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European Thyroid Journal

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https://www.readbyqxmd.com/read/29071241/total-thyroidectomy-for-thyroid-cancer-followed-by-thyroid-storm-due-to-thyrotropin-receptor-antibody-stimulation-of-metastatic-thyroid-tissue
#1
Lars Folkestad, Frans Brandt, Thomas Brix, Marianne Vogsen, Lars Bastholt, Peter Grupe, Jeanette Krogh Petersen, Laszlo Hegedüs
BACKGROUND: Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated thyroid cancer tissue and/or metastases to produce thyroid hormone. CASE: A 68-year-old male, with weight loss and palpitations, was diagnosed with thyrotoxicosis. A later MRI, due to persistent shoulder pain, revealed multiple bone metastases...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071240/atypia-of-undetermined-significance-in-thyroid-fine-needle-aspirates-a-4-year-audit-of-thy3a-reporting
#2
Dorinda Mullen, Sarah Mullins, Aoife Doyle, Rachel K Crowley, Stephen Skehan, Enda W McDermott, Ruth S Prichard, David Gibbons
OBJECTIVE: Thyroid nodules are common within the general population. Cytological analysis of fine needle aspirates (FNAs) of these lesions allows for identification of those that require further surgery. A numerical classification system is in place to streamline reporting. The 3a category is used for lesions that are neither benign nor malignant but show atypia of undetermined significance. We reviewed our use and clinical outcomes of Thy3a over a 4-year period. METHODS: All thyroid FNAs performed at this institute from January 2012 to December 2015 were identified from our laboratory information system using SNOMED codes...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071239/does-graves-orbitopathy-ever-disappear-answers-to-an-old-question
#3
Elena Sabini, Marenza Leo, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVES: There is a general belief that Graves' orbitopathy (GO) is a "chronic" disease, namely that patients' eyes do not return to how they were before GO appeared. Here, we investigate this issue from both the patient's and the physician's point of view. STUDY DESIGN: We studied the disappearance of GO, regardless of treatment, in all consecutive patients with a GO history of at least 10 years who came for a follow-up visit over a period of 5 years. Patients underwent an ophthalmological examination and were asked to answer a questionnaire on self-perception related to GO...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071238/prolonged-duration-of-surgery-predicts-postoperative-hypoparathyroidism-among-patients-undergoing-total-thyroidectomy-in-a-tertiary-referral-centre
#4
Emilie Sonne-Holm, Christoffer Holst Hahn
BACKGROUND: Postoperative hypoparathyroidism is a common complication following total thyroidectomy. The aim of this study was to investigate the incidence of both transient and permanent hypoparathyroidism in patients undergoing total thyroidectomy in a tertiary referral centre and, furthermore, to identify early predictive risk factors. METHODS: Based on a single-institution retrospective review, we identified 582 patients who underwent total thyroidectomy between January 2010 and March 2015...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071237/the-effect-of-daily-versus-weekly-levothyroxine-replacement-on-thyroid-function-test-in-hypothyroid-patients-at-a-tertiary-care-centre-in-haryana
#5
Rajesh Rajput, Vaibhav Pathak
OBJECTIVE: We compare the effect of daily versus weekly levothyroxine (LT4) replacement on thyroid function test (TFT) in hypothyroid patients at a tertiary care centre in Haryana. MATERIALS AND METHODS: This was a randomised crossover study in which 100 hypothyroid patients on a stable LT4 dose were divided into 2 groups of 50 each. In group I, patients were given daily therapy for 6 weeks and then shifted to weekly therapy for the next 6 weeks. In group II, patients were given LT4 once a week for 6 weeks and then switched to daily therapy for the next 6 weeks...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071236/performance-and-specificity-of-6-immunoassays-for-tsh-receptor-antibodies-a-multicenter-study
#6
Tanja Diana, Christian Wüster, Paul D Olivo, Angelica Unterrainer, Jochem König, Michael Kanitz, Artur Bossowski, Brigitte Decallonne, George J Kahaly
BACKGROUND: The measurement of TSH receptor (TSHR) antibodies is warranted for diagnosis of Graves' disease (GD). OBJECTIVE: The performance, detection sensitivity, and specificity of 6 TSHR immunoassays were compared. METHODS: Two bioassays and 4 binding assays (Kronus, Immulite, Kryptor, Dynex) were compared in a dilution study performed in patients with autoimmune thyroid disease. Both bioassays were compared to 2 binding assays using stimulatory (M22) and blocking (K1-70) monoclonal antibody (MAb) mixtures...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071235/effects-of-thyroid-hormone-on-urinary-concentrating-ability
#7
Elske T Massolt, Mahdi Salih, Carolien M Beukhof, Boen L R Kam, J W Burger, W Edward Visser, Ewout J Hoorn, Robin P Peeters
BACKGROUND: Hypothyroidism has been associated with impaired urinary concentrating ability. However, previous reports on thyroid hormone and urinary concentrating ability in humans only studied a limited number of patients with autoimmune thyroid disease or used healthy controls instead of paired analysis within the same patients. OBJECTIVE: To study the urinary concentrating ability in athyreotic patients with differentiated thyroid cancer on and off levothyroxine treatment as they are exposed to different thyroid states as part of their treatment in the absence of an autoimmune disease...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29082210/industry-sponsored-satellite-symposia
#8
Pilar Santisteban, Miloš Žarković
No abstract text is available yet for this article.
