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European Thyroid Journal

Tetsuya Mizokami, Shuji Fukata, Akira Hishinuma, Takahiko Kogai, Katsuhiko Hamada, Tetsushi Maruta, Kiichiro Higashi, Junichi Tajiri
BACKGROUND: Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS) gene mutations. In the lactating mammary gland, iodide is concentrated by NIS, and iodine for thyroid hormone synthesis is thereby supplied to the infant in the breast milk. CASE DESCRIPTION: A 34-year-old Japanese woman was diagnosed with ITD caused by a homozygous NIS gene mutation T354P. She had begun treatment of primary hypothyroidism with levothyroxine at the age of 5...
July 2016: European Thyroid Journal
Laura P B Elbers, Hjalmar A Boon, Maaike I Moes, Bregje van Zaane, Dees P M Brandjes, Eric Fliers, Harry R Büller, Suzanne Cannegieter, Victor E A Gerdes
BACKGROUND: In a recent study of patients using vitamin K antagonists, those with low free thyroxin (FT4) levels within the normal range had a 3- to 5-fold increased risk of major bleeding. We tested the hypothesis that low levels of preoperative FT4 within the reference range are associated with an increased risk of major bleeding during and after bariatric surgery. METHODS: The charts of 2,872 consecutive patients undergoing bariatric surgery were retrospectively screened for bleeding episodes...
July 2016: European Thyroid Journal
Constance Xhaard, Juan J Lence-Anta, Yan Ren, Françoise Borson-Chazot, Geneviève Sassolas, Claire Schvartz, Marc Colonna, Brigitte Lacour, Arlette Danzon, Michel Velten, Enora Clero, Stéphane Maillard, Emilie Marrer, Laurent Bailly, Eugènia Mariné Barjoan, Martin Schlumberger, Jacques Orgiazzi, Elisabeth Adjadj, Celia M Pereda, Silvia Turcios, Milagros Velasco, Mae Chappe, Idalmis Infante, Marlene Bustillo, Anabel García, Sirced Salazar, Regla Rodriguez, Mohamed Amine Benadjaoud, Rosa M Ortiz, Carole Rubino, Florent de Vathaire
PURPOSE: Physical activity has been hypothesized to influence cancer occurrence through several mechanisms. To date, its relation with thyroid cancer risk has been examined in relatively few studies. We pooled 2 case-control studies conducted in Cuba and Eastern France to assess the relationship between self-reported practice of recreational physical activity since childhood and thyroid cancer risk. METHODS: This pooled study included 1,008 cases of differentiated thyroid cancer (DTC) matched with 1,088 controls (age range 9-35 and 17-60 years in the French and Cuban studies, respectively)...
July 2016: European Thyroid Journal
Mario Rotondi, Maria Grazia Castagna, Carlo Cappelli, Cristina Ciuoli, Francesca Coperchini, Francesco Chiofalo, Fabio Maino, Paola Palmitesta, Luca Chiovato, Furio Pacini
BACKGROUND: A possible impact of obesity on the risk of thyroid cancer has been postulated in some studies, but it remains controversial. OBJECTIVE: To investigate the association between obesity and differentiated thyroid carcinoma in a population of unselected patients subjected to fine-needle aspiration cytology (FNAC) for thyroid nodules. METHODS: We retrospectively evaluated the results of FNAC of thyroid nodules in 4,849 patients (3,809 females and 1,040 males; mean age 55...
July 2016: European Thyroid Journal
Eftychia Koukkou, Ioannis Ilias, Irene Mamalis, Georgios G Adonakis, Kostas B Markou
OBJECTIVE: To assess the reliability of thyroglobulin (Tg) as a marker of iodine status during pregnancy. DESIGN: 299 women aged 30.5 ± 4.8 years (mean ± SD) were studied. METHODS: In every subject, we measured urinary iodine concentration (UIC), serum thyrotropin (TSH), Tg, free thyroxine (fT4), Tg autoantibodies (TgAbs) and human chorionic gonadotropin (hCG) levels. We excluded samples with increased TgAbs from the analysis. RESULTS: According to WHO criteria, the study population was iodine deficient in every trimester...
July 2016: European Thyroid Journal
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Patients suffering from Graves' disease (GD) are quite frequent in endocrine clinical practice. In particular, overt hyperthyroidism may be complicated by serious adverse events and requires careful treatment, but its management has changed over the years in both the USA and European Union (EU). OBJECTIVES: To evaluate the current diagnosis and management of patient's with GD in Italy, and compare results with those obtained in previous similar surveys in the USA and EU...
