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European Thyroid Journal

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https://www.readbyqxmd.com/read/28101495/medullary-thyroid-carcinoma-distinction-towards-neuroectodermal-tumours-reply-to-the-letter-by-paschou-and-vryonidou
#1
Mikael Nilsson, E Dillwyn Williams
No abstract text is available yet for this article.
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101494/origin-of-thyroid-c-cells-clinical-interpretation
#2
Stavroula A Paschou, Andromachi Vryonidou
No abstract text is available yet for this article.
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101493/an-invitation-to-join-the-consortium-on-thyroid-and-pregnancy
#3
Tim I M Korevaar, Peter N Taylor, Colin M Dayan, Robin Patrick Peeters
No abstract text is available yet for this article.
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101492/trends-and-predictors-of-chemotherapy-use-among-thyroid-cancer-patients-in-the-national-cancer-database-2004-2013
#4
Stacey A Fedewa, Ahmedin Jemal, Amy Y Chen
BACKGROUND/AIM: Beginning in 2011, the Food and Drug Administration (FDA) approved the use of multikinase inhibitors (MKIs) for medullary thyroid cancers (MTCs), and in 2013 MKIs were approved for metastatic differentiated thyroid cancers (DTCs). However, little is known about the use of chemotherapy in thyroid cancer patients. Thus, the goal of our study was to describe patterns of chemotherapy use, including MKIs, among DTC and MTC patients in the National Cancer Database (NCDB). METHODS: Chemotherapy use, along with other treatment types (surgery and radiation), was assessed between 2004 and 2013...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101491/can-the-american-thyroid-association-risk-of-recurrence-predict-radioiodine-refractory-disease-in-differentiated-thyroid-cancer
#5
Aamna Hassan, Saima Riaz, Humayun Bashir, M Khalid Nawaz, Raza Hussain
OBJECTIVE: The aim of this study was to compare the TNM staging system and the American Thyroid Association (ATA) recurrence risk classification in predicting radioiodine refractory disease (RRD) in differentiated thyroid cancer (DTC) and to analyze the correlation of stimulated thyroglobulin (Tg) levels and rate of Tg elevation with the standardized uptake value on (18)F-fludeoxyglucose (FDG) PET/CT scan. METHODS: RRD was indicated through the retrospective analysis of consecutive (18)F-FDG PET/CT scans in DTC with stimulated Tg >10 ng/ml and negative (131)I NaI whole-body scans (WBS)...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101490/periodic-granulocyte-count-measuring-is-useful-for-detecting-asymptomatic-agranulocytosis-in-antithyroid-drug-treated-patients-with-graves-disease
#6
Hirotoshi Nakamura, Akane Ide, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Akira Miyauchi
OBJECTIVE: Finding agranulocytosis (AG) at an early stage is important to improve outcome, but periodic granulocyte count monitoring is not generally recommended for patients with Graves' disease, because AG develops suddenly. METHOD: At the Kuma Hospital, Graves' patients under antithyroid drug (ATD) treatment in an outpatient clinic have a granulocyte count examination during each visit, and if it is <1,000/μl, a warning is immediately sent to the patient's physician...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101489/correction-of-hypothyroidism-leads-to-change-in-lean-body-mass-without-altering-insulin-resistance
#7
Sangeetha Sirigiri, Suresh Vaikkakara, Alok Sachan, P V L N Srinivasarao, Sunil Epuri, Sailaja Anantarapu, Arun Mukka, Srinivasa Rao Chokkapu, Ashok Venkatanarasu, Ravi Poojari
BACKGROUND: Hypothyroidism is associated with insulin resistance, dyslipidemia, and abnormal body composition. This study assessed changes in body composition and insulin resistance after thyroxine (T4) replacement in overt hypothyroidism. METHODS: In this prospective longitudinal study carried out in a tertiary care center, adult nondiabetic patients with overt hypothyroidism were rendered euthyroid on T4. Anthropometry including skinfold thickness (SFT) at the triceps and subscapularis was recorded...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101488/thyroid-function-and-high-sensitivity-c-reactive-protein-in-cross-sectional-results-from-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil-effect-of-adiposity-and-insulin-resistance
