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Chemical Communications: Chem Comm

Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang, Wei Wang
A green approach for the synthesis of thermodynamically less stable Z-alkenes has been presented through the exploration of visible light promoted photocatalytic E-to-Z isomerization. This protocol features metal-free conditions, which is operationally simple, remarkably clean, and allows the synthesis of both electron-rich and electron-deficient Z-alkenes with diverse functional groups.
November 17, 2017: Chemical Communications: Chem Comm
Takahisa Okuno, Stephan Thürmer, Hirofumi Kanoh
Nanostructured silicon (N-Si) was prepared by anodic electroetching of p-type silicon wafers. The obtained magnetic particles were separated by a permanent neodymium magnet as a magnetic nanostructured silicon (mN-Si). The N-Si and mN-Si exhibited different magnetic properties: the N-Si exhibited ferromagnetic-like behaviour, whereas the mN-Si exhibited superparamagnetic-like behaviour.
November 17, 2017: Chemical Communications: Chem Comm
Shixiong Zhang, Ping Deng, Jing Zhou, Mouxiong Liu, Guojuan Liang, Yan Xiong, Hui Zhou
A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1-0.05 mol%) on a preparative scale (5-50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.
November 17, 2017: Chemical Communications: Chem Comm
Yanying Lu, Qiu Zhang, Mo Han, Jun Chen
Current collectors have a significant role in Na plating and stripping. Here we demonstrate that a three-dimensional (3D) Cu current collector with thin nanowires (<40 nm) can significantly promote the electrochemical deposition stability of Na via tuning a Na metal plating model, therefore contributing to a high efficiency, long lifespan, and low overpotential during electrode/battery cycling.
November 17, 2017: Chemical Communications: Chem Comm
Agnieszka Brandt-Talbot, Lisa Weigand
No abstract text is available yet for this article.
November 17, 2017: Chemical Communications: Chem Comm
Rui-Jie Mi, Jing Sun, Fritz E Kühn, Ming-Dong Zhou, Zhaoqing Xu
A traceless organosilicon template-directed meta-selective-C-H alkenylation of phenols was realized with good yields and high selectivities. The template was readily removable through F(-)-promoted O-Si cleavage under extremely mild conditions or recyclable through a p-TSA catalyzed process. The product was successfully applied in the preparation of a series of meta-alkenylated aromatic compounds.
November 17, 2017: Chemical Communications: Chem Comm
Zengmin Du, Ningfeng Li, Yujie Hua, Yong Shi, Chunyan Bao, Hongbo Zhang, Yi Yang, Qiuning Lin, Linyong Zhu
An extrudable hydrogel with a tunable gelation time under physiological pH ranges based on the phase separation of gelatin and oxidized dextran was demonstrated. We envision that the easy handing properties of this hydrogel combined with thermosensitive physical gelation and postponed chemical reinforcing will provide a platform for 3D bioprinting applications.
November 17, 2017: Chemical Communications: Chem Comm
Jimmy Erik Jakobsson, Gaute Grønnevik, Patrick Johannes Riss
A metal free, phosphane-catalysed protocol for C-F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. With operational ease and mild conditions, the method promises a high potential for radiolabelling of biomolecules...
November 16, 2017: Chemical Communications: Chem Comm
Thirupathi Ravula, Carlo Barnaba, Mukesh Mahajan, G M Anantharamaiah, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy
Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b5. These results highlight the importance of lipid membrane for the function of P450.
November 16, 2017: Chemical Communications: Chem Comm
Mingyang Ji, Brian Daniels, Aileen Shieh, David A Modarelli, Jon R Parquette
This work demonstrates that sonication, followed by polymer-wrapping, is an effective strategy to modulate the length of self-assembled nanotubes. The length distributions of the nanotubes were controlled by varying the amplitude of sonication. Wrapping the nanotubes with ionic polymers suspended the propensity of the nanotube fragments to re-assemble over time into their elongated precursors.