July 2016: European Thyroid Journal
Murat Faik Erdoğan, Özgür Demir, Reyhan Ünlü Ersoy, Kamile Gül, Berna İmge Aydoğan, Ziynet Alphan Üç, Türkan Mete, Sibel Ertek, Uğur Ünlütürk, Bekir Çakır, Yalçın Aral, Serdar Güler, Sevim Güllü, Demet Çorapçıoğlu, Selçuk Dağdelen, Gürbüz Erdoğan
BACKGROUND: The optimal therapeutic choice for Graves' hyperthyroidism in the presence of moderate-severe Graves' orbitopathy (GO) remains controversial. OBJECTIVES: We aimed to compare GO course in patients with moderate-severe GO treated with early total thyroidectomy (TTx) versus antithyroid drug (ATD) regimens, in a prospective, randomized manner. METHODS: Forty-two patients with moderate-severe GO were enrolled. A total of 4.5 g of pulse corticosteroids were given intravenously to all patients before randomization...
July 2016: European Thyroid Journal
Roberto Negro, Giacomo Greco
BACKGROUND: Hypothyroidism is a common endocrine disease associated with increased oxidative stress, increased cardiovascular (CV) risk, CV events and endothelial dysfunction. Endothelial progenitor cells (EPCs) are a well-known marker of CV risk. OBJECTIVE: The aim of this work was to ascertain whether hypothyroidism is associated with lower EPC counts and if treatment with levothyroxine (LT4) or selenium (Se) improves EPC counts compared to placebo. METHODS: Hypothyrod patients (n = 100) were randomly divided into five groups to receive placebo (group A), LT4 (group B) or Se at doses of 83 µg (group C), 166 µg (group D) or 249 µg (group E) for 3 months...
July 2016: European Thyroid Journal
Elen Dias Accordi, Paraskevi Xekouki, Bruna Azevedo, Rodrigo Bertollo de Alexandre, Carla Frasson, Siliane Marie Gantzel, Georgios Z Papadakis, Anna Angelousi, Constantine A Stratakis, Vanessa Santos Sotomaior, Fabio R Faucz
BACKGROUND: Thyroid cancer is the most common endocrine gland malignancy. Advances in understanding the genetic basis for thyroid cancer revealed the potential involvement of several genes in the formation of thyroid tumors. Mutations in the gene coding for succinate dehydrogenase subtype B (SDHB) have been implicated in papillary thyroid cancer (PTC). Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle...
July 2016: European Thyroid Journal
Mikael Nilsson, Dillwyn Williams
We will highlight and put into perspective new lineage tracing data from genetic studies in mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer. This overturns the current concept of a neural crest origin of thyroid C cells referred to in every textbook and dedicated paper to this very day. As will become apparent, except for a single experiment, the neural crest theory has little or no support when the evolution and development of calcitonin-producing cells in the entire chordate family are considered...
July 2016: European Thyroid Journal
Thomas Karrasch, Saskia M Herbst, Ute Hehr, Andreas Schmid, Andreas Schäffler
INTRODUCTION AND BACKGROUND: Familial medullary thyroid cancer (FMTC) is caused by gain of function mutations in the proto-oncogene RET (rearranged during transfection). Missense mutations within exon 14 including p.Val804Met are known to cause FMTC and multiple endocrine neoplasia type 2a/b. The clinical significance of other novel missense variants within this hotspot region of exon 14 is not delineated. CASE DESCRIPTION: A three-generation pedigree of FMTC is presented with the co-occurrence of two missense variants within exon 14 of the RET gene, the known variant p...
March 2016: European Thyroid Journal
Sofie Larsen Rasmussen, Lars Rejnmark, Eva Ebbehøj, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Jakob Bue Bjorner, Torquil Watt
INTRODUCTION AND PURPOSE: Use of electronic questionnaires to collect health-related quality-of-life data has evolved as an alternative to paper questionnaires. For the electronic questionnaire to be used interchangeably with the validated paper questionnaire, measurement properties similar to the original must be demonstrated. The aim of the present study was to assess the equivalence between the paper version and the electronic version of the thyroid-related quality-of-life questionnaire ThyPRO...
