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Chemical Communications: Chem Comm

Talita B Gontijo, Rossimiriam P de Freitas, Guilherme F de Lima, Lucas C D de Rezende, Leandro F Pedrosa, Thaissa L Silva, Marilia O F Goulart, Bruno C Cavalcanti, Claudia Pessoa, Marina P Bruno, José R Corrêa, Flavio S Emery, Eufrânio N da Silva Júnior
For the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research...
October 24, 2016: Chemical Communications: Chem Comm
Gabe Nagy, Tianyuan Peng, Daniel E K Kabotso, Milos V Novotny, Nicola L B Pohl
Given recent advances in automated oligosaccharide synthesis, analytical techniques that can be coupled to a synthetic framework are needed to not just identify but also purify to homogeneity protected carbohydrate compounds at levels of ≥99.5% purity. Herein, an alternate-pump recycling high-performance liquid chromatography (R-HPLC) method has been developed to allow purification of protected carbohydrates at levels of ≥99.5% purity.
October 24, 2016: Chemical Communications: Chem Comm
X R Zhang, Y Zhang, F T Chen, Y Li, S S Zhang
A novel biosensor was developed based on the cation-exchange of CuS nanoparticles (NPs) and Cu(i)-based click chemistry of functionalized gold nanoparticles (AuNPs). As a proof-of-principle, novel applications of this method as a versatile biosensor for single-nucleotide polymorphisms (SNPs) and DNA methyltransferase (MTase) were presented.
October 24, 2016: Chemical Communications: Chem Comm
Kirsten Reuter, Günther Thiele, Thomas Hafner, Frank Uhlig, Carsten von Hänisch
The first hybrid crown ether with two adjacent disilane fragments was synthesized through reaction of O(Si2Me4Cl)2 (3) with O(C2H4OH)2. By means of DFT calculations, the complexation ability of 1,2,4,5-tetrasila[12]crown-4 (7) towards Li(+) was determined to be considerably higher compared to [12]crown-4.
October 24, 2016: Chemical Communications: Chem Comm
Dahao Jiang, Xianyuan Wu, Jun Mao, Jun Ni, Xiaonian Li
Cu-CeO2/AC catalysts exhibited extraordinary catalytic performance in the upgradation of ethanol to n-butanol. To the best of our knowledge, this is the first report that the highest n-butanol yields of 21.6% and nearly 20% could be achieved over heterogeneous catalysts under mild reaction conditions in batch and fixed-bed reactors, respectively. The high catalytic activity, selectivity and stability of these catalysts could be ascribed to the synergy of Cu, CeO2 and the activated carbon support.
October 24, 2016: Chemical Communications: Chem Comm
Thomas C Wilson, Greg McSweeney, Sean Preshlock, Stefan Verhoog, Matthew Tredwell, Thomas Cailly, Véronique Gouverneur
A general method for the copper mediated nucleophilic (123)I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [(123)I]DPA-713, [(123)I]IMPY, [(123)I]MIBG and [(123)I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.
October 24, 2016: Chemical Communications: Chem Comm
Feng Wang, Minhuan Lan, Wai-Pong To, Kai Li, Chun-Nam Lok, Pengfei Wang, Chi-Ming Che
We report an amphiphilic macromolecule containing a cyclometalated gold(iii) complex that self-assembles into nano-sized micelles and also displays a long-lived emissive triplet excited state with a lifetime of 84 μs in degassed water. This amphiphilic Au(III) complex exhibits good biocompatibility and activity towards in vitro photo-toxicity, as well as enhanced permeability and retention effects in vivo.
October 24, 2016: Chemical Communications: Chem Comm
Ching-Yen Tang, Richard T Haasch, Shen J Dillon
The complex nature of Li-ion battery reactions along with their sensitivity to environmental exposure necessitates in situ characterization, particularly for surface sensitive methods. In this work, we demonstrate in situ X-ray photoelectron spectroscopy and in situ Auger electron spectroscopy applied to characterize the evolution of bonding and chemistry during cycling of nanoparticle electrodes. We apply the method to study the conversion reaction associated with Li insertion and extraction from CuO nanoparticle electrodes...
October 24, 2016: Chemical Communications: Chem Comm
Xiaobin Wang, Mingyong Sun, Bo Meng, Xiaoyao Tan, Jian Liu, Shaobin Wang, Shaomin Liu
Herein, we report the in situ synthesis of ZIF-8 membranes on the external surface of asymmetric ZnO-Al2O3 composite hollow fibers. The prepared ZIF-8 hollow fiber membrane exhibits exceeding performance for hydrogen separation and high reproducibility for an easy scale-up.
October 24, 2016: Chemical Communications: Chem Comm
Michael R Dent, Ismael López-Duarte, Callum J Dickson, Phoom Chairatana, Harry L Anderson, Ian R Gould, Douglas Wylie, Aurimas Vyšniauskas, Nicholas J Brooks, Marina K Kuimova
Molecular rotors have emerged as versatile probes of microscopic viscosity in lipid bilayers, although it has proved difficult to find probes that stain both phases equally in phase-separated bilayers. Here, we investigate the use of a membrane-targeting viscosity-sensitive fluorophore based on a thiophene moiety with equal affinity for ordered and disordered lipid domains to probe ordering and viscosity within artificial lipid bilayers and live cell plasma membranes.
