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Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium.
Chemical Communications : Chem Comm 2024 March 29
The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1 H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.
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