#8
Érique José F Peixoto de Miranda, Márcio Sommer Bittencourt, Itamar S Santos, Paulo A Lotufo, Isabela M Benseñor
BACKGROUND: Subclinical hypothyroidism (SCH) is associated with an increased cardiovascular risk, but little information is available about its association with high-sensitivity C-reactive protein (hs-CRP). OBJECTIVES: This study aims to analyze the association between SCH and hs-CRP using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: The study has a cross-sectional design. We included subjects with normal thyroid function (thyroid-stimulating hormone, TSH, 0...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101487/immunoglobulin-g4-related-thyroid-diseases
#9
REVIEW
Dulani Kottahachchi, Duncan J Topliss
Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101486/immunohistochemical-expression-of-estrogen-receptor-%C3%AE-and-progesterone-receptor-in-patients-with-papillary-thyroid-cancer
#10
Giacomo Sturniolo, Carles Zafon, Mariacarla Moleti, Josep Castellví, Francesco Vermiglio, Jordi Mesa
BACKGROUND: Papillary thyroid cancer (PTC) prevalence is nearly 3 times higher in females than in males. This gender difference suggests that growth and progression of PTC might be influenced by female sex hormones. OBJECTIVES: To analyze the expression of both estrogen receptor (ER)-α and progesterone receptor (PR) by immunohistochemistry in 203 PTC patients. METHODS: ER-α and PR expression was evaluated in paraffin-embedded tumor tissue samples of 45 males and 158 females followed up for 7...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101485/minimizing-the-health-effects-of-the-nuclear-accident-in-fukushima-on-thyroids
#11
REVIEW
Shigenobu Nagataki
RESULTS OF THE SCREENING OF THYROIDS: Because of the March 2011 nuclear accident in Fukushima, Japan, the Fukushima Prefecture initiated a thyroid ultrasound examination program. The first cycle of examinations on all children (more than 300,000) of the Fukushima Prefecture identified 116 patients as having malignant or suspected malignant thyroid nodules, and in the second cycle 59 new cases were identified. According to the available data, the thyroid cancers found by the screening are unlikely to be due to radiation, but the possibility cannot be excluded...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843813/biochemical-hyperthyroidism-in-a-newborn-baby-caused-by-assay-interaction-from-biotin-intake
#12
Inge Bülow Pedersen, Peter Laurberg
We describe a case of biochemical neonatal thyrotoxicosis caused by biotin supplementation. Biotin may interact with thyroid function testing to imitate thyrotoxicosis with low thyroid-stimulating hormone and elevated triiodothyronine and thyroxine levels.
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843812/an-unusual-case-of-malignant-struma-ovarii-causing-thyrotoxicosis
#13
Elli Anagnostou, Antonios Polymeris, Georgios Morphopoulos, Alexios Travlos, Vassiliki Sarantopoulou, Irini Papaspyrou
BACKGROUND: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue, accounting for approximately 5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most SO cases are benign with only 5-10% being malignant, and malignant SO causing thyrotoxicosis is very uncommon. CASE: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years previously. The thyroid gland was palpable with a micronodular texture, and the patient was euthyroid under carbimazole...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843811/painful-radiation-thyroiditis-after-131-i-therapy-for-graves-hyperthyroidism-clinical-features-and-ultrasonographic-findings-in-five-cases
#14
Tetsuya Mizokami, Katsuhiko Hamada, Tetsushi Maruta, Kiichiro Higashi, Junichi Tajiri
