We have located links that may give you full text access.
English Abstract
Journal Article
Research Support, Non-U.S. Gov't
[Effect of glucocorticoid on [Ca2+]i induced by high-K+ in single PC12 cells and its characteristics].
Sheng Li Xue Bao : [Acta Physiologica Sinica] 1998 October
The effect of glucocorticoid on the increase of cytosolic free calcium [Ca2+]i) induced by high-K+ was investigated in pheochomocytoma PC12 cells. The main result was as follows: (1) When the cells were preincubated at 37 degrees C for various time intervals in the presence of 10(-5) mol/L of corticosterone and stimulated with 55 mmol/L KCl, an inhibitory effect of corticosterone on delta [Ca2+]i was observed in a time-dependent manner with maximal effect at 5th min and no effect at 25th min. (2) When PC12 cells were preincubated with various concentration of corticosterone at 37 degrees C for 5 min, the inhibitory effect of corticosterone on delta [Ca2+]i induced by 55 mmol/L KCl was concentration-dependent. The effect was found to be maximal at 10(-5) mol/L of corticosterone and disappeared at 10(-9) mol/L of corticosterone. (3) Other steroids such as cortisol, dexamethasone, progesterone, testosterone, 17 beta-estradiol and aldosterone also inhibited the rise of [Ca2+]i evoked by 55 mmol/L KCl in PC12 cells to different extents, i.e., in the rank of P = F > Dex > T > Ald = E2. Cholesterol was ineffective at the concentration up to 10(-5) mol/L for inhibiting [Ca2+]i evoked by 55 mmol/L KCl. (4) Corticosterone could not inhibit the [Ca2+]i rise induced by changing the concentration of extracellular calcium from Ca(2+)-free to 3 mmol/L.
Full text links
Related Resources
Trending Papers
Executive Summary: State-of-the-Art Review: Unintended Consequences: Risk of Opportunistic Infections Associated with Long-term Glucocorticoid Therapies in Adults.Clinical Infectious Diseases 2024 April 11
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review.Epilepsia 2024 April 13
Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.International Journal of Molecular Sciences 2024 April 13
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app