreational physical activity since childhood and thyroid cancer risk. METHODS: This pooled study included 1,008 cases of differentiated thyroid cancer (DTC) matched with 1,088 controls (age range 9-35 and 17-60 years in the French and Cuban studies, respectively)...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493887/obesity-does-not-modify-the-risk-of-differentiated-thyroid-cancer-in-a-cytological-series-of-thyroid-nodules
#14
Mario Rotondi, Maria Grazia Castagna, Carlo Cappelli, Cristina Ciuoli, Francesca Coperchini, Francesco Chiofalo, Fabio Maino, Paola Palmitesta, Luca Chiovato, Furio Pacini
BACKGROUND: A possible impact of obesity on the risk of thyroid cancer has been postulated in some studies, but it remains controversial. OBJECTIVE: To investigate the association between obesity and differentiated thyroid carcinoma in a population of unselected patients subjected to fine-needle aspiration cytology (FNAC) for thyroid nodules. METHODS: We retrospectively evaluated the results of FNAC of thyroid nodules in 4,849 patients (3,809 females and 1,040 males; mean age 55...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493886/serum-thyroglobulin-concentration-is-a-weak-marker-of-iodine-status-in-a-pregnant-population-with-iodine-deficiency
#15
Eftychia Koukkou, Ioannis Ilias, Irene Mamalis, Georgios G Adonakis, Kostas B Markou
OBJECTIVE: To assess the reliability of thyroglobulin (Tg) as a marker of iodine status during pregnancy. DESIGN: 299 women aged 30.5 ± 4.8 years (mean ± SD) were studied. METHODS: In every subject, we measured urinary iodine concentration (UIC), serum thyrotropin (TSH), Tg, free thyroxine (fT4), Tg autoantibodies (TgAbs) and human chorionic gonadotropin (hCG) levels. We excluded samples with increased TgAbs from the analysis. RESULTS: According to WHO criteria, the study population was iodine deficient in every trimester...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493885/a-2015-italian-survey-of-clinical-practice-patterns-in-the-management-of-graves-disease-comparison-with-european-and-north-american-surveys
#16
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Patients suffering from Graves' disease (GD) are quite frequent in endocrine clinical practice. In particular, overt hyperthyroidism may be complicated by serious adverse events and requires careful treatment, but its management has changed over the years in both the USA and European Union (EU). OBJECTIVES: To evaluate the current diagnosis and management of patient's with GD in Italy, and compare results with those obtained in previous similar surveys in the USA and EU...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493884/comparison-of-early-total-thyroidectomy-with-antithyroid-treatment-in-patients-with-moderate-severe-graves-orbitopathy-a-randomized-prospective-trial
#17
Murat Faik Erdoğan, Özgür Demir, Reyhan Ünlü Ersoy, Kamile Gül, Berna İmge Aydoğan, Ziynet Alphan Üç, Türkan Mete, Sibel Ertek, Uğur Ünlütürk, Bekir Çakır, Yalçın Aral, Serdar Güler, Sevim Güllü, Demet Çorapçıoğlu, Selçuk Dağdelen, Gürbüz Erdoğan
BACKGROUND: The optimal therapeutic choice for Graves' hyperthyroidism in the presence of moderate-severe Graves' orbitopathy (GO) remains controversial. OBJECTIVES: We aimed to compare GO course in patients with moderate-severe GO treated with early total thyroidectomy (TTx) versus antithyroid drug (ATD) regimens, in a prospective, randomized manner. METHODS: Forty-two patients with moderate-severe GO were enrolled. A total of 4.5 g of pulse corticosteroids were given intravenously to all patients before randomization...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493883/levothyroxine-but-not-selenium-increases-endothelial-progenitor-cell-counts-in-patients-with-hypothyroidism
#18
Roberto Negro, Giacomo Greco
BACKGROUND: Hypothyroidism is a common endocrine disease associated with increased oxidative stress, increased cardiovascular (CV) risk, CV events and endothelial dysfunction. Endothelial progenitor cells (EPCs) are a well-known marker of CV risk. OBJECTIVE: The aim of this work was to ascertain whether hypothyroidism is associated with lower EPC counts and if treatment with levothyroxine (LT4) or selenium (Se) improves EPC counts compared to placebo. METHODS: Hypothyrod patients (n = 100) were randomly divided into five groups to receive placebo (group A), LT4 (group B) or Se at doses of 83 µg (group C), 166 µg (group D) or 249 µg (group E) for 3 months...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493882/familiar-papillary-thyroid-carcinoma-in-a-large-brazilian-family-is-not-associated-with-succinate-dehydrogenase-defects
#19
Elen Dias Accordi, Paraskevi Xekouki, Bruna Azevedo, Rodrigo Bertollo de Alexandre, Carla Frasson, Siliane Marie Gantzel, Georgios Z Papadakis, Anna Angelousi, Constantine A Stratakis, Vanessa Santos Sotomaior, Fabio R Faucz
BACKGROUND: Thyroid cancer is the most common endocrine gland malignancy. Advances in understanding the genetic basis for thyroid cancer revealed the potential involvement of several genes in the formation of thyroid tumors. Mutations in the gene coding for succinate dehydrogenase subtype B (SDHB) have been implicated in papillary thyroid cancer (PTC). Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27493881/on-the-origin-of-cells-and-derivation-of-thyroid-cancer-c-cell-story-revisited
#20
REVIEW
Mikael Nilsson, Dillwyn Williams
We will highlight and put into perspective new lineage tracing data from genetic studies in mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer. This overturns the current concept of a neural crest origin of thyroid C cells referred to in every textbook and dedicated paper to this very day. As will become apparent, except for a single experiment, the neural crest theory has little or no support when the evolution and development of calcitonin-producing cells in the entire chordate family are considered...
July 2016: European Thyroid Journal
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