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European Thyroid Journal

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https://www.readbyqxmd.com/read/29234626/consumptive-hypothyroidism-case-report-of-hepatic-hemangioendotheliomas-successfully-treated-with-vincristine-and-systematic-review-of-the-syndrome
#1
Marina Weber Pasa, Rafael Selbach Scheffel, André Borsatto Zanella, Ana Luiza Maia, José Miguel Dora
Objectives: To provide a comprehensive description of consumptive hypothyroidism syndrome (CHS), a severe form of hypothyroidism that occurs due to the high expression levels of thyroid hormone inactivation enzyme type 3 deiodinase (D3) in tumors. Study Design: Case report and systematic review. Results: A 7-month-old girl with a diagnosis of massive hepatic hemangioendotheliomas was treated with high doses of thyroid hormones and tumor-directed chemotherapy with vincristine...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234625/insight-into-differentiated-thyroid-cancer-gross-pathological-specimen-shrinkage-and-its-influence-on-tnm-staging
#2
Alexis Lacout, Emmanuel Chamorey, Juliette Thariat, Mostafa El Hajjam, Carole Chevenet, Renaud Schiappa, Pierre Yves Marcy
Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements. Material and Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234624/thyroidectomy-improves-tracheal-anatomy-and-airflow-in-patients-with-nodular-goiter-a-prospective-cohort-study
#3
Jesper Roed Sorensen, Jeppe Faurholdt Lauridsen, Helle Døssing, Nina Nguyen, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
Objective: A large goiter may cause compression of the trachea. The aim of this study was to investigate the impact of thyroidectomy on tracheal anatomy and airflow and to correlate this with changes in health-related quality of life (HRQoL) in patients with benign nodular goiter. Methods: Magnetic resonance images of the neck and respiratory flow-volume curves, including both inspiration and expiration, were performed prior to and 6 months following surgery. HRQoL was measured by selected scales from the thyroid-specific patient-reported outcome (ThyPRO)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234623/are-perinatal-events-risk-factors-for-childhood-thyroid-autoimmunity
#4
Berglind Jonsdottir, Markus Lundgren, Sara Wallengren, Åke Lernmark, Ida Jönsson, Helena Elding Larsson
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse. Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study. Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#5
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234621/neonatal-exposure-to-6-n-propyl-thiouracil-an-anti-thyroid-drug-alters-expression-of-hepatic-dna-methyltransferases-methyl-cpg-binding-proteins-gadd45a-p53-and-pcna-in-adult-male-rats
#6
Suresh Kumar Bunker, Jagneshwar Dandapat, Gagan B N Chainy, Sunil Kumar Sahoo, Prabhat Kumar Nayak
Background: Neonatal 6-n-propyl-2-thiouracil (PTU) exposure to male rats is reported to impair liver function in adulthood. However, the mechanism by which the drug impairs liver function is not well known. Objectives: The objectives of the study were to investigate the effects of neonatal exposure of PTU on the expression of DNA methyltransferases (DNMTs), methyl-DNA binding proteins (MBDs), Gadd45a, p53, and proliferating cell nuclear antigen (PCNA) in adult rat liver...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29167761/european-thyroid-association-guidelines-for-ultrasound-malignancy-risk-stratification-of-thyroid-nodules-in-adults-the-eu-tirads
#7
Gilles Russ, Steen J Bonnema, Murat Faik Erdogan, Cosimo Durante, Rose Ngu, Laurence Leenhardt
Thyroid ultrasound (US) is a key examination for the management of thyroid nodules. Thyroid US is easily accessible, noninvasive, and cost-effective, and is a mandatory step in the workup of thyroid nodules. The main disadvantage of the method is that it is operator dependent. Thyroid US assessment of the risk of malignancy is crucial in patients with nodules, in order to select those who should have a fine needle aspiration (FNA) biopsy performed. Due to the pivotal role of thyroid US in the management of patients with nodules, the European Thyroid Association convened a panel of international experts to set up European guidelines on US risk stratification of thyroid nodules...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071241/total-thyroidectomy-for-thyroid-cancer-followed-by-thyroid-storm-due-to-thyrotropin-receptor-antibody-stimulation-of-metastatic-thyroid-tissue
#8
Lars Folkestad, Frans Brandt, Thomas Brix, Marianne Vogsen, Lars Bastholt, Peter Grupe, Jeanette Krogh Petersen, Laszlo Hegedüs
BACKGROUND: Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated thyroid cancer tissue and/or metastases to produce thyroid hormone. CASE: A 68-year-old male, with weight loss and palpitations, was diagnosed with thyrotoxicosis. A later MRI, due to persistent shoulder pain, revealed multiple bone metastases...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071240/atypia-of-undetermined-significance-in-thyroid-fine-needle-aspirates-a-4-year-audit-of-thy3a-reporting
#9
Dorinda Mullen, Sarah Mullins, Aoife Doyle, Rachel K Crowley, Stephen Skehan, Enda W McDermott, Ruth S Prichard, David Gibbons
OBJECTIVE: Thyroid nodules are common within the general population. Cytological analysis of fine needle aspirates (FNAs) of these lesions allows for identification of those that require further surgery. A numerical classification system is in place to streamline reporting. The 3a category is used for lesions that are neither benign nor malignant but show atypia of undetermined significance. We reviewed our use and clinical outcomes of Thy3a over a 4-year period. METHODS: All thyroid FNAs performed at this institute from January 2012 to December 2015 were identified from our laboratory information system using SNOMED codes...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071239/does-graves-orbitopathy-ever-disappear-answers-to-an-old-question
#10
