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Safety and pharmacokinetics of an intramuscular monoclonal antibody (SB 209763) against respiratory syncytial virus (RSV) in infants and young children at risk for severe RSV disease.

H C Meissner, J R Groothuis, W J Rodriguez, R C Welliver, G Hogg, P H Gray, R Loh, E A Simoes, P Sly, A K Miller, A I Nichols, D K Jorkasky, D E Everitt, K A Thompson
Antimicrobial Agents and Chemotherapy 1999 May
We conducted a multicenter, double-blind, placebo-controlled, randomized trial of a humanized monoclonal antibody against a respiratory syncytial virus (RSV) fusion protein (SB 209763) to evaluate its safety, pharmacokinetics, and fusion inhibition and neutralization titers. Forty-three infants who were either delivered prematurely (

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