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Focal epilepsy in Individuals with Laron syndrome.
Hormone Research in Pædiatrics 2022 March 32
OBJECTIVE: To describe focal epilepsy in patients with Laron syndrome (LS).
METHODS: Data were retrieved from medical records of a single-center cohort of 75 patients with LS.
RESULTS: We describe for the first time four patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus (SE). EEGs in all four patients showed interictal epileptiform discharges (IEDs) in the temporal regions. Three achieved long-term seizure freedom on anti-seizure medications.
CONCLUSION: Patients with LS may be at risk of developing focal epilepsy, that seems to be unrelated to hypoglycemic episodes in childhood.
METHODS: Data were retrieved from medical records of a single-center cohort of 75 patients with LS.
RESULTS: We describe for the first time four patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus (SE). EEGs in all four patients showed interictal epileptiform discharges (IEDs) in the temporal regions. Three achieved long-term seizure freedom on anti-seizure medications.
CONCLUSION: Patients with LS may be at risk of developing focal epilepsy, that seems to be unrelated to hypoglycemic episodes in childhood.
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