BACKGROUND: Radiation thyroiditis caused by (131)I therapy for Graves' hyperthyroidism is asymptomatic in most patients and is rarely associated with pain or fever. Currently, there are few reports on the ultrasonographic findings of radiation thyroiditis after (131)I therapy for Graves' hyperthyroidism. CASE REPORT: We herein report 5 cases with painful radiation thyroiditis (including 2 febrile cases) after (131)I therapy for Graves' hyperthyroidism. The cases included 4 women, aged 49, 50, 76, and 81 years, and 1 man, aged 60 years...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843810/braf-v600e-mutation-has-it-a-role-in-cervical-lymph-node-metastasis-of-papillary-thyroid-cancer
#15
Neslihan Kurtulmus, Burak Ertas, Yesim Saglican, Hakan Kaya, Umit Ince, Mete Duren
BACKGROUND: The BRAF(V600E) mutation is common in papillary thyroid cancer (PTC). Lymph node metastasis (LNM) may be associated with poor prognosis. However, the LNM mechanism remains unclear. OBJECTIVES: Our aim was to evaluate the prevalence of the BRAF(V600E) mutation in primary tumors and accompanying LNM at the time of diagnosis. METHODS: This retrospective study included 51 PTC patients (40 women, 11 men; mean age 40.0 ± 16.5 years; range 6-81) who underwent total thyroidectomy accompanied by a lateral neck dissection due to preoperatively detected LNM...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843809/effect-of-an-outreach-programme-on-vandetanib-safety-in-medullary-thyroid-cancer
#16
Lars Bastholt, Michael C Kreissl, Dagmar Führer, Ana L Maia, Laura D Locati, Léa Maciel, Yi Wu, Kevin N Heller, Alan Webster, Rossella Elisei
OBJECTIVES: Effective management of adverse events (AEs) following vandetanib treatment is important to maximize clinical benefits. We examined whether more frequent contact with vandetanib-treated patients reduced AEs of CTCAE grade 2 or higher. STUDY DESIGN: In this open-label, multicentre, phase III study, patients with locally advanced or metastatic medullary thyroid cancer were randomized to a patient outreach programme (outreach) or a standard AE monitoring schedule (vandetanib control) for 52 weeks...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843808/therapeutic-strategies-and-clinical-outcome-in-papillary-thyroid-microcarcinoma-a-multicenter-observational-study
#17
F Cecoli, E M Ceresola, V Altrinetti, M Cabria, M Cappagli, A Montepagani, C M Cuttica, U Filippi, D Saverino, M Raffa, M Caputo, F Minuto, M Giusti, M Bagnasco
PURPOSE: Papillary thyroid microcarcinoma (MPTC) has an excellent prognosis. We aimed to evaluate the evolution of therapeutic strategies over time and the clinical outcome of MPTC. METHODS: In this retrospective multicenter observational study in a northwest Italian region, patients with intrathyroidal, unifocal tumor ≤1 cm in size, incidentally found at histology or preoperative cytology diagnosis, were included. Exclusion criteria were a previous head-and-neck irradiation and/or node metastases...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843807/relational-stability-of-thyroid-hormones-in-euthyroid-subjects-and-patients-with-autoimmune-thyroid-disease
#18
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
BACKGROUND/AIM: Operating far from its equilibrium resting point, the thyroid gland requires stimulation via feedback-controlled pituitary thyrotropin (TSH) secretion to maintain adequate hormone supply. We explored and defined variations in the expression of control mechanisms and physiological responses across the euthyroid reference range. METHODS: We analyzed the relational equilibria between thyroid parameters defining thyroid production and thyroid conversion in a group of 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#19
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27843805/impaired-repressor-function-in-sumoylation-defective-thyroid-hormone-receptor-isoforms
#20
Joachim M Weitzel
BACKGROUND: Many nuclear receptors are modified by posttranslational modifications. OBJECTIVES: The transcriptional activity of thyroid hormone receptors (TRs) is modified by the influence of its ligand (thyroid hormones T3 and T4), but is also affected by posttranslational modifications. This study focuses on the SUMOylation of TR isoforms and the consequences on transcriptional activity and promoter occupancy. METHODS: SUMOylation of TR wild-type as well as isoform-specific point mutations have been studied in vitro...
September 2016: European Thyroid Journal
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