March 2016: European Thyroid Journal
Nora Dehina, Peter Josef Hofmann, Thomas Behrends, Anja Eckstein, Lutz Schomburg
BACKGROUND: Selenium (Se) is of importance for regular functioning of the immune system and thyroid gland, and may have a health effect in mild Graves' ophthalmopathy (GO). OBJECTIVE: As the Se status declines in inflammation, we analyzed whether GO activity or severity affects the Se status of patients. METHODS: Serum Se and selenoprotein P (SePP) concentrations were retrospectively determined in 84 consecutive GO patients before treatment and compared to their clinical activity score (CAS) and severity of eye changes (NOSPECS) status, and to the concentrations of autoantibodies targeting the TSH receptor (TRAK) or the IGF1 receptor (IGF1R-aAB)...
March 2016: European Thyroid Journal
Mikael Lantz, Jan Calissendorff, Frank Träisk, Leif Tallstedt, Tereza Planck, Ove Törring, Bengt Hallengren, Peter Åsman
BACKGROUND: Orbital morphological changes are often present in patients with Graves' disease (GD) already at diagnosis, and cyclooxygenase type 2 (COX-2) is overexpressed in active Graves' ophthalmopathy (GO). OBJECTIVE: To investigate if adjuvant treatment of GD with the COX inhibitor and peroxisome proliferator-activated receptor-γ (PPAR-γ) antagonist diclofenac decreases the development of ophthalmopathy and if laboratory parameters are affected. METHODS: This is a multicenter trial where 61 subjects were randomized to methimazole (block and replace with l-thyroxine) either with or without diclofenac 50 mg 1 × 2 for 12 months...
March 2016: European Thyroid Journal
Carolina C P S Janovsky, Rui M B Maciel, Cleber P Camacho, Rosalia P Padovani, Claudia C Nakabashi, Ji H Yang, Eduardo Z Malouf, Elza S Ikejiri, M Conceição O C Mamone, Jairo Wagner, Danielle M Andreoni, Rosa Paula M Biscolla
OBJECTIVES: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). STUDY DESIGN: We prospectively followed up 57 patients; 3 months after TT, thyroglobulin (Tg) assessment and neck ultrasonography (US) were performed while patients were taking l-T4, presenting suppressed TSH. Six months after TT, patients underwent stimulated Tg testing and whole-body scan (WBS) after recombinant TSH (rhTSH)...
March 2016: European Thyroid Journal
Stine Linding Andersen, Peter Laurberg
Iodine requirements are increased during pregnancy, predominantly caused by an increase in renal iodide clearance and in the use of iodine for thyroid hormone production. Because iodine deficiency (ID) in pregnancy may be associated with neurodevelopmental deficits in the offspring, a pertinent question is at what level of iodine intake pregnant women should be advised to take iodine-containing supplements. The consensus reached by the WHO/UNICEF/ICCIDD in 2007 was that pregnant women should not be recommended to take iodine-containing supplements if the population in general had been iodine sufficient for at least 2 years...
March 2016: European Thyroid Journal
Riccardo Donzelli, Daria Colligiani, Claudia Kusmic, Martina Sabatini, Leonardo Lorenzini, Alice Accorroni, Monica Nannipieri, Alessandro Saba, Giorgio Iervasi, Riccardo Zucchi
BACKGROUND AND OBJECTIVE: The present study was aimed at determining the effects of experimental hypothyroidism and hyperthyroidism on tissue thyroid hormones by a mass spectrometry-based technique. METHODS: Rats were subjected to propylthiouracil treatment or administration of exogenous triiodothyronine (T3) or thyroxine (T4). Tissue T3 and T4 were measured by liquid chromatography tandem mass spectrometry in the heart, liver, kidney, visceral and subcutaneous adipose tissue, and brain...
March 2016: European Thyroid Journal
Luigi Bartalena, Lelio Baldeschi, Kostas Boboridis, Anja Eckstein, George J Kahaly, Claudio Marcocci, Petros Perros, Mario Salvi, Wilmar M Wiersinga
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease, though severe forms are rare. Management of GO is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient's quality of life. Local measures (artificial tears, ointments and dark glasses) and control of risk factors for progression (smoking and thyroid dysfunction) are recommended for all patients...
March 2016: European Thyroid Journal
Furio Pacini
No abstract text is available yet for this article.
March 2016: European Thyroid Journal
Peter Laurberg
No abstract text is available yet for this article.
March 2016: European Thyroid Journal
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