Elena Sabini, Marenza Leo, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVES: There is a general belief that Graves' orbitopathy (GO) is a "chronic" disease, namely that patients' eyes do not return to how they were before GO appeared. Here, we investigate this issue from both the patient's and the physician's point of view. STUDY DESIGN: We studied the disappearance of GO, regardless of treatment, in all consecutive patients with a GO history of at least 10 years who came for a follow-up visit over a period of 5 years. Patients underwent an ophthalmological examination and were asked to answer a questionnaire on self-perception related to GO...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071238/prolonged-duration-of-surgery-predicts-postoperative-hypoparathyroidism-among-patients-undergoing-total-thyroidectomy-in-a-tertiary-referral-centre
#11
Emilie Sonne-Holm, Christoffer Holst Hahn
BACKGROUND: Postoperative hypoparathyroidism is a common complication following total thyroidectomy. The aim of this study was to investigate the incidence of both transient and permanent hypoparathyroidism in patients undergoing total thyroidectomy in a tertiary referral centre and, furthermore, to identify early predictive risk factors. METHODS: Based on a single-institution retrospective review, we identified 582 patients who underwent total thyroidectomy between January 2010 and March 2015...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071237/the-effect-of-daily-versus-weekly-levothyroxine-replacement-on-thyroid-function-test-in-hypothyroid-patients-at-a-tertiary-care-centre-in-haryana
#12
Rajesh Rajput, Vaibhav Pathak
OBJECTIVE: We compare the effect of daily versus weekly levothyroxine (LT4) replacement on thyroid function test (TFT) in hypothyroid patients at a tertiary care centre in Haryana. MATERIALS AND METHODS: This was a randomised crossover study in which 100 hypothyroid patients on a stable LT4 dose were divided into 2 groups of 50 each. In group I, patients were given daily therapy for 6 weeks and then shifted to weekly therapy for the next 6 weeks. In group II, patients were given LT4 once a week for 6 weeks and then switched to daily therapy for the next 6 weeks...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071236/performance-and-specificity-of-6-immunoassays-for-tsh-receptor-antibodies-a-multicenter-study
#13
Tanja Diana, Christian Wüster, Paul D Olivo, Angelica Unterrainer, Jochem König, Michael Kanitz, Artur Bossowski, Brigitte Decallonne, George J Kahaly
BACKGROUND: The measurement of TSH receptor (TSHR) antibodies is warranted for diagnosis of Graves' disease (GD). OBJECTIVE: The performance, detection sensitivity, and specificity of 6 TSHR immunoassays were compared. METHODS: Two bioassays and 4 binding assays (Kronus, Immulite, Kryptor, Dynex) were compared in a dilution study performed in patients with autoimmune thyroid disease. Both bioassays were compared to 2 binding assays using stimulatory (M22) and blocking (K1-70) monoclonal antibody (MAb) mixtures...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29071235/effects-of-thyroid-hormone-on-urinary-concentrating-ability
#14
Elske T Massolt, Mahdi Salih, Carolien M Beukhof, Boen L R Kam, J W Burger, W Edward Visser, Ewout J Hoorn, Robin P Peeters
BACKGROUND: Hypothyroidism has been associated with impaired urinary concentrating ability. However, previous reports on thyroid hormone and urinary concentrating ability in humans only studied a limited number of patients with autoimmune thyroid disease or used healthy controls instead of paired analysis within the same patients. OBJECTIVE: To study the urinary concentrating ability in athyreotic patients with differentiated thyroid cancer on and off levothyroxine treatment as they are exposed to different thyroid states as part of their treatment in the absence of an autoimmune disease...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29082210/industry-sponsored-satellite-symposia
#15
Pilar Santisteban, Miloš Žarković
No abstract text is available yet for this article.
August 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29082209/scientific-programme
#16
(no author information available yet)
No abstract text is available yet for this article.
August 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868263/next-generation-sequencing-and-association-studies-in-familial-nonmedullary-thyroid-carcinoma-let-s-choose-appropriate-controls
#17
Laure Cazabat, Aglae Terray, Philippe de Mazancourt, Jacques Ropers, Lionel Groussin, Marie-Laure Raffin-Sanson
No abstract text is available yet for this article.
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868262/a-cervical-schwannoma-masquerading-as-a-thyroid-nodule
#18
Sravanthi Nagavalli, Marelle Yehuda, Laron W McPhaul, Andrew G Gianoukakis
BACKGROUND: We present a case of a cervical schwannoma, likely originating from the pharyngeal plexus of the vagal nerve. The lesion masqueraded as a thyroid nodule and magnetic resonance imaging (MRI) assisted in preoperative diagnosis. We review the radiographic characteristics of nerve sheath tumors on MRI as well as the diagnostic cytologic stains which can enhance the possibility of a correct preoperative diagnosis. CASE: We describe a 60-year-old female with dysphagia and a neck mass consistent with a nodular goiter...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868261/nonalcoholic-fatty-liver-disease-is-not-associated-with-thyroid-hormone-levels-and-hypothyroidism-a-systematic-review-and-meta-analysis
#19
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala
BACKGROUND: Whether hypothyroidism is related to nonalcoholic fatty liver disease (NAFLD) is unclear. Thyroid dysfunction is closely related with components of metabolic syndrome. Given the hepatic manifestation of metabolic syndrome, several studies have investigated the association between NAFLD and thyroid dysfunction and have demonstrated inconsistent results. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and thyroid dysfunction...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868260/tpoab-and-thyroid-function-are-not-associated-with-breast-cancer-outcome-evidence-from-a-large-scale-study-using-data-from-the-taxotere-as-adjuvant-chemotherapy-trial-tact-cruk01-001
#20
Ilaria Muller, Lucy S Kilburn, Peter N Taylor, Peter J Barrett-Lee, Judith M Bliss, Paul Ellis, Marian E Ludgate, Colin M Dayan
BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). METHODS: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15...
July 2017: European Thyroid Journal
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