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No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans.
Pharmacogenomics 2018 November
AIM: Recent studies show an association between the endocannabinoid system and pain. In this study, we analyzed the association between two CNR1 gene polymorphisms and pain perception in a northeast Mexican population.
METHODS: Genotypic and allelic frequencies were obtained for both polymorphisms. Pain threshold, tolerance and perception were measured using the cold pressor task.
RESULTS: No significant association between the polymorphisms and pain perception was found (p > 0.05).
CONCLUSION: Genotypic and allelic frequencies for both polymorphisms were reported for the first time in a Mexican population; however, our results suggest that there is not a significant association between these and pain.
METHODS: Genotypic and allelic frequencies were obtained for both polymorphisms. Pain threshold, tolerance and perception were measured using the cold pressor task.
RESULTS: No significant association between the polymorphisms and pain perception was found (p > 0.05).
CONCLUSION: Genotypic and allelic frequencies for both polymorphisms were reported for the first time in a Mexican population; however, our results suggest that there is not a significant association between these and pain.
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