Bin Liu, Jacob Rodriguez, Landon J Kilgallon, Wencong Wang, Yuyan Wang, Aiden Wang, Yutong Dai, Hung V-T Nguyen, Bradley L Pentelute, Jeremiah A Johnson
Polymer-protein bioconjugation offers a powerful strategy to alter the physical properties of proteins, and various synthetic polymer compositions and architectures have been investigated for this purpose. Nevertheless, conjugation of molecular bottlebrush polymers (BPs) to proteins remains an unsolved challenge due to the large size of BPs and a general lack of methods to transform the chain ends of BPs into functional groups suitable for bioconjugation. Here, we present a strategy to address this challenge in the context of BPs prepared by "graft-through" ring-opening metathesis polymerization (ROMP), one of the most powerful methods for BP synthesis...
March 26, 2024: Chemical Communications: Chem Comm