October 24, 2016: Chemical Communications: Chem Comm
Rüdiger Bertermann, Holger Braunschweig, Mehmet Ali Celik, Theresa Dellermann, Hauke Kelch
The reaction of the vicinal biscarbenoid Pip-C[triple bond, length as m-dash]C-Pip with dimethyltin dichloride yields a unique tetraamino-substituted cyclobutadienyl system featuring a dative C-Sn interaction. DFT investigation of the reaction mechanism revealed that coordination of the stannyl fragment to the nucleophilic carbon leads to a metal-stabilised zwitterion, allowing for [2+2] cycloaddition under thermal conditions. The compound features a homoaromatic π-system comprising the three sp(2)-hybridised carbon atoms of the four-membered ring as a consequence of charge separation...
October 24, 2016: Chemical Communications: Chem Comm
Yan Duan, Juan M Clemente-Juan, José L G Fierro, Carlos Giménez-Saiz, Eugenio Coronado
Partial reductive hydrolysis of a penta-Co(II/III) cluster [Co(H2O)2(Co(III)W9O34)(PW9O34)](12-) (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2](22-) (2). This polyoxometalate is made up of two capping [PW9O34](9-) units and two bridging [W7O26](10-) units that assemble to encapsulate a novel deca-Co(II) cluster core comprising octahedral and tetrahedral Co(II) ions.
October 24, 2016: Chemical Communications: Chem Comm
Chanderpratap Singh, Nikhil S, Anwesha Jana, Ashish Kumar Mishra, Amit Paul
Correction for 'Proton conduction through oxygen functionalized few-layer graphene' by Chanderpratap Singh et al., Chem. Commun., 2016, 52, 12661-12664.
October 24, 2016: Chemical Communications: Chem Comm
Ruhuai Mei, Cuiju Zhu, Lutz Ackermann
C-H arylations of weakly coordinating benzoic acids were achieved by versatile ruthenium(ii) catalysis with ample substrate scope. Thus, user-friendly ruthenium(ii) biscarboxylate complexes modified with tricyclohexylphosphine enabled C-H functionalizations with aryl electrophiles. The unique versatility of the ruthenium(ii) catalysis manifold was reflected by facilitating effective C-H activations with aryl, alkenyl and alkynyl halides.
October 21, 2016: Chemical Communications: Chem Comm
Mitsuhiro Ueda, Tamami Ueno, Yuki Suyama, Ilhyong Ryu
Treatment of alkynes with o-methoxycarbonylphenylboronic acid in the presence of a cobalt catalyst resulted in the corresponding 2,3-disubstituted indenones in good yields. Excellent regioselectivities were observed, when silyl aryl alkynes were used. The intermediate 3-silyl-2-aryl-substituted indenones were converted to 2,3-diaryl indenones by a three-step protocol involving C-Si bromination and Suzuki-Miyaura coupling reaction.
October 21, 2016: Chemical Communications: Chem Comm
Katharina Duda, Alexander Himmelspach, Johannes Landmann, Florian Kraus, Maik Finze
Deboronation of closo-1,7-C2B10H12 and 1-R(1)-closo-1,2-C2B10H12 (R(1) = Me, Ph) with anhydrous [Me4N]F yields [Me4N][BHF3] that is the first structurally characterized anion of the series [BHxF4-x](-) (x = 1-3). Deboronation of 9,12-R(2)2-closo-1,7-C2B10H12 (R(2) = H, I) gives a mixture of [Me4N][BHF3] and [Me4N][1-HF2B-9,12-R(2)2-closo-1,2-C2B10H9].
October 21, 2016: Chemical Communications: Chem Comm
Qingchun Xia, Yan Liu, Zijian Li, Wei Gong, Yong Cui
A porous Cr(salen)-MOF can serve as an efficient and effective heterogeneous catalyst for a series of important asymmetric transformations including the Nazarov cyclization, aminolysis reaction, and Diels-Alder and hetero Diels-Alder reactions, resulting in comparable or superior diastereo- or enantioselectivity with respect to the corresponding homogeneous systems.
October 21, 2016: Chemical Communications: Chem Comm
Mitsuhiro Ueda, Tsukasa Sakaguchi, Miho Hayama, Takafumi Nakagawa, Yutaka Matsuo, Aiko Munechika, Shunsuke Yoshida, Hiroshi Yasuda, Ilhyong Ryu
The intermolecular [2+2] cycloaddition of allenol esters, which were in situ generated by Pt-catalyzed 1,3-acyloxy migration of propargylic esters, with C60 proceeded regio- and stereo-selectively to give a novel class of alkylidenecyclobutane-annulated fullerenes. The cyclobutane-annulated fullerene derivatives have high-lying LUMO levels, which gave a high open-circuit voltage in organic solar cell applications. The observed high electron mobility provided a good fill factor compared with the PCBM-based devices...
October 21, 2016: Chemical Communications: Chem Comm
Liu-Zhu Yu, Yin Wei, Min Shi
Copper-catalyzed cascade cyclization of 1,5-enynes with two types of hypervalent reagents was developed via consecutive trifluoromethylazidation/diazidation and intramolecular click reaction (CUAAC), providing one-pot self-assembly of triazole fused isoindolines bearing a trifluoromethyl or an azide moiety. Moreover, the construction of a trifluoromethylcyclopropyl unit, which has been considered as a metabolically stable replacement for a tert-butyl moiety and was difficult to access, was also achieved under trifluoromethylazidation conditions...
October 21, 2016: Chemical Communications: Chem Comm
Benjamin Abécassis, D Martin A Buzza, Qijun Song
No abstract text is available yet for this article.
October 21, 2016: Chemical Communications: Chem Comm
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