August 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29082209/scientific-programme
#9
(no author information available yet)
No abstract text is available yet for this article.
August 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868263/next-generation-sequencing-and-association-studies-in-familial-nonmedullary-thyroid-carcinoma-let-s-choose-appropriate-controls
#10
Laure Cazabat, Aglae Terray, Philippe de Mazancourt, Jacques Ropers, Lionel Groussin, Marie-Laure Raffin-Sanson
No abstract text is available yet for this article.
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868262/a-cervical-schwannoma-masquerading-as-a-thyroid-nodule
#11
Sravanthi Nagavalli, Marelle Yehuda, Laron W McPhaul, Andrew G Gianoukakis
BACKGROUND: We present a case of a cervical schwannoma, likely originating from the pharyngeal plexus of the vagal nerve. The lesion masqueraded as a thyroid nodule and magnetic resonance imaging (MRI) assisted in preoperative diagnosis. We review the radiographic characteristics of nerve sheath tumors on MRI as well as the diagnostic cytologic stains which can enhance the possibility of a correct preoperative diagnosis. CASE: We describe a 60-year-old female with dysphagia and a neck mass consistent with a nodular goiter...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868261/nonalcoholic-fatty-liver-disease-is-not-associated-with-thyroid-hormone-levels-and-hypothyroidism-a-systematic-review-and-meta-analysis
#12
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala
BACKGROUND: Whether hypothyroidism is related to nonalcoholic fatty liver disease (NAFLD) is unclear. Thyroid dysfunction is closely related with components of metabolic syndrome. Given the hepatic manifestation of metabolic syndrome, several studies have investigated the association between NAFLD and thyroid dysfunction and have demonstrated inconsistent results. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and thyroid dysfunction...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868260/tpoab-and-thyroid-function-are-not-associated-with-breast-cancer-outcome-evidence-from-a-large-scale-study-using-data-from-the-taxotere-as-adjuvant-chemotherapy-trial-tact-cruk01-001
#13
Ilaria Muller, Lucy S Kilburn, Peter N Taylor, Peter J Barrett-Lee, Judith M Bliss, Paul Ellis, Marian E Ludgate, Colin M Dayan
BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). METHODS: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868259/radioiodine-ablation-following-thyroidectomy-for-differentiated-thyroid-cancer-literature-review-of-utility-dose-and-toxicity
#14
REVIEW
Nicholas S Andresen, John M Buatti, Hamed H Tewfik, Nitin A Pagedar, Carryn M Anderson, John M Watkins
Management recommendations for differentiated thyroid cancer are evolving. Total thyroidectomy is the backbone of curative-intent therapy, with radioiodine ablation (RAI) of the thyroid remnant routinely performed, in order to facilitate serologic surveillance and reduce recurrence risk. Several single-institution series have identified patient subsets for whom recurrence risk is sufficiently low that RAI may not be indicated. Further, the appropriate dose of RAI specific to variable clinicopathologic presentations remains poorly defined...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868258/thyroid-autoimmunity-and-thyroid-cancer-review-focused-on-cytological-studies
#15
REVIEW
Francesco Boi, Fabiana Pani, Stefano Mariotti
The association between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) has been originally suggested by retrospective pathological studies and has recently been re-evaluated and proposed on the basis of several fine-needle aspiration cytology (FNAC) studies. In FNAC studies, the association between HT and PTC is based on the comparison of anti-thyroid autoantibodies (ATA) (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb]), thyroid function (TSH), and cytology with histology of thyroid nodules and lymphocytic thyroid infiltration (LTI) of operated thyroid glands...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868257/serum-mirnas-as-biomarkers-for-the-diagnosis-and-prognosis-of-thyroid-cancer-a-comprehensive-review-of-the-literature
