Hisataka Sabe, Ari Hashimoto, Shigeru Hashimoto, Tsukasa Oikawa
The mevalonate pathway results in the prenylation of small GTPases, which are pivotal for oncogenesis and cancer malignancies. However, inhibitors of this pathway, such as statins, have not necessarily produced favorable results in clinical trials. We recently identified properties of statin responders, together with the underlying molecular mechanisms and simple biomarkers to predict these responders.
July 2016: Molecular & Cellular Oncology