November 16, 2017: Chemical Communications: Chem Comm
Monisha Singha, Sayantani Roy, Satya Deo Pandey, Subhendu Sekhar Bag, Prabuddha Bhattacharya, Mainak Das, Anindya S Ghosh, Debashis Ray, Amit Basak
This work describes the synthesis of azidonaphthalimide carboxylic acids which act as fluorescent templates with a built-in photoreactive group and a linker thus simplifying the design of protein labeling agents. These were separately connected to selectivity hands like a sulfonamide and ampicillin for successful labeling/detection of HCAII and PBPs, respectively.
November 16, 2017: Chemical Communications: Chem Comm
Adam C Sedgwick, Hai-Hao Han, Jordan E Gardiner, Steven D Bull, Xiao-Peng He, Tony D James
Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).
November 16, 2017: Chemical Communications: Chem Comm
Beatrice Castellani, Eleonora Diamanti, Daniela Pizzirani, Piero Tardia, Martina Maccesi, Natalia Realini, Paola Magotti, Gianpiero Garau, Thomas Bakkum, Silvia Rivara, Marco Mor, Daniele Piomelli
N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.
November 16, 2017: Chemical Communications: Chem Comm
Chiara Colletto, Jordi Burés, Igor Larrosa
We have discovered that the dba ligand in the commonly used Pd2(dba)3·CHCl3 cross-coupling pre-catalyst is susceptible to bis-arylation when used in the presence of aryl iodides. The in situ formed dbaAr2 ligands result in Pd-species with altered catalytic activity. In the case of study, the room temperature C3 arylation of benzo[b]thiophenes with aryl iodides, we have observed a marked catalyst deactivation when dba is arylated with electron-deficient aryl iodides, accounting for the poor yields obtained in the C3 arylation reactions with these aryl iodides...
November 16, 2017: Chemical Communications: Chem Comm
M H Wright, Y Tao, J Drechsel, J Krysiak, S Chamni, A Weigert-Munoz, N L Harvey, D Romo, S A Sieber
The spongiolactones are marine natural products with an unusual rearranged spongiane skeleton and a fused β-lactone ring. These compounds have potential anticancer properties but their mode of action has yet to be explored. Here we employ activity-based protein profiling to identify the targets of a more potent spongiolactone derivative in live cancer cells, and compare these to the targets of a simpler β-lactone. These hits provide the first insights into the covalent mechanism of action of this natural product class...
November 16, 2017: Chemical Communications: Chem Comm
E Etemadi-Davan, N Iranpoor
An efficient Ni(COD)2/dppf catalyzed olefination of Ar-O-TCT as synthetic equivalents of aryl halides is described. Activation of C-O bonds in phenols as readily available compounds was achieved with 2,4,6-trichloro-1,3,5-triazine (TCT). This method provides practical access to 1,2-disubstituted olefins in high yields and high functional group compatibility.
November 16, 2017: Chemical Communications: Chem Comm
Naifang Liu, Sheng-Li Huang, Xiaogang Liu, He-Kuan Luo, T S Andy Hor
A series of trapezoidal metallacycles were synthesized by the selective combination of a rigid with a flexible arm. [2]Catenane 3 was obtained by self-assembly when the cavity size of the trapezoidal rings was optimised.
November 16, 2017: Chemical Communications: Chem Comm
Anqi Zhang, Lan Yao, Ming An
The acid-labile behavior of di-substituted maleamic acid (DMA) and its equilibrium with di-substituted maleimide (DMI) are exploited to build an ultra acid-sensitive, small molecule prodrug that can be activated by tumor extracellular pH (pHe) in the range of 6.5-6.9. Such a DMA prodrug reversed the unfavorable pH-profile of doxorubicin (Dox), which may improve its therapeutic window.
November 16, 2017: Chemical Communications: Chem Comm
Wen-Ming Wan, Andrew W Baggett, Fei Cheng, Huina Lin, Ashley N Lamm, Shih-Yuan Liu, Frieder Jäkle
Correction for 'Synthesis by free radical polymerization and properties of BN-polystyrene and BN-poly(vinylbiphenyl)' by Wen-Ming Wan et al., Chem. Commun., 2016, 52, 13616-13619.
November 16, 2017: Chemical Communications: Chem Comm
Meng Tian, Juanjuan Li, Shumiao Zhang, Lihua Guo, Xiangdong He, Deliang Kong, Hairong Zhang, Zhe Liu
Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η(6)-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.
November 16, 2017: Chemical Communications: Chem Comm
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