#16
REVIEW
Mohammad-Reza Mahmoudian-Sani, Ameneh Mehri-Ghahfarrokhi, Majid Asadi-Samani, Gholam-Reza Mobini
BACKGROUND/OBJECTIVES: Thyroid cancer is the most common endocrine malignancy and accounts for 1% of cancers. In recent years, there has been much interest in the feasibility of using miRNAs or miRNA panels as biomarkers for the diagnosis of thyroid cancer. miRNAs are noncoding RNAs with 21-23 nucleotides that are highly conserved during evolution. They have been proposed as regulators of gene expression, apoptosis, cancer, and cell growth and differentiation. METHODS: The Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science were searched...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28785544/tremelimumab-induced-graves-hyperthyroidism
#17
Earn H Gan, Anna L Mitchell, Ruth Plummer, Simon Pearce, Petros Perros
Tremelimumab and ipilimumab are monoclonal antibodies directed against the extracellular domain of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and have been used as immunotherapies against immune checkpoints that suppress T-cell activation. Anti-CTLA-4 antibody-based therapies have been shown to be effective in treating various cancers including metastatic melanoma. However, a few immune-related adverse events including hypophysitis and thyroid disorder have been reported, mostly developed within the first year of receiving treatment...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28785543/should-age-at-diagnosis-be-included-as-an-additional-variable-in-the-risk-of-recurrence-classification-system-in-patients-with-differentiated-thyroid-cancer
#18
Fabián Pitoia, Fernando Jerkovich, Anabella Smulever, Gabriela Brenta, Fernanda Bueno, Graciela Cross
OBJECTIVE: To evaluate the influence of age at diagnosis on the frequency of structural incomplete response (SIR) according to the modified risk of recurrence (RR) staging system from the American Thyroid Association guidelines. PATIENTS AND METHODS: We performed a retrospective analysis of 268 patients with differentiated thyroid cancer (DTC) followed up for at least 3 years after initial treatment (total thyroidectomy and remnant ablation). The median follow-up in the whole cohort was 74...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28785542/survey-of-clinical-practice-patterns-in-the-management-of-992-hyperthyroid-patients-in-france
#19
Bernard Goichot, Stéphane Bouée, Claire Castello-Bridoux, Philippe Caron
BACKGROUND: Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries. METHODS: A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Diagnosis and treatment modalities were recorded from hyperthyroid patients with Graves disease (GD, n = 802), multinodular goiter (MNG, n = 121), and toxic adenoma (TA, n = 69)...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28785541/hypothyroid-patients-encoding-combined-mct10-and-dio2-gene-polymorphisms-may-prefer-l-t3-l-t4-combination-treatment-data-using-a-blind-randomized-clinical-study
#20
Allan Carlé, Jens Faber, Rudi Steffensen, Peter Laurberg, Birte Nygaard
OBJECTIVES: In previous studies, around half of all hypothyroid patients preferred levo-thyroxine (L-T4) + levo-triiodothyronine (L-T3) combination therapy, 25% preferred T4, and 25% had no preference. The reason for this is yet to be explored. METHODS: A total of 45 overtly autoimmune, hypothyroid patients - now euthyroid on ≥6 months' L-T4 therapy - participated in a prospective, double-blind, cross-over study. The patients were randomized into 2 groups of either 3 continuous months' L-T4 therapy followed by 3 months' combination therapy or vice versa...
July 2017: European Thyroid Journal
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