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New link between the RNA polymerase II-CTD and replication stress.
Molecular & Cellular Oncology 2021 April 19
Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.
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